Apraxia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities. (Human Disease Ontology, DOID_0060135)
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Genes

331 genes co-occuring with the disease Apraxia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
APTX aprataxin 3.009
TARDBP TAR DNA binding protein 3.003
MAPT microtubule-associated protein tau 2.97
GRN granulin 2.799
C9ORF72 chromosome 9 open reading frame 72 2.723
SETX senataxin 2.647
PSEN1 presenilin 1 2.572
FOXP2 forkhead box P2 2.56
APP amyloid beta (A4) precursor protein 2.555
PSEN2 presenilin 2 2.513
MECP2 methyl CpG binding protein 2 2.458
CHMP2B charged multivesicular body protein 2B 2.451
PRNP prion protein 2.449
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.448
APOE apolipoprotein E 2.436
FUS FUS RNA binding protein 2.382
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.308
VCP valosin containing protein 2.218
PNKP polynucleotide kinase 3'-phosphatase 2.18
BCHE butyrylcholinesterase 2.151
TDP1 tyrosyl-DNA phosphodiesterase 1 2.139
CNTNAP2 contactin associated protein-like 2 2.061
ACHE acetylcholinesterase (Yt blood group) 2.024
NEFL neurofilament, light polypeptide 1.979
AHI1 Abelson helper integration site 1 1.964
NPHP1 nephronophthisis 1 (juvenile) 1.96
CDKL5 cyclin-dependent kinase-like 5 1.96
MOBP myelin-associated oligodendrocyte basic protein 1.946
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 1.945
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 1.889
LRRK2 leucine-rich repeat kinase 2 1.88
BDNF brain-derived neurotrophic factor 1.873
TMEM67 transmembrane protein 67 1.872
CC2D2A coiled-coil and C2 domain containing 2A 1.843
MAOB monoamine oxidase B 1.827
RD3 retinal degeneration 3 1.826
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 1.82
PNMA2 paraneoplastic Ma antigen 2 1.817
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.811
LGI1 leucine-rich, glioma inactivated 1 1.808
TREM2 triggering receptor expressed on myeloid cells 2 1.782
TXNDC9 thioredoxin domain containing 9 1.768
BACE1 beta-site APP-cleaving enzyme 1 1.762
BIN1 bridging integrator 1 1.752
SFTPC surfactant protein C 1.738
FOXG1 forkhead box G1 1.721
ATM ATM serine/threonine kinase 1.71
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 1.709
DPP6 dipeptidyl-peptidase 6 1.706
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 1.694
CHD1 chromodomain helicase DNA binding protein 1 1.692
TMEM106B transmembrane protein 106B 1.687
ATP13A2 ATPase type 13A2 1.684
RPGRIP1L RPGRIP1-like 1.682
LAMA1 laminin, alpha 1 1.682
UBQLN2 ubiquilin 2 1.67
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 1.655
DCTN1 dynactin 1 1.651
POLG polymerase (DNA directed), gamma 1.647
CEP290 centrosomal protein 290kDa 1.646
CP ceruloplasmin (ferroxidase) 1.639
DPP10 dipeptidyl-peptidase 10 (non-functional) 1.638
AMPH amphiphysin 1.635
FMR1 fragile X mental retardation 1 1.633
KITLG KIT ligand 1.621
PRKN parkin RBR E3 ubiquitin protein ligase 1.62
TCTN1 tectonic family member 1 1.617
ZIC4 Zic family member 4 1.614
ATXN2 ataxin 2 1.603
AFP alpha-fetoprotein 1.602
PHF1 PHD finger protein 1 1.602
HTT huntingtin 1.601
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 1.588
STX6 syntaxin 6 1.579
TMEM216 transmembrane protein 216 1.575
IGLON5 IgLON family member 5 1.574
DPYSL5 dihydropyrimidinase-like 5 1.572
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.571
GFAP glial fibrillary acidic protein 1.563
RBM8A RNA binding motif protein 8A 1.553
KIAA0586 KIAA0586 1.538
FAM149B1 family with sequence similarity 149, member B1 1.537
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 1.535
CSF1R colony stimulating factor 1 receptor 1.529
ATXN7 ataxin 7 1.516
ALB albumin 1.514
CHD3 chromodomain helicase DNA binding protein 3 1.508
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 1.508
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 1.506
PINK1 PTEN induced putative kinase 1 1.505
SOD1 superoxide dismutase 1, soluble 1.505
KIAA0319 KIAA0319 1.504
NOTCH3 notch 3 1.496
MBP myelin basic protein 1.491
DNAAF4 dynein axonemal assembly factor 4 1.489
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 1.487
THAP1 THAP domain containing, apoptosis associated protein 1 1.484
TBK1 TANK-binding kinase 1 1.482
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.477
IL6 interleukin 6 1.477
OFD1 oral-facial-digital syndrome 1 1.476
NPC2 Niemann-Pick disease, type C2 1.471
MAOA monoamine oxidase A 1.47
GATAD2B GATA zinc finger domain containing 2B 1.465
CRP C-reactive protein, pentraxin-related 1.456
PARK7 parkinson protein 7 1.451
PANK2 pantothenate kinase 2 1.451
TMEM237 transmembrane protein 237 1.45
CHAT choline O-acetyltransferase 1.447
TCTN2 tectonic family member 2 1.446
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 1.442
TOR1A torsin family 1, member A (torsin A) 1.439
TCTN3 tectonic family member 3 1.436
H1-2 H1.2 linker histone, cluster member 1.434
ENO2 enolase 2 (gamma, neuronal) 1.425
CIZ1 CDKN1A interacting zinc finger protein 1 1.423
MOG myelin oligodendrocyte glycoprotein 1.422
LIG3 ligase III, DNA, ATP-dependent 1.419
SQSTM1 sequestosome 1 1.418
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.416
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 1.413
FXN frataxin 1.413
COQ8A coenzyme Q8A 1.412
FOXP1 forkhead box P1 1.412
S100B S100 calcium binding protein B 1.41
CKM creatine kinase, muscle 1.409
SUFU suppressor of fused homolog (Drosophila) 1.406
CD19 CD19 molecule 1.399
CTSF cathepsin F 1.397
SRPX2 sushi-repeat containing protein, X-linked 2 1.396
ACE angiotensin I converting enzyme 1.396
TBP TATA box binding protein 1.395
DCDC2 doublecortin domain containing 2 1.395
ERC1 ELKS/RAB6-interacting/CAST family member 1 1.393
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 1.392
CKB creatine kinase, brain 1.387
OPTN optineurin 1.384
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.383
KIF7 kinesin family member 7 1.383
CKMT1B creatine kinase, mitochondrial 1B 1.382
IL1B interleukin 1, beta 1.381
CEP120 centrosomal protein 120kDa 1.378
NPC1 Niemann-Pick disease, type C1 1.378
CHD4 chromodomain helicase DNA binding protein 4 1.374
CELF5 CUGBP, Elav-like family member 5 1.36
OSTF1 osteoclast stimulating factor 1 1.357
MKS1 Meckel syndrome, type 1 1.356
NRXN1 neurexin 1 1.355
CA4 carbonic anhydrase IV 1.349
NPHP4 nephronophthisis 4 1.348
CHD8 chromodomain helicase DNA binding protein 8 1.328
FBXO7 F-box protein 7 1.323
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 1.322
LRRC4C leucine rich repeat containing 4C 1.321
IGHMBP2 immunoglobulin mu binding protein 2 1.315
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1.313
SOX1 SRY (sex determining region Y)-box 1 1.304
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 1.302
B9D2 B9 protein domain 2 1.296
TNF tumor necrosis factor 1.291
CNTNAP5 contactin associated protein-like 5 1.29
FAM221A family with sequence similarity 221, member A 1.282
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 1.276
DLG4 discs, large homolog 4 (Drosophila) 1.275
PLAT plasminogen activator, tissue 1.274
P4HB prolyl 4-hydroxylase, beta polypeptide 1.272
TH tyrosine hydroxylase 1.267
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 1.267
BRAT1 BRCA1-associated ATM activator 1 1.265
NRGN neurogranin (protein kinase C substrate, RC3) 1.263
LRTM2 leucine-rich repeats and transmembrane domains 2 1.261
OR6P1 olfactory receptor, family 6, subfamily P, member 1 1.259
NFXL1 nuclear transcription factor, X-box binding-like 1 1.259
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 1.258
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.258
MRS2 MRS2 magnesium transporter 1.257
CDK5 cyclin-dependent kinase 5 1.256
FIG4 FIG4 phosphoinositide 5-phosphatase 1.254
OR8J3 olfactory receptor, family 8, subfamily J, member 3 1.252
TRIM8 tripartite motif containing 8 1.25
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.247
OR5T2 olfactory receptor, family 5, subfamily T, member 2 1.239
SPG11 spastic paraplegia 11 (autosomal recessive) 1.238
SLF1 SMC5-SMC6 complex localization factor 1 1.237
SYNJ1 synaptojanin 1 1.237
DSCAML1 Down syndrome cell adhesion molecule like 1 1.234
MROH8 maestro heat-like repeat family member 8 1.231
NRXN2 neurexin 2 1.229
STXBP1 syntaxin binding protein 1 1.225
RCVRN recoverin 1.224
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.224
RTN4 reticulon 4 1.223
AARS2 alanyl-tRNA synthetase 2, mitochondrial 1.22
CD4 CD4 molecule 1.218
ARL13B ADP-ribosylation factor-like 13B 1.216
CNTNAP1 contactin associated protein 1 1.215
TMEM138 transmembrane protein 138 1.212
SIGMAR1 sigma non-opioid intracellular receptor 1 1.211
ARMC9 armadillo repeat containing 9 1.209
NGF nerve growth factor (beta polypeptide) 1.207
ELP4 elongator acetyltransferase complex subunit 4 1.207
SHANK3 SH3 and multiple ankyrin repeat domains 3 1.204
PIF1 PIF1 5'-to-3' DNA helicase 1.2
ADCY5 adenylate cyclase 5 1.2
TOP1 topoisomerase (DNA) I 1.199
FEN1 flap structure-specific endonuclease 1 1.197
INS insulin 1.19
OR52B2 olfactory receptor, family 52, subfamily B, member 2 1.189
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.187
INA internexin neuronal intermediate filament protein, alpha 1.186
GSK3B glycogen synthase kinase 3 beta 1.185
ITK IL2-inducible T-cell kinase 1.183
FA2H fatty acid 2-hydroxylase 1.179
SMAD9 SMAD family member 9 1.179
PVALB parvalbumin 1.178
ATP7B ATPase, Cu++ transporting, beta polypeptide 1.177
SNCB synuclein, beta 1.177
SCN1A sodium channel, voltage gated, type I alpha subunit 1.176
CYREN cell cycle regulator of NHEJ 1.168
NBN nibrin 1.168
CALB1 calbindin 1, 28kDa 1.167
ANO3 anoctamin 3 1.167
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 1.167
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 1.165
NEU2 sialidase 2 (cytosolic sialidase) 1.163
RGMB repulsive guidance molecule family member b 1.157
AK5 adenylate kinase 5 1.156
TMEM215 transmembrane protein 215 1.153
DRD2 dopamine receptor D2 1.151
KIF1C-AS1 KIF1C antisense RNA 1 1.147
SETBP1 SET binding protein 1 1.145
COMT catechol-O-methyltransferase 1.142
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.141
CDR2 cerebellar degeneration-related protein 2, 62kDa 1.139
AUTS2 autism susceptibility candidate 2 1.138
DNAH8 dynein, axonemal, heavy chain 8 1.136
GALC galactosylceramidase 1.135
ZNF182 zinc finger protein 182 1.134
OR8I2 olfactory receptor, family 8, subfamily I, member 2 1.133
TOR2A torsin family 2, member A 1.132
PICALM phosphatidylinositol binding clathrin assembly protein 1.131
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1.13
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 1.129
ZNF212 zinc finger protein 212 1.128
FAM222A family with sequence similarity 222, member A 1.128
ZHX2 zinc fingers and homeoboxes 2 1.126
IFT74 intraflagellar transport 74 1.125
LIG4 ligase IV, DNA, ATP-dependent 1.124
CLU clusterin 1.117
DNER delta/notch-like EGF repeat containing 1.116
RAD50 RAD50 homolog (S. cerevisiae) 1.115
C19ORF12 chromosome 19 open reading frame 12 1.114
CNTN4 contactin 4 1.11
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 1.109
CREB1 cAMP responsive element binding protein 1 1.108
NGLY1 N-glycanase 1 1.108
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.107
UBE3A ubiquitin protein ligase E3A 1.106
OGG1 8-oxoguanine DNA glycosylase 1.106
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 1.103
GRID2 glutamate receptor, ionotropic, delta 2 1.102
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 1.101
THOC2 THO complex 2 1.099
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 1.096
PPP1R3C protein phosphatase 1, regulatory subunit 3C 1.095
SYP synaptophysin 1.093
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.093
KLK4 kallikrein-related peptidase 4 1.092
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 1.092
PKNOX2 PBX/knotted 1 homeobox 2 1.091
NEFH neurofilament, heavy polypeptide 1.081
ATN1 atrophin 1 1.076
IL10 interleukin 10 1.074
INTS9 integrator complex subunit 9 1.073
NOP56 NOP56 ribonucleoprotein 1.071
ITM2B integral membrane protein 2B 1.07
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 1.07
XPA xeroderma pigmentosum, complementation group A 1.069
KIF13B kinesin family member 13B 1.064
NHEJ1 nonhomologous end-joining factor 1 1.063
CD68 CD68 molecule 1.061
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 1.061
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 1.059
CBS cystathionine-beta-synthase 1.058
SPAST spastin 1.057
ATXN3 ataxin 3 1.055
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.054
NKRF NFKB repressing factor 1.053
AIF1 allograft inflammatory factor 1 1.051
WASHC4 WASH complex subunit 4 1.049
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.048
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.048
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 1.045
ATXN1 ataxin 1 1.045
CD8A CD8a molecule 1.042
TYROBP TYRO protein tyrosine kinase binding protein 1.041
F3 coagulation factor III (thromboplastin, tissue factor) 1.04
ATXN10 ataxin 10 1.037
CCL2 chemokine (C-C motif) ligand 2 1.033
CCNF cyclin F 1.033
CELF4 CUGBP, Elav-like family member 4 1.032
KATNAL2 katanin p60 subunit A-like 2 1.031
GALT galactose-1-phosphate uridylyltransferase 1.031
IQCB1 IQ motif containing B1 1.03
DOCK6 dedicator of cytokinesis 6 1.03
CPZ carboxypeptidase Z 1.028
SACS sacsin molecular chaperone 1.025
DCP1B decapping mRNA 1B 1.025
ATP13A4 ATPase type 13A4 1.025
SGCE sarcoglycan, epsilon 1.024
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.023
CMIP c-Maf inducing protein 1.023
SHANK2 SH3 and multiple ankyrin repeat domains 2 1.021
NTNG1 netrin G1 1.021
IL1A interleukin 1, alpha 1.02
GBE1 glucan (1,4-alpha-), branching enzyme 1 1.018
IGF1 insulin-like growth factor 1 (somatomedin C) 1.018
C2CD3 C2 calcium-dependent domain containing 3 1.018
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.017
MLX MLX, MAX dimerization protein 1.016
SCN2A sodium channel, voltage gated, type II alpha subunit 1.015
DOCK4 dedicator of cytokinesis 4 1.015
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 1.014
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 1.009
NEIL1 nei endonuclease VIII-like 1 (E. coli) 1.008
NCSTN nicastrin 1.008
IQSEC2 IQ motif and Sec7 domain 2 1.007
IFNG interferon, gamma 1.006
TSPO translocator protein (18kDa) 1.003
DPY19L1 dpy-19-like 1 (C. elegans) 1.002
TMEM231 transmembrane protein 231 1.0