| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aprepitant perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aprepitant_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.0638238 |
| TMEM41B | transmembrane protein 41B | 0.0592745 |
| GCG | glucagon | 0.0540691 |
| AREG | amphiregulin | 0.0480268 |
| PTMA | prothymosin, alpha | 0.0446443 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0407134 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0392775 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.038057 |
| MKI67 | marker of proliferation Ki-67 | 0.0356407 |
| VCL | vinculin | 0.0353622 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0324392 |
| JMJD1C | jumonji domain containing 1C | 0.0303881 |
| OGA | O-GlcNAcase | 0.0291213 |
| NKTR | natural killer cell triggering receptor | 0.02737 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0272716 |
| BBX | bobby sox homolog (Drosophila) | 0.027109 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0269711 |
| AAK1 | AP2 associated kinase 1 | 0.0261045 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0259037 |
| RPS8 | ribosomal protein S8 | 0.0257903 |
| MED13L | mediator complex subunit 13-like | 0.025545 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0237215 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0236922 |
| RTN4 | reticulon 4 | 0.0236743 |
| EXOC6B | exocyst complex component 6B | 0.0226811 |
| ZNF148 | zinc finger protein 148 | 0.0223851 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0223813 |
| CRACD | capping protein inhibiting regulator of actin dynamics | 0.0221018 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0216788 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0215975 |
| CEP70 | centrosomal protein 70kDa | 0.0215824 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.0215424 |
| RPL36A | ribosomal protein L36a | 0.0215177 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0212399 |
| ANK2 | ankyrin 2, neuronal | 0.0208078 |
| EXOC6 | exocyst complex component 6 | 0.020571 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0204282 |
| KIAA1328 | KIAA1328 | 0.0203882 |
| CEP170 | centrosomal protein 170kDa | 0.020368 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0202026 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0201748 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0200845 |
| BCHE | butyrylcholinesterase | 0.0200649 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0197927 |
| RPLP1 | ribosomal protein, large, P1 | 0.0197894 |
| S100A6 | S100 calcium binding protein A6 | 0.019368 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0193206 |
| SETD5 | SET domain containing 5 | 0.0193063 |
| USP53 | ubiquitin specific peptidase 53 | 0.0189276 |
| RPL26 | ribosomal protein L26 | 0.0188613 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0186057 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0185316 |
| CCNY | cyclin Y | 0.0184986 |
| SLC49A4 | solute carrier family 49 member 4 | 0.0184688 |
| UVRAG | UV radiation resistance associated | 0.0184247 |
| MAP4 | microtubule-associated protein 4 | 0.018416 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0183733 |
| PUM2 | pumilio RNA-binding family member 2 | 0.018298 |
| SSH2 | slingshot protein phosphatase 2 | 0.0180802 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0180643 |
| KLC1 | kinesin light chain 1 | 0.0175666 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0175502 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0175355 |
| CDK19 | cyclin-dependent kinase 19 | 0.0174376 |
| SMYD3 | SET and MYND domain containing 3 | 0.0174051 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0174036 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0172597 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0172004 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0171873 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0171698 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0171142 |
| ABHD3 | abhydrolase domain containing 3 | 0.0169401 |
| RPS29 | ribosomal protein S29 | 0.0168138 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0166997 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0166966 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0166488 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.016646 |
| PRKD3 | protein kinase D3 | 0.0166127 |
| VCAN | versican | 0.0165879 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0164438 |
| NEK7 | NIMA-related kinase 7 | 0.0164232 |
| ZFR | zinc finger RNA binding protein | 0.0163503 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0161012 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0160178 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0159988 |
| NCOA1 | nuclear receptor coactivator 1 | 0.0158888 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0157121 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0157115 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0156989 |
| WDR41 | WD repeat domain 41 | 0.0156868 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0156846 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0155533 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0155275 |
| NCK1 | NCK adaptor protein 1 | 0.0154374 |
| RPS12 | ribosomal protein S12 | 0.0154277 |
| TXNL4A | thioredoxin-like 4A | 0.0154263 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | 0.0153995 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0153684 |
| TSG101 | tumor susceptibility 101 | 0.0153642 |
| RPS14 | ribosomal protein S14 | 0.0152256 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.205374 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.184262 |
| NLGN1 | neuroligin 1 | -0.155274 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0989349 |
| PCDH7 | protocadherin 7 | -0.0922498 |
| DPYD | dihydropyrimidine dehydrogenase | -0.088625 |
| MMP12 | matrix metallopeptidase 12 | -0.088115 |
| CCN2 | cellular communication network factor 2 | -0.0857674 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0824942 |
| EGR1 | early growth response 1 | -0.0780245 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0725968 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0720273 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0719754 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0686119 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.067861 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0669022 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0648817 |
| ANXA1 | annexin A1 | -0.0601426 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0552645 |
| USP34 | ubiquitin specific peptidase 34 | -0.0524269 |
| LDHA | lactate dehydrogenase A | -0.0517988 |
| CCNL1 | cyclin L1 | -0.0512761 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0509075 |
| CCND1 | cyclin D1 | -0.0499678 |
| PCBP2 | poly(rC) binding protein 2 | -0.0495919 |
| ZNF804A | zinc finger protein 804A | -0.0482094 |
| POTEF | POTE ankyrin domain family, member F | -0.047895 |
| TENM3 | teneurin transmembrane protein 3 | -0.0471403 |
| KIF5B | kinesin family member 5B | -0.0454324 |
| HMGA2 | high mobility group AT-hook 2 | -0.0450193 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0449506 |
| BRD2 | bromodomain containing 2 | -0.044911 |
| ACTG1 | actin gamma 1 | -0.0448195 |
| CALR | calreticulin | -0.0433417 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0422017 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0417365 |
| DST | dystonin | -0.0414499 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0403489 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0403064 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0402116 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0391258 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0389851 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0378764 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0378664 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0370972 |
| SYT1 | synaptotagmin I | -0.0369527 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0364161 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.036376 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0363517 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0363454 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0354037 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0353771 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0352823 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0351127 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0347799 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0346362 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0346019 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0340617 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0339657 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0337446 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0334793 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.033457 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0322808 |
| NHSL1 | NHS-like 1 | -0.0318263 |
| PRR16 | proline rich 16 | -0.0316571 |
| CDK6 | cyclin-dependent kinase 6 | -0.0315729 |
| MEMO1 | mediator of cell motility 1 | -0.0313204 |
| MGAT4C | MGAT4 family, member C | -0.0313181 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0303361 |
| ZNF638 | zinc finger protein 638 | -0.0301439 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.0301357 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0300926 |
| RHOA | ras homolog family member A | -0.0299754 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0295325 |
| EHBP1 | EH domain binding protein 1 | -0.0291529 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0291192 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0290824 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0287082 |
| NRXN3 | neurexin 3 | -0.0285568 |
| UBAP2 | ubiquitin associated protein 2 | -0.0283897 |
| DTNA | dystrobrevin, alpha | -0.0283771 |
| PTMS | parathymosin | -0.0282752 |
| PFN1 | profilin 1 | -0.0282082 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0279156 |
| EPHA5 | EPH receptor A5 | -0.0278457 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0277827 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.027563 |
| AXIN2 | axin 2 | -0.0274171 |
| MAP1B | microtubule-associated protein 1B | -0.0273382 |
| MATR3 | matrin 3 | -0.02693 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0268112 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0267078 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0266309 |
| PGK1 | phosphoglycerate kinase 1 | -0.0259215 |
| YBX1 | Y box binding protein 1 | -0.025838 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0257349 |
| INTS6 | integrator complex subunit 6 | -0.0257063 |
| CANX | calnexin | -0.0255752 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0252897 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0252365 |
