| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aprepitant perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Aprepitant_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0938958 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.066212 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0493232 |
| RPL11 | ribosomal protein L11 | 0.049161 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0473872 |
| TOP1 | topoisomerase (DNA) I | 0.0461363 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0452064 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0439405 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0428132 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0425496 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0422306 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0405894 |
| AFDN | afadin, adherens junction formation factor | 0.0378259 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0361952 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0349141 |
| GOLGA4 | golgin A4 | 0.0348693 |
| SPOPL | speckle-type POZ protein-like | 0.0341357 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0340341 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0334226 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0324279 |
| C3 | complement component 3 | 0.0320875 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0318313 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0309029 |
| USP3 | ubiquitin specific peptidase 3 | 0.0303203 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0303019 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0302867 |
| ERBIN | erbb2 interacting protein | 0.0300476 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0299477 |
| VEGFA | vascular endothelial growth factor A | 0.0299219 |
| JAG1 | jagged 1 | 0.0294472 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0294428 |
| RPL31 | ribosomal protein L31 | 0.0285751 |
| ARRDC3 | arrestin domain containing 3 | 0.0284075 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0283311 |
| RBM25 | RNA binding motif protein 25 | 0.0281444 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.028105 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0279078 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0278943 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0276837 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0275956 |
| MRTFA | myocardin related transcription factor A | 0.027337 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0270624 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0269981 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0268927 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0262954 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.026011 |
| CRLS1 | cardiolipin synthase 1 | 0.0259286 |
| RPLP0 | ribosomal protein, large, P0 | 0.0257892 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0257785 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.025615 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0256106 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0252812 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0252554 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0251474 |
| USP47 | ubiquitin specific peptidase 47 | 0.0251292 |
| RPL9 | ribosomal protein L9 | 0.0249699 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.024663 |
| COPA | coatomer protein complex, subunit alpha | 0.0246481 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0246196 |
| YTHDC1 | YTH domain containing 1 | 0.0245987 |
| FNIP1 | folliculin interacting protein 1 | 0.0245663 |
| CHKA | choline kinase alpha | 0.0244564 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0242595 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0240793 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0238083 |
| DIAPH1 | diaphanous-related formin 1 | 0.0238063 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0233999 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0233201 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0233199 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0233181 |
| SNX9 | sorting nexin 9 | 0.0232251 |
| PUM2 | pumilio RNA-binding family member 2 | 0.023039 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0229947 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0229914 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0226499 |
| RBM33 | RNA binding motif protein 33 | 0.0224284 |
| SPAG9 | sperm associated antigen 9 | 0.0223777 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0222568 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0220843 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0220473 |
| RBM6 | RNA binding motif protein 6 | 0.0219284 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.021891 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0218306 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0215395 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0215306 |
| PDE8A | phosphodiesterase 8A | 0.0214828 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0214527 |
| VCL | vinculin | 0.0214067 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0213516 |
| LUZP1 | leucine zipper protein 1 | 0.0210318 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0209981 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0209899 |
| ITGA6 | integrin, alpha 6 | 0.0209547 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.020931 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0209165 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0206608 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0205748 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0199969 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.01974 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0196313 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.436057 |
| EHBP1 | EH domain binding protein 1 | -0.120602 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.120122 |
| FN1 | fibronectin 1 | -0.119439 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.10363 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0840525 |
| GPC6 | glypican 6 | -0.0779485 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0674102 |
| CP | ceruloplasmin (ferroxidase) | -0.0673977 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0583617 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0561719 |
| PEG3 | paternally expressed 3 | -0.0560285 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0547208 |
| ENO1 | enolase 1, (alpha) | -0.0530523 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0521384 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0519806 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0483922 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0475437 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0474186 |
| DSPP | dentin sialophosphoprotein | -0.0459883 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0453036 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0445196 |
| CNKSR3 | CNKSR family member 3 | -0.0411087 |
| ATP10A | ATPase, class V, type 10A | -0.0409458 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0405396 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0385946 |
| TMEM123 | transmembrane protein 123 | -0.0382578 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0371454 |
| GNAS | GNAS complex locus | -0.0366528 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0365019 |
| FRMD5 | FERM domain containing 5 | -0.0358951 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0358822 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0350344 |
| ATXN1 | ataxin 1 | -0.0346457 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0344485 |
| FOXP1 | forkhead box P1 | -0.0337267 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0333941 |
| DST | dystonin | -0.0330554 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0328897 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0328341 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0323717 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0323223 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0315662 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0312748 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0310622 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.0306619 |
| KRT23 | keratin 23, type I | -0.0306 |
| NHSL1 | NHS-like 1 | -0.0302476 |
| STK17A | serine/threonine kinase 17a | -0.0300815 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0297419 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0293388 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0289029 |
| H1-0 | H1.0 linker histone | -0.0283135 |
| CDK6 | cyclin-dependent kinase 6 | -0.0273656 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0271933 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0268898 |
| AHNAK | AHNAK nucleoprotein | -0.0266 |
| HMGA2 | high mobility group AT-hook 2 | -0.0258712 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0258068 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0256794 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0256099 |
| TBCK | TBC1 domain containing kinase | -0.0255627 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0253233 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0250322 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0248655 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0246078 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0243455 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.024231 |
| ITGA1 | integrin, alpha 1 | -0.0242163 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0241939 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0238841 |
| APOB | apolipoprotein B | -0.0235914 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0231504 |
| RRBP1 | ribosome binding protein 1 | -0.0231361 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0229864 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0228719 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.022814 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0224891 |
| TPM4 | tropomyosin 4 | -0.0219165 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0218621 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0218267 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0211846 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0210449 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0209689 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0208021 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0207432 |
| CPQ | carboxypeptidase Q | -0.0206161 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0200881 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0200367 |
| USP34 | ubiquitin specific peptidase 34 | -0.0200127 |
| TCF12 | transcription factor 12 | -0.0196605 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0195441 |
| DISC1 | disrupted in schizophrenia 1 | -0.0195435 |
| PLIN2 | perilipin 2 | -0.0191339 |
| GK | glycerol kinase | -0.0191104 |
| KIZ | kizuna centrosomal protein | -0.0188177 |
| KAZN | kazrin, periplakin interacting protein | -0.0187192 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0186435 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0185866 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.018576 |
