Aprepitant_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aprepitant perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aprepitant_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.150905
DST dystonin 0.102953
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0956511
SPAG9 sperm associated antigen 9 0.0948617
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0917442
TMSB4X thymosin beta 4, X-linked 0.0853471
CANX calnexin 0.0850503
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.068816
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0682543
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0654046
EFNA5 ephrin-A5 0.0625055
PGK1 phosphoglycerate kinase 1 0.0603828
KDM3A lysine (K)-specific demethylase 3A 0.0586423
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0568322
TPT1 tumor protein, translationally-controlled 1 0.0541806
PTMA prothymosin, alpha 0.0537732
CLIP2 CAP-GLY domain containing linker protein 2 0.0507714
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0501763
ERRFI1 ERBB receptor feedback inhibitor 1 0.05014
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0500197
ARRDC3 arrestin domain containing 3 0.049339
EPHA4 EPH receptor A4 0.0472659
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.047204
MACF1 microtubule-actin crosslinking factor 1 0.0462695
HOOK2 hook microtubule-tethering protein 2 0.0448466
TNS3 tensin 3 0.0447231
SOD2 superoxide dismutase 2, mitochondrial 0.0441897
ESYT2 extended synaptotagmin-like protein 2 0.0415765
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0412281
CALR calreticulin 0.0410916
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0403364
TRIO trio Rho guanine nucleotide exchange factor 0.0392882
NAMPT nicotinamide phosphoribosyltransferase 0.0385435
SQSTM1 sequestosome 1 0.0375342
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0374491
LRRC49 leucine rich repeat containing 49 0.0373458
EEF2 eukaryotic translation elongation factor 2 0.0367693
TMEM123 transmembrane protein 123 0.0365451
MYOF myoferlin 0.0358952
MYH9 myosin, heavy chain 9, non-muscle 0.0358182
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0350219
WSB1 WD repeat and SOCS box containing 1 0.0349713
SLK STE20-like kinase 0.0348423
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0345864
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0339308
EIF1 eukaryotic translation initiation factor 1 0.0339034
BZW1 basic leucine zipper and W2 domains 1 0.0336983
PLK2 polo-like kinase 2 0.0329607
SERINC1 serine incorporator 1 0.0322524
FNIP1 folliculin interacting protein 1 0.0310779
YEATS2 YEATS domain containing 2 0.0306896
DLG1 discs, large homolog 1 (Drosophila) 0.0305101
LOXL2 lysyl oxidase-like 2 0.0304022
DDIT4 DNA-damage-inducible transcript 4 0.0298138
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0297996
HDAC9 histone deacetylase 9 0.0297001
APP amyloid beta (A4) precursor protein 0.0294157
CAMTA1 calmodulin binding transcription activator 1 0.0294104
DENND1A DENN/MADD domain containing 1A 0.0292604
EIF4H eukaryotic translation initiation factor 4H 0.0288584
BIRC2 baculoviral IAP repeat containing 2 0.0286842
RAB1A RAB1A, member RAS oncogene family 0.0286133
NUP58 nucleoporin 58 0.0280083
DOCK11 dedicator of cytokinesis 11 0.0279685
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0278741
ADAM10 ADAM metallopeptidase domain 10 0.0276474
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0269019
CSMD3 CUB and Sushi multiple domains 3 0.0268914
EIF4A2 eukaryotic translation initiation factor 4A2 0.026806
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0264255
KRT18 keratin 18, type I 0.0261948
SDK1 sidekick cell adhesion molecule 1 0.0260235
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0259509
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0259215
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0258922
OGA O-GlcNAcase 0.0252815
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0252256
RAI1 retinoic acid induced 1 0.0247331
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0241525
WASF2 WAS protein family, member 2 0.0240184
ANLN anillin, actin binding protein 0.0239718
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0238895
MARCHF6 membrane associated ring-CH-type finger 6 0.023818
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.02369
GANAB glucosidase, alpha; neutral AB 0.0233237
MBNL2 muscleblind-like splicing regulator 2 0.0233018
SCAF4 SR-related CTD-associated factor 4 0.0232599
PYGL phosphorylase, glycogen, liver 0.02311
ZNF292 zinc finger protein 292 0.0229666
HELZ helicase with zinc finger 0.0229606
VEGFA vascular endothelial growth factor A 0.0225898
FXR1 fragile X mental retardation, autosomal homolog 1 0.0225764
ANXA2 annexin A2 0.0225659
KLF6 Kruppel-like factor 6 0.0225183
SMAD3 SMAD family member 3 0.0222506
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0221441
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0220815
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0220629
HLA-B major histocompatibility complex, class I, B 0.0220502
TTC3 tetratricopeptide repeat domain 3 0.0220149

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.331491
VIM vimentin -0.3211
MT2A metallothionein 2A -0.236455
TMSB10 thymosin beta 10 -0.159291
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.113413
UBC ubiquitin C -0.0905926
PSD3 pleckstrin and Sec7 domain containing 3 -0.0880523
POTEF POTE ankyrin domain family, member F -0.0674443
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.064068
MT1E metallothionein 1E -0.0621302
LOC112694756 uncharaterized LOC112694756 -0.0578629
TXNRD1 thioredoxin reductase 1 -0.0575611
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0554169
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0547616
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0538969
ACTG1 actin gamma 1 -0.0517374
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.051691
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.049508
GCLM glutamate-cysteine ligase, modifier subunit -0.0476739
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0466563
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0459081
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0454196
ZMYND8 zinc finger, MYND-type containing 8 -0.0452636
KMT2E lysine (K)-specific methyltransferase 2E -0.0445154
EGR1 early growth response 1 -0.0439471
SMC4 structural maintenance of chromosomes 4 -0.0431313
ADGRG6 adhesion G protein-coupled receptor G6 -0.0431061
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0422
CENPF centromere protein F, 350/400kDa -0.0414818
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.04135
RPL23 ribosomal protein L23 -0.0413125
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0412034
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0411803
SON SON DNA binding protein -0.0400843
S100A10 S100 calcium binding protein A10 -0.0388863
SDCCAG8 serologically defined colon cancer antigen 8 -0.0366455
SRRM2 serine/arginine repetitive matrix 2 -0.0361084
WWTR1 WW domain containing transcription regulator 1 -0.035495
EMP1 epithelial membrane protein 1 -0.0350986
WARS1 tryptophanyl-tRNA synthetase 1 -0.0350525
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0342906
ENO1 enolase 1, (alpha) -0.0337367
SPRY4 sprouty homolog 4 (Drosophila) -0.0331106
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0324722
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.032103
MT1X metallothionein 1X -0.0318646
SEPTIN7 septin 7 -0.0316437
RPLP1 ribosomal protein, large, P1 -0.0313051
BCAR3 breast cancer anti-estrogen resistance 3 -0.0312722
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0303461
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0297974
RIGI RNA sensor RIG-I -0.0296117
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0296056
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.029018
TPI1 triosephosphate isomerase 1 -0.0288973
PRRC2C proline-rich coiled-coil 2C -0.0288353
DARS1 aspartyl-tRNA synthetase 1 -0.0286615
RPS27A ribosomal protein S27a -0.028232
MYADM myeloid-associated differentiation marker -0.027262
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0272444
PKM pyruvate kinase, muscle -0.0269049
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0268331
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.02666
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0264421
BPTF bromodomain PHD finger transcription factor -0.0261718
FERMT1 fermitin family member 1 -0.0260599
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0260466
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.025737
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0254815
FTL ferritin, light polypeptide -0.0253697
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0252273
S100A6 S100 calcium binding protein A6 -0.0251963
CCDC88A coiled-coil domain containing 88A -0.0251834
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0249321
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0248339
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0246072
RPL28 ribosomal protein L28 -0.0245306
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0242428
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0239149
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0238857
ERCC1 excision repair cross-complementation group 1 -0.0238552
RPLP2 ribosomal protein, large, P2 -0.0235873
THSD4 thrombospondin, type I, domain containing 4 -0.0235115
RPS24 ribosomal protein S24 -0.0232381
PFN1 profilin 1 -0.023198
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0231475
USP34 ubiquitin specific peptidase 34 -0.0229753
CHD9 chromodomain helicase DNA binding protein 9 -0.0228861
HMGA1 high mobility group AT-hook 1 -0.0225117
JMJD1C jumonji domain containing 1C -0.0222374
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0221874
NCEH1 neutral cholesterol ester hydrolase 1 -0.022147
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0219235
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0216463
PDIA3 protein disulfide isomerase family A, member 3 -0.0216406
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0215882
EIF5B eukaryotic translation initiation factor 5B -0.0215083
CDK6 cyclin-dependent kinase 6 -0.0213901
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0213205
PHF21A PHD finger protein 21A -0.0211043