Apoptosome Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms. (Gene Ontology, GO_0043293)
External Link http://amigo.geneontology.org/amigo/term/GO:0043293
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3 proteins localized to the Apoptosome cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
APAF1 apoptotic peptidase activating factor 1 5.0
CASP9 caspase 9, apoptosis-related cysteine peptidase 5.0
CYCS cytochrome c, somatic 3.0