Arbutin_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Arbutin perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Arbutin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.3298
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.310711
C3 complement component 3 0.20503
ERRFI1 ERBB receptor feedback inhibitor 1 0.144282
RPL3 ribosomal protein L3 0.116007
DSPP dentin sialophosphoprotein 0.111174
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.096211
FNDC3B fibronectin type III domain containing 3B 0.074704
IGF2 insulin-like growth factor 2 0.0743265
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0727421
LDHA lactate dehydrogenase A 0.0701135
TF transferrin 0.0695781
MYH9 myosin, heavy chain 9, non-muscle 0.0691879
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.06873
VEGFA vascular endothelial growth factor A 0.0676216
A2M alpha-2-macroglobulin 0.0554163
APLP2 amyloid beta (A4) precursor-like protein 2 0.0542205
PEG3 paternally expressed 3 0.0537364
DDIT4 DNA-damage-inducible transcript 4 0.049638
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0480593
SOD2 superoxide dismutase 2, mitochondrial 0.0438987
EEF2 eukaryotic translation elongation factor 2 0.043825
AKAP12 A kinase (PRKA) anchor protein 12 0.0413995
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.039843
APOB apolipoprotein B 0.0386533
PCBP2 poly(rC) binding protein 2 0.037304
SESTD1 SEC14 and spectrin domains 1 0.0366215
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0362322
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0358996
NKD1 naked cuticle homolog 1 (Drosophila) 0.0349453
TPM4 tropomyosin 4 0.0341787
TRIO trio Rho guanine nucleotide exchange factor 0.0341355
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0336437
AFDN afadin, adherens junction formation factor 0.0329433
KRT18 keratin 18, type I 0.0326784
INSIG2 insulin induced gene 2 0.0325393
CP ceruloplasmin (ferroxidase) 0.0325321
EIF3A eukaryotic translation initiation factor 3, subunit A 0.030281
FAT1 FAT atypical cadherin 1 0.0295249
SEPTIN9 septin 9 0.0294593
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.027423
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0273503
RPL4 ribosomal protein L4 0.0271066
DTNA dystrobrevin, alpha 0.0265294
FXR1 fragile X mental retardation, autosomal homolog 1 0.026527
TOP1 topoisomerase (DNA) I 0.0257361
APP amyloid beta (A4) precursor protein 0.0253466
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0252565
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0250308
CSDE1 cold shock domain containing E1, RNA-binding 0.0249673
WDFY2 WD repeat and FYVE domain containing 2 0.0248776
EML4 echinoderm microtubule associated protein like 4 0.0245566
ABAT 4-aminobutyrate aminotransferase 0.0245426
PLIN2 perilipin 2 0.0244327
PTPRM protein tyrosine phosphatase, receptor type, M 0.0244007
FBF1 Fas (TNFRSF6) binding factor 1 0.0242294
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0239816
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0238448
YTHDC1 YTH domain containing 1 0.023686
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0236076
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0234914
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0228689
RBM19 RNA binding motif protein 19 0.0225734
SET SET nuclear proto-oncogene 0.0221844
GIGYF2 GRB10 interacting GYF protein 2 0.0221738
NCOR2 nuclear receptor corepressor 2 0.022167
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0221247
RPL13A ribosomal protein L13a 0.0220177
HSPA1B heat shock 70kDa protein 1B 0.0219034
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0217447
AHR aryl hydrocarbon receptor 0.0217213
ZFAND3 zinc finger, AN1-type domain 3 0.0216291
RAB6A RAB6A, member RAS oncogene family 0.0216138
PDIA6 protein disulfide isomerase family A, member 6 0.0214751
PLEC plectin 0.0210511
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0206971
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0203631
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0202109
LRRC1 leucine rich repeat containing 1 0.0201233
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0200196
ADAM9 ADAM metallopeptidase domain 9 0.0199203
AHSG alpha-2-HS-glycoprotein 0.0199027
CHMP4B charged multivesicular body protein 4B 0.0198993
TNS1 tensin 1 0.019796
BIRC6 baculoviral IAP repeat containing 6 0.0196695
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0194509
HDGF hepatoma-derived growth factor 0.0194442
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0194142
TM4SF1 transmembrane 4 L six family member 1 0.0193301
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0193091
DIDO1 death inducer-obliterator 1 0.0191176
ARHGAP26 Rho GTPase activating protein 26 0.0190374
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0187697
IGFBP3 insulin-like growth factor binding protein 3 0.0185788
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0184184
XPO1 exportin 1 0.0182695
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0178188
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0177519
GMDS GDP-mannose 4,6-dehydratase 0.0176418
TCP1 t-complex 1 0.0176249

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.266761
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.168311
TIMP1 TIMP metallopeptidase inhibitor 1 -0.127871
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1034
RPLP1 ribosomal protein, large, P1 -0.0900959
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0842444
IGFBP1 insulin-like growth factor binding protein 1 -0.0802938
TPT1 tumor protein, translationally-controlled 1 -0.073324
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0632228
FTL ferritin, light polypeptide -0.0619443
RPS24 ribosomal protein S24 -0.0607165
RPS19 ribosomal protein S19 -0.0557262
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0472465
RPLP2 ribosomal protein, large, P2 -0.0451595
RPL26 ribosomal protein L26 -0.0446956
RPL34 ribosomal protein L34 -0.0443043
RPL32 ribosomal protein L32 -0.0427038
RPL35A ribosomal protein L35a -0.0420932
RPL37A ribosomal protein L37a -0.0414389
LOC112694756 uncharaterized LOC112694756 -0.0412063
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0410471
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0407249
TMSB10 thymosin beta 10 -0.0389189
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.038739
RPL23 ribosomal protein L23 -0.0379502
RPS21 ribosomal protein S21 -0.0375684
GPC6 glypican 6 -0.0375317
RPS12 ribosomal protein S12 -0.0373905
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0358495
KIF21A kinesin family member 21A -0.0346409
RPS6 ribosomal protein S6 -0.0345769
RPLP0 ribosomal protein, large, P0 -0.0343637
CCL20 chemokine (C-C motif) ligand 20 -0.0332675
RPS3 ribosomal protein S3 -0.0332121
RPL31 ribosomal protein L31 -0.0328765
FOXP1 forkhead box P1 -0.0323541
RPL11 ribosomal protein L11 -0.0322285
RPL38 ribosomal protein L38 -0.0321586
ZMYND8 zinc finger, MYND-type containing 8 -0.0318448
PDGFB platelet-derived growth factor beta polypeptide -0.0313574
VCL vinculin -0.0312972
RPS23 ribosomal protein S23 -0.0311394
RPS29 ribosomal protein S29 -0.0306034
EPAS1 endothelial PAS domain protein 1 -0.0303378
JMJD1C jumonji domain containing 1C -0.0295355
RPS10 ribosomal protein S10 -0.0290954
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0290323
RPS8 ribosomal protein S8 -0.0289398
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0280605
RPS16 ribosomal protein S16 -0.0274691
ZBTB20 zinc finger and BTB domain containing 20 -0.0273405
RPS27A ribosomal protein S27a -0.0272062
SVIL supervillin -0.0266009
MT1X metallothionein 1X -0.0262059
RPS13 ribosomal protein S13 -0.0262005
GPC3 glypican 3 -0.025878
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0253492
LCN2 lipocalin 2 -0.024314
RPL7A ribosomal protein L7a -0.024298
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0240621
RPL5 ribosomal protein L5 -0.0237445
RPL12 ribosomal protein L12 -0.0235194
RACK1 receptor for activated C kinase 1 -0.0231417
IER3 immediate early response 3 -0.0218071
NDRG1 N-myc downstream regulated 1 -0.0217983
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.021748
HMGA1 high mobility group AT-hook 1 -0.0216923
RPL9 ribosomal protein L9 -0.0216423
ANXA5 annexin A5 -0.0212508
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0212253
RPS15 ribosomal protein S15 -0.0208327
RPS14 ribosomal protein S14 -0.0207625
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0205368
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0205076
RAD51B RAD51 paralog B -0.0204543
RPL10A ribosomal protein L10a -0.0203399
RPS5 ribosomal protein S5 -0.0201537
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0201457
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0195539
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0194487
HINT1 histidine triad nucleotide binding protein 1 -0.0194275
ATP5F1E ATP synthase F1 subunit epsilon -0.0190782
APOC1 apolipoprotein C-I -0.0190617
RPL19 ribosomal protein L19 -0.0190484
RPL28 ribosomal protein L28 -0.0189944
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0189795
S100A9 S100 calcium binding protein A9 -0.0187995
RPL35 ribosomal protein L35 -0.0187713
ITGA1 integrin, alpha 1 -0.0186117
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0185953
RHOB ras homolog family member B -0.0184587
EGR1 early growth response 1 -0.018353
RPL30 ribosomal protein L30 -0.0177981
SOX4 SRY (sex determining region Y)-box 4 -0.0177298
KLF6 Kruppel-like factor 6 -0.0176721
RPL7 ribosomal protein L7 -0.0175212
PNISR PNN-interacting serine/arginine-rich protein -0.0174641
HPCAL1 hippocalcin-like 1 -0.0174551
TAS2R14 taste receptor, type 2, member 14 -0.0174536
ATF4 activating transcription factor 4 -0.017355