| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aprepitant perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aprepitant_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.211044 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.192747 |
| NDRG1 | N-myc downstream regulated 1 | 0.14024 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.121968 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.096832 |
| STC1 | stanniocalcin 1 | 0.0926473 |
| VIM | vimentin | 0.0901427 |
| VEGFA | vascular endothelial growth factor A | 0.0783427 |
| GOLGA4 | golgin A4 | 0.0708195 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0696517 |
| COL1A2 | collagen, type I, alpha 2 | 0.0620939 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0590374 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0582593 |
| ATP13A3 | ATPase type 13A3 | 0.058155 |
| LOXL2 | lysyl oxidase-like 2 | 0.0570513 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0525074 |
| FN1 | fibronectin 1 | 0.0508859 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0494241 |
| SPAG9 | sperm associated antigen 9 | 0.0465407 |
| CALR | calreticulin | 0.0453819 |
| CLMP | CXADR-like membrane protein | 0.044177 |
| ARRDC3 | arrestin domain containing 3 | 0.0436165 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0404614 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.040399 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0383936 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0373835 |
| RASA2 | RAS p21 protein activator 2 | 0.0372017 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0360475 |
| ADM | adrenomedullin | 0.0355704 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0352623 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0342501 |
| NAV2 | neuron navigator 2 | 0.0341845 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0334725 |
| POSTN | periostin, osteoblast specific factor | 0.0327595 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0314936 |
| SQLE | squalene epoxidase | 0.0314599 |
| FMNL2 | formin-like 2 | 0.0301904 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0298962 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0295201 |
| GANAB | glucosidase, alpha; neutral AB | 0.029041 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0283252 |
| PLEC | plectin | 0.028274 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0281016 |
| SDC2 | syndecan 2 | 0.0275883 |
| DOCK5 | dedicator of cytokinesis 5 | 0.027165 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0265784 |
| COPA | coatomer protein complex, subunit alpha | 0.0261893 |
| RNF13 | ring finger protein 13 | 0.02602 |
| MYO9B | myosin IXB | 0.0256551 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0256016 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0255039 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0252178 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0251825 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.025006 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0245019 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.023601 |
| FAM107B | family with sequence similarity 107, member B | 0.0235571 |
| CD59 | CD59 molecule, complement regulatory protein | 0.023372 |
| NGLY1 | N-glycanase 1 | 0.0228396 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0228267 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0227675 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0226778 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0225932 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0225738 |
| CANX | calnexin | 0.0224159 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0222736 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0219203 |
| HAS2 | hyaluronan synthase 2 | 0.0219051 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0218699 |
| FOXJ3 | forkhead box J3 | 0.0217708 |
| NUP58 | nucleoporin 58 | 0.0217522 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0215654 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0214715 |
| TMEM41B | transmembrane protein 41B | 0.021284 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0211614 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0211323 |
| SRP54 | signal recognition particle 54kDa | 0.0210582 |
| HIPK1 | homeodomain interacting protein kinase 1 | 0.0210413 |
| TMF1 | TATA element modulatory factor 1 | 0.021023 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.020904 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0208659 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0207341 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0204617 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0204115 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0203902 |
| USP36 | ubiquitin specific peptidase 36 | 0.0203478 |
| COG5 | component of oligomeric golgi complex 5 | 0.0201814 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.0200078 |
| VMP1 | vacuole membrane protein 1 | 0.0200031 |
| MRTFA | myocardin related transcription factor A | 0.019828 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.0195967 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0195822 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0194106 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0193286 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.019305 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0190854 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0190003 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0188896 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0188328 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0185425 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.227686 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0958513 |
| CDH13 | cadherin 13 | -0.0941306 |
| COL1A1 | collagen, type I, alpha 1 | -0.0874502 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0866922 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0860397 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0755484 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0738386 |
| CALD1 | caldesmon 1 | -0.0614855 |
| CNTN5 | contactin 5 | -0.0570398 |
| FNDC3B | fibronectin type III domain containing 3B | -0.056895 |
| CADM1 | cell adhesion molecule 1 | -0.0498476 |
| DST | dystonin | -0.0492539 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0492512 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0491384 |
| RPS6 | ribosomal protein S6 | -0.0484924 |
| TMSB10 | thymosin beta 10 | -0.0468303 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0466059 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0460905 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0454868 |
| EGFR | epidermal growth factor receptor | -0.0453686 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0452092 |
| ASPH | aspartate beta-hydroxylase | -0.0451067 |
| ACTG1 | actin gamma 1 | -0.0437508 |
| IER3 | immediate early response 3 | -0.0432907 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0428476 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0414345 |
| RUNX1 | runt-related transcription factor 1 | -0.0407856 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0402063 |
| GLIS3 | GLIS family zinc finger 3 | -0.0394935 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0394577 |
| IL6ST | interleukin 6 signal transducer | -0.0375761 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.037048 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0368419 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0368162 |
| PRELID2 | PRELI domain containing 2 | -0.0357828 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0354347 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0353931 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0347217 |
| RPS8 | ribosomal protein S8 | -0.0340683 |
| RPL35A | ribosomal protein L35a | -0.0339876 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0335689 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0334965 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0332501 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0320714 |
| RPS20 | ribosomal protein S20 | -0.0319906 |
| FOXP1 | forkhead box P1 | -0.0317396 |
| RIGI | RNA sensor RIG-I | -0.0307137 |
| TPM1 | tropomyosin 1 (alpha) | -0.0301781 |
| IRF1 | interferon regulatory factor 1 | -0.030176 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0301689 |
| TENM3 | teneurin transmembrane protein 3 | -0.0300977 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0293457 |
| EXOC4 | exocyst complex component 4 | -0.0292372 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0290941 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0290537 |
| MAP1B | microtubule-associated protein 1B | -0.0273912 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0273902 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.027274 |
| YBX1 | Y box binding protein 1 | -0.0271491 |
| QKI | QKI, KH domain containing, RNA binding | -0.0271416 |
| ATXN1 | ataxin 1 | -0.0270662 |
| NREP | neuronal regeneration related protein | -0.0267112 |
| FBN1 | fibrillin 1 | -0.0265536 |
| NABP1 | nucleic acid binding protein 1 | -0.0264053 |
| RPS3 | ribosomal protein S3 | -0.0262286 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0262252 |
| NAV3 | neuron navigator 3 | -0.0261959 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0260813 |
| AHR | aryl hydrocarbon receptor | -0.0259994 |
| COL5A1 | collagen, type V, alpha 1 | -0.0259112 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0257708 |
| PKM | pyruvate kinase, muscle | -0.0252402 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0249738 |
| RPS19 | ribosomal protein S19 | -0.0249524 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0246793 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0246531 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0246504 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.024504 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0244799 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0242275 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0240664 |
| RPL11 | ribosomal protein L11 | -0.024065 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.023694 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0234977 |
| RPL8 | ribosomal protein L8 | -0.0233191 |
| EBF1 | early B-cell factor 1 | -0.0232257 |
| CUX1 | cut-like homeobox 1 | -0.0231043 |
| RPS24 | ribosomal protein S24 | -0.0229699 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0227115 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0226725 |
| RPLP1 | ribosomal protein, large, P1 | -0.0224063 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.022071 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0219763 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0218393 |
| INTS6 | integrator complex subunit 6 | -0.0214971 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0211219 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0210597 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0210165 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0210132 |
