| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aprepitant perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aprepitant_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.158805 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.107784 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0969871 |
| ZNF292 | zinc finger protein 292 | 0.0959789 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.091862 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0783112 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.078017 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0761438 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0744587 |
| CD109 | CD109 molecule | 0.070016 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0662246 |
| CADM1 | cell adhesion molecule 1 | 0.064438 |
| VIM | vimentin | 0.0627074 |
| ATXN1 | ataxin 1 | 0.062588 |
| ATP13A3 | ATPase type 13A3 | 0.0610378 |
| YTHDC1 | YTH domain containing 1 | 0.0593301 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0590963 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0584415 |
| CALR | calreticulin | 0.0583815 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.057083 |
| NUP153 | nucleoporin 153kDa | 0.0560718 |
| CCDC88A | coiled-coil domain containing 88A | 0.0540487 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0534134 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0531842 |
| EFNA5 | ephrin-A5 | 0.0522683 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0522345 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0515336 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0508043 |
| MTF2 | metal response element binding transcription factor 2 | 0.0506854 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0505644 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0502411 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.050207 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0492453 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0489902 |
| RTN4 | reticulon 4 | 0.0481602 |
| NCKAP1 | NCK-associated protein 1 | 0.0471135 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0469581 |
| NUP58 | nucleoporin 58 | 0.0457295 |
| GPHN | gephyrin | 0.0434993 |
| DST | dystonin | 0.0433791 |
| PGK1 | phosphoglycerate kinase 1 | 0.0431925 |
| HLA-B | major histocompatibility complex, class I, B | 0.042635 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0425571 |
| SPPL3 | signal peptide peptidase like 3 | 0.0423109 |
| OPTN | optineurin | 0.0421536 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0418767 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0415079 |
| RAB1A | RAB1A, member RAS oncogene family | 0.041296 |
| STC1 | stanniocalcin 1 | 0.040758 |
| KIF13A | kinesin family member 13A | 0.0402463 |
| SON | SON DNA binding protein | 0.0393344 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.0391839 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0389116 |
| PKN2 | protein kinase N2 | 0.0388193 |
| NFX1 | nuclear transcription factor, X-box binding 1 | 0.0383742 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0380608 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0377881 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0376842 |
| RBM25 | RNA binding motif protein 25 | 0.0373564 |
| AREG | amphiregulin | 0.0373343 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0372366 |
| RAB14 | RAB14, member RAS oncogene family | 0.0372089 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0370429 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0369644 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0368157 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.036626 |
| RBM6 | RNA binding motif protein 6 | 0.0365225 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0364271 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0363545 |
| NEK7 | NIMA-related kinase 7 | 0.0353896 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0353514 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0353092 |
| SUCO | SUN domain containing ossification factor | 0.0346492 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0343894 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0342885 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0342348 |
| ACTN4 | actinin, alpha 4 | 0.0341812 |
| PHIP | pleckstrin homology domain interacting protein | 0.0341064 |
| CCNY | cyclin Y | 0.0337055 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.033598 |
| TPM3 | tropomyosin 3 | 0.0334762 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0334749 |
| HDAC9 | histone deacetylase 9 | 0.0333635 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.033197 |
| ABI1 | abl-interactor 1 | 0.0329481 |
| RPS19 | ribosomal protein S19 | 0.0325628 |
| QKI | QKI, KH domain containing, RNA binding | 0.0321986 |
| RPL37A | ribosomal protein L37a | 0.0318954 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0313595 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0313571 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0306055 |
| HLA-A | major histocompatibility complex, class I, A | 0.0305317 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.030531 |
| CANX | calnexin | 0.0305231 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0305003 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0303167 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0301253 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0300163 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0298063 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0296192 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.120878 |
| MYO1E | myosin IE | -0.113608 |
| FN1 | fibronectin 1 | -0.0912986 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0873694 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0798537 |
| FTL | ferritin, light polypeptide | -0.0766671 |
| LAMB3 | laminin, beta 3 | -0.0753002 |
| VMP1 | vacuole membrane protein 1 | -0.0711432 |
| TXNRD1 | thioredoxin reductase 1 | -0.0675401 |
| LMO7 | LIM domain 7 | -0.0628989 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0593012 |
| ANXA2 | annexin A2 | -0.057778 |
| KRT17 | keratin 17, type I | -0.05692 |
| KYNU | kynureninase | -0.0557636 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0541668 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0533764 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0518888 |
| NDRG1 | N-myc downstream regulated 1 | -0.0514912 |
| OSMR | oncostatin M receptor | -0.0511612 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0496489 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0476968 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0470832 |
| LAMC2 | laminin, gamma 2 | -0.0459553 |
| GRB10 | growth factor receptor-bound protein 10 | -0.045739 |
| CYTH1 | cytohesin 1 | -0.0452941 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0450208 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0444579 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0443179 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.043879 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0435333 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0433649 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | -0.0430139 |
| PDE10A | phosphodiesterase 10A | -0.0429714 |
| GPC6 | glypican 6 | -0.0425078 |
| EZR | ezrin | -0.0421757 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0419458 |
| GOLGB1 | golgin B1 | -0.0418768 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0416408 |
| S100A10 | S100 calcium binding protein A10 | -0.0415474 |
| MCL1 | myeloid cell leukemia 1 | -0.0415459 |
| SDC4 | syndecan 4 | -0.0407873 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0407847 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0406147 |
| SVIL | supervillin | -0.0398338 |
| TMSB10 | thymosin beta 10 | -0.0392114 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0391575 |
| TJP1 | tight junction protein 1 | -0.0388958 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0388788 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.038869 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0382795 |
| OXSR1 | oxidative stress responsive 1 | -0.0377784 |
| DIAPH1 | diaphanous-related formin 1 | -0.0374294 |
| SMAD3 | SMAD family member 3 | -0.0368779 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0366637 |
| SRP54 | signal recognition particle 54kDa | -0.0365488 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0358332 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0352968 |
| PARD3 | par-3 family cell polarity regulator | -0.0352498 |
| INTS6 | integrator complex subunit 6 | -0.0352385 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.035075 |
| COPA | coatomer protein complex, subunit alpha | -0.034955 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.033654 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0336009 |
| CUX1 | cut-like homeobox 1 | -0.0335976 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0335357 |
| USP53 | ubiquitin specific peptidase 53 | -0.0334312 |
| RAB10 | RAB10, member RAS oncogene family | -0.0334167 |
| RORA | RAR-related orphan receptor A | -0.0333925 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0330453 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0330437 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0330405 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0328625 |
| NRG1 | neuregulin 1 | -0.0327895 |
| MT2A | metallothionein 2A | -0.0324389 |
| FAM13B | family with sequence similarity 13, member B | -0.0324002 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0321801 |
| TBC1D15 | TBC1 domain family, member 15 | -0.0320137 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0318132 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0313939 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0311804 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0311655 |
| RPL35A | ribosomal protein L35a | -0.0311445 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0310594 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0302708 |
| MED13 | mediator complex subunit 13 | -0.030195 |
| DENND4A | DENN/MADD domain containing 4A | -0.030137 |
| PRKCA | protein kinase C, alpha | -0.029972 |
| ARF1 | ADP-ribosylation factor 1 | -0.0296565 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0296462 |
| PTMA | prothymosin, alpha | -0.0294257 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0293894 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0291806 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0291206 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0288083 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0285389 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0285054 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0284874 |
| JUN | jun proto-oncogene | -0.0283009 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0282464 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0278347 |
