Arbutin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Arbutin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Arbutin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0888041
RPL3 ribosomal protein L3 0.0835955
LPIN1 lipin 1 0.0649919
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0624077
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0623061
SEPTIN9 septin 9 0.0580126
DSCAM Down syndrome cell adhesion molecule 0.0555605
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0544009
FMN1 formin 1 0.0500045
MEF2A myocyte enhancer factor 2A 0.043955
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0436613
CSNK1A1 casein kinase 1, alpha 1 0.0429984
PCBP2 poly(rC) binding protein 2 0.0394237
DTNA dystrobrevin, alpha 0.0369459
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0365965
NAMPT nicotinamide phosphoribosyltransferase 0.0355437
NALF1 NALCN channel auxiliary factor 1 0.0353051
DST dystonin 0.0349895
HELZ helicase with zinc finger 0.0347578
FAM13A family with sequence similarity 13, member A 0.0347257
MEIS2 Meis homeobox 2 0.0346107
SSBP3 single stranded DNA binding protein 3 0.0340696
ADGRG6 adhesion G protein-coupled receptor G6 0.0331906
PTEN phosphatase and tensin homolog 0.0331538
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0326519
KCTD3 potassium channel tetramerization domain containing 3 0.0322259
MACF1 microtubule-actin crosslinking factor 1 0.0319811
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0316574
NBAS neuroblastoma amplified sequence 0.0315922
NREP neuronal regeneration related protein 0.0310513
LIMCH1 LIM and calponin homology domains 1 0.0307502
PRPF8 pre-mRNA processing factor 8 0.0305667
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0303236
ZNF292 zinc finger protein 292 0.0299344
COPA coatomer protein complex, subunit alpha 0.0298664
CANX calnexin 0.0297923
VEGFA vascular endothelial growth factor A 0.0297528
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0289351
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0287102
INSIG2 insulin induced gene 2 0.0284098
XPO1 exportin 1 0.0282658
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0278622
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0276509
KDM4C lysine (K)-specific demethylase 4C 0.0269418
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0268974
SRRM2 serine/arginine repetitive matrix 2 0.0267396
CSDE1 cold shock domain containing E1, RNA-binding 0.0266394
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0264378
FRMD6 FERM domain containing 6 0.0262189
TENT5A terminal nucleotidyltransferase 5A 0.0259114
ITPRID2 ITPR interacting domain containing 2 0.0256965
PELI1 pellino E3 ubiquitin protein ligase 1 0.0250232
SIK3 SIK family kinase 3 0.0248361
ANO6 anoctamin 6 0.0242805
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0241417
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0240303
USP34 ubiquitin specific peptidase 34 0.0239934
EWSR1 EWS RNA-binding protein 1 0.0237187
CEMIP cell migration inducing protein, hyaluronan binding 0.0235489
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0235014
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0232913
ADARB1 adenosine deaminase, RNA-specific, B1 0.0232877
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0231827
PDE4D phosphodiesterase 4D, cAMP-specific 0.0229165
LDHA lactate dehydrogenase A 0.0229053
FXR1 fragile X mental retardation, autosomal homolog 1 0.0228108
AFF4 AF4/FMR2 family, member 4 0.0227997
CCNL1 cyclin L1 0.0226605
ZNF148 zinc finger protein 148 0.0226093
ANKRD11 ankyrin repeat domain 11 0.0224806
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0221853
ZMIZ1 zinc finger, MIZ-type containing 1 0.0221443
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0220448
TTC17 tetratricopeptide repeat domain 17 0.0218913
TRIP12 thyroid hormone receptor interactor 12 0.0214934
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0213852
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0213759
PLEC plectin 0.0213727
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0213008
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0212949
BCLAF1 BCL2-associated transcription factor 1 0.0212205
NCOR2 nuclear receptor corepressor 2 0.0211341
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0210901
SSBP2 single-stranded DNA binding protein 2 0.0209634
GOLGA4 golgin A4 0.0209265
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.0209063
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0208394
NFE2L1 nuclear factor, erythroid 2-like 1 0.0208187
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0206247
CD46 CD46 molecule, complement regulatory protein 0.0205215
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0204698
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.020297
FNDC3A fibronectin type III domain containing 3A 0.0202081
MYH9 myosin, heavy chain 9, non-muscle 0.0201357
GSK3B glycogen synthase kinase 3 beta 0.0198213
PUM2 pumilio RNA-binding family member 2 0.0197304
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0197107
CKAP5 cytoskeleton associated protein 5 0.0196902
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0196194
CCNG2 cyclin G2 0.0196041

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.380693
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.290566
PTMA prothymosin, alpha -0.174693
VIM vimentin -0.132979
AKAP12 A kinase (PRKA) anchor protein 12 -0.104728
ACTG1 actin gamma 1 -0.0946358
RPL23 ribosomal protein L23 -0.0874107
EIF1 eukaryotic translation initiation factor 1 -0.0855874
RPLP1 ribosomal protein, large, P1 -0.0848461
RPS6 ribosomal protein S6 -0.0830007
RPL19 ribosomal protein L19 -0.0794201
RPL35A ribosomal protein L35a -0.0775963
RPL34 ribosomal protein L34 -0.0773041
TMSB10 thymosin beta 10 -0.0756786
B2M beta-2-microglobulin -0.0717032
RPS24 ribosomal protein S24 -0.0647295
RPL38 ribosomal protein L38 -0.0632458
IER3 immediate early response 3 -0.0618134
S100A6 S100 calcium binding protein A6 -0.0587383
FTL ferritin, light polypeptide -0.0583657
RPS27A ribosomal protein S27a -0.0574809
TPT1 tumor protein, translationally-controlled 1 -0.0541534
KPNB1 karyopherin (importin) beta 1 -0.0532454
RPL37A ribosomal protein L37a -0.0527192
RPL12 ribosomal protein L12 -0.0506169
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0483399
RPL26 ribosomal protein L26 -0.0462145
RPLP0 ribosomal protein, large, P0 -0.0456221
RPL36 ribosomal protein L36 -0.0452429
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0446099
RPS19 ribosomal protein S19 -0.0442145
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0441593
RPL31 ribosomal protein L31 -0.0407595
VCL vinculin -0.0399488
LMNA lamin A/C -0.0393044
RPS3 ribosomal protein S3 -0.0371158
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0364852
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0362977
H3-3B H3.3 histone B -0.0362732
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0359582
ARID4B AT rich interactive domain 4B (RBP1-like) -0.035809
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0349608
RPS14 ribosomal protein S14 -0.0345542
RPS27 ribosomal protein S27 -0.0341774
PTPRD protein tyrosine phosphatase, receptor type, D -0.0337043
RPL35 ribosomal protein L35 -0.0336958
CEP350 centrosomal protein 350kDa -0.033571
EIF5B eukaryotic translation initiation factor 5B -0.0335451
RPL30 ribosomal protein L30 -0.033151
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0322494
RPS21 ribosomal protein S21 -0.0317851
EGR1 early growth response 1 -0.0311378
RPS12 ribosomal protein S12 -0.0305306
NIPBL Nipped-B homolog (Drosophila) -0.0302214
RPS16 ribosomal protein S16 -0.0302064
COL1A1 collagen, type I, alpha 1 -0.0298878
S100A9 S100 calcium binding protein A9 -0.0297521
RPS29 ribosomal protein S29 -0.0294945
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0293811
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0290864
RPL32 ribosomal protein L32 -0.0290567
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0288184
VDAC1 voltage-dependent anion channel 1 -0.0285548
RPS23 ribosomal protein S23 -0.0283999
RPS25 ribosomal protein S25 -0.0283886
RPL28 ribosomal protein L28 -0.0278567
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0276197
RPS8 ribosomal protein S8 -0.027581
HIP1 huntingtin interacting protein 1 -0.0275116
TPI1 triosephosphate isomerase 1 -0.0271708
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0260508
KLF6 Kruppel-like factor 6 -0.0259684
SSH2 slingshot protein phosphatase 2 -0.0259376
RPL36A ribosomal protein L36a -0.0258322
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0253095
CCND1 cyclin D1 -0.0249972
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0249013
TRIB2 tribbles pseudokinase 2 -0.0248932
RPS15 ribosomal protein S15 -0.0245869
RPL37 ribosomal protein L37 -0.0245242
RPS13 ribosomal protein S13 -0.024417
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0240742
HMGB2 high mobility group box 2 -0.0238653
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0237993
S100A10 S100 calcium binding protein A10 -0.0236351
RPL27 ribosomal protein L27 -0.0235969
STC1 stanniocalcin 1 -0.0233278
TPM4 tropomyosin 4 -0.0233075
HMGA1 high mobility group AT-hook 1 -0.0231934
PLAT plasminogen activator, tissue -0.0229095
RPL9 ribosomal protein L9 -0.0226049
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0225717
GNAS GNAS complex locus -0.0225217
RPS11 ribosomal protein S11 -0.0222046
FKBP10 FK506 binding protein 10, 65 kDa -0.0220935
CREBBP CREB binding protein -0.0219711
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0219657
RPL8 ribosomal protein L8 -0.0218377
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0215901
RHOBTB3 Rho-related BTB domain containing 3 -0.0214924