Aprepitant_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aprepitant perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aprepitant_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMNL2 formin-like 2 0.072173
GOLGA4 golgin A4 0.0713389
PTMA prothymosin, alpha 0.0691708
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0668824
DSCAM Down syndrome cell adhesion molecule 0.0653187
MACF1 microtubule-actin crosslinking factor 1 0.0627203
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0575322
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0571978
CHD1 chromodomain helicase DNA binding protein 1 0.0569718
EEF2 eukaryotic translation elongation factor 2 0.0531319
DGKD diacylglycerol kinase, delta 130kDa 0.0461798
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0456418
ITCH itchy E3 ubiquitin protein ligase 0.044658
TAS2R14 taste receptor, type 2, member 14 0.0443079
DERA deoxyribose-phosphate aldolase (putative) 0.0428294
HILPDA hypoxia inducible lipid droplet-associated 0.0421412
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0415509
EIF1 eukaryotic translation initiation factor 1 0.0414101
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0402568
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0396482
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0370682
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0364929
PRKCE protein kinase C, epsilon 0.0359138
UBP1 upstream binding protein 1 (LBP-1a) 0.0355557
SS18 synovial sarcoma translocation, chromosome 18 0.0350502
TMEM41B transmembrane protein 41B 0.0349547
JMJD1C jumonji domain containing 1C 0.0344389
CAPRIN2 caprin family member 2 0.0344339
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0342677
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0339665
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0338938
MRE11 MRE11 homolog, double strand break repair nuclease 0.0335249
OSMR oncostatin M receptor 0.0333453
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0333213
GLS2 glutaminase 2 (liver, mitochondrial) 0.0331521
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0324226
AKAP13 A kinase (PRKA) anchor protein 13 0.0323379
UBE2K ubiquitin-conjugating enzyme E2K 0.0317787
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0317555
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0313977
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0311499
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0309268
ATP13A3 ATPase type 13A3 0.0309059
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0305707
USP53 ubiquitin specific peptidase 53 0.0298801
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0293639
WAC WW domain containing adaptor with coiled-coil 0.0293273
TM9SF2 transmembrane 9 superfamily member 2 0.0283863
WDR43 WD repeat domain 43 0.0282405
GAPVD1 GTPase activating protein and VPS9 domains 1 0.0282169
RPL37 ribosomal protein L37 0.0278913
ATG7 autophagy related 7 0.0274057
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0271918
MCTP1 multiple C2 domains, transmembrane 1 0.0268858
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0268081
KLC1 kinesin light chain 1 0.0266451
RBM39 RNA binding motif protein 39 0.0262138
ANKRD36 ankyrin repeat domain 36 0.0259745
IRAK2 interleukin-1 receptor-associated kinase 2 0.0258253
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0257841
TNIP1 TNFAIP3 interacting protein 1 0.0256116
GGNBP2 gametogenetin binding protein 2 0.0251896
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0250765
PEAK1 pseudopodium-enriched atypical kinase 1 0.0250344
SQSTM1 sequestosome 1 0.024924
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0248245
CAND1 cullin-associated and neddylation-dissociated 1 0.0247198
SOS1 son of sevenless homolog 1 (Drosophila) 0.0246699
RBM25 RNA binding motif protein 25 0.0245489
SFXN1 sideroflexin 1 0.0245327
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0242983
YLPM1 YLP motif containing 1 0.0239693
ARHGAP5 Rho GTPase activating protein 5 0.0239274
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0236843
N4BP2L2 NEDD4 binding protein 2-like 2 0.023654
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0236487
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0236282
ENO2 enolase 2 (gamma, neuronal) 0.023503
MYO9B myosin IXB 0.0234785
BABAM2 BRISC and BRCA1 A complex member 2 0.0234344
RSRC2 arginine/serine-rich coiled-coil 2 0.0233798
ANKRD17 ankyrin repeat domain 17 0.0233792
EP400 E1A binding protein p400 0.0233364
CASC3 cancer susceptibility candidate 3 0.0231148
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0230818
SAR1B secretion associated, Ras related GTPase 1B 0.023079
RPS3 ribosomal protein S3 0.0228837
ECPAS Ecm29 proteasome adaptor and scaffold 0.0228482
TENT2 terminal nucleotidyltransferase 2 0.0225563
WNK1 WNK lysine deficient protein kinase 1 0.0224273
ADAM10 ADAM metallopeptidase domain 10 0.0224017
SETD2 SET domain containing 2 0.0222648
XPO1 exportin 1 0.0222418
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0221447
VMP1 vacuole membrane protein 1 0.0221222
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0220296
CPAP centrosome assembly and centriole elongation protein 0.0220042
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.0219709
PARD3 par-3 family cell polarity regulator 0.0218742
NAP1L1 nucleosome assembly protein 1-like 1 0.0218139

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.178458
TMSB10 thymosin beta 10 -0.0717041
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0675389
LDHA lactate dehydrogenase A -0.0597466
IER3 immediate early response 3 -0.0478947
RPLP1 ribosomal protein, large, P1 -0.0457845
VIM vimentin -0.0402207
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0400083
PNRC1 proline-rich nuclear receptor coactivator 1 -0.039614
MT2A metallothionein 2A -0.0374226
CENPF centromere protein F, 350/400kDa -0.0373024
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0368296
LGALS1 lectin, galactoside-binding, soluble, 1 -0.035864
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0349204
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0348054
FMN1 formin 1 -0.0344244
MYO9A myosin IXA -0.0326226
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0322323
AHNAK AHNAK nucleoprotein -0.0314569
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0306084
SMYD3 SET and MYND domain containing 3 -0.0301986
POTEF POTE ankyrin domain family, member F -0.03
KIAA1328 KIAA1328 -0.0299709
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.02951
RPL37A ribosomal protein L37a -0.0294694
TUBB4B tubulin, beta 4B class IVb -0.0288346
FNBP1 formin binding protein 1 -0.0288172
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0285982
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0280981
RUNX1 runt-related transcription factor 1 -0.0277079
MKI67 marker of proliferation Ki-67 -0.0276367
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0268603
LOC112694756 uncharaterized LOC112694756 -0.0265891
DOCK5 dedicator of cytokinesis 5 -0.026539
RORA RAR-related orphan receptor A -0.0259413
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0259266
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.025655
APOLD1 apolipoprotein L domain containing 1 -0.0254047
KIF5B kinesin family member 5B -0.0252373
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0249418
TUBA1B tubulin, alpha 1b -0.0248542
TAOK1 TAO kinase 1 -0.0247489
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0247127
RPL12 ribosomal protein L12 -0.024548
DENND1A DENN/MADD domain containing 1A -0.0241421
KIF4A kinesin family member 4A -0.0241018
PDE8A phosphodiesterase 8A -0.0226204
TXNRD1 thioredoxin reductase 1 -0.0225883
DOCK3 dedicator of cytokinesis 3 -0.0225478
SLC38A2 solute carrier family 38, member 2 -0.0223946
ACTN4 actinin, alpha 4 -0.0222282
TPX2 TPX2, microtubule-associated -0.0221893
CALU calumenin -0.0220556
ZC3H12C zinc finger CCCH-type containing 12C -0.0220004
S100A10 S100 calcium binding protein A10 -0.0218478
ISG15 ISG15 ubiquitin-like modifier -0.0217665
MORF4L1 mortality factor 4 like 1 -0.0217175
HMGA2 high mobility group AT-hook 2 -0.0216539
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0216495
SRSF11 serine/arginine-rich splicing factor 11 -0.0215046
SAP30BP SAP30 binding protein -0.0214913
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0213545
BZW1 basic leucine zipper and W2 domains 1 -0.0213375
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0212766
SGO2 shugoshin 2 -0.021257
FTH1 ferritin, heavy polypeptide 1 -0.0210118
SMAD3 SMAD family member 3 -0.0209056
PRKN parkin RBR E3 ubiquitin protein ligase -0.0207007
TRIO trio Rho guanine nucleotide exchange factor -0.0205828
CAV1 caveolin 1, caveolae protein, 22kDa -0.0205532
S100A9 S100 calcium binding protein A9 -0.0205456
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0205325
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0202825
PRC1 protein regulator of cytokinesis 1 -0.0202657
EZR ezrin -0.0201386
RNF111 ring finger protein 111 -0.0200749
PDE10A phosphodiesterase 10A -0.0198772
TPI1 triosephosphate isomerase 1 -0.0198515
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0197702
PARD3B par-3 family cell polarity regulator beta -0.0197609
ZFHX3 zinc finger homeobox 3 -0.0197183
STAG2 stromal antigen 2 -0.0195361
CAVIN1 caveolae associated protein 1 -0.0194628
RPL36 ribosomal protein L36 -0.0193523
ITGA6 integrin, alpha 6 -0.0193172
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0192827
ALCAM activated leukocyte cell adhesion molecule -0.0191454
EFNA5 ephrin-A5 -0.0191034
MECP2 methyl CpG binding protein 2 -0.0190904
RPS19 ribosomal protein S19 -0.0190449
SCAPER S-phase cyclin A-associated protein in the ER -0.0190334
TPM4 tropomyosin 4 -0.0189268
RAB21 RAB21, member RAS oncogene family -0.0189174
CLINT1 clathrin interactor 1 -0.0188783
AURKA aurora kinase A -0.0188143
BBS9 Bardet-Biedl syndrome 9 -0.0187462
KPNB1 karyopherin (importin) beta 1 -0.0186524
ATG12 autophagy related 12 -0.0186254
HLA-C major histocompatibility complex, class I, C -0.0185864
ATF7IP activating transcription factor 7 interacting protein -0.0184525