Apoptosome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms. (Gene Ontology, GO_0043293)
External Link http://amigo.geneontology.org/amigo/term/GO:0043293
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Genes

1000 proteins co-occuring with the Apoptosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
APAF1 apoptotic peptidase activating factor 1 4.0
CASP9 caspase 9, apoptosis-related cysteine peptidase 3.882
CYCS cytochrome c, somatic 3.799
CASP3 caspase 3, apoptosis-related cysteine peptidase 3.512
CASP8 caspase 8, apoptosis-related cysteine peptidase 3.442
DIABLO diablo, IAP-binding mitochondrial protein 3.377
BCL2 B-cell CLL/lymphoma 2 3.358
BAX BCL2-associated X protein 3.288
BCL2L1 BCL2-like 1 3.216
CASP7 caspase 7, apoptosis-related cysteine peptidase 3.094
FADD Fas (TNFRSF6)-associated via death domain 3.055
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 3.033
BCL2L11 BCL2-like 11 (apoptosis facilitator) 3.025
MCL1 myeloid cell leukemia 1 2.963
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.952
ENDOG endonuclease G 2.935
FASLG Fas ligand (TNF superfamily, member 6) 2.924
HTRA2 HtrA serine peptidase 2 2.912
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.878
BCL2L2 BCL2-like 2 2.84
TP53 tumor protein p53 2.812
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 2.779
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.779
RTL10 retrotransposon Gag like 10 2.773
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.747
BID BH3 interacting domain death agonist 2.735
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.709
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.708
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 2.697
CFLAR CASP8 and FADD-like apoptosis regulator 2.695
TRADD TNFRSF1A-associated via death domain 2.692
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.672
HRK harakiri, BCL2 interacting protein 2.628
ANXA5 annexin A5 2.584
BIRC2 baculoviral IAP repeat containing 2 2.567
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.547
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.545
TNF tumor necrosis factor 2.532
PARP1 poly (ADP-ribose) polymerase 1 2.53
BBC3 BCL2 binding component 3 2.521
BMF Bcl2 modifying factor 2.517
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.505
BIK BCL2-interacting killer (apoptosis-inducing) 2.5
BAK1 BCL2-antagonist/killer 1 2.5
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.463
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.444
BCL2A1 BCL2-related protein A1 2.423
BIRC5 baculoviral IAP repeat containing 5 2.418
PIDD1 p53-induced death domain protein 1 2.417
RIPK3 receptor-interacting serine-threonine kinase 3 2.415
BOK BCL2-related ovarian killer 2.397
BIRC3 baculoviral IAP repeat containing 3 2.391
MLKL mixed lineage kinase domain-like 2.387
HSPA4 heat shock 70kDa protein 4 2.324
CLSTN1 calsyntenin 1 2.215
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.214
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 2.214
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.213
IL1B interleukin 1, beta 2.205
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.182
JUN jun proto-oncogene 2.181
BECN1 beclin 1, autophagy related 2.18
NLRC4 NLR family, CARD domain containing 4 2.178
NAIP NLR family, apoptosis inhibitory protein 2.176
GSDMD gasdermin D 2.17
PPIF peptidylprolyl isomerase F 2.16
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.158
GSDME gasdermin E 2.14
HSPB1 heat shock 27kDa protein 1 2.127
HSPB2 heat shock 27kDa protein 2 2.125
BIRC7 baculoviral IAP repeat containing 7 2.124
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.117
IL18 interleukin 18 2.113
TCHP trichoplein, keratin filament binding 2.107
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 2.102
HSPB3 heat shock 27kDa protein 3 2.097
NLRP1 NLR family, pyrin domain containing 1 2.089
BAD BCL2-associated agonist of cell death 2.082
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 2.068
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.037
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.032
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.027
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.025
PXDNL peroxidasin-like 2.023
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.011
VDAC1 voltage-dependent anion channel 1 2.007
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.004
AIM2 absent in melanoma 2 1.997
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.993
IL6 interleukin 6 1.991
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.985
MAPK8 mitogen-activated protein kinase 8 1.979
GSDMA gasdermin A 1.974
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.972
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.971
DNTT DNA nucleotidylexotransferase 1.97
CCND1 cyclin D1 1.967
GPX7 glutathione peroxidase 7 1.956
GPX8 glutathione peroxidase 8 (putative) 1.955
GPX3 glutathione peroxidase 3 1.953
GPX2 glutathione peroxidase 2 1.952
GPX6 glutathione peroxidase 6 1.951
GPX5 glutathione peroxidase 5 1.949
NLRP3 NLR family, pyrin domain containing 3 1.943
PTEN phosphatase and tensin homolog 1.94
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.939
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.937
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 1.932
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.922
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.922
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 1.918
ATG5 autophagy related 5 1.899
ANXA8L1 annexin A8-like 1 1.895
CDK2 cyclin-dependent kinase 2 1.895
ULK1 unc-51 like autophagy activating kinase 1 1.869
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.869
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.865
TGFB1 transforming growth factor, beta 1 1.858
IFNG interferon, gamma 1.851
FOXO3 forkhead box O3 1.85
CDK4 cyclin-dependent kinase 4 1.842
MEFV Mediterranean fever 1.839
PYCARD PYD and CARD domain containing 1.837
TANK TRAF family member-associated NFKB activator 1.835
DDIT3 DNA-damage-inducible transcript 3 1.834
EGFR epidermal growth factor receptor 1.834
ATM ATM serine/threonine kinase 1.828
DNM1L dynamin 1-like 1.82
BIRC6 baculoviral IAP repeat containing 6 1.813
ATG7 autophagy related 7 1.809
CDPF1 cysteine-rich, DPF motif domain containing 1 1.808
CCNL2 cyclin L2 1.807
CTSS cathepsin S 1.804
MAPK3 mitogen-activated protein kinase 3 1.802
FBF1 Fas (TNFRSF6) binding factor 1 1.801
GPX4 glutathione peroxidase 4 1.791
TLR4 toll-like receptor 4 1.785
ERN1 endoplasmic reticulum to nucleus signaling 1 1.77
SIRT1 sirtuin 1 1.767
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.765
ATF6 activating transcription factor 6 1.762
CDK1 cyclin-dependent kinase 1 1.762
NFE2L2 nuclear factor, erythroid 2-like 2 1.761
ATG12 autophagy related 12 1.758
HMOX1 heme oxygenase 1 1.756
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.753
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 1.749
ZNF395 zinc finger protein 395 1.748
MMP9 matrix metallopeptidase 9 1.746
CCNB1 cyclin B1 1.744
GSK3B glycogen synthase kinase 3 beta 1.739
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 1.723
CASP14 caspase 14, apoptosis-related cysteine peptidase 1.717
COX4I1 cytochrome c oxidase subunit IV isoform 1 1.716
CHEK1 checkpoint kinase 1 1.713
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.712
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.707
ERBB2 erb-b2 receptor tyrosine kinase 2 1.698
CD8A CD8a molecule 1.697
DIAPH1 diaphanous-related formin 1 1.695
HSPA1B heat shock 70kDa protein 1B 1.691
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.69
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.683
HMGB1 high mobility group box 1 1.682
PINK1 PTEN induced putative kinase 1 1.679
DNAH8 dynein, axonemal, heavy chain 8 1.679
IL1A interleukin 1, alpha 1.676
VDAC2 voltage-dependent anion channel 2 1.676
MFN2 mitofusin 2 1.674
NGF nerve growth factor (beta polypeptide) 1.666
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.659
APIP APAF1 interacting protein 1.655
E2F1 E2F transcription factor 1 1.651
INS insulin 1.65
CD4 CD4 molecule 1.649
IGF1 insulin-like growth factor 1 (somatomedin C) 1.641
CHEK2 checkpoint kinase 2 1.641
PCSK1 proprotein convertase subtilisin/kexin type 1 1.64
IL10 interleukin 10 1.64
EGF epidermal growth factor 1.639
CCNA2 cyclin A2 1.635
ATG3 autophagy related 3 1.633
CCNA1 cyclin A1 1.632
CYLD cylindromatosis (turban tumor syndrome) 1.624
ESR1 estrogen receptor 1 1.624
MCU mitochondrial calcium uniporter 1.622
CREB1 cAMP responsive element binding protein 1 1.621
KEAP1 kelch-like ECH-associated protein 1 1.621
CTSB cathepsin B 1.62
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 1.619
CDK6 cyclin-dependent kinase 6 1.619
DAPK1 death-associated protein kinase 1 1.616
CDKN2A cyclin-dependent kinase inhibitor 2A 1.615
BAG1 BCL2-associated athanogene 1.613
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 1.613
ZBP1 Z-DNA binding protein 1 1.609
GSR glutathione reductase 1.609
RIGI RNA sensor RIG-I 1.608
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 1.605
CARD8 caspase recruitment domain family, member 8 1.603
IFNB1 interferon, beta 1, fibroblast 1.6
MAVS mitochondrial antiviral signaling protein 1.591
MMP2 matrix metallopeptidase 2 1.59
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 1.587
CXCL8 chemokine (C-X-C motif) ligand 8 1.581
HDAC9 histone deacetylase 9 1.577
MFN1 mitofusin 1 1.574
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.568
XDH xanthine dehydrogenase 1.563
TLR3 toll-like receptor 3 1.563
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 1.558
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.558
CHUK conserved helix-loop-helix ubiquitous kinase 1.556
FOXO1 forkhead box O1 1.554
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.552
NGB neuroglobin 1.551
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.542
BCL2L14 BCL2-like 14 (apoptosis facilitator) 1.534
CCL2 chemokine (C-C motif) ligand 2 1.534
HSPA8 heat shock 70kDa protein 8 1.531
MYD88 myeloid differentiation primary response 88 1.529
MAP3K13 mitogen-activated protein kinase kinase kinase 13 1.528
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.528
PGAM5 phosphoglycerate mutase family member 5 1.525
GSDMB gasdermin B 1.523
XBP1 X-box binding protein 1 1.522
NLRP6 NLR family, pyrin domain containing 6 1.518
METAP1 methionyl aminopeptidase 1 1.514
PANX1 pannexin 1 1.511
ATG13 autophagy related 13 1.51
RB1CC1 RB1-inducible coiled-coil 1 1.506
PRKN parkin RBR E3 ubiquitin protein ligase 1.505
SQSTM1 sequestosome 1 1.504
CDKN3 cyclin-dependent kinase inhibitor 3 1.502
BDNF brain-derived neurotrophic factor 1.501
NOD2 nucleotide-binding oligomerization domain containing 2 1.499
JAK2 Janus kinase 2 1.498
NLRP7 NLR family, pyrin domain containing 7 1.498
IRF3 interferon regulatory factor 3 1.496
BCL2L13 BCL2-like 13 (apoptosis facilitator) 1.488
PCNA proliferating cell nuclear antigen 1.484
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.483
ATF4 activating transcription factor 4 1.482
TRIAP1 TP53 regulated inhibitor of apoptosis 1 1.48
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 1.477
DAPK3 death-associated protein kinase 3 1.476
BCL10 B-cell CLL/lymphoma 10 1.476
DAXX death-domain associated protein 1.474
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.473
CARD18 caspase recruitment domain family, member 18 1.473
MAP3K12 mitogen-activated protein kinase kinase kinase 12 1.471
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.466
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.462
XAF1 XIAP associated factor 1 1.459
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.457
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.456
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.456
XKR8 XK, Kell blood group complex subunit-related family, member 8 1.455
IL2 interleukin 2 1.455
GABARAPL1 GABA(A) receptor-associated protein like 1 1.455
NOD1 nucleotide-binding oligomerization domain containing 1 1.451
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.449
CDC25C cell division cycle 25C 1.445
TLR2 toll-like receptor 2 1.441
DAPK2 death-associated protein kinase 2 1.44
CALR calreticulin 1.437
EFS embryonal Fyn-associated substrate 1.437
SOD2 superoxide dismutase 2, mitochondrial 1.436
NLRP12 NLR family, pyrin domain containing 12 1.434
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.432
TRAF1 TNF receptor-associated factor 1 1.431
RIPK2 receptor-interacting serine-threonine kinase 2 1.426
STAT1 signal transducer and activator of transcription 1, 91kDa 1.424
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.423
CGAS cyclic GMP-AMP synthase 1.423
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.42
MAPK1 mitogen-activated protein kinase 1 1.419
DRAM1 DNA-damage regulated autophagy modulator 1 1.414
BCL2L12 BCL2-like 12 (proline rich) 1.412
MFF mitochondrial fission factor 1.412
PTMA prothymosin, alpha 1.409
GSDMC gasdermin C 1.405
GADD45A growth arrest and DNA-damage-inducible, alpha 1.404
EIF3M eukaryotic translation initiation factor 3, subunit M 1.397
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 1.397
TFAM transcription factor A, mitochondrial 1.395
APP amyloid beta (A4) precursor protein 1.392
CD44 CD44 molecule (Indian blood group) 1.392
TXNIP thioredoxin interacting protein 1.389
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 1.389
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.38
ATG14 autophagy related 14 1.374
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 1.374
H2AX H2A.X variant histone 1.372
CTSD cathepsin D 1.371
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.37
PPARG peroxisome proliferator-activated receptor gamma 1.368
FOS FBJ murine osteosarcoma viral oncogene homolog 1.365
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.363
MOAP1 modulator of apoptosis 1 1.362
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.36
CAPN2 calpain 2, (m/II) large subunit 1.356
SOD1 superoxide dismutase 1, soluble 1.355
CD274 CD274 molecule 1.354
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 1.353
MAPK9 mitogen-activated protein kinase 9 1.351
IGF1R insulin-like growth factor 1 receptor 1.35
RNASE3 ribonuclease, RNase A family, 3 1.349
NOX4 NADPH oxidase 4 1.347
NGFR nerve growth factor receptor 1.344
MAP2K1 mitogen-activated protein kinase kinase 1 1.344
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 1.342
MAP2K4 mitogen-activated protein kinase kinase 4 1.331
TMBIM6 transmembrane BAX inhibitor motif containing 6 1.329
SIRT3 sirtuin 3 1.329
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1.328
BRCA1 breast cancer 1, early onset 1.328
MAP1S microtubule-associated protein 1S 1.327
NANOS3 nanos homolog 3 (Drosophila) 1.327
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.326
PPID peptidylprolyl isomerase D 1.324
CALML3 calmodulin-like 3 1.323
PERP PERP, TP53 apoptosis effector 1.322
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.322
KRT18 keratin 18, type I 1.321
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.32
ICAM1 intercellular adhesion molecule 1 1.319
NQO1 NAD(P)H dehydrogenase, quinone 1 1.319
IL4 interleukin 4 1.319
CALML6 calmodulin-like 6 1.317
CALML4 calmodulin-like 4 1.317
CALML5 calmodulin-like 5 1.316
CYBB cytochrome b-245, beta polypeptide 1.315
FN1 fibronectin 1 1.315
IFNA1 interferon, alpha 1 1.308
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.302
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.302
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.301
IFIH1 interferon induced with helicase C domain 1 1.301
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 1.299
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.299
PJVK pejvakin 1.297
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 1.292
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.291
IL3 interleukin 3 1.291
SCIN scinderin 1.288
CD40 CD40 molecule, TNF receptor superfamily member 5 1.288
BCAP31 B-cell receptor-associated protein 31 1.28
AMBRA1 autophagy/beclin-1 regulator 1 1.28
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.276
ELAVL1 ELAV like RNA binding protein 1 1.276
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.273
GSN gelsolin 1.273
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 1.272
AGXT alanine-glyoxylate aminotransferase 1.271
NLRP4 NLR family, pyrin domain containing 4 1.271
TBK1 TANK-binding kinase 1 1.27
PRKCD protein kinase C, delta 1.27
CIAO2A cytosolic iron-sulfur assembly component 2A 1.268
MAP2K3 mitogen-activated protein kinase kinase 3 1.267
ATG10 autophagy related 10 1.265
TLR9 toll-like receptor 9 1.265
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.263
SLTM SAFB-like, transcription modulator 1.262
CDC25A cell division cycle 25A 1.26
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 1.257
MDM4 MDM4, p53 regulator 1.254
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.253
SNAI1 snail family zinc finger 1 1.252
MAP1B microtubule-associated protein 1B 1.249
PKM pyruvate kinase, muscle 1.249
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.247
EDAR ectodysplasin A receptor 1.247
DENR density-regulated protein 1.236
CUL3 cullin 3 1.236
ESR2 estrogen receptor 2 (ER beta) 1.23
MINDY3 MINDY lysine 48 deubiquitinase 3 1.229
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.228
FUNDC1 FUN14 domain containing 1 1.225
EIF4E eukaryotic translation initiation factor 4E 1.223
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.222
ACO1 aconitase 1, soluble 1.22
MPO myeloperoxidase 1.22
UVRAG UV radiation resistance associated 1.22
MAPK14 mitogen-activated protein kinase 14 1.218
EPX eosinophil peroxidase 1.217
PTK2 protein tyrosine kinase 2 1.215
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1.215
HTRA1 HtrA serine peptidase 1 1.215
MAP3K7 mitogen-activated protein kinase kinase kinase 7 1.214
NINJ1 ninjurin 1 1.214
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.214
ATG4D autophagy related 4D, cysteine peptidase 1.213
OMA1 OMA1 zinc metallopeptidase 1.212
STK11 serine/threonine kinase 11 1.211
TFRC transferrin receptor 1.209
HDAC6 histone deacetylase 6 1.207
BAG4 BCL2-associated athanogene 4 1.205
IL17F interleukin 17F 1.204
EP300 E1A binding protein p300 1.201
CD40LG CD40 ligand 1.201
CIITA class II, major histocompatibility complex, transactivator 1.199
IFI16 interferon, gamma-inducible protein 16 1.198
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.198
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 1.198
NWD1 NACHT and WD repeat domain containing 1 1.195
ATG101 autophagy related 101 1.195
IRAK1 interleukin-1 receptor-associated kinase 1 1.195
NOTCH1 notch 1 1.19
TP73 tumor protein p73 1.19
ATF3 activating transcription factor 3 1.189
CAPN1 calpain 1, (mu/I) large subunit 1.189
ACO2 aconitase 2, mitochondrial 1.187
TRAF5 TNF receptor-associated factor 5 1.184
ACHE acetylcholinesterase (Yt blood group) 1.183
ULK2 unc-51 like autophagy activating kinase 2 1.182
NEK7 NIMA-related kinase 7 1.182
KDR kinase insert domain receptor 1.182
CXCR4 chemokine (C-X-C motif) receptor 4 1.181
MED12 mediator complex subunit 12 1.181
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 1.181
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1.181
SH3RF1 SH3 domain containing ring finger 1 1.18
H3C13 H3 clustered histone 13 1.18
ERC2 ELKS/RAB6-interacting/CAST family member 2 1.179
H3-4 H3.4 histone, cluster member 1.179
H3C7 H3 clustered histone 7 1.179
H3-3B H3.3 histone B 1.178
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 1.177
H3-5 H3.5 histone 1.176
H3-7 H3.7 histone (putative) 1.176
IRF1 interferon regulatory factor 1 1.175
HDAC1 histone deacetylase 1 1.174
MT1E metallothionein 1E 1.172
VDAC3 voltage-dependent anion channel 3 1.172
TP53INP1 tumor protein p53 inducible nuclear protein 1 1.171
RNF31 ring finger protein 31 1.171
NANOS1 nanos homolog 1 (Drosophila) 1.171
LTA lymphotoxin alpha 1.171
ACIN1 apoptotic chromatin condensation inducer 1 1.169
MIEF2 mitochondrial elongation factor 2 1.166
AVEN apoptosis, caspase activation inhibitor 1.164
NLRC5 NLR family, CARD domain containing 5 1.163
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 1.162
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1.162
CARD9 caspase recruitment domain family, member 9 1.162
TXNDC9 thioredoxin domain containing 9 1.161
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.16
PTRH2 peptidyl-tRNA hydrolase 2 1.16
NME1 NME/NM23 nucleoside diphosphate kinase 1 1.16
ELANE elastase, neutrophil expressed 1.158
FLT3 fms-related tyrosine kinase 3 1.158
NOX1 NADPH oxidase 1 1.153
PEA15 phosphoprotein enriched in astrocytes 15 1.153
API5 apoptosis inhibitor 5 1.148
NLRX1 NLR family member X1 1.147
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.143
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.143
MYH14 myosin, heavy chain 14, non-muscle 1.143
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.142
TIGAR TP53 induced glycolysis regulatory phosphatase 1.142
ATG4B autophagy related 4B, cysteine peptidase 1.142
PARK7 parkinson protein 7 1.142
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 1.139
MGMT O-6-methylguanine-DNA methyltransferase 1.139
DICER1 dicer 1, ribonuclease type III 1.138
BAG3 BCL2-associated athanogene 3 1.137
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.137
SMDT1 single-pass membrane protein with aspartate-rich tail 1 1.134
CXCL12 chemokine (C-X-C motif) ligand 12 1.133
AGER advanced glycosylation end product-specific receptor 1.13
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 1.13
TERT telomerase reverse transcriptase 1.129
CTRL chymotrypsin-like 1.129
NFE2 nuclear factor, erythroid 2 1.128
ACSL4 acyl-CoA synthetase long-chain family member 4 1.128
TRAF3 TNF receptor-associated factor 3 1.125
IL1R1 interleukin 1 receptor, type I 1.125
JAK1 Janus kinase 1 1.123
TPT1 tumor protein, translationally-controlled 1 1.123
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.121
RB1 retinoblastoma 1 1.121
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 1.119
STAT5A signal transducer and activator of transcription 5A 1.118
RPTOR regulatory associated protein of MTOR, complex 1 1.116
PROM1 prominin 1 1.115
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.113
BECN2 beclin 2 1.112
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 1.111
MIA3 melanoma inhibitory activity family, member 3 1.106
CDK5 cyclin-dependent kinase 5 1.106
SOCS1 suppressor of cytokine signaling 1 1.105
IL15 interleukin 15 1.103
CCL5 chemokine (C-C motif) ligand 5 1.101
BFAR bifunctional apoptosis regulator 1.097
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.097
LGALS4 lectin, galactoside-binding, soluble, 4 1.097
SHARPIN SHANK-associated RH domain interactor 1.096
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.096
PCSK9 proprotein convertase subtilisin/kexin type 9 1.094
CAV1 caveolin 1, caveolae protein, 22kDa 1.094
RHOA ras homolog family member A 1.094
TXN2 thioredoxin 2 1.093
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 1.093
STAT5B signal transducer and activator of transcription 5B 1.092
ALK anaplastic lymphoma receptor tyrosine kinase 1.092
SIVA1 SIVA1, apoptosis-inducing factor 1.091
NLRP14 NLR family, pyrin domain containing 14 1.09
CD34 CD34 molecule 1.09
LGALS3 lectin, galactoside-binding, soluble, 3 1.09
DCXR dicarbonyl/L-xylulose reductase 1.088
SMAD3 SMAD family member 3 1.085
MAP2K7 mitogen-activated protein kinase kinase 7 1.085
ADGRB1 adhesion G protein-coupled receptor B1 1.085
TSC2 tuberous sclerosis 2 1.084
DUSP12 dual specificity phosphatase 12 1.084
TIMP1 TIMP metallopeptidase inhibitor 1 1.083
HOOK2 hook microtubule-tethering protein 2 1.082
MALT1 MALT1 paracaspase 1.081
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 1.081
MAP3K11 mitogen-activated protein kinase kinase kinase 11 1.08
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.08
PLK1 polo-like kinase 1 1.079
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.078
HSPE1 heat shock 10kDa protein 1 1.076
TRIM17 tripartite motif containing 17 1.076
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 1.075
CDC42 cell division cycle 42 1.074
DUOX1 dual oxidase 1 1.071
HRAS Harvey rat sarcoma viral oncogene homolog 1.07
GRAMD4 GRAM domain containing 4 1.07
CANX calnexin 1.069
RAD50 RAD50 homolog (S. cerevisiae) 1.069
CCND2 cyclin D2 1.069
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.066
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.063
CSF3 colony stimulating factor 3 (granulocyte) 1.063
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.063
SYK spleen tyrosine kinase 1.062
WEE1 WEE1 G2 checkpoint kinase 1.061
LMNB1 lamin B1 1.06
PLAT plasminogen activator, tissue 1.059
LOX lysyl oxidase 1.059
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.057
SMAD2 SMAD family member 2 1.056
CD47 CD47 molecule 1.056
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.055
PTPRC protein tyrosine phosphatase, receptor type, C 1.054
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.052
SMAD4 SMAD family member 4 1.052
CDK9 cyclin-dependent kinase 9 1.052
RUBCN rubicon autophagy regulator 1.051
HDAC2 histone deacetylase 2 1.05
MAOA monoamine oxidase A 1.049
MIURF mitochondrial elongation factor 1 upstream open reading frame 1.049
INSR insulin receptor 1.047
BCR breakpoint cluster region 1.046
MAPK7 mitogen-activated protein kinase 7 1.046
ATF5 activating transcription factor 5 1.045
CALCOCO2 calcium binding and coiled-coil domain 2 1.044
SIRT2 sirtuin 2 1.044
PPARA peroxisome proliferator-activated receptor alpha 1.044
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.043
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 1.042
MAP2K6 mitogen-activated protein kinase kinase 6 1.041
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 1.041
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 1.04
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 1.038
IRF7 interferon regulatory factor 7 1.038
FBXO32 F-box protein 32 1.037
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 1.037
TRAF4 TNF receptor-associated factor 4 1.035
AKT3 v-akt murine thymoma viral oncogene homolog 3 1.035
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 1.035
GLB1 galactosidase, beta 1 1.034
TOP2B topoisomerase (DNA) II beta 180kDa 1.034
CD300C CD300c molecule 1.034
MAOB monoamine oxidase B 1.033
SHH sonic hedgehog 1.033
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 1.033
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 1.033
APOE apolipoprotein E 1.032
FGF4 fibroblast growth factor 4 1.029
CXCL10 chemokine (C-X-C motif) ligand 10 1.028
VCAM1 vascular cell adhesion molecule 1 1.026
IRAK4 interleukin-1 receptor-associated kinase 4 1.025
LMNB2 lamin B2 1.024
KLRK1 killer cell lectin-like receptor subfamily K, member 1 1.023
SPTAN1 spectrin, alpha, non-erythrocytic 1 1.021
IL13 interleukin 13 1.02
IGFBP3 insulin-like growth factor binding protein 3 1.02
PARL presenilin associated, rhomboid-like 1.02
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.019
FGF7 fibroblast growth factor 7 1.019
PKN2 protein kinase N2 1.019
RAD9A RAD9 homolog A (S. pombe) 1.018
RHEB Ras homolog enriched in brain 1.018
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 1.018
CREBBP CREB binding protein 1.018
ZEB1 zinc finger E-box binding homeobox 1 1.017
NANOS2 nanos homolog 2 (Drosophila) 1.017
GLRX glutaredoxin (thioltransferase) 1.014
SCARB1 scavenger receptor class B, member 1 1.014
FGF3 fibroblast growth factor 3 1.013
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 1.012
MAPK11 mitogen-activated protein kinase 11 1.007
LEP leptin 1.007
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 1.006
IL33 interleukin 33 1.006
FGF8 fibroblast growth factor 8 (androgen-induced) 1.005
IFT122 intraflagellar transport 122 1.004
FGF9 fibroblast growth factor 9 1.003
PACS2 phosphofurin acidic cluster sorting protein 2 1.003
FGF20 fibroblast growth factor 20 1.003
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 1.002
SARM1 sterile alpha and TIR motif containing 1 1.002
AXL AXL receptor tyrosine kinase 1.002
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.001
MMP1 matrix metallopeptidase 1 1.0
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 1.0
HIPK2 homeodomain interacting protein kinase 2 0.998
FGF16 fibroblast growth factor 16 0.998
IRS1 insulin receptor substrate 1 0.998
TGFA transforming growth factor, alpha 0.997
USP9X ubiquitin specific peptidase 9, X-linked 0.996
XPO1 exportin 1 0.995
TSPO translocator protein (18kDa) 0.995
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.992
PTS 6-pyruvoyltetrahydropterin synthase 0.991
PLAU plasminogen activator, urokinase 0.99
FOXO4 forkhead box O4 0.988
NCF1 neutrophil cytosolic factor 1 0.988
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.987
PGR progesterone receptor 0.986
FGF5 fibroblast growth factor 5 0.986
TFEB transcription factor EB 0.985
AURKB aurora kinase B 0.984
FGF22 fibroblast growth factor 22 0.983
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.983
FGF18 fibroblast growth factor 18 0.982
FGF6 fibroblast growth factor 6 0.982
SOCS3 suppressor of cytokine signaling 3 0.982
BCLAF1 BCL2-associated transcription factor 1 0.981
BRCA2 breast cancer 2, early onset 0.98
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.98
SCARB2 scavenger receptor class B, member 2 0.978
NLRP8 NLR family, pyrin domain containing 8 0.977
FGF17 fibroblast growth factor 17 0.975
RNF144B ring finger protein 144B 0.975
DCK deoxycytidine kinase 0.973
FGF10 fibroblast growth factor 10 0.973
KAT2B K(lysine) acetyltransferase 2B 0.973
NCOA4 nuclear receptor coactivator 4 0.971
LYN LYN proto-oncogene, Src family tyrosine kinase 0.971
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.971
CD86 CD86 molecule 0.97
CD36 CD36 molecule (thrombospondin receptor) 0.97
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.969
DROSHA drosha, ribonuclease type III 0.968
AXIN1 axin 1 0.967
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.967
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 0.967
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.965
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.964
FLT1 fms-related tyrosine kinase 1 0.964
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.963
DAND5 DAN domain family member 5, BMP antagonist 0.963
PRKCB protein kinase C, beta 0.963
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.963
SNAI2 snail family zinc finger 2 0.962
CARD11 caspase recruitment domain family, member 11 0.961
PSEN1 presenilin 1 0.961
CARD6 caspase recruitment domain family, member 6 0.96
FAF1 Fas (TNFRSF6) associated factor 1 0.959
CS citrate synthase 0.956
MARCHF5 membrane associated ring-CH-type finger 5 0.956
GADD45B growth arrest and DNA-damage-inducible, beta 0.954
SESN2 sestrin 2 0.954
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.954
PRKCA protein kinase C, alpha 0.954
DDB2 damage-specific DNA binding protein 2, 48kDa 0.953
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.953
UBE2S ubiquitin-conjugating enzyme E2S 0.952
DNPEP aspartyl aminopeptidase 0.951
IDO1 indoleamine 2,3-dioxygenase 1 0.951
ACE angiotensin I converting enzyme 0.95
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.95
SIRT6 sirtuin 6 0.948
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.946
UBL4A ubiquitin-like 4A 0.945
PECAM1 platelet/endothelial cell adhesion molecule 1 0.945
HNF1A HNF1 homeobox A 0.945
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.942
CD63 CD63 molecule 0.942
GJA1 gap junction protein, alpha 1, 43kDa 0.942
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.941
ALOX15 arachidonate 15-lipoxygenase 0.94
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.94
WNT3 wingless-type MMTV integration site family, member 3 0.939
ADAM17 ADAM metallopeptidase domain 17 0.938
EGR1 early growth response 1 0.938
MERTK MER proto-oncogene, tyrosine kinase 0.938
SOX2 SRY (sex determining region Y)-box 2 0.938
IL5 interleukin 5 0.937
CTSG cathepsin G 0.936
IL7 interleukin 7 0.935
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.935
HMOX2 heme oxygenase 2 0.934
CA9 carbonic anhydrase IX 0.934
CKM creatine kinase, muscle 0.934
CDC37 cell division cycle 37 0.933
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.933
CD28 CD28 molecule 0.931
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.931
SH3GLB1 SH3-domain GRB2-like endophilin B1 0.93
EDN1 endothelin 1 0.93
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.93
KLHL10 kelch-like family member 10 0.929
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 0.929
MICU1 mitochondrial calcium uptake 1 0.927
PAWR PRKC, apoptosis, WT1, regulator 0.924
NBR1 neighbor of BRCA1 gene 1 0.923
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.923
TIMD4 T-cell immunoglobulin and mucin domain containing 4 0.923
UBE3A ubiquitin protein ligase E3A 0.922
CCNI cyclin I 0.922
UXT ubiquitously-expressed, prefoldin-like chaperone 0.921
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.921
TXNRD1 thioredoxin reductase 1 0.921
EFHD2 EF-hand domain family, member D2 0.92
ERCC1 excision repair cross-complementation group 1 0.919
TIMP3 TIMP metallopeptidase inhibitor 3 0.919
TOP2A topoisomerase (DNA) II alpha 170kDa 0.919
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.919
ATP11C ATPase, class VI, type 11C 0.919
CKMT1B creatine kinase, mitochondrial 1B 0.918
FOXO6 forkhead box O6 0.916
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.915
CD19 CD19 molecule 0.915
CXCR2 chemokine (C-X-C motif) receptor 2 0.914
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.911
CCL3 chemokine (C-C motif) ligand 3 0.911
ZUP1 zinc finger containing ubiquitin peptidase 1 0.911
GSTP1 glutathione S-transferase pi 1 0.909
GABARAP GABA(A) receptor-associated protein 0.909
MSH2 mutS homolog 2 0.908
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.907
NLRP13 NLR family, pyrin domain containing 13 0.906
THBS1 thrombospondin 1 0.906
DDIT4 DNA-damage-inducible transcript 4 0.905
RARA retinoic acid receptor, alpha 0.905
GAS6 growth arrest-specific 6 0.905
SEPTIN4 septin 4 0.904
CCNE2 cyclin E2 0.903
OCLN occludin 0.903
RICTOR RPTOR independent companion of MTOR, complex 2 0.902
AHR aryl hydrocarbon receptor 0.902
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.9
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.899
PLEK pleckstrin 0.899
OPTN optineurin 0.898
NLRP10 NLR family, pyrin domain containing 10 0.898
MMP7 matrix metallopeptidase 7 0.897
GCLC glutamate-cysteine ligase, catalytic subunit 0.897
PLEK2 pleckstrin 2 0.897
E2F4 E2F transcription factor 4, p107/p130-binding 0.896
C1D C1D nuclear receptor corepressor 0.895
LAMP1 lysosomal-associated membrane protein 1 0.894
HUS1 HUS1 checkpoint homolog (S. pombe) 0.894
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.893
TJP1 tight junction protein 1 0.893
MRPS7 mitochondrial ribosomal protein S7 0.892
TOMM70 translocase of outer mitochondrial membrane 70 0.892
GSK3A glycogen synthase kinase 3 alpha 0.889
TLR7 toll-like receptor 7 0.889
BCL2L15 BCL2-like 15 0.888
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 0.888
CKB creatine kinase, brain 0.888
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.887
MFGE8 milk fat globule-EGF factor 8 protein 0.886
YBX1 Y box binding protein 1 0.885
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.885
CD70 CD70 molecule 0.885
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 0.884
MAPK13 mitogen-activated protein kinase 13 0.884
SIRT5 sirtuin 5 0.884
LDHA lactate dehydrogenase A 0.884
GLI1 GLI family zinc finger 1 0.884
TRIM39 tripartite motif containing 39 0.884
MMP3 matrix metallopeptidase 3 0.883
SIAH1 siah E3 ubiquitin protein ligase 1 0.881
FOXP3 forkhead box P3 0.881
TOP1 topoisomerase (DNA) I 0.881
NAMPT nicotinamide phosphoribosyltransferase 0.88
GRB2 growth factor receptor-bound protein 2 0.88
SP100 SP100 nuclear antigen 0.879
GBP5 guanylate binding protein 5 0.879
CARD16 caspase recruitment domain family, member 16 0.878
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.878
GLUL glutamate-ammonia ligase 0.877
S100A9 S100 calcium binding protein A9 0.877
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.877
SESN1 sestrin 1 0.876
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.875
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.875
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.875
FKBP8 FK506 binding protein 8, 38kDa 0.875
PDK2 pyruvate dehydrogenase kinase, isozyme 2 0.873
ITCH itchy E3 ubiquitin protein ligase 0.872
NANOG Nanog homeobox 0.872
JMY junction mediating and regulatory protein, p53 cofactor 0.872
TYMS thymidylate synthetase 0.871
HSF1 heat shock transcription factor 1 0.871
POU5F1 POU class 5 homeobox 1 0.871
IMMT inner membrane protein, mitochondrial 0.871
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.87
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.869
MAU2 MAU2 sister chromatid cohesion factor 0.868
ATG4A autophagy related 4A, cysteine peptidase 0.868
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.867
MAPK12 mitogen-activated protein kinase 12 0.867
BCL6 B-cell CLL/lymphoma 6 0.866
REXO2 RNA exonuclease 2 0.866
CD80 CD80 molecule 0.865
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.864
GRID1 glutamate receptor, ionotropic, delta 1 0.864
GFAP glial fibrillary acidic protein 0.863
PYDC2 pyrin domain containing 2 0.863
CHKA choline kinase alpha 0.862
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.861
NRF1 nuclear respiratory factor 1 0.861
TGFBR1 transforming growth factor, beta receptor 1 0.86
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 0.86
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.86
PADI4 peptidyl arginine deiminase, type IV 0.859
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.859
TP53BP1 tumor protein p53 binding protein 1 0.858
LCK LCK proto-oncogene, Src family tyrosine kinase 0.856
TRAT1 T cell receptor associated transmembrane adaptor 1 0.856
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.856
IL22 interleukin 22 0.855
TOP1MT topoisomerase (DNA) I, mitochondrial 0.855
FYN FYN proto-oncogene, Src family tyrosine kinase 0.855
TRAP1 TNF receptor-associated protein 1 0.854
DHODH dihydroorotate dehydrogenase (quinone) 0.853
OTUD5 OTU deubiquitinase 5 0.852
GLS2 glutaminase 2 (liver, mitochondrial) 0.851
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.849
SELE selectin E 0.848
ERBB3 erb-b2 receptor tyrosine kinase 3 0.847
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.846
CSF1 colony stimulating factor 1 (macrophage) 0.846
MITF microphthalmia-associated transcription factor 0.844
RAD17 RAD17 homolog (S. pombe) 0.844
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.843
HSPB6 heat shock protein, alpha-crystallin-related, B6 0.843
CDK7 cyclin-dependent kinase 7 0.842
PLG plasminogen 0.841
PRDX3 peroxiredoxin 3 0.839
ANXA1 annexin A1 0.838
AURKA aurora kinase A 0.835
MBTPS2 membrane-bound transcription factor peptidase, site 2 0.834
H2BC21 H2B clustered histone 21 0.834
CYBA cytochrome b-245, alpha polypeptide 0.832
RARB retinoic acid receptor, beta 0.831
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.831
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.829
SAMD9 sterile alpha motif domain containing 9 0.827
ANO6 anoctamin 6 0.827
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 0.825
CIB1 calcium and integrin binding 1 (calmyrin) 0.824
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.824
PLCG1 phospholipase C, gamma 1 0.823
LY96 lymphocyte antigen 96 0.822
CARD10 caspase recruitment domain family, member 10 0.822
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.821
LAMP2 lysosomal-associated membrane protein 2 0.821
LTF lactotransferrin 0.821
CCN2 cellular communication network factor 2 0.821
TH tyrosine hydroxylase 0.819
GADD45G growth arrest and DNA-damage-inducible, gamma 0.819
SPHK1 sphingosine kinase 1 0.819
PIWIL4 piwi-like RNA-mediated gene silencing 4 0.819
SIRPA signal-regulatory protein alpha 0.818
EIF4A1 eukaryotic translation initiation factor 4A1 0.818
KLF4 Kruppel-like factor 4 (gut) 0.817
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.817
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.816
CTSL cathepsin L 0.815
LCN2 lipocalin 2 0.815
HDAC3 histone deacetylase 3 0.815
CD38 CD38 molecule 0.815
FOXM1 forkhead box M1 0.814
DUOX2 dual oxidase 2 0.814
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.814
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.813
IL32 interleukin 32 0.813
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.813
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.812
GCG glucagon 0.812
BACE1 beta-site APP-cleaving enzyme 1 0.811
PI3 peptidase inhibitor 3, skin-derived 0.809
HSH2D hematopoietic SH2 domain containing 0.809
KRT38 keratin 38, type I 0.808
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.807
SIRT4 sirtuin 4 0.807
PHB2 prohibitin 2 0.807
CCND3 cyclin D3 0.807
MUC1 mucin 1, cell surface associated 0.806
CRYZ crystallin, zeta (quinone reductase) 0.806
CLEC7A C-type lectin domain family 7, member A 0.804
KAT2A K(lysine) acetyltransferase 2A 0.804
EIF4A2 eukaryotic translation initiation factor 4A2 0.804
TRIM26 tripartite motif containing 26 0.803
CENPV centromere protein V 0.803
ERN2 endoplasmic reticulum to nucleus signaling 2 0.803
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.802
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.802
GFER growth factor, augmenter of liver regeneration 0.8
FTH1 ferritin, heavy polypeptide 1 0.8
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.8
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.8
EPAS1 endothelial PAS domain protein 1 0.8
FGF13 fibroblast growth factor 13 0.799
GZMM granzyme M (lymphocyte met-ase 1) 0.799
ALOX5 arachidonate 5-lipoxygenase 0.799
LONP1 lon peptidase 1, mitochondrial 0.798
ATG4C autophagy related 4C, cysteine peptidase 0.798
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.797
CCNE1 cyclin E1 0.797
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.796
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.796
AGO2 argonaute RISC catalytic component 2 0.796
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.796
COMMD3-BMI1 COMMD3-BMI1 readthrough 0.796
DEDD2 death effector domain containing 2 0.796
DPP4 dipeptidyl-peptidase 4 0.796
NTF3 neurotrophin 3 0.795
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.795
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.795
PDPK1 3-phosphoinositide dependent protein kinase 1 0.795
FAM133A family with sequence similarity 133, member A 0.795
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.794
NES nestin 0.794
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.794
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.794
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 0.793
PELI1 pellino E3 ubiquitin protein ligase 1 0.793
IGF2 insulin-like growth factor 2 0.792
SESN3 sestrin 3 0.792
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.792
ERVW-1 endogenous retrovirus group W, member 1 0.792
PRDX1 peroxiredoxin 1 0.791
MB myoglobin 0.79
TLR5 toll-like receptor 5 0.79
HDAC4 histone deacetylase 4 0.789
CXCL2 chemokine (C-X-C motif) ligand 2 0.787
PRELID3A PRELI domain containing 3A 0.787
H2AC20 H2A clustered histone 20 0.787
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 0.786
H2AC19 H2A clustered histone 19 0.786
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 0.785
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.784
C1QBP complement component 1, q subcomponent binding protein 0.783
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 0.783
SPHK2 sphingosine kinase 2 0.783
AIF1 allograft inflammatory factor 1 0.782
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 0.781
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.78
PML promyelocytic leukemia 0.78
CD24 CD24 molecule 0.778
RHOT1 ras homolog family member T1 0.778
CDC25B cell division cycle 25B 0.778
ANG angiogenin, ribonuclease, RNase A family, 5 0.778
MAPT microtubule-associated protein tau 0.777
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.776
SYNGAP1 synaptic Ras GTPase activating protein 1 0.776
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.775
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.774
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 0.774
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.773
ZAR1 zygote arrest 1 0.771
NLRP2B NLR family pyrin domain containing 2B 0.771
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.77
BTK Bruton agammaglobulinemia tyrosine kinase 0.769
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.768
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.768
WWTR1 WW domain containing transcription regulator 1 0.768
FAIM Fas apoptotic inhibitory molecule 0.768
SHISA5 shisa family member 5 0.767
UBA1 ubiquitin-like modifier activating enzyme 1 0.766
SIGMAR1 sigma non-opioid intracellular receptor 1 0.766
XPO5 exportin 5 0.766
JUND jun D proto-oncogene 0.766
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.766
PLK3 polo-like kinase 3 0.765
PRKD1 protein kinase D1 0.764
TIMP2 TIMP metallopeptidase inhibitor 2 0.764
NLRP11 NLR family, pyrin domain containing 11 0.764
H1-0 H1.0 linker histone 0.764