| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aprepitant perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aprepitant_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.121362 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.107623 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0755084 |
| FBN1 | fibrillin 1 | 0.0637586 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0581367 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0523137 |
| FNDC3B | fibronectin type III domain containing 3B | 0.051039 |
| COL3A1 | collagen, type III, alpha 1 | 0.0490011 |
| LOXL2 | lysyl oxidase-like 2 | 0.0487816 |
| OGA | O-GlcNAcase | 0.0461221 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0436943 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.043163 |
| SBF2 | SET binding factor 2 | 0.043154 |
| NAV2 | neuron navigator 2 | 0.0428426 |
| NDRG1 | N-myc downstream regulated 1 | 0.0427182 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0425892 |
| ATP13A3 | ATPase type 13A3 | 0.0411276 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0405838 |
| FLNB | filamin B, beta | 0.0390701 |
| GOLGA4 | golgin A4 | 0.0361237 |
| CD109 | CD109 molecule | 0.0359702 |
| GPC6 | glypican 6 | 0.0352514 |
| COL1A2 | collagen, type I, alpha 2 | 0.0352386 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0347534 |
| AUTS2 | autism susceptibility candidate 2 | 0.0344491 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0331187 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0310287 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0296548 |
| FNIP1 | folliculin interacting protein 1 | 0.029557 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.029359 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0287742 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0286858 |
| RASA2 | RAS p21 protein activator 2 | 0.0286495 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0281826 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0280979 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.028002 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0277819 |
| AFDN | afadin, adherens junction formation factor | 0.0275725 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0265889 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0263599 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0262266 |
| ARRDC3 | arrestin domain containing 3 | 0.0259181 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0255703 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0252235 |
| OPTN | optineurin | 0.0249847 |
| TMOD1 | tropomodulin 1 | 0.0240698 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0237166 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0235831 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0231846 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0230532 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0229758 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | 0.0229097 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.022836 |
| FMNL2 | formin-like 2 | 0.0223134 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0221877 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.022132 |
| YEATS2 | YEATS domain containing 2 | 0.0220986 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0214613 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0210196 |
| APP | amyloid beta (A4) precursor protein | 0.0209476 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.020888 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0208596 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0207592 |
| SEPTIN9 | septin 9 | 0.0205265 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0204189 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.0202444 |
| XPO1 | exportin 1 | 0.0202107 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0198494 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0198368 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0196571 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0194041 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0193215 |
| ATP11B | ATPase, class VI, type 11B | 0.0190367 |
| COG5 | component of oligomeric golgi complex 5 | 0.0190077 |
| STC1 | stanniocalcin 1 | 0.0189492 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0189058 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0188379 |
| ZBTB7C | zinc finger and BTB domain containing 7C | 0.0188144 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0187362 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.018654 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.018579 |
| THBS2 | thrombospondin 2 | 0.0185514 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0184405 |
| HELZ | helicase with zinc finger | 0.0184379 |
| WTAP | Wilms tumor 1 associated protein | 0.0183453 |
| PCGF5 | polycomb group ring finger 5 | 0.0183189 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0182748 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.0182263 |
| ANKRD36 | ankyrin repeat domain 36 | 0.018006 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0178386 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0178249 |
| FRMD5 | FERM domain containing 5 | 0.0177861 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0176391 |
| MEF2A | myocyte enhancer factor 2A | 0.0176351 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0175493 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0174212 |
| NOTCH2 | notch 2 | 0.0173486 |
| NGLY1 | N-glycanase 1 | 0.0173399 |
| KIF13A | kinesin family member 13A | 0.0172977 |
| LRRC49 | leucine rich repeat containing 49 | 0.0172034 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.173298 |
| TMSB10 | thymosin beta 10 | -0.160489 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.141273 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.12783 |
| MAP1B | microtubule-associated protein 1B | -0.121749 |
| VIM | vimentin | -0.111788 |
| CDH13 | cadherin 13 | -0.101397 |
| FN1 | fibronectin 1 | -0.093742 |
| COL5A1 | collagen, type V, alpha 1 | -0.0908116 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0891794 |
| PODXL | podocalyxin-like | -0.0821693 |
| NAV1 | neuron navigator 1 | -0.0785513 |
| POTEF | POTE ankyrin domain family, member F | -0.0777375 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0728044 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0724889 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0719303 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0694922 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0691299 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0672593 |
| S100A10 | S100 calcium binding protein A10 | -0.066034 |
| RIGI | RNA sensor RIG-I | -0.0643174 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0636967 |
| SUCNR1 | succinate receptor 1 | -0.0630521 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0604924 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0577077 |
| MX2 | MX dynamin-like GTPase 2 | -0.0576914 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0487401 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0485397 |
| ASPH | aspartate beta-hydroxylase | -0.0448692 |
| LMNA | lamin A/C | -0.0434608 |
| SP100 | SP100 nuclear antigen | -0.0433995 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0432838 |
| TPM4 | tropomyosin 4 | -0.0431559 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0428678 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0420967 |
| PRSS23 | protease, serine, 23 | -0.0417651 |
| PKM | pyruvate kinase, muscle | -0.0403933 |
| TAGLN2 | transgelin 2 | -0.0373645 |
| LRRC17 | leucine rich repeat containing 17 | -0.0370567 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.036935 |
| PLXNA2 | plexin A2 | -0.0363016 |
| LDHA | lactate dehydrogenase A | -0.0359253 |
| SLC39A11 | solute carrier family 39, member 11 | -0.035692 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0354752 |
| EGFR | epidermal growth factor receptor | -0.0342094 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0325709 |
| B2M | beta-2-microglobulin | -0.0322972 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.032039 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0317918 |
| CUX1 | cut-like homeobox 1 | -0.0316878 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0316502 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0314287 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0314238 |
| IL7R | interleukin 7 receptor | -0.0314075 |
| CDK6 | cyclin-dependent kinase 6 | -0.0312237 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0308446 |
| PCDH7 | protocadherin 7 | -0.0307211 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.030564 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0304506 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0298925 |
| DCLK2 | doublecortin-like kinase 2 | -0.0296769 |
| CSTB | cystatin B (stefin B) | -0.0292843 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0291008 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0290434 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0287032 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0286762 |
| CCND1 | cyclin D1 | -0.0285787 |
| MEIS2 | Meis homeobox 2 | -0.0282615 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0282251 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0281822 |
| TPM1 | tropomyosin 1 (alpha) | -0.0280485 |
| HLA-B | major histocompatibility complex, class I, B | -0.0279039 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0277137 |
| MT2A | metallothionein 2A | -0.0276113 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0274613 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0274088 |
| SMC4 | structural maintenance of chromosomes 4 | -0.02707 |
| EFNA5 | ephrin-A5 | -0.0270065 |
| HLA-C | major histocompatibility complex, class I, C | -0.0267529 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0267484 |
| S100A6 | S100 calcium binding protein A6 | -0.0267004 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0266645 |
| ACTG1 | actin gamma 1 | -0.0265344 |
| RNF213 | ring finger protein 213 | -0.0265241 |
| DIAPH3 | diaphanous-related formin 3 | -0.025943 |
| SEPTIN7 | septin 7 | -0.0256708 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0256609 |
| FSTL1 | follistatin-like 1 | -0.0253821 |
| ENO1 | enolase 1, (alpha) | -0.0252983 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0245945 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0245547 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0240836 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0240737 |
| KIAA1549L | KIAA1549-like | -0.0239815 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0239342 |
| S100A4 | S100 calcium binding protein A4 | -0.0233052 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0232346 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0231941 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0230684 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0229733 |
