| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Arbutin perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Arbutin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.158679 |
| FBN1 | fibrillin 1 | 0.118964 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0917648 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0612273 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0589922 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0572449 |
| LOXL2 | lysyl oxidase-like 2 | 0.0543201 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0540296 |
| FLNB | filamin B, beta | 0.053032 |
| NAV2 | neuron navigator 2 | 0.0470453 |
| OGA | O-GlcNAcase | 0.0461911 |
| APP | amyloid beta (A4) precursor protein | 0.0439523 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0433924 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0417791 |
| OPTN | optineurin | 0.0416111 |
| NDRG1 | N-myc downstream regulated 1 | 0.0414842 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0410357 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0392343 |
| LDHA | lactate dehydrogenase A | 0.0391509 |
| SEPTIN9 | septin 9 | 0.0384045 |
| SBF2 | SET binding factor 2 | 0.0361027 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0350207 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0348354 |
| C1D | C1D nuclear receptor corepressor | 0.0340965 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0337296 |
| FLNA | filamin A, alpha | 0.0336767 |
| GPC6 | glypican 6 | 0.0333149 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0329982 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.031101 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0302467 |
| SQSTM1 | sequestosome 1 | 0.0301078 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0296037 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0290986 |
| CD109 | CD109 molecule | 0.0287021 |
| COL1A2 | collagen, type I, alpha 2 | 0.0284074 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0280637 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0280597 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0280502 |
| ARRDC3 | arrestin domain containing 3 | 0.0273381 |
| VEGFA | vascular endothelial growth factor A | 0.0270527 |
| GOLGA4 | golgin A4 | 0.0269221 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0268505 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0267979 |
| ATP13A3 | ATPase type 13A3 | 0.0267124 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0262884 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0261637 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0261236 |
| RPL3 | ribosomal protein L3 | 0.0259794 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0258394 |
| AUTS2 | autism susceptibility candidate 2 | 0.0250537 |
| CANX | calnexin | 0.0249542 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0245886 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0244462 |
| INSIG2 | insulin induced gene 2 | 0.0243571 |
| UBC | ubiquitin C | 0.0240791 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0231957 |
| CLU | clusterin | 0.0231772 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0225078 |
| PLEC | plectin | 0.0222469 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0216305 |
| FMNL2 | formin-like 2 | 0.0215755 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0215544 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0215372 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0213766 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0213668 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0212534 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0210257 |
| STC1 | stanniocalcin 1 | 0.0208494 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.020786 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0207716 |
| HDLBP | high density lipoprotein binding protein | 0.0206897 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0206543 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0205837 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.020132 |
| ADAR | adenosine deaminase, RNA-specific | 0.0200584 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0199197 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0198502 |
| SETD5 | SET domain containing 5 | 0.0196002 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0194736 |
| FNIP1 | folliculin interacting protein 1 | 0.0193595 |
| MMP12 | matrix metallopeptidase 12 | 0.019028 |
| YEATS2 | YEATS domain containing 2 | 0.0186985 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0186777 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0186773 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0186685 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0186501 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0185329 |
| MEF2A | myocyte enhancer factor 2A | 0.0185088 |
| TMOD1 | tropomodulin 1 | 0.018334 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0181634 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0181426 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.018044 |
| ZBTB7C | zinc finger and BTB domain containing 7C | 0.0180081 |
| ANK2 | ankyrin 2, neuronal | 0.017786 |
| PCGF5 | polycomb group ring finger 5 | 0.0177633 |
| TSC22D2 | TSC22 domain family, member 2 | 0.017701 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0176975 |
| LRRC49 | leucine rich repeat containing 49 | 0.0176876 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0176555 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0176233 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.315979 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.229434 |
| TMSB10 | thymosin beta 10 | -0.202347 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.170953 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.167182 |
| FN1 | fibronectin 1 | -0.156447 |
| MAP1B | microtubule-associated protein 1B | -0.135977 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.127322 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.123343 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0995701 |
| CDH13 | cadherin 13 | -0.0965335 |
| LOX | lysyl oxidase | -0.0962755 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0891711 |
| S100A10 | S100 calcium binding protein A10 | -0.0886048 |
| PLAT | plasminogen activator, tissue | -0.0843295 |
| PODXL | podocalyxin-like | -0.0827259 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0809483 |
| B2M | beta-2-microglobulin | -0.079615 |
| SUCNR1 | succinate receptor 1 | -0.0782327 |
| CSTB | cystatin B (stefin B) | -0.0750081 |
| COL5A1 | collagen, type V, alpha 1 | -0.0700294 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0695657 |
| S100A6 | S100 calcium binding protein A6 | -0.0648106 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0645242 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0643542 |
| POTEF | POTE ankyrin domain family, member F | -0.0632812 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0610577 |
| LMNA | lamin A/C | -0.058936 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0577579 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0558317 |
| PRSS23 | protease, serine, 23 | -0.0547783 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0535717 |
| MX2 | MX dynamin-like GTPase 2 | -0.0535331 |
| HLA-B | major histocompatibility complex, class I, B | -0.0518924 |
| RIGI | RNA sensor RIG-I | -0.0518025 |
| LRRC17 | leucine rich repeat containing 17 | -0.0492736 |
| NAV1 | neuron navigator 1 | -0.0488163 |
| TAGLN2 | transgelin 2 | -0.0483102 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0472848 |
| CYTH3 | cytohesin 3 | -0.0452104 |
| MT2A | metallothionein 2A | -0.0449996 |
| ASPH | aspartate beta-hydroxylase | -0.0446744 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0438495 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.043552 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0428386 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0403083 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0379752 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.037931 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0379293 |
| DCLK2 | doublecortin-like kinase 2 | -0.0377619 |
| PLXNA2 | plexin A2 | -0.0368663 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0366806 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0364272 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0354349 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0351552 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0345985 |
| S100A11 | S100 calcium binding protein A11 | -0.0341106 |
| IL7R | interleukin 7 receptor | -0.0336248 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0335375 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0333575 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0333276 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0332576 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0328361 |
| HLA-C | major histocompatibility complex, class I, C | -0.0327451 |
| PCDH7 | protocadherin 7 | -0.0322324 |
| S100A4 | S100 calcium binding protein A4 | -0.0320607 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0319583 |
| KRT81 | keratin 81, type II | -0.0319461 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0318592 |
| FNDC3A | fibronectin type III domain containing 3A | -0.031784 |
| PFN1 | profilin 1 | -0.0311501 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0310915 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0305255 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0297702 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0295589 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0294025 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0292446 |
| CUX1 | cut-like homeobox 1 | -0.0292217 |
| SEPTIN7 | septin 7 | -0.0292094 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0291987 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0289476 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0281782 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0280199 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0273548 |
| CD44 | CD44 molecule (Indian blood group) | -0.0270661 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0269205 |
| SP100 | SP100 nuclear antigen | -0.0267918 |
| FMN2 | formin 2 | -0.0266089 |
| PKM | pyruvate kinase, muscle | -0.0264941 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0260281 |
| FSTL1 | follistatin-like 1 | -0.0259116 |
| MYADM | myeloid-associated differentiation marker | -0.0258786 |
| EFNA5 | ephrin-A5 | -0.0258129 |
| ANXA2 | annexin A2 | -0.02508 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0250453 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0248903 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0248688 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0241006 |
| RASAL2 | RAS protein activator like 2 | -0.0238447 |
| MED13L | mediator complex subunit 13-like | -0.0236167 |
