Appendicitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever. (Human Disease Ontology, DOID_8337)
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Genes

250 genes co-occuring with the disease Appendicitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CRP C-reactive protein, pentraxin-related 3.518
IL6 interleukin 6 2.459
ALB albumin 2.424
LRG1 leucine-rich alpha-2-glycoprotein 1 2.42
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.38
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.261
F2 coagulation factor II (thrombin) 2.247
TNF tumor necrosis factor 2.227
CHGA chromogranin A 2.165
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.153
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.152
SYP synaptophysin 2.126
IL1B interleukin 1, beta 2.101
F3 coagulation factor III (thromboplastin, tissue factor) 2.075
KRT20 keratin 20, type I 2.043
CXCL8 chemokine (C-X-C motif) ligand 8 2.026
IL10 interleukin 10 2.011
ACE2 angiotensin I converting enzyme 2 1.982
KRT7 keratin 7, type II 1.96
CD4 CD4 molecule 1.937
CDX2 caudal type homeobox 2 1.913
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.912
MPO myeloperoxidase 1.894
IFNG interferon, gamma 1.846
INS insulin 1.827
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.825
CD34 CD34 molecule 1.824
AFP alpha-fetoprotein 1.809
CSF3 colony stimulating factor 3 (granulocyte) 1.797
MME membrane metallo-endopeptidase 1.785
IL1A interleukin 1, alpha 1.782
CD8A CD8a molecule 1.752
IL17A interleukin 17A 1.744
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.732
MEFV Mediterranean fever 1.731
SST somatostatin 1.729
NPPB natriuretic peptide B 1.722
PTX3 pentraxin 3, long 1.717
ELANE elastase, neutrophil expressed 1.706
NCAM1 neural cell adhesion molecule 1 1.698
LTF lactotransferrin 1.68
IL4 interleukin 4 1.66
SPARCL1 SPARC-like 1 (hevin) 1.654
TLR4 toll-like receptor 4 1.641
ACE angiotensin I converting enzyme 1.637
KNG1 kininogen 1 1.63
CD68 CD68 molecule 1.627
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.625
CKM creatine kinase, muscle 1.613
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.589
CKMT1B creatine kinase, mitochondrial 1B 1.588
IL2 interleukin 2 1.587
CKB creatine kinase, brain 1.586
NOD2 nucleotide-binding oligomerization domain containing 2 1.581
CALB2 calbindin 2 1.579
LBP lipopolysaccharide binding protein 1.574
LCN2 lipocalin 2 1.567
ENO2 enolase 2 (gamma, neuronal) 1.546
AVP arginine vasopressin 1.545
SAA2 serum amyloid A2 1.544
IRF2BP1 interferon regulatory factor 2 binding protein 1 1.539
IFRD2 interferon-related developmental regulator 2 1.517
HP haptoglobin 1.516
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.51
SAA1 serum amyloid A1 1.508
MUC2 mucin 2, oligomeric mucus/gel-forming 1.507
TAC1 tachykinin, precursor 1 1.507
BCL6 B-cell CLL/lymphoma 6 1.503
CD5 CD5 molecule 1.501
TP53 tumor protein p53 1.5
CCL2 chemokine (C-C motif) ligand 2 1.496
KRAS Kirsten rat sarcoma viral oncogene homolog 1.485
IL5 interleukin 5 1.444
S100A9 S100 calcium binding protein A9 1.442
PTPRC protein tyrosine phosphatase, receptor type, C 1.439
ADGRG3 adhesion G protein-coupled receptor G3 1.426
IL13 interleukin 13 1.411
ANO1 anoctamin 1, calcium activated chloride channel 1.41
GCG glucagon 1.409
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 1.408
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.399
DEFA1B defensin, alpha 1B 1.377
CD19 CD19 molecule 1.371
BCL2 B-cell CLL/lymphoma 2 1.369
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.361
TLR2 toll-like receptor 2 1.36
CCL3 chemokine (C-C motif) ligand 3 1.356
VIP vasoactive intestinal peptide 1.354
SMIM20 small integral membrane protein 20 1.353
CD79A CD79a molecule, immunoglobulin-associated alpha 1.343
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.342
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.334
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.332
IL18 interleukin 18 1.331
MMP9 matrix metallopeptidase 9 1.329
GAST gastrin 1.326
JUN jun proto-oncogene 1.325
CTSG cathepsin G 1.321
IL22 interleukin 22 1.318
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.315
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.308
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.302
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.3
MLH1 mutL homolog 1 1.295
TGFB1 transforming growth factor, beta 1 1.291
MUC1 mucin 1, cell surface associated 1.289
IFNA1 interferon, alpha 1 1.289
PLAT plasminogen activator, tissue 1.287
PAX8 paired box 8 1.286
PADI4 peptidyl arginine deiminase, type IV 1.275
POMC proopiomelanocortin 1.274
JAK2 Janus kinase 2 1.272
PLG plasminogen 1.271
SPN sialophorin 1.269
S100A8 S100 calcium binding protein A8 1.267
FABP2 fatty acid binding protein 2, intestinal 1.266
CXCL10 chemokine (C-X-C motif) ligand 10 1.263
REN renin 1.259
PITX2 paired-like homeodomain 2 1.251
ESR1 estrogen receptor 1 1.248
PAX5 paired box 5 1.245
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.24
HMGB1 high mobility group box 1 1.234
WT1 Wilms tumor 1 1.23
MSH6 mutS homolog 6 1.23
PECAM1 platelet/endothelial cell adhesion molecule 1 1.222
IFNB1 interferon, beta 1, fibroblast 1.22
ALK anaplastic lymphoma receptor tyrosine kinase 1.216
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.214
PRTN3 proteinase 3 1.214
GNAS GNAS complex locus 1.212
OCLN occludin 1.207
CCL20 chemokine (C-C motif) ligand 20 1.207
VWF von Willebrand factor 1.206
ICAM1 intercellular adhesion molecule 1 1.202
MYD88 myeloid differentiation primary response 88 1.199
MSH2 mutS homolog 2 1.199
PXDN peroxidasin 1.198
TMPRSS2 transmembrane protease, serine 2 1.197
DNAH12 dynein, axonemal, heavy chain 12 1.196
SAA4 serum amyloid A4, constitutive 1.195
PXDNL peroxidasin-like 1.194
KLKB1 kallikrein B, plasma (Fletcher factor) 1 1.193
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 1.192
NLRP3 NLR family, pyrin domain containing 3 1.19
IL1RN interleukin 1 receptor antagonist 1.189
PGR progesterone receptor 1.188
REG3G regenerating islet-derived 3 gamma 1.182
FOXP3 forkhead box P3 1.177
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.177
ORM1 orosomucoid 1 1.174
UBAC1 UBA domain containing 1 1.174
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.173
F12 coagulation factor XII (Hageman factor) 1.17
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 1.167
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.166
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.165
APP amyloid beta (A4) precursor protein 1.157
SDC1 syndecan 1 1.156
ADA adenosine deaminase 1.151
C4A complement component 4A (Rodgers blood group) 1.149
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.148
REG1A regenerating islet-derived 1 alpha 1.147
CAMP cathelicidin antimicrobial peptide 1.145
CD274 CD274 molecule 1.144
TTR transthyretin 1.144
MVK mevalonate kinase 1.141
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.14
HMBS hydroxymethylbilane synthase 1.14
VCAM1 vascular cell adhesion molecule 1 1.139
MEN1 multiple endocrine neoplasia I 1.135
TJP1 tight junction protein 1 1.133
DNTT DNA nucleotidylexotransferase 1.126
JAK1 Janus kinase 1 1.121
TYK2 tyrosine kinase 2 1.119
SELE selectin E 1.116
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.116
PPY pancreatic polypeptide 1.112
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 1.111
PF4 platelet factor 4 1.104
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.104
THBD thrombomodulin 1.104
CCL11 chemokine (C-C motif) ligand 11 1.098
C3 complement component 3 1.096
ADM adrenomedullin 1.095
SCUBE1 signal peptide, CUB domain, EGF-like 1 1.095
IL9 interleukin 9 1.093
ACTB actin, beta 1.092
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.091
JAK3 Janus kinase 3 1.09
FFAR2 free fatty acid receptor 2 1.09
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 1.089
S100A12 S100 calcium binding protein A12 1.086
RFTN1 raftlin, lipid raft linker 1 1.086
MMP8 matrix metallopeptidase 8 1.081
EGFR epidermal growth factor receptor 1.078
CD40LG CD40 ligand 1.078
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.078
IL7 interleukin 7 1.076
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.074
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.071
DPP4 dipeptidyl-peptidase 4 1.071
ERBB2 erb-b2 receptor tyrosine kinase 2 1.07
MUC6 mucin 6, oligomeric mucus/gel-forming 1.068
F8 coagulation factor VIII, procoagulant component 1.066
CCL4 chemokine (C-C motif) ligand 4 1.066
IFI35 interferon-induced protein 35 1.065
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.065
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.064
FNDC5 fibronectin type III domain containing 5 1.063
HAMP hepcidin antimicrobial peptide 1.061
DNAH3 dynein, axonemal, heavy chain 3 1.06
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.059
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 1.057
INKA1 inka box actin regulator 1 1.057
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.052
NF1 neurofibromin 1 1.051
TGM2 transglutaminase 2 1.046
DEFA3 defensin, alpha 3, neutrophil-specific 1.046
ACR acrosin 1.044
CCND1 cyclin D1 1.04
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.038
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 1.038
C4B complement component 4B (Chido blood group) 1.038
IGF1 insulin-like growth factor 1 (somatomedin C) 1.037
H3C12 H3 clustered histone 12 1.035
PRL prolactin 1.034
PTH parathyroid hormone 1.032
SAA2-SAA4 SAA2-SAA4 readthrough 1.03
SSTR2 somatostatin receptor 2 1.026
TIGIT T cell immunoreceptor with Ig and ITIM domains 1.025
CD38 CD38 molecule 1.024
MAGED2 melanoma antigen family D2 1.024
H3-5 H3.5 histone 1.024
H3-4 H3.4 histone, cluster member 1.023
CD28 CD28 molecule 1.023
PDPN podoplanin 1.022
TLR5 toll-like receptor 5 1.017
LEP leptin 1.017
FN1 fibronectin 1 1.017
H3-3B H3.3 histone B 1.016
NAP1L1 nucleosome assembly protein 1-like 1 1.014
H3C13 H3 clustered histone 13 1.012
PLAU plasminogen activator, urokinase 1.012
IL15 interleukin 15 1.009
IFNA2 interferon, alpha 2 1.007
GHRL ghrelin/obestatin prepropeptide 1.006
DEFB4A defensin, beta 4A 1.004
TLR9 toll-like receptor 9 1.002
CXCR1 chemokine (C-X-C motif) receptor 1 1.001