Aprepitant_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aprepitant perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aprepitant_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.119376
PABPC1 poly(A) binding protein, cytoplasmic 1 0.107354
FN1 fibronectin 1 0.101151
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0980079
MYH9 myosin, heavy chain 9, non-muscle 0.0973062
CALR calreticulin 0.0928521
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0909605
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0889482
APLP2 amyloid beta (A4) precursor-like protein 2 0.0847394
ADAM9 ADAM metallopeptidase domain 9 0.0842674
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0773227
UBA6 ubiquitin-like modifier activating enzyme 6 0.0652405
VEGFA vascular endothelial growth factor A 0.064505
ARRDC3 arrestin domain containing 3 0.0623768
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0610927
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0592765
FNDC3B fibronectin type III domain containing 3B 0.0554856
TPM3 tropomyosin 3 0.0537729
YTHDC1 YTH domain containing 1 0.053724
HSPA8 heat shock 70kDa protein 8 0.0535775
MYO6 myosin VI 0.0533595
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0514693
WAC WW domain containing adaptor with coiled-coil 0.0510091
PLEC plectin 0.0509908
GRB10 growth factor receptor-bound protein 10 0.0503245
PARD3 par-3 family cell polarity regulator 0.0493591
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0477904
MSN moesin 0.0470002
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0455252
KRT18 keratin 18, type I 0.0452702
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.045146
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0449327
FAM13A family with sequence similarity 13, member A 0.0448788
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0444247
CANX calnexin 0.0440757
KDM6A lysine (K)-specific demethylase 6A 0.0436781
EEF2 eukaryotic translation elongation factor 2 0.0434731
FXR1 fragile X mental retardation, autosomal homolog 1 0.0421229
MXD1 MAX dimerization protein 1 0.0420046
RCOR1 REST corepressor 1 0.0407051
NUP58 nucleoporin 58 0.0403881
SEC23A Sec23 homolog A (S. cerevisiae) 0.0396487
ANXA1 annexin A1 0.0391155
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0388504
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0370324
PCBP2 poly(rC) binding protein 2 0.036766
SLMAP sarcolemma associated protein 0.0362785
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0356788
MARCHF6 membrane associated ring-CH-type finger 6 0.0354966
SCAF4 SR-related CTD-associated factor 4 0.0353253
DSPP dentin sialophosphoprotein 0.0351407
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0349733
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0348403
RSRC2 arginine/serine-rich coiled-coil 2 0.0344589
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0334742
RAB1A RAB1A, member RAS oncogene family 0.0334316
PTMA prothymosin, alpha 0.0334053
TJP2 tight junction protein 2 0.032669
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0322018
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0318446
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0316783
TSC22D2 TSC22 domain family, member 2 0.0316524
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0316415
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0315707
MSMO1 methylsterol monooxygenase 1 0.0310373
NAP1L4 nucleosome assembly protein 1-like 4 0.0306876
MACF1 microtubule-actin crosslinking factor 1 0.0305351
ATP13A3 ATPase type 13A3 0.0301319
TRA2B transformer 2 beta homolog (Drosophila) 0.0299166
RTN4 reticulon 4 0.0296502
EEF1G eukaryotic translation elongation factor 1 gamma 0.029339
CDC73 cell division cycle 73 0.0284879
SFPQ splicing factor proline/glutamine-rich 0.0282565
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0281003
SOD2 superoxide dismutase 2, mitochondrial 0.0280452
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0280259
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0279754
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0274526
RYBP RING1 and YY1 binding protein 0.0272755
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0270575
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0270485
RASA2 RAS p21 protein activator 2 0.0268744
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0265589
ITCH itchy E3 ubiquitin protein ligase 0.0263429
PAPOLA poly(A) polymerase alpha 0.0262043
RYK receptor-like tyrosine kinase 0.0259377
HDGF hepatoma-derived growth factor 0.0259013
MKRN1 makorin ring finger protein 1 0.0251083
PTK2 protein tyrosine kinase 2 0.0250191
IRF6 interferon regulatory factor 6 0.0249549
KDM3A lysine (K)-specific demethylase 3A 0.0249075
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0248016
PPARD peroxisome proliferator-activated receptor delta 0.0247328
SPAG9 sperm associated antigen 9 0.0247188
TNIP1 TNFAIP3 interacting protein 1 0.0245841
TFPI2 tissue factor pathway inhibitor 2 0.0245123
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0244682
EIF4B eukaryotic translation initiation factor 4B 0.0244319
FLNB filamin B, beta 0.0244053
CNN3 calponin 3, acidic 0.0242032

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.287829
ACTG1 actin gamma 1 -0.126291
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.117481
TMSB10 thymosin beta 10 -0.106156
SAMD4A sterile alpha motif domain containing 4A -0.089476
LMO7 LIM domain 7 -0.088181
EFNA5 ephrin-A5 -0.0880128
ALCAM activated leukocyte cell adhesion molecule -0.0797779
IGFBP3 insulin-like growth factor binding protein 3 -0.0746852
S100A10 S100 calcium binding protein A10 -0.071646
FTL ferritin, light polypeptide -0.0698249
S100A6 S100 calcium binding protein A6 -0.0692105
RPLP1 ribosomal protein, large, P1 -0.0675025
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0662857
SLC38A1 solute carrier family 38, member 1 -0.063284
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0613113
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.059515
LOC112694756 uncharaterized LOC112694756 -0.05178
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0517536
RPL34 ribosomal protein L34 -0.0514749
EXT1 exostosin glycosyltransferase 1 -0.0502164
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0490617
ARF1 ADP-ribosylation factor 1 -0.0490416
LIMCH1 LIM and calponin homology domains 1 -0.048998
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0488034
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0466529
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0455872
RUNX1 runt-related transcription factor 1 -0.0425816
RPL32 ribosomal protein L32 -0.0424618
EGFR epidermal growth factor receptor -0.0421652
RPL23 ribosomal protein L23 -0.0419948
ZBTB20 zinc finger and BTB domain containing 20 -0.0412738
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0409251
CD2AP CD2-associated protein -0.0408596
RPL30 ribosomal protein L30 -0.0400237
CCND1 cyclin D1 -0.0381548
SP100 SP100 nuclear antigen -0.0380306
RPL35A ribosomal protein L35a -0.0378731
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0376187
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0376001
RACK1 receptor for activated C kinase 1 -0.036946
IFI16 interferon, gamma-inducible protein 16 -0.0368109
CEP350 centrosomal protein 350kDa -0.0364602
SQSTM1 sequestosome 1 -0.0364127
RPS23 ribosomal protein S23 -0.0361273
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0357553
ATXN1 ataxin 1 -0.0354666
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0349225
PLSCR1 phospholipid scramblase 1 -0.0338749
MBNL1 muscleblind-like splicing regulator 1 -0.0338217
RASAL2 RAS protein activator like 2 -0.0334298
FBXL2 F-box and leucine-rich repeat protein 2 -0.0334171
NPC2 Niemann-Pick disease, type C2 -0.0333873
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0332165
OSMR oncostatin M receptor -0.0328968
ARHGAP5 Rho GTPase activating protein 5 -0.0328692
NF1 neurofibromin 1 -0.0328093
MYO1E myosin IE -0.0326892
IFI27 interferon, alpha-inducible protein 27 -0.0325045
FRMD5 FERM domain containing 5 -0.0319821
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0314116
MAP4 microtubule-associated protein 4 -0.03141
RNF213 ring finger protein 213 -0.0313618
IFITM3 interferon induced transmembrane protein 3 -0.0312782
RPS5 ribosomal protein S5 -0.0310147
RPL37A ribosomal protein L37a -0.030843
MYOF myoferlin -0.0304382
RPS16 ribosomal protein S16 -0.0300502
UBC ubiquitin C -0.0300377
EGR1 early growth response 1 -0.0299008
STAT1 signal transducer and activator of transcription 1, 91kDa -0.029215
IFI6 interferon, alpha-inducible protein 6 -0.0288294
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0287151
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0286426
CSTB cystatin B (stefin B) -0.0286117
RHOA ras homolog family member A -0.0285881
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.02851
MCTP2 multiple C2 domains, transmembrane 2 -0.0283749
RPS25 ribosomal protein S25 -0.0283147
CDK13 cyclin-dependent kinase 13 -0.0277927
GOLGB1 golgin B1 -0.0273672
ETV6 ets variant 6 -0.0273556
NIPBL Nipped-B homolog (Drosophila) -0.0272852
LOXL2 lysyl oxidase-like 2 -0.0272757
GNAS GNAS complex locus -0.0272362
PATJ PATJ crumbs cell polarity complex component -0.0272113
SGMS2 sphingomyelin synthase 2 -0.0271575
MX2 MX dynamin-like GTPase 2 -0.0270099
LPP LIM domain containing preferred translocation partner in lipoma -0.0269972
TBCA tubulin folding cofactor A -0.0269544
BLZF1 basic leucine zipper nuclear factor 1 -0.0267402
MAML2 mastermind-like 2 (Drosophila) -0.0266199
RPL37 ribosomal protein L37 -0.0264704
RPS3 ribosomal protein S3 -0.0264299
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0264151
TOP1 topoisomerase (DNA) I -0.026361
RPLP2 ribosomal protein, large, P2 -0.02636
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0262947
FNIP1 folliculin interacting protein 1 -0.0259814
RPS27A ribosomal protein S27a -0.0258586