| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aprepitant perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aprepitant_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.128963 |
| SMOX | spermine oxidase | 0.0779971 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0649837 |
| MT2A | metallothionein 2A | 0.0571334 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0546331 |
| OGA | O-GlcNAcase | 0.0542855 |
| DOCK5 | dedicator of cytokinesis 5 | 0.053887 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0537493 |
| CD109 | CD109 molecule | 0.0536473 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0524333 |
| ETNK1 | ethanolamine kinase 1 | 0.0523131 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0494437 |
| GOLGA4 | golgin A4 | 0.0483944 |
| OSMR | oncostatin M receptor | 0.0463575 |
| CAB39 | calcium binding protein 39 | 0.0451974 |
| ARRDC3 | arrestin domain containing 3 | 0.0420082 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0382964 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.038045 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0372134 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0367956 |
| PELO | pelota homolog (Drosophila) | 0.0362619 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.036189 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0343758 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0343686 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0337601 |
| TMEM165 | transmembrane protein 165 | 0.0330662 |
| SUCO | SUN domain containing ossification factor | 0.03295 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0327078 |
| SMAD3 | SMAD family member 3 | 0.0325129 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0317527 |
| AFDN | afadin, adherens junction formation factor | 0.0315145 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0314693 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0309111 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0304082 |
| WDR26 | WD repeat domain 26 | 0.0303582 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.029869 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0298354 |
| FAF2 | Fas associated factor family member 2 | 0.0295879 |
| WDR45B | WD repeat domain 45B | 0.0293694 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.029023 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0287893 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0284713 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0284416 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0283138 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.028147 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0281102 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0279139 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0277865 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0277742 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.02767 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.027386 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.027188 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0265679 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.026542 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0264699 |
| FOXO3 | forkhead box O3 | 0.0263835 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | 0.0262931 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0261474 |
| YME1L1 | YME1-like 1 ATPase | 0.0261317 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0259573 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0258365 |
| SRP54 | signal recognition particle 54kDa | 0.0256206 |
| CEP192 | centrosomal protein 192kDa | 0.0255182 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0254025 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.025394 |
| CDC73 | cell division cycle 73 | 0.0252913 |
| TMEM156 | transmembrane protein 156 | 0.0249907 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0248654 |
| NBAS | neuroblastoma amplified sequence | 0.0246023 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0245407 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0245001 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0244081 |
| WASL | Wiskott-Aldrich syndrome-like | 0.0244032 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0242448 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0242446 |
| COG5 | component of oligomeric golgi complex 5 | 0.0239731 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0239268 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0238243 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0235493 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0234345 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0234009 |
| DENND5B | DENN/MADD domain containing 5B | 0.023267 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0229855 |
| HOMER2 | homer scaffolding protein 2 | 0.022926 |
| NUP58 | nucleoporin 58 | 0.0228049 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0226184 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.0225415 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0225362 |
| SFXN1 | sideroflexin 1 | 0.0225111 |
| GANAB | glucosidase, alpha; neutral AB | 0.0225005 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0223161 |
| COPA | coatomer protein complex, subunit alpha | 0.0221895 |
| YTHDC1 | YTH domain containing 1 | 0.0221049 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | 0.0218659 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0218479 |
| ADD3 | adducin 3 (gamma) | 0.0217847 |
| RNF24 | ring finger protein 24 | 0.021728 |
| RUNX2 | runt-related transcription factor 2 | 0.0214907 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0211249 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0211163 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.240429 |
| FN1 | fibronectin 1 | -0.216156 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.136352 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.128402 |
| HMGA2 | high mobility group AT-hook 2 | -0.117725 |
| ASPH | aspartate beta-hydroxylase | -0.10648 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0732313 |
| SYT1 | synaptotagmin I | -0.0671129 |
| LMNA | lamin A/C | -0.066046 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0652037 |
| GLIS3 | GLIS family zinc finger 3 | -0.0625353 |
| TMSB10 | thymosin beta 10 | -0.0611767 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0555191 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0551852 |
| INTS6 | integrator complex subunit 6 | -0.0539834 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0466316 |
| VCL | vinculin | -0.0461744 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.045964 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0451678 |
| RAI14 | retinoic acid induced 14 | -0.0451622 |
| AEBP2 | AE binding protein 2 | -0.0447399 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0441904 |
| GNAS | GNAS complex locus | -0.0440244 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0436919 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0433837 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0431592 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0430779 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0416526 |
| RPS6 | ribosomal protein S6 | -0.0401319 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0399765 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0396759 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0396239 |
| IER3 | immediate early response 3 | -0.0395733 |
| SQSTM1 | sequestosome 1 | -0.0387562 |
| EMP1 | epithelial membrane protein 1 | -0.038726 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0378232 |
| S100A10 | S100 calcium binding protein A10 | -0.0373896 |
| PKM | pyruvate kinase, muscle | -0.0370694 |
| ACTG1 | actin gamma 1 | -0.0369697 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0365693 |
| POTEF | POTE ankyrin domain family, member F | -0.0363084 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0362769 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0347956 |
| PLIN2 | perilipin 2 | -0.0342751 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0341392 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0341335 |
| EZR | ezrin | -0.0338667 |
| RNF213 | ring finger protein 213 | -0.0327582 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0325395 |
| MYOF | myoferlin | -0.032494 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0310009 |
| FTL | ferritin, light polypeptide | -0.0306499 |
| ARF1 | ADP-ribosylation factor 1 | -0.0303606 |
| LRRC23 | leucine rich repeat containing 23 | -0.0302781 |
| MAP1B | microtubule-associated protein 1B | -0.0302168 |
| RPLP1 | ribosomal protein, large, P1 | -0.0300928 |
| DSTN | destrin (actin depolymerizing factor) | -0.0299264 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0293173 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0292665 |
| ENO1 | enolase 1, (alpha) | -0.0287591 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0286304 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0279267 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0271985 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0270444 |
| S100A6 | S100 calcium binding protein A6 | -0.026914 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0266855 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0265901 |
| ATF3 | activating transcription factor 3 | -0.026411 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0262945 |
| RPS20 | ribosomal protein S20 | -0.0262883 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.025896 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0257337 |
| HLA-B | major histocompatibility complex, class I, B | -0.0256496 |
| EGR1 | early growth response 1 | -0.0256009 |
| RPL35A | ribosomal protein L35a | -0.0252462 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.025149 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0250668 |
| RPS24 | ribosomal protein S24 | -0.0249994 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0249144 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0247834 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0247604 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0246014 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0245701 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0243259 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0242434 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0238526 |
| RPL37A | ribosomal protein L37a | -0.0238356 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0237584 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0235926 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.023487 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0233019 |
| TPR | translocated promoter region, nuclear basket protein | -0.0228429 |
| DST | dystonin | -0.0227555 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.022527 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0225131 |
| MCL1 | myeloid cell leukemia 1 | -0.0224686 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0223569 |
| H1-0 | H1.0 linker histone | -0.0223401 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.022314 |
| SP100 | SP100 nuclear antigen | -0.0222056 |
