| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aprepitant perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Aprepitant_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.17095 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.152147 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0975514 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0947063 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0895193 |
| GRAMD1B | GRAM domain containing 1B | 0.0635188 |
| ADAR | adenosine deaminase, RNA-specific | 0.059778 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0550211 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0543954 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.054156 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.053646 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.052741 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.049594 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0460349 |
| TMEM41B | transmembrane protein 41B | 0.0458704 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0437546 |
| OGA | O-GlcNAcase | 0.0432972 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0396985 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0393502 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0382021 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0377507 |
| FLOT1 | flotillin 1 | 0.0377203 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0367864 |
| ANKRD36B | ankyrin repeat domain 36B | 0.0365733 |
| KRT18 | keratin 18, type I | 0.0364592 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.036301 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0358396 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0357734 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0346433 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0345768 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0344261 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0342448 |
| RTN4 | reticulon 4 | 0.0328559 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0327797 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0325421 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0322742 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0322034 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0320485 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0319845 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0317597 |
| JAK1 | Janus kinase 1 | 0.0313992 |
| SMAD3 | SMAD family member 3 | 0.0303564 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0302971 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0301866 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0299162 |
| CTTN | cortactin | 0.0298128 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0292576 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0292238 |
| RAB10 | RAB10, member RAS oncogene family | 0.0291852 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0289324 |
| RLIM | ring finger protein, LIM domain interacting | 0.0283287 |
| IL6ST | interleukin 6 signal transducer | 0.0278747 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0277263 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0275509 |
| ANO6 | anoctamin 6 | 0.0275493 |
| RASAL2 | RAS protein activator like 2 | 0.0274125 |
| SBF2 | SET binding factor 2 | 0.0271859 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0271049 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0266941 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0265875 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.026159 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0259138 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0258862 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0256196 |
| CEP192 | centrosomal protein 192kDa | 0.0255347 |
| TPM3 | tropomyosin 3 | 0.0254591 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0252264 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0251819 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0251753 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.0247315 |
| XPO1 | exportin 1 | 0.0246104 |
| CCNT1 | cyclin T1 | 0.0246068 |
| RRM2 | ribonucleotide reductase M2 | 0.0244375 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0240726 |
| MYPN | myopalladin | 0.0240201 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0239692 |
| CEP95 | centrosomal protein 95kDa | 0.0238632 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0236756 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 0.023632 |
| ANKRD17 | ankyrin repeat domain 17 | 0.023573 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0235668 |
| RBM33 | RNA binding motif protein 33 | 0.0233667 |
| RNF169 | ring finger protein 169 | 0.0232344 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0231349 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0230246 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0229694 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0226447 |
| ANXA5 | annexin A5 | 0.0225426 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0223718 |
| PCNX1 | pecanex 1 | 0.0223215 |
| TJP1 | tight junction protein 1 | 0.0222641 |
| STK4 | serine/threonine kinase 4 | 0.0220913 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0220857 |
| CCND2 | cyclin D2 | 0.0218256 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0218231 |
| UBAP2L | ubiquitin associated protein 2-like | 0.021602 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.021388 |
| USP22 | ubiquitin specific peptidase 22 | 0.0213455 |
| ERBIN | erbb2 interacting protein | 0.021209 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0211632 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.147026 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.143254 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0957443 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0955289 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0928463 |
| ACTG1 | actin gamma 1 | -0.0755364 |
| EGR1 | early growth response 1 | -0.072591 |
| POTEF | POTE ankyrin domain family, member F | -0.0636074 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0626917 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0603359 |
| TMSB10 | thymosin beta 10 | -0.0565894 |
| PTMA | prothymosin, alpha | -0.0546398 |
| RPS3 | ribosomal protein S3 | -0.0544247 |
| HMGA2 | high mobility group AT-hook 2 | -0.0500718 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0497439 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0468213 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0455676 |
| ZNF638 | zinc finger protein 638 | -0.0441599 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0431759 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0429403 |
| GOLGB1 | golgin B1 | -0.0428097 |
| RPS8 | ribosomal protein S8 | -0.0427762 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0427394 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0410257 |
| IER3 | immediate early response 3 | -0.0399862 |
| RPL37A | ribosomal protein L37a | -0.039744 |
| RSF1 | remodeling and spacing factor 1 | -0.0396331 |
| RYR3 | ryanodine receptor 3 | -0.039619 |
| BBX | bobby sox homolog (Drosophila) | -0.0391364 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0386283 |
| BPTF | bromodomain PHD finger transcription factor | -0.0364765 |
| GNAS | GNAS complex locus | -0.0359112 |
| IGF2 | insulin-like growth factor 2 | -0.0359003 |
| MORF4L2 | mortality factor 4 like 2 | -0.0352507 |
| USP34 | ubiquitin specific peptidase 34 | -0.0349958 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0349885 |
| FMNL2 | formin-like 2 | -0.0347272 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0346935 |
| HLA-B | major histocompatibility complex, class I, B | -0.0339334 |
| PDE10A | phosphodiesterase 10A | -0.033927 |
| NDRG1 | N-myc downstream regulated 1 | -0.0339039 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0337267 |
| NOP58 | NOP58 ribonucleoprotein | -0.0328219 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0323424 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0322484 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0318615 |
| BRD2 | bromodomain containing 2 | -0.0314951 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0312422 |
| CAVIN1 | caveolae associated protein 1 | -0.031014 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0309365 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0308864 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0305661 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0302732 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0299358 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0297917 |
| RPL37 | ribosomal protein L37 | -0.0291522 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0290068 |
| NF1 | neurofibromin 1 | -0.0288926 |
| LOXL2 | lysyl oxidase-like 2 | -0.0287217 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0278463 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0277049 |
| ANKRD11 | ankyrin repeat domain 11 | -0.027635 |
| LRRC23 | leucine rich repeat containing 23 | -0.0274389 |
| BNC2 | basonuclin 2 | -0.027437 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0274266 |
| RPL36 | ribosomal protein L36 | -0.0272646 |
| FUS | FUS RNA binding protein | -0.0270648 |
| PTK2 | protein tyrosine kinase 2 | -0.0269869 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | -0.0268284 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0266777 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0263805 |
| RPS10 | ribosomal protein S10 | -0.0263467 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0261812 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0259818 |
| CCNL1 | cyclin L1 | -0.0259005 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0258596 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0257119 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0248167 |
| RPL28 | ribosomal protein L28 | -0.0247251 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0246897 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0244889 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0243854 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0237904 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0236059 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0235409 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0234009 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0233243 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0232695 |
| JUN | jun proto-oncogene | -0.0231143 |
| TPM4 | tropomyosin 4 | -0.0230797 |
| SPECC1L | sperm antigen with calponin homology and coiled-coil domains 1-like | -0.0229727 |
| PKM | pyruvate kinase, muscle | -0.022931 |
| MTDH | metadherin | -0.0229216 |
| ATG7 | autophagy related 7 | -0.0228427 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0225167 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0223143 |
| AAK1 | AP2 associated kinase 1 | -0.0222982 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0221838 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0221512 |
| RBM39 | RNA binding motif protein 39 | -0.0220736 |
