Arbutin_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Arbutin perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Arbutin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.304361
LDHA lactate dehydrogenase A 0.187921
MYH9 myosin, heavy chain 9, non-muscle 0.150642
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.145365
VEGFA vascular endothelial growth factor A 0.133897
COL6A3 collagen, type VI, alpha 3 0.132983
PABPC1 poly(A) binding protein, cytoplasmic 1 0.11495
CANX calnexin 0.113586
EEF2 eukaryotic translation elongation factor 2 0.107915
CXCL8 chemokine (C-X-C motif) ligand 8 0.106313
RPL3 ribosomal protein L3 0.0963983
CALR calreticulin 0.0874115
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.086431
FTH1 ferritin, heavy polypeptide 1 0.0792477
FLNA filamin A, alpha 0.0735076
PLEC plectin 0.0699572
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.067157
RPL13A ribosomal protein L13a 0.0651287
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0625628
PTMA prothymosin, alpha 0.0607533
RPL11 ribosomal protein L11 0.0584732
TPM4 tropomyosin 4 0.0555852
IGFBP3 insulin-like growth factor binding protein 3 0.0540948
VIM vimentin 0.0518323
COL4A1 collagen, type IV, alpha 1 0.0502793
FTL ferritin, light polypeptide 0.0487413
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0483129
CADM1 cell adhesion molecule 1 0.0481505
TMSB10 thymosin beta 10 0.0469248
APP amyloid beta (A4) precursor protein 0.0464624
ENO1 enolase 1, (alpha) 0.0463516
RPL18A ribosomal protein L18a 0.0461808
CSDE1 cold shock domain containing E1, RNA-binding 0.0442167
TPM2 tropomyosin 2 (beta) 0.0438503
RPL35A ribosomal protein L35a 0.0416522
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0414353
RPL23 ribosomal protein L23 0.040572
RPS8 ribosomal protein S8 0.0398297
SOD2 superoxide dismutase 2, mitochondrial 0.039829
EIF1 eukaryotic translation initiation factor 1 0.0398228
RPL8 ribosomal protein L8 0.0393043
HDLBP high density lipoprotein binding protein 0.0389844
AXL AXL receptor tyrosine kinase 0.0389533
RPS4X ribosomal protein S4, X-linked 0.0386667
NDRG1 N-myc downstream regulated 1 0.0369073
MANF mesencephalic astrocyte-derived neurotrophic factor 0.0367208
YBX1 Y box binding protein 1 0.0361241
DDIT4 DNA-damage-inducible transcript 4 0.0355156
FXR1 fragile X mental retardation, autosomal homolog 1 0.0329401
GOLGA4 golgin A4 0.0326765
RPL19 ribosomal protein L19 0.0323652
TMSB4X thymosin beta 4, X-linked 0.0321672
EEF1G eukaryotic translation elongation factor 1 gamma 0.0316676
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0302811
POSTN periostin, osteoblast specific factor 0.0291077
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0288309
APLP2 amyloid beta (A4) precursor-like protein 2 0.0286695
COL6A1 collagen, type VI, alpha 1 0.0285154
CAMTA1 calmodulin binding transcription activator 1 0.0282879
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0281089
GNAS GNAS complex locus 0.0280313
TNIP1 TNFAIP3 interacting protein 1 0.0278765
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0274507
RPL37 ribosomal protein L37 0.0273698
MT2A metallothionein 2A 0.0273231
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.027206
CALU calumenin 0.0271908
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0270775
RPLP1 ribosomal protein, large, P1 0.0270771
PCBP2 poly(rC) binding protein 2 0.0262662
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0262227
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0259235
RPS19 ribosomal protein S19 0.0256703
HYOU1 hypoxia up-regulated 1 0.0255613
UBC ubiquitin C 0.0253957
DPYSL2 dihydropyrimidinase-like 2 0.0253882
ADM adrenomedullin 0.0247889
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0241517
RPS6 ribosomal protein S6 0.0241235
MCL1 myeloid cell leukemia 1 0.0240291
ACTN1 actinin, alpha 1 0.0237195
CD99 CD99 molecule 0.0236678
RPL7 ribosomal protein L7 0.0236078
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0233357
TOP2A topoisomerase (DNA) II alpha 170kDa 0.023255
COTL1 coactosin-like F-actin binding protein 1 0.0226346
PDIA6 protein disulfide isomerase family A, member 6 0.0225064
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0224169
RPS20 ribosomal protein S20 0.0221736
COL4A2 collagen, type IV, alpha 2 0.0220869
HLA-A major histocompatibility complex, class I, A 0.0220833
RPL12 ribosomal protein L12 0.0220039
SPAG9 sperm associated antigen 9 0.0219458
ICAM1 intercellular adhesion molecule 1 0.0219132
TUBB tubulin, beta class I 0.0218827
PLAU plasminogen activator, urokinase 0.0217557
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0216441
FLNB filamin B, beta 0.0215726
CPNE1 copine I 0.0213488
RPL37A ribosomal protein L37a 0.0213168

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.17231
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.153675
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.105342
CDH13 cadherin 13 -0.101442
PSD3 pleckstrin and Sec7 domain containing 3 -0.0982467
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0894153
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0852533
CD44 CD44 molecule (Indian blood group) -0.0717603
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0697018
WWTR1 WW domain containing transcription regulator 1 -0.0667918
ZBTB20 zinc finger and BTB domain containing 20 -0.0664332
GLIS3 GLIS family zinc finger 3 -0.0663655
EXT1 exostosin glycosyltransferase 1 -0.0642678
TGFBI transforming growth factor, beta-induced, 68kDa -0.0640694
VCAN versican -0.0599246
ASPH aspartate beta-hydroxylase -0.0588177
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0541835
IL6ST interleukin 6 signal transducer -0.0538131
LTBP1 latent transforming growth factor beta binding protein 1 -0.0533586
COL1A1 collagen, type I, alpha 1 -0.0533011
HMGA2 high mobility group AT-hook 2 -0.0520682
TRPS1 trichorhinophalangeal syndrome I -0.0519575
LOX lysyl oxidase -0.0505572
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0470133
DPYD dihydropyrimidine dehydrogenase -0.0443948
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0429097
STC1 stanniocalcin 1 -0.041617
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0376849
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0376665
DST dystonin -0.0375833
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0370291
ZBTB38 zinc finger and BTB domain containing 38 -0.0368349
IGFBP7 insulin-like growth factor binding protein 7 -0.0359214
RUNX1 runt-related transcription factor 1 -0.0358081
COL5A1 collagen, type V, alpha 1 -0.0333006
NAV1 neuron navigator 1 -0.0328035
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0314434
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0312476
TRIO trio Rho guanine nucleotide exchange factor -0.0310946
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0307419
HAS2 hyaluronan synthase 2 -0.0307406
CNTN5 contactin 5 -0.0302796
NRP1 neuropilin 1 -0.0297464
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0295777
EGFR epidermal growth factor receptor -0.0289181
OXR1 oxidation resistance 1 -0.0283252
ELL2 elongation factor, RNA polymerase II, 2 -0.0278169
PDE10A phosphodiesterase 10A -0.0270021
FBN1 fibrillin 1 -0.0268833
CLMP CXADR-like membrane protein -0.0266443
FNDC3B fibronectin type III domain containing 3B -0.0257002
FOXP1 forkhead box P1 -0.0255656
VEGFC vascular endothelial growth factor C -0.0251851
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0248175
RPS2 ribosomal protein S2 -0.0243473
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0241535
ADAM12 ADAM metallopeptidase domain 12 -0.0237942
BBS9 Bardet-Biedl syndrome 9 -0.0233817
LPP LIM domain containing preferred translocation partner in lipoma -0.0230806
FER fer (fps/fes related) tyrosine kinase -0.0230699
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0229879
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0229558
EHBP1 EH domain binding protein 1 -0.0222442
PDE4D phosphodiesterase 4D, cAMP-specific -0.0219958
ABI3BP ABI family, member 3 (NESH) binding protein -0.0219197
OSMR oncostatin M receptor -0.0218749
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.021817
ATXN1 ataxin 1 -0.0217885
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0215256
MAP4 microtubule-associated protein 4 -0.0214464
DOCK5 dedicator of cytokinesis 5 -0.0214384
SLC22A23 solute carrier family 22, member 23 -0.0208238
NREP neuronal regeneration related protein -0.0208219
SORBS2 sorbin and SH3 domain containing 2 -0.020498
MTSS1 metastasis suppressor 1 -0.0203777
CUX1 cut-like homeobox 1 -0.020318
ZFPM2 zinc finger protein, FOG family member 2 -0.0203008
ECE1 endothelin converting enzyme 1 -0.0201538
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0198485
F3 coagulation factor III (thromboplastin, tissue factor) -0.0197978
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0195967
ANKH ANKH inorganic pyrophosphate transport regulator -0.0193431
JMJD1C jumonji domain containing 1C -0.0193046
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0191772
VMP1 vacuole membrane protein 1 -0.0188713
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0187982
ANO6 anoctamin 6 -0.0187621
PICALM phosphatidylinositol binding clathrin assembly protein -0.0186236
MAML2 mastermind-like 2 (Drosophila) -0.0183276
FBXL13 F-box and leucine-rich repeat protein 13 -0.0182796
ALCAM activated leukocyte cell adhesion molecule -0.0181853
RASAL2 RAS protein activator like 2 -0.0180831
JARID2 jumonji, AT rich interactive domain 2 -0.0179524
WNT5A wingless-type MMTV integration site family, member 5A -0.0179237
CPQ carboxypeptidase Q -0.0175362
CDK14 cyclin-dependent kinase 14 -0.017503
SETBP1 SET binding protein 1 -0.0171495
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0168692
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0167891
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0166514