| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aprepitant perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aprepitant_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EFHD2 | EF-hand domain family, member D2 | 0.0854431 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0821445 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.076968 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0751122 |
| ARRDC3 | arrestin domain containing 3 | 0.0711688 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0703188 |
| SQLE | squalene epoxidase | 0.0668631 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0647972 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0627656 |
| PLS3 | plastin 3 | 0.0620219 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0619934 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0617328 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0605459 |
| KRT17 | keratin 17, type I | 0.0600645 |
| FLNB | filamin B, beta | 0.0576421 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0575645 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0561212 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0553176 |
| MSN | moesin | 0.054094 |
| NAV2 | neuron navigator 2 | 0.0537491 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0525433 |
| MEF2A | myocyte enhancer factor 2A | 0.0524935 |
| PGK1 | phosphoglycerate kinase 1 | 0.0515012 |
| RNF19B | ring finger protein 19B | 0.0480477 |
| LAMC2 | laminin, gamma 2 | 0.0480023 |
| PTMA | prothymosin, alpha | 0.0468398 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0456119 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0453436 |
| CD9 | CD9 molecule | 0.0438536 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0436175 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0435571 |
| GOLGA4 | golgin A4 | 0.0432701 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0429019 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0422018 |
| MCL1 | myeloid cell leukemia 1 | 0.0413291 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0412138 |
| LMO7 | LIM domain 7 | 0.0406849 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0402081 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0401298 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0400963 |
| CLU | clusterin | 0.0396092 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0387705 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.038613 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0385496 |
| LUZP1 | leucine zipper protein 1 | 0.0385225 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0383324 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0382928 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0374513 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0373208 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0372139 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0368614 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0361327 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0360855 |
| B2M | beta-2-microglobulin | 0.0359577 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0357721 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0349938 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0349202 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0346936 |
| SUCO | SUN domain containing ossification factor | 0.0346554 |
| NDRG1 | N-myc downstream regulated 1 | 0.0338253 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0336899 |
| KIAA1671 | KIAA1671 | 0.0336332 |
| RPL21 | ribosomal protein L21 | 0.0333804 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0332935 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0326195 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0323357 |
| FNIP1 | folliculin interacting protein 1 | 0.0321968 |
| PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | 0.0318607 |
| SPAG9 | sperm associated antigen 9 | 0.031384 |
| SEPTIN9 | septin 9 | 0.0313436 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0313083 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0312764 |
| PLEC | plectin | 0.0311525 |
| ATP13A3 | ATPase type 13A3 | 0.0311286 |
| SRP54 | signal recognition particle 54kDa | 0.0308648 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0308283 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0306011 |
| FMNL2 | formin-like 2 | 0.0302038 |
| TPM3 | tropomyosin 3 | 0.0301672 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0300436 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0299385 |
| SLK | STE20-like kinase | 0.029929 |
| RNF145 | ring finger protein 145 | 0.0289342 |
| RCOR1 | REST corepressor 1 | 0.0287718 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0285232 |
| CUL4B | cullin 4B | 0.0284524 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0281549 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0280613 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0279385 |
| HLA-A | major histocompatibility complex, class I, A | 0.0278359 |
| MEGF6 | multiple EGF-like-domains 6 | 0.0276461 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.027606 |
| YOD1 | YOD1 deubiquitinase | 0.0273691 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0272733 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0271027 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0268815 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0267259 |
| PODXL | podocalyxin-like | 0.0264627 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0263467 |
| ADM | adrenomedullin | 0.0262503 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.265315 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.171135 |
| DPYD | dihydropyrimidine dehydrogenase | -0.101288 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0977382 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0932358 |
| FOXP1 | forkhead box P1 | -0.0927859 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0882415 |
| EMP1 | epithelial membrane protein 1 | -0.0875895 |
| MYOF | myoferlin | -0.0817846 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0804421 |
| TMSB10 | thymosin beta 10 | -0.0795301 |
| PRELID2 | PRELI domain containing 2 | -0.075407 |
| GNAS | GNAS complex locus | -0.0710028 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0699243 |
| ANXA1 | annexin A1 | -0.0689069 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0685351 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0636661 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0636359 |
| MORF4L2 | mortality factor 4 like 2 | -0.0590594 |
| ASPH | aspartate beta-hydroxylase | -0.0589381 |
| EZR | ezrin | -0.05523 |
| ARF1 | ADP-ribosylation factor 1 | -0.054431 |
| OSMR | oncostatin M receptor | -0.0539082 |
| CD44 | CD44 molecule (Indian blood group) | -0.0518601 |
| SMYD3 | SET and MYND domain containing 3 | -0.051645 |
| ACTN4 | actinin, alpha 4 | -0.0512398 |
| S100A10 | S100 calcium binding protein A10 | -0.049731 |
| RRBP1 | ribosome binding protein 1 | -0.0487871 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0472781 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0472442 |
| RIN2 | Ras and Rab interactor 2 | -0.0467734 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0457262 |
| MECOM | MDS1 and EVI1 complex locus | -0.0450153 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0446966 |
| IGF2 | insulin-like growth factor 2 | -0.042487 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0420264 |
| CAVIN1 | caveolae associated protein 1 | -0.0414658 |
| NRG1 | neuregulin 1 | -0.0410798 |
| TXNRD1 | thioredoxin reductase 1 | -0.0390695 |
| NEK7 | NIMA-related kinase 7 | -0.0368127 |
| POTEF | POTE ankyrin domain family, member F | -0.0367397 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0366695 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0364625 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0362432 |
| DSTN | destrin (actin depolymerizing factor) | -0.0360643 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.0357214 |
| PLAT | plasminogen activator, tissue | -0.0351963 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0349765 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0347515 |
| ANXA2 | annexin A2 | -0.0334859 |
| FSCN1 | fascin actin-bundling protein 1 | -0.033429 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0331713 |
| SULF1 | sulfatase 1 | -0.0325365 |
| DUSP4 | dual specificity phosphatase 4 | -0.0322555 |
| EXOC6B | exocyst complex component 6B | -0.0319232 |
| EGR1 | early growth response 1 | -0.0315921 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0314712 |
| SULF2 | sulfatase 2 | -0.0309437 |
| KRT6A | keratin 6A, type II | -0.0307884 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0304819 |
| CENPF | centromere protein F, 350/400kDa | -0.0299295 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0297589 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0297209 |
| RPLP1 | ribosomal protein, large, P1 | -0.0291517 |
| IER3 | immediate early response 3 | -0.0287434 |
| CNTNAP3 | contactin associated protein-like 3 | -0.0286293 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.028589 |
| RACK1 | receptor for activated C kinase 1 | -0.028501 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0282104 |
| ACTG1 | actin gamma 1 | -0.0280359 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0279043 |
| HDLBP | high density lipoprotein binding protein | -0.0278603 |
| FUS | FUS RNA binding protein | -0.0277115 |
| NRCAM | neuronal cell adhesion molecule | -0.0275781 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0274327 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0272232 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0270426 |
| RPS24 | ribosomal protein S24 | -0.0266891 |
| RIOK3 | RIO kinase 3 | -0.0266012 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0265469 |
| FOXO1 | forkhead box O1 | -0.0262328 |
| LMNA | lamin A/C | -0.0259463 |
| CRACDL | CRACD like | -0.0258149 |
| NFIA | nuclear factor I/A | -0.0256738 |
| ITGA6 | integrin, alpha 6 | -0.025614 |
| TNS4 | tensin 4 | -0.0253027 |
| MYO9A | myosin IXA | -0.0253023 |
| ITGB4 | integrin, beta 4 | -0.025165 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0248076 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0246974 |
| HMGA2 | high mobility group AT-hook 2 | -0.0246629 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.024539 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0245164 |
| MKI67 | marker of proliferation Ki-67 | -0.0243957 |
| AOPEP | aminopeptidase O (putative) | -0.0237549 |
| RBM39 | RNA binding motif protein 39 | -0.0233712 |
| METTL15 | methyltransferase like 15 | -0.0233189 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0232827 |
| HM13 | histocompatibility (minor) 13 | -0.0230677 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0230098 |
