| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135413536 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Aprepitant relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABHD2 | abhydrolase domain containing 2 | 1.91 |
| PIP | prolactin-induced protein | 1.36 |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | 0.91 |
| ERICH5 | glutamate-rich 5 | 0.82 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | 0.77 |
| PRELID3B | PRELI domain containing 3B | 0.77 |
| SMIM26 | small integral membrane protein 26 | 0.74 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.74 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.73 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | 0.72 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.72 |
| ZBTB12 | zinc finger and BTB domain containing 12 | 0.7 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.68 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.68 |
| LOXL2 | lysyl oxidase-like 2 | 0.67 |
| MID1IP1 | MID1 interacting protein 1 | 0.65 |
| E2F8 | E2F transcription factor 8 | 0.63 |
| PLEKHG6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | 0.62 |
| GON7 | GON7 subunit of KEOPS complex | 0.62 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.6 |
| ZHX3 | zinc fingers and homeoboxes 3 | 0.6 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.57 |
| MCL1 | myeloid cell leukemia 1 | 0.56 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.54 |
| IL10RB | interleukin 10 receptor, beta | 0.54 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.54 |
| PPP1R2B | PPP1R2 family member B | 0.53 |
| KSR2 | kinase suppressor of ras 2 | 0.51 |
| XTBD1 | XRN2 binding domain containing 1 | 0.51 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.51 |
| AMOT | angiomotin | 0.51 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | 0.51 |
| CHRD | chordin | 0.5 |
| MIEN1 | migration and invasion enhancer 1 | 0.49 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.48 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.47 |
| ZNF77 | zinc finger protein 77 | 0.46 |
| PFDN4 | prefoldin subunit 4 | 0.45 |
| IQCG | IQ motif containing G | 0.45 |
| UBQLN2 | ubiquilin 2 | 0.45 |
| H1-0 | H1.0 linker histone | 0.45 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | 0.44 |
| OAF | OAF homolog (Drosophila) | 0.44 |
| FRK | fyn-related Src family tyrosine kinase | 0.44 |
| MED8 | mediator complex subunit 8 | 0.44 |
| AGRN | agrin | 0.44 |
| TP53 | tumor protein p53 | 0.44 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.44 |
| LPIN1 | lipin 1 | 0.43 |
| SGTB | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta | 0.43 |
| ZNF511 | zinc finger protein 511 | 0.43 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | 0.42 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | 0.42 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.42 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | 0.41 |
| PEX19 | peroxisomal biogenesis factor 19 | 0.41 |
| FRRS1 | ferric-chelate reductase 1 | 0.4 |
| ZC3HAV1L | zinc finger CCCH-type, antiviral 1-like | 0.39 |
| KLHL25 | kelch-like family member 25 | 0.39 |
| COL1A1 | collagen, type I, alpha 1 | 0.39 |
| NOMO1 | NODAL modulator 1 | 0.39 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | 0.39 |
| HYKK | hydroxylysine kinase | 0.39 |
| DPP4 | dipeptidyl-peptidase 4 | 0.39 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.39 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | 0.38 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.38 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.38 |
| TMSB10 | thymosin beta 10 | 0.38 |
| HSH2D | hematopoietic SH2 domain containing | 0.38 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.38 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | 0.37 |
| TP73 | tumor protein p73 | 0.37 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.37 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.37 |
| ZNF692 | zinc finger protein 692 | 0.37 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 0.36 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.36 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.36 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.36 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.36 |
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 | 0.36 |
| BAG3 | BCL2-associated athanogene 3 | 0.36 |
| TMEM98 | transmembrane protein 98 | 0.35 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.35 |
| MED10 | mediator complex subunit 10 | 0.35 |
| JAG1 | jagged 1 | 0.35 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 0.35 |
| PLAUR | plasminogen activator, urokinase receptor | 0.35 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.35 |
| MYL6B | myosin, light chain 6B, alkali, smooth muscle and non-muscle | 0.35 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.34 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.34 |
| LYPLA2 | lysophospholipase II | 0.34 |
| KLHL23 | kelch-like family member 23 | 0.34 |
| FHIT | fragile histidine triad | 0.34 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.34 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.34 |
| LDLR | low density lipoprotein receptor | 0.34 |
| IRF9 | interferon regulatory factor 9 | 0.34 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTPRB | protein tyrosine phosphatase, receptor type, B | -2.52 |
| LRRC46 | leucine rich repeat containing 46 | -2.37 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | -1.49 |
| THAP9 | THAP domain containing 9 | -1.42 |
| DNM1L | dynamin 1-like | -1.07 |
| KLHL29 | kelch-like family member 29 | -1.06 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.03 |
| SH2B2 | SH2B adaptor protein 2 | -0.92 |
| NF1 | neurofibromin 1 | -0.84 |
| TMEM260 | transmembrane protein 260 | -0.81 |
| ANKLE1 | ankyrin repeat and LEM domain containing 1 | -0.8 |
| ATG10 | autophagy related 10 | -0.78 |
| ENO1 | enolase 1, (alpha) | -0.77 |
| MUC16 | mucin 16, cell surface associated | -0.74 |
| ZNF653 | zinc finger protein 653 | -0.73 |
| ANKRD26 | ankyrin repeat domain 26 | -0.71 |
| YBX3 | Y box binding protein 3 | -0.69 |
| OTC | ornithine carbamoyltransferase | -0.68 |
| TMEM97 | transmembrane protein 97 | -0.65 |
| NMU | neuromedin U | -0.64 |
| FMNL3 | formin-like 3 | -0.63 |
| NEB | nebulin | -0.61 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | -0.59 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.59 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.58 |
| ANKRD13D | ankyrin repeat domain 13 family, member D | -0.56 |
| UBE2Q2 | ubiquitin-conjugating enzyme E2Q family member 2 | -0.54 |
| SLC35F3 | solute carrier family 35, member F3 | -0.54 |
| STC2 | stanniocalcin 2 | -0.54 |
| FAR1 | fatty acyl CoA reductase 1 | -0.53 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.52 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.51 |
| CAPN6 | calpain 6 | -0.49 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.49 |
| RNF145 | ring finger protein 145 | -0.49 |
| COQ2 | coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | -0.48 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.48 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.48 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | -0.46 |
| RMI2 | RecQ mediated genome instability 2 | -0.45 |
| SP140L | SP140 nuclear body protein-like | -0.44 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.44 |
| GPC1 | glypican 1 | -0.43 |
| ATP13A2 | ATPase type 13A2 | -0.43 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | -0.42 |
| FGF2 | fibroblast growth factor 2 (basic) | -0.42 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.42 |
| KMT5A | lysine methyltransferase 5A | -0.42 |
| GPC4 | glypican 4 | -0.41 |
| BHMT | betaine--homocysteine S-methyltransferase | -0.4 |
| MAF1 | MAF1 homolog (S. cerevisiae) | -0.4 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.4 |
| TRDMT1 | tRNA aspartic acid methyltransferase 1 | -0.4 |
| PLAU | plasminogen activator, urokinase | -0.39 |
| LMBR1 | limb development membrane protein 1 | -0.39 |
| BFAR | bifunctional apoptosis regulator | -0.39 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.39 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.39 |
| RAD51D | RAD51 paralog D | -0.39 |
| DIPK1B | divergent protein kinase domain 1B | -0.39 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.38 |
| CHURC1 | churchill domain containing 1 | -0.38 |
| TYMS | thymidylate synthetase | -0.37 |
| GRAMD1A | GRAM domain containing 1A | -0.37 |
| DESI2 | desumoylating isopeptidase 2 | -0.37 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | -0.37 |
| SLC25A17 | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | -0.37 |
| PAQR7 | progestin and adipoQ receptor family member VII | -0.37 |
| MR1 | major histocompatibility complex, class I-related | -0.37 |
| ING5 | inhibitor of growth family, member 5 | -0.36 |
| MTFP1 | mitochondrial fission process 1 | -0.36 |
| MCOLN1 | mucolipin 1 | -0.36 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.36 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | -0.36 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.36 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.36 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.35 |
| SLC7A6 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | -0.35 |
| BAIAP2 | BAI1-associated protein 2 | -0.35 |
| ZNF451 | zinc finger protein 451 | -0.34 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.34 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | -0.34 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.34 |
| KLHDC2 | kelch domain containing 2 | -0.34 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.34 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | -0.34 |
| SATB1 | SATB homeobox 1 | -0.34 |
| TTYH2 | tweety family member 2 | -0.33 |
| H3C1 | H3 clustered histone 1 | -0.33 |
| DOP1A | DOP1 leucine zipper like protein A | -0.33 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | -0.33 |
| MLH3 | mutL homolog 3 | -0.33 |
| FIZ1 | FLT3-interacting zinc finger 1 | -0.33 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | -0.33 |
| DALRD3 | DALR anticodon binding domain containing 3 | -0.32 |
| BRMS1 | breast cancer metastasis suppressor 1 | -0.32 |
| M1AP | meiosis 1 associated protein | -0.32 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.32 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.31 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.31 |
