| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aprepitant perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aprepitant_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0889716 |
| WDR43 | WD repeat domain 43 | 0.0706833 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0599945 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.05874 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0488238 |
| RASAL2 | RAS protein activator like 2 | 0.0453692 |
| RBM39 | RNA binding motif protein 39 | 0.0444 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0438557 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0435952 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0435168 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0431336 |
| ERBIN | erbb2 interacting protein | 0.0429493 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0421495 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0420369 |
| RTN4 | reticulon 4 | 0.0410588 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0406146 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.040434 |
| PTK2 | protein tyrosine kinase 2 | 0.0399106 |
| ZNF292 | zinc finger protein 292 | 0.0386104 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0385043 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0384763 |
| YBX3 | Y box binding protein 3 | 0.0384148 |
| NUP58 | nucleoporin 58 | 0.0374675 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0373389 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0371117 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0360338 |
| PFDN2 | prefoldin subunit 2 | 0.0346185 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0337749 |
| USP3 | ubiquitin specific peptidase 3 | 0.033146 |
| ZNF207 | zinc finger protein 207 | 0.0327362 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0323357 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0320228 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0317334 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0315963 |
| SPAG9 | sperm associated antigen 9 | 0.0314129 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0313992 |
| YTHDC1 | YTH domain containing 1 | 0.030827 |
| YME1L1 | YME1-like 1 ATPase | 0.0307512 |
| RBM33 | RNA binding motif protein 33 | 0.0307135 |
| SBF2 | SET binding factor 2 | 0.030488 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0304236 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0302855 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0300952 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0300511 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0299769 |
| RHEB | Ras homolog enriched in brain | 0.0298853 |
| RBM25 | RNA binding motif protein 25 | 0.0297805 |
| MORF4L1 | mortality factor 4 like 1 | 0.0297004 |
| CUL3 | cullin 3 | 0.0292775 |
| TFG | TRK-fused gene | 0.0290175 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0289992 |
| RNF145 | ring finger protein 145 | 0.0284515 |
| SIK3 | SIK family kinase 3 | 0.0284357 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0283812 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0279733 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0279437 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.027716 |
| GOLGA4 | golgin A4 | 0.0275731 |
| EWSR1 | EWS RNA-binding protein 1 | 0.027545 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.027508 |
| FMNL2 | formin-like 2 | 0.0274103 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0273461 |
| CTNNBL1 | catenin, beta like 1 | 0.0272261 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0271357 |
| TPD52 | tumor protein D52 | 0.0267279 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0266217 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0264018 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0262208 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0262117 |
| JAK1 | Janus kinase 1 | 0.0260805 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0259815 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0259321 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0258333 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0258124 |
| RCOR1 | REST corepressor 1 | 0.0257047 |
| FBXO11 | F-box protein 11 | 0.0256304 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0251726 |
| SETD5 | SET domain containing 5 | 0.0251706 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0250338 |
| WTAP | Wilms tumor 1 associated protein | 0.0248706 |
| FAM168A | family with sequence similarity 168, member A | 0.0248099 |
| GOLT1B | golgi transport 1B | 0.0247043 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0245543 |
| COG5 | component of oligomeric golgi complex 5 | 0.0244782 |
| PCNX1 | pecanex 1 | 0.0243871 |
| CDC73 | cell division cycle 73 | 0.0241372 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0239972 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.023947 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.023939 |
| NOP58 | NOP58 ribonucleoprotein | 0.0239193 |
| PRPF39 | pre-mRNA processing factor 39 | 0.0239041 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0237579 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0237338 |
| FOXJ3 | forkhead box J3 | 0.0235923 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0235654 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.0235098 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0233995 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0231862 |
| UIMC1 | ubiquitin interaction motif containing 1 | 0.0231114 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | 0.0230531 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.231993 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.137871 |
| FTL | ferritin, light polypeptide | -0.126506 |
| MT2A | metallothionein 2A | -0.0996623 |
| POTEF | POTE ankyrin domain family, member F | -0.097702 |
| IGF2 | insulin-like growth factor 2 | -0.0965174 |
| TMSB10 | thymosin beta 10 | -0.0936384 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.075387 |
| PKM | pyruvate kinase, muscle | -0.0735199 |
| ACTG1 | actin gamma 1 | -0.0687574 |
| VIM | vimentin | -0.0631426 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0585681 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0551426 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0547878 |
| FGB | fibrinogen beta chain | -0.0530427 |
| LDHA | lactate dehydrogenase A | -0.0521395 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0500497 |
| EGR1 | early growth response 1 | -0.0488391 |
| IER3 | immediate early response 3 | -0.0424808 |
| ASPH | aspartate beta-hydroxylase | -0.0421392 |
| PFN1 | profilin 1 | -0.0420198 |
| ENO1 | enolase 1, (alpha) | -0.0376384 |
| MCL1 | myeloid cell leukemia 1 | -0.037383 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0341829 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0332938 |
| HMGA1 | high mobility group AT-hook 1 | -0.0329502 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0325813 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0324794 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0323625 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0289695 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0280322 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0278875 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0274136 |
| RPLP1 | ribosomal protein, large, P1 | -0.0274077 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0262468 |
| WWOX | WW domain containing oxidoreductase | -0.0260862 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0260711 |
| RPL19 | ribosomal protein L19 | -0.0259428 |
| TAGLN2 | transgelin 2 | -0.0256736 |
| TPI1 | triosephosphate isomerase 1 | -0.0256432 |
| S100A10 | S100 calcium binding protein A10 | -0.0251859 |
| RPS8 | ribosomal protein S8 | -0.0251454 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0249946 |
| RPS6 | ribosomal protein S6 | -0.0246668 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0245622 |
| MORF4L2 | mortality factor 4 like 2 | -0.0242887 |
| YBX1 | Y box binding protein 1 | -0.024087 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0240256 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0238729 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.02371 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0232984 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.023292 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0230302 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0225601 |
| GNAS | GNAS complex locus | -0.022532 |
| BICC1 | BicC family RNA binding protein 1 | -0.022466 |
| S100A6 | S100 calcium binding protein A6 | -0.0223086 |
| PFKP | phosphofructokinase, platelet | -0.021999 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0218858 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0217318 |
| TPM4 | tropomyosin 4 | -0.0217261 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0213419 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0210526 |
| RPL23 | ribosomal protein L23 | -0.0209732 |
| TXNRD1 | thioredoxin reductase 1 | -0.0209314 |
| HMGB1 | high mobility group box 1 | -0.0208624 |
| HLA-B | major histocompatibility complex, class I, B | -0.020735 |
| RPL28 | ribosomal protein L28 | -0.0205756 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0205285 |
| TUBB | tubulin, beta class I | -0.0203691 |
| NNMT | nicotinamide N-methyltransferase | -0.020344 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0202587 |
| RPS19 | ribosomal protein S19 | -0.0202101 |
| LDHB | lactate dehydrogenase B | -0.0198047 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0196896 |
| RPS3 | ribosomal protein S3 | -0.0192411 |
| EFNA5 | ephrin-A5 | -0.0191271 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0190498 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0190374 |
| RPL37A | ribosomal protein L37a | -0.0188973 |
| CAVIN1 | caveolae associated protein 1 | -0.0187587 |
| ANXA2 | annexin A2 | -0.0187429 |
| RPS25 | ribosomal protein S25 | -0.0187333 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0181636 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0180312 |
| HLA-A | major histocompatibility complex, class I, A | -0.0178063 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.017785 |
| RPS24 | ribosomal protein S24 | -0.017718 |
| RPL4 | ribosomal protein L4 | -0.0176667 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0173802 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0172129 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0172034 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0172009 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | -0.0170128 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0170065 |
| S100A11 | S100 calcium binding protein A11 | -0.016988 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0166762 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0165401 |
| RSPO3 | R-spondin 3 | -0.0165085 |
| MYOF | myoferlin | -0.016232 |
