Aprepitant_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aprepitant perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aprepitant_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.13825
DST dystonin 0.115693
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.110735
SPAG9 sperm associated antigen 9 0.0965166
ZFAND3 zinc finger, AN1-type domain 3 0.0900804
HDAC9 histone deacetylase 9 0.0860692
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0812784
ANKRD33B ankyrin repeat domain 33B 0.0810197
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.080008
ZNF292 zinc finger protein 292 0.0797482
SRP54 signal recognition particle 54kDa 0.067495
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0640552
TSC22D2 TSC22 domain family, member 2 0.063732
COL3A1 collagen, type III, alpha 1 0.0634942
FNDC3B fibronectin type III domain containing 3B 0.0598105
NCKAP1 NCK-associated protein 1 0.0594637
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0561139
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0549736
TMSB4X thymosin beta 4, X-linked 0.0548576
MARCHF6 membrane associated ring-CH-type finger 6 0.0544026
RAD21 RAD21 homolog (S. pombe) 0.0540839
KDM3A lysine (K)-specific demethylase 3A 0.0537156
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0531259
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.052265
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0520863
TPM3 tropomyosin 3 0.0520624
FXR1 fragile X mental retardation, autosomal homolog 1 0.0518365
CALR calreticulin 0.0518058
CDC73 cell division cycle 73 0.0508009
NCOR1 nuclear receptor corepressor 1 0.0506394
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0505069
ADAM9 ADAM metallopeptidase domain 9 0.0502015
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0494068
RBM39 RNA binding motif protein 39 0.0483576
PICALM phosphatidylinositol binding clathrin assembly protein 0.0476761
TRA2A transformer 2 alpha homolog (Drosophila) 0.0476516
NAMPT nicotinamide phosphoribosyltransferase 0.0474404
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0469649
TRIO trio Rho guanine nucleotide exchange factor 0.0451536
NAP1L1 nucleosome assembly protein 1-like 1 0.0450826
STRN3 striatin, calmodulin binding protein 3 0.0442268
KDM6A lysine (K)-specific demethylase 6A 0.0439602
MB21D2 Mab-21 domain containing 2 0.043825
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0437379
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0432487
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0426832
APP amyloid beta (A4) precursor protein 0.0418623
PDGFC platelet derived growth factor C 0.0411945
MYH9 myosin, heavy chain 9, non-muscle 0.0408604
THBS1 thrombospondin 1 0.0408424
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0401871
MEMO1 mediator of cell motility 1 0.0400198
PUM2 pumilio RNA-binding family member 2 0.0399224
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.039632
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0392736
STAG2 stromal antigen 2 0.0388242
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0382944
FBXO11 F-box protein 11 0.0380283
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0379588
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0366155
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0363517
ZEB2 zinc finger E-box binding homeobox 2 0.0361655
RAB1A RAB1A, member RAS oncogene family 0.0361438
RAD23B RAD23 homolog B (S. cerevisiae) 0.0357614
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0354121
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0349766
SERINC1 serine incorporator 1 0.0349061
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0348807
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0348018
CXADR coxsackie virus and adenovirus receptor 0.0347426
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0347352
COLEC11 collectin sub-family member 11 0.0341867
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0341297
PUM1 pumilio RNA-binding family member 1 0.0336865
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0336585
EMP1 epithelial membrane protein 1 0.0336061
FNIP1 folliculin interacting protein 1 0.0335792
ENAH enabled homolog (Drosophila) 0.0334639
ANXA1 annexin A1 0.0331439
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0330455
IFRD1 interferon-related developmental regulator 1 0.0329859
TLK2 tousled-like kinase 2 0.0328225
RASAL2 RAS protein activator like 2 0.0324877
B2M beta-2-microglobulin 0.03229
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0320415
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0319005
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0317499
JUN jun proto-oncogene 0.0317342
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0315177
ANXA2 annexin A2 0.0313362
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.031234
MTF2 metal response element binding transcription factor 2 0.0311064
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0309307
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0308903
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0307433
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0307027
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.030514
RHEB Ras homolog enriched in brain 0.0304918
TBC1D12 TBC1 domain family, member 12 0.0303362
HMGB2 high mobility group box 2 0.0302457

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.167576
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.158282
VIM vimentin -0.127728
CDH10 cadherin 10, type 2 (T2-cadherin) -0.114055
RPS6 ribosomal protein S6 -0.0886094
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0851142
COL11A1 collagen, type XI, alpha 1 -0.072147
RPLP1 ribosomal protein, large, P1 -0.0713535
RPS16 ribosomal protein S16 -0.0669699
POTEF POTE ankyrin domain family, member F -0.0668577
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0662394
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0648558
GNAS GNAS complex locus -0.064729
CADM2 cell adhesion molecule 2 -0.0601633
MDK midkine (neurite growth-promoting factor 2) -0.0591139
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0585291
ACTG1 actin gamma 1 -0.0542188
PCDH9 protocadherin 9 -0.0535005
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0528208
FTL ferritin, light polypeptide -0.0511289
RPS19 ribosomal protein S19 -0.050417
RPS8 ribosomal protein S8 -0.0503303
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0486675
RPL28 ribosomal protein L28 -0.0455959
RPLP0 ribosomal protein, large, P0 -0.0442546
RPL30 ribosomal protein L30 -0.0432998
NTM neurotrimin -0.0428582
RPL37 ribosomal protein L37 -0.0428552
ENO1 enolase 1, (alpha) -0.0427075
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0422202
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0419898
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0414298
RPS12 ribosomal protein S12 -0.0410664
RPL32 ribosomal protein L32 -0.0389991
RPL37A ribosomal protein L37a -0.0371124
RPL11 ribosomal protein L11 -0.0371066
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0358483
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0351011
PFN1 profilin 1 -0.0348033
RPS23 ribosomal protein S23 -0.0343851
RPL35A ribosomal protein L35a -0.034217
COL5A2 collagen, type V, alpha 2 -0.0337634
LOC102724023 ES1 protein homolog, mitochondrial -0.0329643
CNRIP1 cannabinoid receptor interacting protein 1 -0.0328276
RPL23 ribosomal protein L23 -0.0323496
RPS10 ribosomal protein S10 -0.0318993
RPLP2 ribosomal protein, large, P2 -0.0317783
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0316073
RPS21 ribosomal protein S21 -0.0312378
PARD3B par-3 family cell polarity regulator beta -0.0310872
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.030658
WASF2 WAS protein family, member 2 -0.0300385
RACK1 receptor for activated C kinase 1 -0.0298751
RPL7A ribosomal protein L7a -0.029556
DARS1 aspartyl-tRNA synthetase 1 -0.0293889
RPS4X ribosomal protein S4, X-linked -0.0290086
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0284007
RPL31 ribosomal protein L31 -0.0282857
RPL19 ribosomal protein L19 -0.0277356
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -0.027615
CSMD3 CUB and Sushi multiple domains 3 -0.0271275
RAD51B RAD51 paralog B -0.0269491
LDHA lactate dehydrogenase A -0.0269332
FOXP2 forkhead box P2 -0.0267048
SRRM2 serine/arginine repetitive matrix 2 -0.0266043
LRRC4C leucine rich repeat containing 4C -0.0265433
RPS3 ribosomal protein S3 -0.0264455
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0261043
RPS13 ribosomal protein S13 -0.0259655
DOCK5 dedicator of cytokinesis 5 -0.0258013
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0253222
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0251415
SIK2 salt-inducible kinase 2 -0.0249345
ATP5MG ATP synthase membrane subunit g -0.024772
H1-0 H1.0 linker histone -0.0246595
PRELID2 PRELI domain containing 2 -0.0245906
BMPR1A bone morphogenetic protein receptor, type IA -0.0244723
PRTG protogenin -0.0244311
LOC112694756 uncharaterized LOC112694756 -0.0242234
RPS24 ribosomal protein S24 -0.0240478
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0236876
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0235396
RPL9 ribosomal protein L9 -0.0234582
NIPBL Nipped-B homolog (Drosophila) -0.0234112
CHD9 chromodomain helicase DNA binding protein 9 -0.0234083
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -0.0233596
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0232065
BPTF bromodomain PHD finger transcription factor -0.0231201
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.0229831
S100A10 S100 calcium binding protein A10 -0.0229372
TUT4 terminal uridylyl transferase 4 -0.0228071
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0227881
ZC3H15 zinc finger CCCH-type containing 15 -0.0227225
RPL36 ribosomal protein L36 -0.0226977
RPL39 ribosomal protein L39 -0.0226958
DSTN destrin (actin depolymerizing factor) -0.0226643
RPL12 ribosomal protein L12 -0.0224986
RPS25 ribosomal protein S25 -0.0224953
RPS20 ribosomal protein S20 -0.0224919
ZFP30 ZFP30 zinc finger protein -0.0224666