Apnea Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Lack of breathing with no movement of the respiratory muscles and no exchange of air in the lungs. This term refers to a disposition to have recurrent episodes of apnea rather than to a single event. (Human Phenotype Ontology, HP_0002104)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D001049
Similar Terms
Downloads & Tools

Genes

203 genes/proteins associated with the disease Apnea from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.88009
BCHE butyrylcholinesterase 2.88009
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 2.88009
FOS FBJ murine osteosarcoma viral oncogene homolog 2.29071
TNF tumor necrosis factor 2.23035
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.17479
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.17187
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.1208
MAPK1 mitogen-activated protein kinase 1 2.11294
MAPK3 mitogen-activated protein kinase 3 2.04692
IL6 interleukin 6 2.03394
IL1B interleukin 1, beta 2.02892
CRH corticotropin releasing hormone 2.01883
POMC proopiomelanocortin 1.99322
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.97742
BCL2 B-cell CLL/lymphoma 2 1.91797
EGR1 early growth response 1 1.90804
BAX BCL2-associated X protein 1.87559
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.86907
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.8361
JUN jun proto-oncogene 1.8183
REN renin 1.80661
OPRM1 opioid receptor, mu 1 1.79197
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1.77917
NOS2 nitric oxide synthase 2, inducible 1.76694
BDNF brain-derived neurotrophic factor 1.74321
CAT catalase 1.71952
GSK3B glycogen synthase kinase 3 beta 1.71687
NPY neuropeptide Y 1.71009
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.70886
FAS Fas cell surface death receptor 1.70782
CALCA calcitonin-related polypeptide alpha 1.70574
TP53 tumor protein p53 1.66425
CREB1 cAMP responsive element binding protein 1 1.65974
TH tyrosine hydroxylase 1.64101
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.62893
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.6199
DRD2 dopamine receptor D2 1.60664
CCL2 chemokine (C-C motif) ligand 2 1.60641
CXCL8 chemokine (C-X-C motif) ligand 8 1.59966
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.59311
IL10 interleukin 10 1.58748
ACHE acetylcholinesterase (Yt blood group) 1.5721
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.56632
PENK proenkephalin 1.5619
GFAP glial fibrillary acidic protein 1.55723
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.53892
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.53796
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.5143
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.48479
CCND1 cyclin D1 1.47219
DUSP1 dual specificity phosphatase 1 1.47193
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.46595
IL2 interleukin 2 1.46093
S100B S100 calcium binding protein B 1.45697
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.44927
MPO myeloperoxidase 1.44681
PRL prolactin 1.43482
OPRK1 opioid receptor, kappa 1 1.43076
IFNG interferon, gamma 1.4275
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.42535
NEFH neurofilament, heavy polypeptide 1.42508
ICAM1 intercellular adhesion molecule 1 1.41748
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.41424
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 1.41396
JUNB jun B proto-oncogene 1.41091
CNR1 cannabinoid receptor 1 (brain) 1.40732
VEGFA vascular endothelial growth factor A 1.40064
OPRD1 opioid receptor, delta 1 1.39952
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.39897
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.3917
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.38835
HMOX1 heme oxygenase 1 1.38752
SOD2 superoxide dismutase 2, mitochondrial 1.38752
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.38128
AVP arginine vasopressin 1.37846
EGR2 early growth response 2 1.3759
CES2 carboxylesterase 2 1.36648
CDK4 cyclin-dependent kinase 4 1.36504
TAC1 tachykinin, precursor 1 1.36218
BCL2L1 BCL2-like 1 1.35531
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.34227
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.33966
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.33761
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.33494
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.33375
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.32577
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.32251
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.31596
CYCS cytochrome c, somatic 1.30727
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 1.30421
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.3036
MAOA monoamine oxidase A 1.30269
FGF2 fibroblast growth factor 2 (basic) 1.2895
IL1A interleukin 1, alpha 1.28241
CHRM1 cholinergic receptor, muscarinic 1 1.2821
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.27533
EDN1 endothelin 1 1.27132
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.26669
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.26607
PER1 period circadian clock 1 1.26359
ADORA1 adenosine A1 receptor 1.25713
PRKCD protein kinase C, delta 1.2509
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.24935
SDC4 syndecan 4 1.24718
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.2437
ARC activity-regulated cytoskeleton-associated protein 1.23743
ADCY8 adenylate cyclase 8 (brain) 1.2336
APAF1 apoptotic peptidase activating factor 1 1.22469
VCAM1 vascular cell adhesion molecule 1 1.22436
MAPK14 mitogen-activated protein kinase 14 1.2137
MAPK8 mitogen-activated protein kinase 8 1.21337
PER2 period circadian clock 2 1.21271
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.20913
PDYN prodynorphin 1.20687
TUBA4A tubulin, alpha 4a 1.20097
INS insulin 1.19445
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.18981
PDE4B phosphodiesterase 4B, cAMP-specific 1.1786
SGK1 serum/glucocorticoid regulated kinase 1 1.17662
MCL1 myeloid cell leukemia 1 1.17333
CSNK2A1 casein kinase 2, alpha 1 polypeptide 1.17235
LEP leptin 1.16967
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.16533
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.165
VIP vasoactive intestinal peptide 1.16467
SPP1 secreted phosphoprotein 1 1.16368
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.16104
HOMER1 homer scaffolding protein 1 1.16104
KLHL24 kelch-like family member 24 1.14989
HSPA1A heat shock 70kDa protein 1A 1.14816
OXT oxytocin/neurophysin I prepropeptide 1.14747
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.14575
GNAS GNAS complex locus 1.14268
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 1.14098
PLP1 proteolipid protein 1 1.14064
EGFR epidermal growth factor receptor 1.13724
IL4 interleukin 4 1.13518
SQLE squalene epoxidase 1.13279
EFNA2 ephrin-A2 1.13041
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.11877
RB1 retinoblastoma 1 1.11571
LMO7 LIM domain 7 1.11396
ARRB1 arrestin, beta 1 1.11396
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.1129
ALB albumin 1.11081
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.10977
EFNA1 ephrin-A1 1.10907
PRKCE protein kinase C, epsilon 1.10527
MAOB monoamine oxidase B 1.10317
NGFR nerve growth factor receptor 1.09963
PRKCA protein kinase C, alpha 1.09927
BDKRB2 bradykinin receptor B2 1.09681
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.09436
CYBB cytochrome b-245, beta polypeptide 1.09226
ADRA1A adrenoceptor alpha 1A 1.09083
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 1.09083
ADRA2A adrenoceptor alpha 2A 1.09047
NGF nerve growth factor (beta polypeptide) 1.08975
DUSP6 dual specificity phosphatase 6 1.08797
NPY1R neuropeptide Y receptor Y1 1.08478
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 1.07589
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.07553
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.07269
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.07234
APOE apolipoprotein E 1.07093
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.06987
CLU clusterin 1.06479
XDH xanthine dehydrogenase 1.06479
NPPA natriuretic peptide A 1.06479
TRHR thyrotropin-releasing hormone receptor 1.06261
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 1.06152
BTBD11 BTB (POZ) domain containing 11 1.06152
PRPF38B pre-mRNA processing factor 38B 1.06152
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.05828
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1.05386
CCNG2 cyclin G2 1.05312
CHRM3 cholinergic receptor, muscarinic 3 1.05312
NUPR1 nuclear protein, transcriptional regulator, 1 1.05126
GCK glucokinase (hexokinase 4) 1.05052
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.04978
BTG3 BTG family, member 3 1.04574
E2F1 E2F transcription factor 1 1.04352
CTSB cathepsin B 1.03976
CREM cAMP responsive element modulator 1.03939
ADORA2A adenosine A2a receptor 1.03939
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.03419
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.03345
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.03271
ATM ATM serine/threonine kinase 1.03235
LPL lipoprotein lipase 1.03235
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.03235
CHRM2 cholinergic receptor, muscarinic 2 1.03197
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 1.02708
CXCL10 chemokine (C-X-C motif) ligand 10 1.02522
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.02151
GPRC5B G protein-coupled receptor, class C, group 5, member B 1.01966
CHRM5 cholinergic receptor, muscarinic 5 1.01399
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.01399
IDI1 isopentenyl-diphosphate delta isomerase 1 1.01399
PDE10A phosphodiesterase 10A 1.01324
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 1.01099
CCL3 chemokine (C-C motif) ligand 3 1.01025