| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aprepitant perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Aprepitant_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMC2 | laminin, gamma 2 | 0.101 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0780325 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0683148 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0665355 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0652737 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0515329 |
| OSMR | oncostatin M receptor | 0.0504763 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0487105 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0415528 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0380337 |
| LMO7 | LIM domain 7 | 0.0367672 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0354647 |
| SPAG9 | sperm associated antigen 9 | 0.0339518 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0321047 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0314335 |
| MGAT4C | MGAT4 family, member C | 0.0297149 |
| ARRDC3 | arrestin domain containing 3 | 0.0295469 |
| DSPP | dentin sialophosphoprotein | 0.0284821 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0283334 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0280607 |
| AHNAK | AHNAK nucleoprotein | 0.0277815 |
| FDPS | farnesyl diphosphate synthase | 0.0270909 |
| VCL | vinculin | 0.0269249 |
| PLEC | plectin | 0.0268792 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0264945 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0256521 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0252862 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0246875 |
| MCL1 | myeloid cell leukemia 1 | 0.0240427 |
| LIPH | lipase, member H | 0.0234123 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0233761 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0227332 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.022041 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0219743 |
| NGLY1 | N-glycanase 1 | 0.0218314 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0212767 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0212446 |
| RASA2 | RAS p21 protein activator 2 | 0.0208139 |
| MYO5B | myosin VB | 0.0207528 |
| RCOR1 | REST corepressor 1 | 0.0201177 |
| ECT2 | epithelial cell transforming 2 | 0.0198868 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0193942 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0191734 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.019138 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0188939 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0186853 |
| B3GNT5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 0.0180741 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0178564 |
| KIAA0040 | KIAA0040 | 0.0174786 |
| RHOV | ras homolog family member V | 0.0173556 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0172633 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0172252 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.017106 |
| FBXO34 | F-box protein 34 | 0.0167703 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0166202 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0165972 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0162818 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0159742 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.015911 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0158234 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0155031 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0154662 |
| TMEM41B | transmembrane protein 41B | 0.0154381 |
| RNF169 | ring finger protein 169 | 0.0153457 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0151437 |
| LAMB3 | laminin, beta 3 | 0.015067 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0148932 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0147856 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0146794 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0145401 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.014458 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0143472 |
| RNF213 | ring finger protein 213 | 0.0143124 |
| EFNA5 | ephrin-A5 | 0.0143088 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | 0.0139915 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 0.0139268 |
| ABLIM1 | actin binding LIM protein 1 | 0.0138603 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0138514 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0136135 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0135341 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.013391 |
| ZNF217 | zinc finger protein 217 | 0.0133286 |
| PPP6R2 | protein phosphatase 6, regulatory subunit 2 | 0.0133092 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0132856 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0132111 |
| ITGB5 | integrin, beta 5 | 0.0131826 |
| MKI67 | marker of proliferation Ki-67 | 0.0131257 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0131077 |
| DUSP5 | dual specificity phosphatase 5 | 0.013087 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0129692 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0127116 |
| TJP1 | tight junction protein 1 | 0.0125764 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0124849 |
| ADAR | adenosine deaminase, RNA-specific | 0.0123905 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0123255 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | 0.0121782 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0121606 |
| CTSL | cathepsin L | 0.012018 |
| TFCP2 | transcription factor CP2 | 0.0119358 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0118724 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.292099 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.190463 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.083225 |
| RPS3 | ribosomal protein S3 | -0.0794535 |
| MT2A | metallothionein 2A | -0.0792034 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0741236 |
| EGFR | epidermal growth factor receptor | -0.0679587 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0663958 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0661407 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0648407 |
| JMJD1C | jumonji domain containing 1C | -0.0644789 |
| TXNRD1 | thioredoxin reductase 1 | -0.0644662 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0637298 |
| RUNX1 | runt-related transcription factor 1 | -0.0609192 |
| MYOF | myoferlin | -0.0609032 |
| PKM | pyruvate kinase, muscle | -0.0572182 |
| SEC61G | Sec61 gamma subunit | -0.056738 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0562596 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0513131 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0512238 |
| UBC | ubiquitin C | -0.0502856 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0479149 |
| PTMA | prothymosin, alpha | -0.0477872 |
| FAM13A | family with sequence similarity 13, member A | -0.0475207 |
| RBM39 | RNA binding motif protein 39 | -0.0473396 |
| MORF4L2 | mortality factor 4 like 2 | -0.0447445 |
| ASPH | aspartate beta-hydroxylase | -0.0439703 |
| TMEM165 | transmembrane protein 165 | -0.0435737 |
| HYOU1 | hypoxia up-regulated 1 | -0.0435686 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0429389 |
| RPS25 | ribosomal protein S25 | -0.0427052 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0424887 |
| CD163L1 | CD163 molecule-like 1 | -0.0418445 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0409735 |
| GOLGA4 | golgin A4 | -0.0400797 |
| GOLGB1 | golgin B1 | -0.0395075 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0389628 |
| RPS6 | ribosomal protein S6 | -0.0378114 |
| DTNA | dystrobrevin, alpha | -0.0373531 |
| INTS6 | integrator complex subunit 6 | -0.0369396 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.036867 |
| HELZ | helicase with zinc finger | -0.0367254 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0367138 |
| RPS2 | ribosomal protein S2 | -0.0364504 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0362835 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.036275 |
| IRS2 | insulin receptor substrate 2 | -0.03614 |
| RPL37A | ribosomal protein L37a | -0.0358682 |
| RPLP1 | ribosomal protein, large, P1 | -0.0345396 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0344994 |
| GRAMD1B | GRAM domain containing 1B | -0.0344213 |
| USP34 | ubiquitin specific peptidase 34 | -0.0338538 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0331671 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0326726 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0324525 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0321782 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0318769 |
| SON | SON DNA binding protein | -0.0313951 |
| CEP350 | centrosomal protein 350kDa | -0.0311882 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.031133 |
| CDCP1 | CUB domain containing protein 1 | -0.0309168 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0307044 |
| RPS8 | ribosomal protein S8 | -0.03055 |
| RPS12 | ribosomal protein S12 | -0.0301349 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0299589 |
| EMP1 | epithelial membrane protein 1 | -0.0299414 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0293308 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.0293088 |
| TES | testin LIM domain protein | -0.0292134 |
| SMYD3 | SET and MYND domain containing 3 | -0.0292068 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0291543 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0289813 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0286746 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0286722 |
| NDRG1 | N-myc downstream regulated 1 | -0.0283771 |
| CANX | calnexin | -0.0283707 |
| ZNF292 | zinc finger protein 292 | -0.0282185 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0281246 |
| MLF1 | myeloid leukemia factor 1 | -0.0270327 |
| SLMAP | sarcolemma associated protein | -0.027018 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0267273 |
| RPS23 | ribosomal protein S23 | -0.0265502 |
| MATR3 | matrin 3 | -0.0264322 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0263379 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0258457 |
| TFG | TRK-fused gene | -0.0254784 |
| CUL4A | cullin 4A | -0.0248894 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0242131 |
| TMF1 | TATA element modulatory factor 1 | -0.0240986 |
| ACTG1 | actin gamma 1 | -0.0240576 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0240051 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0239623 |
| ATF4 | activating transcription factor 4 | -0.0237065 |
| PER2 | period circadian clock 2 | -0.0236064 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0235689 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.02356 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0234544 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0233458 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0233256 |
| BRD2 | bromodomain containing 2 | -0.0232302 |
