Aprepitant_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aprepitant perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aprepitant_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GOLGA4 golgin A4 0.120574
NAMPT nicotinamide phosphoribosyltransferase 0.11679
DSCAM Down syndrome cell adhesion molecule 0.0776655
SOD2 superoxide dismutase 2, mitochondrial 0.0713027
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0699656
OGA O-GlcNAcase 0.0672369
FNDC3B fibronectin type III domain containing 3B 0.0669265
KMT2C lysine (K)-specific methyltransferase 2C 0.0642476
KDM3A lysine (K)-specific demethylase 3A 0.0627685
GRB10 growth factor receptor-bound protein 10 0.0619495
TRIO trio Rho guanine nucleotide exchange factor 0.0619291
FAM13A family with sequence similarity 13, member A 0.0616282
RBM39 RNA binding motif protein 39 0.0615605
SPAG9 sperm associated antigen 9 0.0545583
NGLY1 N-glycanase 1 0.0542083
ATP13A3 ATPase type 13A3 0.0539328
WAC WW domain containing adaptor with coiled-coil 0.0535146
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0526044
KDM2A lysine (K)-specific demethylase 2A 0.0493669
RAB1A RAB1A, member RAS oncogene family 0.0484667
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0480152
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0474923
SRP54 signal recognition particle 54kDa 0.0471092
ITCH itchy E3 ubiquitin protein ligase 0.0469834
CD109 CD109 molecule 0.046773
NBAS neuroblastoma amplified sequence 0.0446477
CTNND1 catenin (cadherin-associated protein), delta 1 0.0433307
CANX calnexin 0.0426335
UBA6 ubiquitin-like modifier activating enzyme 6 0.0423389
SETD5 SET domain containing 5 0.0423342
COPA coatomer protein complex, subunit alpha 0.0421491
USP3 ubiquitin specific peptidase 3 0.0420832
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0418251
RICTOR RPTOR independent companion of MTOR, complex 2 0.0409649
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0404127
SIK3 SIK family kinase 3 0.0401848
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0401762
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.039891
RAB8B RAB8B, member RAS oncogene family 0.0391628
SEC23A Sec23 homolog A (S. cerevisiae) 0.0385836
UBE2H ubiquitin-conjugating enzyme E2H 0.038056
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0380439
AHR aryl hydrocarbon receptor 0.0379776
DLG1 discs, large homolog 1 (Drosophila) 0.0375309
YTHDC1 YTH domain containing 1 0.0366231
YME1L1 YME1-like 1 ATPase 0.0364468
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0363495
PICALM phosphatidylinositol binding clathrin assembly protein 0.0359622
PUM2 pumilio RNA-binding family member 2 0.0355081
ARRDC3 arrestin domain containing 3 0.0345443
SUCO SUN domain containing ossification factor 0.0344227
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0342054
MARCHF6 membrane associated ring-CH-type finger 6 0.0341379
BIRC6 baculoviral IAP repeat containing 6 0.034043
DOCK5 dedicator of cytokinesis 5 0.0338631
ADD3 adducin 3 (gamma) 0.0332311
SEC31A SEC31 homolog A (S. cerevisiae) 0.0320924
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0315915
ADM adrenomedullin 0.0310597
ANKRD17 ankyrin repeat domain 17 0.030731
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0306156
YEATS2 YEATS domain containing 2 0.0304077
AKAP12 A kinase (PRKA) anchor protein 12 0.0303179
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0302138
FAM107B family with sequence similarity 107, member B 0.0299194
STRN3 striatin, calmodulin binding protein 3 0.0297396
MON2 MON2 homolog (S. cerevisiae) 0.029611
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0295539
TTC3 tetratricopeptide repeat domain 3 0.0292386
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0290624
ELL2 elongation factor, RNA polymerase II, 2 0.0289652
HELZ helicase with zinc finger 0.0288901
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0288445
LRRC49 leucine rich repeat containing 49 0.0284033
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0281744
ESYT2 extended synaptotagmin-like protein 2 0.0280759
COG5 component of oligomeric golgi complex 5 0.027846
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0275041
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0273211
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0272491
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0269782
FNIP1 folliculin interacting protein 1 0.0268384
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0264821
PID1 phosphotyrosine interaction domain containing 1 0.0264029
ELP2 elongator acetyltransferase complex subunit 2 0.0261655
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0261623
VMP1 vacuole membrane protein 1 0.0260982
SERINC1 serine incorporator 1 0.0260286
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0260043
CHD1 chromodomain helicase DNA binding protein 1 0.0258137
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0257374
CLTC clathrin, heavy chain (Hc) 0.0256392
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0255371
CEP95 centrosomal protein 95kDa 0.0254593
FBXL13 F-box and leucine-rich repeat protein 13 0.0254104
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0251401
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0251335
FLNB filamin B, beta 0.0251043
TAS2R14 taste receptor, type 2, member 14 0.025081
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0248872

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.354925
TMSB10 thymosin beta 10 -0.20858
MT2A metallothionein 2A -0.15609
VIM vimentin -0.154287
FTL ferritin, light polypeptide -0.14262
FN1 fibronectin 1 -0.10174
RPLP1 ribosomal protein, large, P1 -0.0856436
HMGA2 high mobility group AT-hook 2 -0.0739238
RPS19 ribosomal protein S19 -0.071988
NRG1 neuregulin 1 -0.0718283
CDH13 cadherin 13 -0.0712334
CD44 CD44 molecule (Indian blood group) -0.0704417
GLCCI1 glucocorticoid induced 1 -0.0679226
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0644566
EGR1 early growth response 1 -0.062692
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0596352
POTEF POTE ankyrin domain family, member F -0.0574459
PKM pyruvate kinase, muscle -0.0545835
HMGA1 high mobility group AT-hook 1 -0.053339
RPS6 ribosomal protein S6 -0.0524131
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.052179
NDRG1 N-myc downstream regulated 1 -0.0513184
RPL35A ribosomal protein L35a -0.0506512
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0490442
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0488137
DPYD dihydropyrimidine dehydrogenase -0.0480483
RPL23 ribosomal protein L23 -0.0443881
B2M beta-2-microglobulin -0.0443463
MTSS1 metastasis suppressor 1 -0.0438891
PTMA prothymosin, alpha -0.0437702
ANTXR2 anthrax toxin receptor 2 -0.0420272
RPL31 ribosomal protein L31 -0.0417035
PDE4D phosphodiesterase 4D, cAMP-specific -0.0415877
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0410532
RPL32 ribosomal protein L32 -0.0406231
PSD3 pleckstrin and Sec7 domain containing 3 -0.0404984
RPS8 ribosomal protein S8 -0.0403369
SYT1 synaptotagmin I -0.0401867
SDK1 sidekick cell adhesion molecule 1 -0.0399779
RPLP2 ribosomal protein, large, P2 -0.0394277
S100A10 S100 calcium binding protein A10 -0.0393562
RPL34 ribosomal protein L34 -0.0393412
RPL36 ribosomal protein L36 -0.0387278
SAMD9 sterile alpha motif domain containing 9 -0.038611
CDCP1 CUB domain containing protein 1 -0.0377927
RPL37A ribosomal protein L37a -0.0369937
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0364711
LOC102724023 ES1 protein homolog, mitochondrial -0.0359247
RPL28 ribosomal protein L28 -0.0355842
RPS24 ribosomal protein S24 -0.0337464
EIF1 eukaryotic translation initiation factor 1 -0.0333945
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0333037
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0331333
IER3 immediate early response 3 -0.0326777
RNF213 ring finger protein 213 -0.0324035
RPS12 ribosomal protein S12 -0.0307347
RPS23 ribosomal protein S23 -0.0306712
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0303739
MX2 MX dynamin-like GTPase 2 -0.0302564
LOC112694756 uncharaterized LOC112694756 -0.0300695
STC1 stanniocalcin 1 -0.03004
LRMDA leucine rich melanocyte differentiation associated -0.0300166
IFITM3 interferon induced transmembrane protein 3 -0.0299251
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0299036
RPS5 ribosomal protein S5 -0.0297722
SP100 SP100 nuclear antigen -0.0296449
PDIA3 protein disulfide isomerase family A, member 3 -0.0296128
RPS29 ribosomal protein S29 -0.0292075
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0291762
RPS25 ribosomal protein S25 -0.0290018
SLC38A1 solute carrier family 38, member 1 -0.0288845
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0288719
RPS21 ribosomal protein S21 -0.0283967
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0281026
PFN1 profilin 1 -0.0278298
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0277291
IFI44L interferon-induced protein 44-like -0.0275964
PLIN2 perilipin 2 -0.0275315
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0273225
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0272631
RACK1 receptor for activated C kinase 1 -0.0269121
NTN4 netrin 4 -0.0267682
RPL11 ribosomal protein L11 -0.0265602
RPS16 ribosomal protein S16 -0.0263589
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0262721
S100A6 S100 calcium binding protein A6 -0.0254881
TMSB4X thymosin beta 4, X-linked -0.0253548
RPL37 ribosomal protein L37 -0.0251413
NRP1 neuropilin 1 -0.0250912
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0250106
MYADM myeloid-associated differentiation marker -0.0249219
LOX lysyl oxidase -0.0246145
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0243
RPL30 ribosomal protein L30 -0.0242521
RPL19 ribosomal protein L19 -0.0241903
DST dystonin -0.0240433
IFI6 interferon, alpha-inducible protein 6 -0.0240418
BTG1 B-cell translocation gene 1, anti-proliferative -0.024034
MECOM MDS1 and EVI1 complex locus -0.0240074
RPS11 ribosomal protein S11 -0.0240009