Aprepitant_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aprepitant perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aprepitant_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.0900504
EXT1 exostosin glycosyltransferase 1 0.0811585
NRG1 neuregulin 1 0.0689493
PLAT plasminogen activator, tissue 0.0552331
SEPTIN9 septin 9 0.0548978
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0510586
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0438826
PARD3 par-3 family cell polarity regulator 0.0434319
CDC27 cell division cycle 27 0.0426307
ZFC3H1 zinc finger, C3H1-type containing 0.0423705
PSD3 pleckstrin and Sec7 domain containing 3 0.0421699
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0403755
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0402907
AKAP12 A kinase (PRKA) anchor protein 12 0.0394131
NCOR2 nuclear receptor corepressor 2 0.0387183
AHR aryl hydrocarbon receptor 0.0383903
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0378959
FMN1 formin 1 0.0377497
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0364656
ITPRID2 ITPR interacting domain containing 2 0.0360329
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0360172
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0357368
ARRDC3 arrestin domain containing 3 0.0351127
XPO1 exportin 1 0.034581
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.034544
NRIP1 nuclear receptor interacting protein 1 0.0344506
TNRC6B trinucleotide repeat containing 6B 0.0329641
PICALM phosphatidylinositol binding clathrin assembly protein 0.0326978
PDE8A phosphodiesterase 8A 0.0314091
RBM33 RNA binding motif protein 33 0.0302418
PUM2 pumilio RNA-binding family member 2 0.029843
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0297467
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0295904
MYH10 myosin, heavy chain 10, non-muscle 0.0289775
YTHDC1 YTH domain containing 1 0.0284581
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0273913
CENPC centromere protein C 0.0266883
HMGB2 high mobility group box 2 0.0266282
TMF1 TATA element modulatory factor 1 0.0265983
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0265359
PELI1 pellino E3 ubiquitin protein ligase 1 0.0262953
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0262547
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0260737
TOP2B topoisomerase (DNA) II beta 180kDa 0.0259093
PRPF3 pre-mRNA processing factor 3 0.0255753
ATP13A3 ATPase type 13A3 0.0255536
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0255465
EIF4B eukaryotic translation initiation factor 4B 0.0253
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0247988
OGA O-GlcNAcase 0.0246546
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0246087
ADARB1 adenosine deaminase, RNA-specific, B1 0.024108
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0238011
ZNF146 zinc finger protein 146 0.0236057
MYH9 myosin, heavy chain 9, non-muscle 0.0235614
ZCCHC7 zinc finger, CCHC domain containing 7 0.0233489
NAF1 nuclear assembly factor 1 ribonucleoprotein 0.0233126
RUNX1 runt-related transcription factor 1 0.0231371
GOLGA4 golgin A4 0.0230103
ARHGAP9 Rho GTPase activating protein 9 0.0226852
MIS18BP1 MIS18 binding protein 1 0.0226017
TRIO trio Rho guanine nucleotide exchange factor 0.0225454
CANX calnexin 0.02242
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0221762
KDM6A lysine (K)-specific demethylase 6A 0.0221067
ZFAND3 zinc finger, AN1-type domain 3 0.0220071
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0218658
UBA6 ubiquitin-like modifier activating enzyme 6 0.0218158
LSAMP limbic system-associated membrane protein 0.021652
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0216244
VEGFA vascular endothelial growth factor A 0.0215252
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0212293
SNX13 sorting nexin 13 0.021226
SERINC1 serine incorporator 1 0.0210984
MKI67 marker of proliferation Ki-67 0.0210572
KIF14 kinesin family member 14 0.0209584
BIRC6 baculoviral IAP repeat containing 6 0.0209404
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0208787
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0208584
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0208494
MCL1 myeloid cell leukemia 1 0.0207593
FMNL2 formin-like 2 0.0207557
MED13L mediator complex subunit 13-like 0.0206645
MORC3 MORC family CW-type zinc finger 3 0.0205943
TENT5A terminal nucleotidyltransferase 5A 0.0203334
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0203211
EIF3A eukaryotic translation initiation factor 3, subunit A 0.020312
PLPP1 phospholipid phosphatase 1 0.0200456
SREBF2 sterol regulatory element binding transcription factor 2 0.0200174
N4BP2L2 NEDD4 binding protein 2-like 2 0.0199465
OSBPL1A oxysterol binding protein-like 1A 0.0199379
RAB1A RAB1A, member RAS oncogene family 0.0198184
FAM114A1 family with sequence similarity 114, member A1 0.0197784
DSCAM Down syndrome cell adhesion molecule 0.019729
TTC3 tetratricopeptide repeat domain 3 0.0197136
EGFR epidermal growth factor receptor 0.0195986
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0195313
KCTD3 potassium channel tetramerization domain containing 3 0.0195068
SSH1 slingshot protein phosphatase 1 0.0194939
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0194262

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.363688
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.168416
RPS6 ribosomal protein S6 -0.0993408
SYT1 synaptotagmin I -0.0973319
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0883642
ZBTB20 zinc finger and BTB domain containing 20 -0.0823478
VIM vimentin -0.0819428
RPL23 ribosomal protein L23 -0.077083
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0719681
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0702015
RPL34 ribosomal protein L34 -0.0669295
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0658161
PTPRD protein tyrosine phosphatase, receptor type, D -0.063091
DCAF7 DDB1 and CUL4 associated factor 7 -0.0583618
RPL19 ribosomal protein L19 -0.0571707
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0570742
PTMA prothymosin, alpha -0.0560308
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0548086
PCDH9 protocadherin 9 -0.0535865
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0534367
RPL35A ribosomal protein L35a -0.05211
RPS24 ribosomal protein S24 -0.0514423
RPLP1 ribosomal protein, large, P1 -0.0510021
RPLP0 ribosomal protein, large, P0 -0.0491906
RPL31 ribosomal protein L31 -0.0485225
RPL32 ribosomal protein L32 -0.0472533
IER3 immediate early response 3 -0.0467353
TLE4 transducin-like enhancer of split 4 -0.0458149
CCDC47 coiled-coil domain containing 47 -0.0443426
RPS8 ribosomal protein S8 -0.0442569
CD36 CD36 molecule (thrombospondin receptor) -0.0430421
GPBP1 GC-rich promoter binding protein 1 -0.0420899
RPS3 ribosomal protein S3 -0.0409622
HMGB1 high mobility group box 1 -0.040885
ACTG1 actin gamma 1 -0.0405517
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0403784
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0395923
RPL27 ribosomal protein L27 -0.0388987
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0386474
TMSB10 thymosin beta 10 -0.0384978
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0383599
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.037139
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0365013
BPTF bromodomain PHD finger transcription factor -0.0364147
RPL38 ribosomal protein L38 -0.0362538
RPS19 ribosomal protein S19 -0.0362186
RPS17 ribosomal protein S17 -0.0360685
RACK1 receptor for activated C kinase 1 -0.0355247
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0352763
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0347236
RPL36 ribosomal protein L36 -0.0344488
FTL ferritin, light polypeptide -0.0331774
RBM39 RNA binding motif protein 39 -0.03314
MEIS2 Meis homeobox 2 -0.0331267
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.032041
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0315598
CADM2 cell adhesion molecule 2 -0.0315066
WDR26 WD repeat domain 26 -0.0314489
RPS11 ribosomal protein S11 -0.0302001
SON SON DNA binding protein -0.0300721
NF1 neurofibromin 1 -0.0297885
ZNF609 zinc finger protein 609 -0.0297168
RTN4 reticulon 4 -0.0290154
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0290104
RPL13A ribosomal protein L13a -0.0289708
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0288088
RPS25 ribosomal protein S25 -0.0287772
TPT1 tumor protein, translationally-controlled 1 -0.0287746
FNBP1 formin binding protein 1 -0.0287487
RPS27A ribosomal protein S27a -0.0285528
RPS5 ribosomal protein S5 -0.0283076
BLZF1 basic leucine zipper nuclear factor 1 -0.0280263
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0279945
RPL11 ribosomal protein L11 -0.0279417
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0273888
RPS15 ribosomal protein S15 -0.0273763
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0270602
B2M beta-2-microglobulin -0.027006
PNISR PNN-interacting serine/arginine-rich protein -0.0269878
POTEF POTE ankyrin domain family, member F -0.0267938
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0267754
DNAH14 dynein, axonemal, heavy chain 14 -0.0260877
KDM3A lysine (K)-specific demethylase 3A -0.0259294
RALYL RALY RNA binding protein-like -0.0257338
MEF2A myocyte enhancer factor 2A -0.0255108
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0254691
RIOK3 RIO kinase 3 -0.0254286
SEC31A SEC31 homolog A (S. cerevisiae) -0.0253834
ARHGAP24 Rho GTPase activating protein 24 -0.0253673
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0250095
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.024415
SOX4 SRY (sex determining region Y)-box 4 -0.0243673
RPS2 ribosomal protein S2 -0.0242677
PFN1 profilin 1 -0.0241377
ARF4 ADP-ribosylation factor 4 -0.0237813
AFF1 AF4/FMR2 family, member 1 -0.0237448
FKBP10 FK506 binding protein 10, 65 kDa -0.0236831
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0234921
RPL18 ribosomal protein L18 -0.0230873
PDIA3 protein disulfide isomerase family A, member 3 -0.0230632