Apoptosis Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
External Link https://www.kegg.jp/entry/hsa04210
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Genes

136 proteins participating in the Apoptosis pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACTG1 actin gamma 1
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
APAF1 apoptotic peptidase activating factor 1
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CFLAR CASP8 and FADD-like apoptosis regulator
CHUK conserved helix-loop-helix ubiquitous kinase
CLSTN1 calsyntenin 1
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSF cathepsin F
CTSH cathepsin H
CTSK cathepsin K
CTSL cathepsin L
CTSO cathepsin O
CTSS cathepsin S
CTSV cathepsin V
CTSW cathepsin W
CTSZ cathepsin Z
CYCS cytochrome c, somatic
DAB2IP DAB2 interacting protein
DAXX death-domain associated protein
DDIT3 DNA-damage-inducible transcript 3
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DIABLO diablo, IAP-binding mitochondrial protein
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ENDOG endonuclease G
ERN1 endoplasmic reticulum to nucleus signaling 1
FADD Fas (TNFRSF6)-associated via death domain
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HRAS Harvey rat sarcoma viral oncogene homolog
HRK harakiri, BCL2 interacting protein
HTRA2 HtrA serine peptidase 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL3 interleukin 3
IL3RA interleukin 3 receptor, alpha (low affinity)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUN jun proto-oncogene
LMNA lamin A/C
LMNB1 lamin B1
LMNB2 lamin B2
LNCEGFL7OS lncRNA EGFL7 opposite strand
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MCL1 myeloid cell leukemia 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGF nerve growth factor (beta polypeptide)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PARP3 poly (ADP-ribose) polymerase family, member 3
PARP4 poly (ADP-ribose) polymerase family, member 4
PDPK1 3-phosphoinositide dependent protein kinase 1
PIDD1 p53-induced death domain protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POTEF POTE ankyrin domain family, member F
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASE3 ribonuclease, RNase A family, 3
SEPTIN4 septin 4
SPTAN1 spectrin, alpha, non-erythrocytic 1
TANK TRAF family member-associated NFKB activator
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
TUBA3E tubulin, alpha 3e
TUBA4A tubulin, alpha 4a
TUBA8 tubulin, alpha 8
TUBAL3 tubulin, alpha-like 3
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF395 zinc finger protein 395