Aprepitant_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aprepitant perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aprepitant_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0954194
EREG epiregulin 0.0851533
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0817491
FAM13A family with sequence similarity 13, member A 0.081295
MED13L mediator complex subunit 13-like 0.0776673
WAC WW domain containing adaptor with coiled-coil 0.0728651
GOLGA4 golgin A4 0.0707021
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0705639
TXNIP thioredoxin interacting protein 0.0689139
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0675229
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0669569
EPS8 epidermal growth factor receptor pathway substrate 8 0.066186
RAB1A RAB1A, member RAS oncogene family 0.0626876
ITGA6 integrin, alpha 6 0.0604669
GSK3B glycogen synthase kinase 3 beta 0.0602184
UBA6 ubiquitin-like modifier activating enzyme 6 0.0574215
KDM6A lysine (K)-specific demethylase 6A 0.0567822
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.056616
MACF1 microtubule-actin crosslinking factor 1 0.0561292
ZFAND3 zinc finger, AN1-type domain 3 0.0540284
RNF145 ring finger protein 145 0.0535267
AREG amphiregulin 0.0532842
NDRG1 N-myc downstream regulated 1 0.0524022
KMT2E lysine (K)-specific methyltransferase 2E 0.0523007
PICALM phosphatidylinositol binding clathrin assembly protein 0.05105
PUM2 pumilio RNA-binding family member 2 0.0505624
VEGFA vascular endothelial growth factor A 0.0497657
OGA O-GlcNAcase 0.0493345
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0488291
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0483264
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0477628
ESYT2 extended synaptotagmin-like protein 2 0.0475016
TFG TRK-fused gene 0.0470995
ANKRD11 ankyrin repeat domain 11 0.0466457
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0462549
KRT18 keratin 18, type I 0.046147
DSCAM Down syndrome cell adhesion molecule 0.0459859
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0453691
RBM39 RNA binding motif protein 39 0.0444224
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0442956
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0433753
RREB1 ras responsive element binding protein 1 0.0429151
VMP1 vacuole membrane protein 1 0.0429024
YTHDC1 YTH domain containing 1 0.0427249
EEF2 eukaryotic translation elongation factor 2 0.0424356
SETD5 SET domain containing 5 0.0424116
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0422884
ADAM17 ADAM metallopeptidase domain 17 0.0416963
SPAG9 sperm associated antigen 9 0.0414263
RAP1B RAP1B, member of RAS oncogene family 0.0413111
CCNY cyclin Y 0.0410279
FAT1 FAT atypical cadherin 1 0.0409264
MXD1 MAX dimerization protein 1 0.0408538
COPA coatomer protein complex, subunit alpha 0.040629
ITPRID2 ITPR interacting domain containing 2 0.0404022
NUP58 nucleoporin 58 0.0402207
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0401385
UBE2H ubiquitin-conjugating enzyme E2H 0.0399143
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0394914
YME1L1 YME1-like 1 ATPase 0.039006
MYH9 myosin, heavy chain 9, non-muscle 0.0388541
BIRC6 baculoviral IAP repeat containing 6 0.0381816
ZMYM2 zinc finger, MYM-type 2 0.0368742
RAB6A RAB6A, member RAS oncogene family 0.0368727
PARD3 par-3 family cell polarity regulator 0.0368693
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0367384
GARS1 glycyl-tRNA synthetase 1 0.0357057
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0349424
LMO7 LIM domain 7 0.0348883
FNDC3B fibronectin type III domain containing 3B 0.0348718
MBNL2 muscleblind-like splicing regulator 2 0.0343334
SEC31A SEC31 homolog A (S. cerevisiae) 0.0342497
USP3 ubiquitin specific peptidase 3 0.0342126
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0341158
HELZ helicase with zinc finger 0.0340876
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0339281
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0339104
IARS1 isoleucyl-tRNA synthetase 1 0.0337862
CSDE1 cold shock domain containing E1, RNA-binding 0.0336223
MED13 mediator complex subunit 13 0.0334881
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0334805
MARCHF6 membrane associated ring-CH-type finger 6 0.0334156
DDIT4 DNA-damage-inducible transcript 4 0.0333822
ESRP1 epithelial splicing regulatory protein 1 0.0332204
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0329279
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0329242
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0327137
TPM3 tropomyosin 3 0.0324885
WDR43 WD repeat domain 43 0.0324381
SEC23A Sec23 homolog A (S. cerevisiae) 0.0319532
COG5 component of oligomeric golgi complex 5 0.0317266
STRN3 striatin, calmodulin binding protein 3 0.0314028
NCKAP1 NCK-associated protein 1 0.0313446
KDM3A lysine (K)-specific demethylase 3A 0.0312712
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0310014
CCNL1 cyclin L1 0.0309193
PTBP3 polypyrimidine tract binding protein 3 0.0308895
TRA2A transformer 2 alpha homolog (Drosophila) 0.0308596
KMT2C lysine (K)-specific methyltransferase 2C 0.0307322
NCOR1 nuclear receptor corepressor 1 0.0304952

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.2103
TMSB10 thymosin beta 10 -0.138478
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.128885
NPSR1 neuropeptide S receptor 1 -0.106751
RPLP1 ribosomal protein, large, P1 -0.0989694
RPS6 ribosomal protein S6 -0.0936422
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0876754
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0779224
FTL ferritin, light polypeptide -0.0773171
ALCAM activated leukocyte cell adhesion molecule -0.0686403
NALF1 NALCN channel auxiliary factor 1 -0.0669777
RPS19 ribosomal protein S19 -0.0604115
RPL36 ribosomal protein L36 -0.0566453
CCND1 cyclin D1 -0.052648
RPL35A ribosomal protein L35a -0.0526128
ACTG1 actin gamma 1 -0.0518994
MT2A metallothionein 2A -0.0507276
RPS8 ribosomal protein S8 -0.0505005
RPLP2 ribosomal protein, large, P2 -0.050293
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0491147
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0482631
PDE4D phosphodiesterase 4D, cAMP-specific -0.0480858
ONECUT3 one cut homeobox 3 -0.0467123
RPL34 ribosomal protein L34 -0.0455234
FHIT fragile histidine triad -0.0445767
RPL12 ribosomal protein L12 -0.0435862
TPT1 tumor protein, translationally-controlled 1 -0.0424449
RPS24 ribosomal protein S24 -0.0413416
EZR ezrin -0.0413365
RPL32 ribosomal protein L32 -0.0413029
HMGB1 high mobility group box 1 -0.0408072
RPL37A ribosomal protein L37a -0.0403345
S100A10 S100 calcium binding protein A10 -0.0402156
CEMIP cell migration inducing protein, hyaluronan binding -0.0398785
RPS29 ribosomal protein S29 -0.0380879
LOC112694756 uncharaterized LOC112694756 -0.0378996
RPL31 ribosomal protein L31 -0.037779
RPL28 ribosomal protein L28 -0.0376075
RPS23 ribosomal protein S23 -0.0370693
RPL9 ribosomal protein L9 -0.0364622
AGR2 anterior gradient 2 -0.0362552
RPS25 ribosomal protein S25 -0.0361178
TNS4 tensin 4 -0.0358853
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0353366
ZBTB20 zinc finger and BTB domain containing 20 -0.0346206
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.034446
CADPS Ca++-dependent secretion activator -0.0338462
S100A6 S100 calcium binding protein A6 -0.0332402
RPL30 ribosomal protein L30 -0.0328902
RPL38 ribosomal protein L38 -0.0326361
PKM pyruvate kinase, muscle -0.0323034
RPL26 ribosomal protein L26 -0.0322245
VDAC1 voltage-dependent anion channel 1 -0.0317863
RPL13A ribosomal protein L13a -0.0316838
EIF5B eukaryotic translation initiation factor 5B -0.0311108
RPL11 ribosomal protein L11 -0.0308755
RAD51B RAD51 paralog B -0.0307588
RPL19 ribosomal protein L19 -0.0306941
RPS27A ribosomal protein S27a -0.0304205
RPL23 ribosomal protein L23 -0.030357
SMYD3 SET and MYND domain containing 3 -0.0302856
RPL7A ribosomal protein L7a -0.0301454
RPS27 ribosomal protein S27 -0.0298699
RPL37 ribosomal protein L37 -0.0296845
TUBB4B tubulin, beta 4B class IVb -0.0296146
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0293884
CD44 CD44 molecule (Indian blood group) -0.0293561
EGR1 early growth response 1 -0.0290763
RPS16 ribosomal protein S16 -0.0288162
RPS20 ribosomal protein S20 -0.0286034
RPL27A ribosomal protein L27a -0.0280714
MAML3 mastermind-like 3 (Drosophila) -0.0278555
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0277567
PKP4 plakophilin 4 -0.0268111
RPL4 ribosomal protein L4 -0.026769
GCC2 GRIP and coiled-coil domain containing 2 -0.0263717
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0260735
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0255693
RPLP0 ribosomal protein, large, P0 -0.0253189
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.025264
RPL5 ribosomal protein L5 -0.025066
RPL18 ribosomal protein L18 -0.0250325
SLC35F3 solute carrier family 35, member F3 -0.0248055
TRAPPC9 trafficking protein particle complex 9 -0.0246599
RPS3 ribosomal protein S3 -0.0243262
PTPRG protein tyrosine phosphatase, receptor type, G -0.0242494
RPS12 ribosomal protein S12 -0.0240656
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0238514
PTPRK protein tyrosine phosphatase, receptor type, K -0.0236972
FBXL17 F-box and leucine-rich repeat protein 17 -0.0229486
TPM4 tropomyosin 4 -0.0225893
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0223729
LDHB lactate dehydrogenase B -0.0221365
H1-0 H1.0 linker histone -0.022058
IER3 immediate early response 3 -0.0220406
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0219531
POTEF POTE ankyrin domain family, member F -0.0217873
TSC22D1 TSC22 domain family, member 1 -0.02175
RPL35 ribosomal protein L35 -0.0213272
NRXN3 neurexin 3 -0.0212933