Aprepitant_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aprepitant perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aprepitant_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MCL1 myeloid cell leukemia 1 0.0432459
TFPI2 tissue factor pathway inhibitor 2 0.030629
ARRDC3 arrestin domain containing 3 0.0282955
KMT2E lysine (K)-specific methyltransferase 2E 0.0251276
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.023843
KDM6A lysine (K)-specific demethylase 6A 0.0227158
OGA O-GlcNAcase 0.0221835
SOD2 superoxide dismutase 2, mitochondrial 0.021212
UBA6 ubiquitin-like modifier activating enzyme 6 0.0210924
NGLY1 N-glycanase 1 0.0199949
SPAG9 sperm associated antigen 9 0.019253
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0188014
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0184917
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.018441
IGFBP3 insulin-like growth factor binding protein 3 0.0180616
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0178583
ESYT2 extended synaptotagmin-like protein 2 0.0175534
PDGFA platelet-derived growth factor alpha polypeptide 0.0173609
ATP13A3 ATPase type 13A3 0.0173369
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0165026
STC1 stanniocalcin 1 0.0160498
SDK1 sidekick cell adhesion molecule 1 0.0156186
PICALM phosphatidylinositol binding clathrin assembly protein 0.0154163
ERRFI1 ERBB receptor feedback inhibitor 1 0.0153329
SMOC1 SPARC related modular calcium binding 1 0.0151396
FMNL2 formin-like 2 0.0149108
COPA coatomer protein complex, subunit alpha 0.0147834
HELZ helicase with zinc finger 0.0142315
FNIP1 folliculin interacting protein 1 0.0142064
NBAS neuroblastoma amplified sequence 0.0141877
GOLGA4 golgin A4 0.0136498
ANKRD36 ankyrin repeat domain 36 0.0134087
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0130579
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0129304
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0126964
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0126415
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0125706
TENT2 terminal nucleotidyltransferase 2 0.0125659
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0125341
WAC WW domain containing adaptor with coiled-coil 0.012446
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0123455
NUP58 nucleoporin 58 0.0123262
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0122649
MACF1 microtubule-actin crosslinking factor 1 0.0122236
ITCH itchy E3 ubiquitin protein ligase 0.0122037
SEC23A Sec23 homolog A (S. cerevisiae) 0.0119682
CD109 CD109 molecule 0.0118984
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0116684
AKAP12 A kinase (PRKA) anchor protein 12 0.0116619
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0116355
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.011611
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0115426
AUTS2 autism susceptibility candidate 2 0.0111471
FAM13A family with sequence similarity 13, member A 0.0110707
GSK3B glycogen synthase kinase 3 beta 0.0109288
STC2 stanniocalcin 2 0.0107707
FLNB filamin B, beta 0.0107149
ITPRID2 ITPR interacting domain containing 2 0.0107015
SRP54 signal recognition particle 54kDa 0.0106372
ADAM9 ADAM metallopeptidase domain 9 0.0105827
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0104841
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0104633
SUCO SUN domain containing ossification factor 0.0104556
DSCAM Down syndrome cell adhesion molecule 0.0104206
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0102992
CTBP2 C-terminal binding protein 2 0.0102533
PIAS2 protein inhibitor of activated STAT, 2 0.0101525
RAB18 RAB18, member RAS oncogene family 0.0101334
EIF4B eukaryotic translation initiation factor 4B 0.010056
KMT2C lysine (K)-specific methyltransferase 2C 0.00997335
DNER delta/notch-like EGF repeat containing 0.00994427
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.00991034
CEP70 centrosomal protein 70kDa 0.00989938
SETD5 SET domain containing 5 0.00987727
N4BP2L2 NEDD4 binding protein 2-like 2 0.00985287
CHD1L chromodomain helicase DNA binding protein 1-like 0.00975754
SFPQ splicing factor proline/glutamine-rich 0.00967755
RIC1 RAB6A GEF complex partner 1 0.00965994
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00950318
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0094863
CDK19 cyclin-dependent kinase 19 0.00937641
RAB6A RAB6A, member RAS oncogene family 0.00935478
RAB1A RAB1A, member RAS oncogene family 0.00932623
ANO6 anoctamin 6 0.00925096
AKAP13 A kinase (PRKA) anchor protein 13 0.00917785
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.00916778
VMP1 vacuole membrane protein 1 0.0090521
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.00902192
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.00899958
ELL2 elongation factor, RNA polymerase II, 2 0.00890775
GRB10 growth factor receptor-bound protein 10 0.00871292
INSIG2 insulin induced gene 2 0.00867116
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.00865618
PDE8A phosphodiesterase 8A 0.00859973
TMEM41B transmembrane protein 41B 0.00855545
GANAB glucosidase, alpha; neutral AB 0.00851736
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.00847175
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.00842963
RASA2 RAS p21 protein activator 2 0.00841945
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0083087

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.325544
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175803
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.166449
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.14337
PSD3 pleckstrin and Sec7 domain containing 3 -0.138284
TMSB10 thymosin beta 10 -0.131383
PDE10A phosphodiesterase 10A -0.126819
FN1 fibronectin 1 -0.110901
EFNA5 ephrin-A5 -0.109836
TXNRD1 thioredoxin reductase 1 -0.105414
COL5A2 collagen, type V, alpha 2 -0.104306
NALF1 NALCN channel auxiliary factor 1 -0.103343
ASPH aspartate beta-hydroxylase -0.10098
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.100274
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0980847
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0942893
RPLP1 ribosomal protein, large, P1 -0.0840073
SMYD3 SET and MYND domain containing 3 -0.0832159
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0809255
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0739709
FTL ferritin, light polypeptide -0.073206
COL8A1 collagen, type VIII, alpha 1 -0.072152
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0711715
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0686627
RPS6 ribosomal protein S6 -0.066683
RPS24 ribosomal protein S24 -0.0616637
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0614861
CDH13 cadherin 13 -0.05987
COL4A5 collagen, type IV, alpha 5 -0.0595323
PRKN parkin RBR E3 ubiquitin protein ligase -0.0586998
PM20D1 peptidase M20 domain containing 1 -0.0585544
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0579713
NAMPT nicotinamide phosphoribosyltransferase -0.0578735
NRCAM neuronal cell adhesion molecule -0.0573145
P3H2 prolyl 3-hydroxylase 2 -0.0554806
TRIO trio Rho guanine nucleotide exchange factor -0.052233
MYOF myoferlin -0.0508195
GRAMD1B GRAM domain containing 1B -0.0493603
MAML3 mastermind-like 3 (Drosophila) -0.0472463
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0463664
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.04618
RPL31 ribosomal protein L31 -0.0456277
RPL23 ribosomal protein L23 -0.0455991
ACTG1 actin gamma 1 -0.0438786
RPL37A ribosomal protein L37a -0.0437664
RPS8 ribosomal protein S8 -0.0432479
LDHA lactate dehydrogenase A -0.0431446
PTMA prothymosin, alpha -0.0428647
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0424579
RPL35A ribosomal protein L35a -0.0422978
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0413049
BASP1 brain abundant, membrane attached signal protein 1 -0.0411303
GNAS GNAS complex locus -0.0407515
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0407128
RPS19 ribosomal protein S19 -0.0403346
NCOA7 nuclear receptor coactivator 7 -0.0403208
VIM vimentin -0.0400099
RPL19 ribosomal protein L19 -0.0397351
ANTXR1 anthrax toxin receptor 1 -0.0396786
RPS23 ribosomal protein S23 -0.0396376
RPL26 ribosomal protein L26 -0.0395919
EIF1 eukaryotic translation initiation factor 1 -0.0392657
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.038771
RPL7A ribosomal protein L7a -0.0385797
PALLD palladin, cytoskeletal associated protein -0.038513
GDA guanine deaminase -0.0384111
AKR1C1 aldo-keto reductase family 1, member C1 -0.0380596
RPS4X ribosomal protein S4, X-linked -0.0379404
PKM pyruvate kinase, muscle -0.0368175
PBX1 pre-B-cell leukemia homeobox 1 -0.036706
TPT1 tumor protein, translationally-controlled 1 -0.0363498
PTPRM protein tyrosine phosphatase, receptor type, M -0.0363354
TNPO1 transportin 1 -0.0361212
LOC112694756 uncharaterized LOC112694756 -0.0359092
EIF4A1 eukaryotic translation initiation factor 4A1 -0.035283
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0345093
SRGN serglycin -0.0339301
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0337063
RPS21 ribosomal protein S21 -0.0336387
PRDX1 peroxiredoxin 1 -0.0334918
RACK1 receptor for activated C kinase 1 -0.0332686
RPS3 ribosomal protein S3 -0.0330348
RPLP2 ribosomal protein, large, P2 -0.0325643
ENO1 enolase 1, (alpha) -0.0324766
CADM2 cell adhesion molecule 2 -0.0324244
RPL38 ribosomal protein L38 -0.0321801
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0321149
RPL12 ribosomal protein L12 -0.0320808
LSAMP limbic system-associated membrane protein -0.0319239
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0318977
RPL37 ribosomal protein L37 -0.0317515
S100A10 S100 calcium binding protein A10 -0.0317276
B2M beta-2-microglobulin -0.0314713
RPL34 ribosomal protein L34 -0.0311623
PTGR1 prostaglandin reductase 1 -0.0311498
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0310702
RPS12 ribosomal protein S12 -0.0310533
RPLP0 ribosomal protein, large, P0 -0.030578
HLA-B major histocompatibility complex, class I, B -0.0305419
DST dystonin -0.0302606