Aprepitant_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aprepitant perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

193 genes differentially expressed following the Aprepitant_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.235298
PDE10A phosphodiesterase 10A 0.137051
PTK2 protein tyrosine kinase 2 0.126132
LDHA lactate dehydrogenase A 0.115026
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.113712
GPC6 glypican 6 0.109739
NALF1 NALCN channel auxiliary factor 1 0.108282
FNDC3B fibronectin type III domain containing 3B 0.102518
FBXO11 F-box protein 11 0.0990863
TRIO trio Rho guanine nucleotide exchange factor 0.0978386
FLNB filamin B, beta 0.0972191
KMT2C lysine (K)-specific methyltransferase 2C 0.0948579
AKAP9 A kinase (PRKA) anchor protein 9 0.0948364
LIMCH1 LIM and calponin homology domains 1 0.088448
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0881795
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0860749
DST dystonin 0.0844977
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.081803
MYOF myoferlin 0.0815658
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0804597
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0791846
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0774712
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0765401
WSB1 WD repeat and SOCS box containing 1 0.0761627
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.073082
AFF4 AF4/FMR2 family, member 4 0.0724289
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0713908
PSD3 pleckstrin and Sec7 domain containing 3 0.0712938
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0692194
PDIA3 protein disulfide isomerase family A, member 3 0.0651027
EZR ezrin 0.0619224
ERRFI1 ERBB receptor feedback inhibitor 1 0.0612225
TPM4 tropomyosin 4 0.0607256
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0605366
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0598099
HELZ helicase with zinc finger 0.0596761
USP3 ubiquitin specific peptidase 3 0.0588753
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0581793
AKAP13 A kinase (PRKA) anchor protein 13 0.0570257
TRA2A transformer 2 alpha homolog (Drosophila) 0.056967
IGFBP3 insulin-like growth factor binding protein 3 0.0560966
GNAS GNAS complex locus 0.0544264
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0532128
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0531496
SND1 staphylococcal nuclease and tudor domain containing 1 0.0529881
ZBTB20 zinc finger and BTB domain containing 20 0.0517343
CALR calreticulin 0.0511929
MYO1E myosin IE 0.0509813
GNPDA1 glucosamine-6-phosphate deaminase 1 0.050612
KDM6A lysine (K)-specific demethylase 6A 0.0498194
RNMT RNA (guanine-7-) methyltransferase 0.048557
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.047703
KMT2E lysine (K)-specific methyltransferase 2E 0.0463427
RPS8 ribosomal protein S8 0.0461578
PAPOLA poly(A) polymerase alpha 0.0450564
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0442032
TSC22D2 TSC22 domain family, member 2 0.043382
RNF145 ring finger protein 145 0.0429946
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0429904
PUM2 pumilio RNA-binding family member 2 0.0424782
PDE4D phosphodiesterase 4D, cAMP-specific 0.0410851
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0402207
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0385628
SEC31A SEC31 homolog A (S. cerevisiae) 0.038043
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0379254
ZFAND3 zinc finger, AN1-type domain 3 0.0379197
BIRC6 baculoviral IAP repeat containing 6 0.03763
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0370241
RPL12 ribosomal protein L12 0.0356308
CALU calumenin 0.0345651
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0344914
FNDC3A fibronectin type III domain containing 3A 0.0343263
HLA-A major histocompatibility complex, class I, A 0.0338566
DSCAM Down syndrome cell adhesion molecule 0.0333063
HOOK2 hook microtubule-tethering protein 2 0.0319493
GLIS3 GLIS family zinc finger 3 0.0312611
FBL fibrillarin 0.0306598
SPAG9 sperm associated antigen 9 0.0304953
EFNA5 ephrin-A5 0.03032
ESYT2 extended synaptotagmin-like protein 2 0.0301748
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0292079
NCOR1 nuclear receptor corepressor 1 0.029055
NAMPT nicotinamide phosphoribosyltransferase 0.0276213
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.026296
DDIT4 DNA-damage-inducible transcript 4 0.0262953
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0231118
PCBP3 poly(rC) binding protein 3 0.0221375
NAP1L1 nucleosome assembly protein 1-like 1 0.0221154
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0221065
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0217036
ANKRD11 ankyrin repeat domain 11 0.0212221
OGA O-GlcNAcase 0.0212186
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0209901
ATP13A3 ATPase type 13A3 0.0206633
CANX calnexin 0.019362
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0192259
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0189808
RPL19 ribosomal protein L19 0.0182622
RPS21 ribosomal protein S21 0.0178624
MYH9 myosin, heavy chain 9, non-muscle 0.0178565

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.160608
VIM vimentin -0.155029
TPT1 tumor protein, translationally-controlled 1 -0.141287
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.135509
RPS6 ribosomal protein S6 -0.132669
MT2A metallothionein 2A -0.112201
HDLBP high density lipoprotein binding protein -0.106078
PTMA prothymosin, alpha -0.105678
RPLP1 ribosomal protein, large, P1 -0.0998084
CCNI cyclin I -0.0991048
PRKCA protein kinase C, alpha -0.0971393
EGFR epidermal growth factor receptor -0.095583
FN1 fibronectin 1 -0.0955447
TXNIP thioredoxin interacting protein -0.0952165
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0938221
LMO7 LIM domain 7 -0.0864076
MORF4L2 mortality factor 4 like 2 -0.0858655
ATP11A ATPase, class VI, type 11A -0.0854108
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0842414
SP100 SP100 nuclear antigen -0.0840327
FTL ferritin, light polypeptide -0.0824023
RPL26 ribosomal protein L26 -0.0809268
NKD1 naked cuticle homolog 1 (Drosophila) -0.0776227
VCL vinculin -0.0758204
RBM25 RNA binding motif protein 25 -0.0739861
LOC102724023 ES1 protein homolog, mitochondrial -0.070656
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0702952
MCL1 myeloid cell leukemia 1 -0.0700298
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0687798
B2M beta-2-microglobulin -0.0681855
FTH1 ferritin, heavy polypeptide 1 -0.0647358
MACF1 microtubule-actin crosslinking factor 1 -0.0645678
CD44 CD44 molecule (Indian blood group) -0.063853
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0637204
HMGA2 high mobility group AT-hook 2 -0.0636674
GOLGA4 golgin A4 -0.0629956
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0620514
PRRC2C proline-rich coiled-coil 2C -0.0608658
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0590645
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0584466
LMNA lamin A/C -0.0580987
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0560307
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0544413
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0538815
THSD4 thrombospondin, type I, domain containing 4 -0.053362
PDE8A phosphodiesterase 8A -0.0520339
SLTM SAFB-like, transcription modulator -0.051771
RICTOR RPTOR independent companion of MTOR, complex 2 -0.049241
SMYD3 SET and MYND domain containing 3 -0.0465379
MED13 mediator complex subunit 13 -0.0458834
RPS16 ribosomal protein S16 -0.0452237
LPP LIM domain containing preferred translocation partner in lipoma -0.0448848
SLC38A2 solute carrier family 38, member 2 -0.0441117
NOP58 NOP58 ribonucleoprotein -0.0423545
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0416524
OSMR oncostatin M receptor -0.0407067
PCBP2 poly(rC) binding protein 2 -0.0385043
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.037838
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0352868
KIF5B kinesin family member 5B -0.0351182
RPL23 ribosomal protein L23 -0.0338603
EEF2 eukaryotic translation elongation factor 2 -0.0333486
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0331073
RPL35A ribosomal protein L35a -0.0330012
JMJD1C jumonji domain containing 1C -0.0325351
EIF1 eukaryotic translation initiation factor 1 -0.0323465
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.030584
RPS24 ribosomal protein S24 -0.0286423
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0285635
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0271703
MYO10 myosin X -0.0267584
TPR translocated promoter region, nuclear basket protein -0.0264536
ANKRD12 ankyrin repeat domain 12 -0.0259314
AHNAK AHNAK nucleoprotein -0.0237894
KTN1 kinectin 1 (kinesin receptor) -0.0212619
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0212462
SETD5 SET domain containing 5 -0.0205497
GARS1 glycyl-tRNA synthetase 1 -0.0164095
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0163819
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0161133
PTPRM protein tyrosine phosphatase, receptor type, M -0.0158735
ATXN1 ataxin 1 -0.0152217
ANKHD1 ankyrin repeat and KH domain containing 1 -0.014945
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0143062
ENO1 enolase 1, (alpha) -0.0133952
EXT1 exostosin glycosyltransferase 1 -0.0106575
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0105679
PGK1 phosphoglycerate kinase 1 -0.00637182
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00475492
ACTG1 actin gamma 1 -0.00459324
CDK6 cyclin-dependent kinase 6 -0.0035929
UGCG UDP-glucose ceramide glucosyltransferase -0.00221646
RAB1A RAB1A, member RAS oncogene family -3.58048E-4