Apoptosis - multiple species Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Apoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The major players are caspases, caspase inhibitors, members of the Bcl-2 family of pro- and anti-apoptotic proteins and adaptors of the Ced-4/APAF-1 type. Mammals, by comparison with Caenorhabditis and Drosophila, exhibit highly complex extrinsic and intrinsic pathways for apoptosis induction. However, recent analyses of whole genome sequences from cnidarians (e.g. Hydra) suggest that the caspase and Bcl-2 families were already highly complex in cnidarians and that Caenorhabditis and Drosophila lost many of the genes involved in apoptosis. (Kyoto Encyclopedia of Genes and Genomes, hsa04215)
External Link https://www.kegg.jp/entry/hsa04215
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Genes

32 proteins participating in the Apoptosis - multiple species pathway from the KEGG Pathways 2026 dataset.

Symbol Name
APAF1 apoptotic peptidase activating factor 1
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BECN1 beclin 1, autophagy related
BECN2 beclin 2
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BIRC6 baculoviral IAP repeat containing 6
BIRC7 baculoviral IAP repeat containing 7
BOK BCL2-related ovarian killer
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CYCS cytochrome c, somatic
DIABLO diablo, IAP-binding mitochondrial protein
FADD Fas (TNFRSF6)-associated via death domain
HTRA2 HtrA serine peptidase 2
MAPK10 mitogen-activated protein kinase 10
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
NGFR nerve growth factor receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
SEPTIN4 septin 4
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase