Arbutin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Arbutin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Arbutin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.209424
PLEC plectin 0.139025
MYH9 myosin, heavy chain 9, non-muscle 0.134414
RPL3 ribosomal protein L3 0.0827813
FLNA filamin A, alpha 0.0809471
AHNAK AHNAK nucleoprotein 0.0763494
MTSS1 metastasis suppressor 1 0.0744404
LDHA lactate dehydrogenase A 0.0698095
MSN moesin 0.0693449
CEMIP cell migration inducing protein, hyaluronan binding 0.0659905
APLP2 amyloid beta (A4) precursor-like protein 2 0.0641242
BLCAP bladder cancer associated protein 0.0640542
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0601108
SMAD3 SMAD family member 3 0.0550761
MCL1 myeloid cell leukemia 1 0.0521423
PODXL podocalyxin-like 0.0510973
TRIO trio Rho guanine nucleotide exchange factor 0.0495487
MPRIP myosin phosphatase Rho interacting protein 0.0477029
MYOF myoferlin 0.0466562
NCOR2 nuclear receptor corepressor 2 0.0458324
CPNE1 copine I 0.0456482
DOCK5 dedicator of cytokinesis 5 0.0453636
MACF1 microtubule-actin crosslinking factor 1 0.0449769
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0446691
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0443004
APP amyloid beta (A4) precursor protein 0.0420164
SULF1 sulfatase 1 0.0419139
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0410351
AMOTL1 angiomotin like 1 0.0391909
MEGF6 multiple EGF-like-domains 6 0.0384412
EHBP1L1 EH domain binding protein 1-like 1 0.0379389
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0379039
PRELID2 PRELI domain containing 2 0.0365561
PDLIM5 PDZ and LIM domain 5 0.0357211
BCL2L1 BCL2-like 1 0.0356544
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0354927
RAI14 retinoic acid induced 14 0.034812
TGM2 transglutaminase 2 0.0339601
NRIP1 nuclear receptor interacting protein 1 0.0336713
HDLBP high density lipoprotein binding protein 0.0335096
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0329983
TPM3 tropomyosin 3 0.0324324
CEP250 centrosomal protein 250kDa 0.0320601
FOXO1 forkhead box O1 0.031925
BCAR3 breast cancer anti-estrogen resistance 3 0.0315577
SLC35F3 solute carrier family 35, member F3 0.0315239
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0313021
LMO7 LIM domain 7 0.0312146
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0308788
CANX calnexin 0.0304464
DSCAM Down syndrome cell adhesion molecule 0.0298096
PRSS23 protease, serine, 23 0.0294125
AHNAK2 AHNAK nucleoprotein 2 0.0290368
ACTN1 actinin, alpha 1 0.0286511
MYO10 myosin X 0.0283726
PSD3 pleckstrin and Sec7 domain containing 3 0.0282387
ARHGAP23 Rho GTPase activating protein 23 0.0280209
ANXA11 annexin A11 0.0272245
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0268766
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0266453
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.026536
LAMC2 laminin, gamma 2 0.0262246
OSMR oncostatin M receptor 0.0261464
DPYSL2 dihydropyrimidinase-like 2 0.0252165
NEK7 NIMA-related kinase 7 0.0252134
THSD4 thrombospondin, type I, domain containing 4 0.0250564
DIDO1 death inducer-obliterator 1 0.0246911
AOPEP aminopeptidase O (putative) 0.0240802
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0238755
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0232992
CUL4B cullin 4B 0.0232035
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0231521
ZMIZ1 zinc finger, MIZ-type containing 1 0.0228958
EIF4H eukaryotic translation initiation factor 4H 0.0228692
KIAA1217 KIAA1217 0.0225389
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0225325
CAPRIN2 caprin family member 2 0.0225202
TBC1D22A TBC1 domain family, member 22A 0.0223484
RIN2 Ras and Rab interactor 2 0.0222915
ASPH aspartate beta-hydroxylase 0.0222061
SEPTIN9 septin 9 0.0217573
EEF2 eukaryotic translation elongation factor 2 0.0215097
SULF2 sulfatase 2 0.0214127
NAV2 neuron navigator 2 0.0213572
RPL18A ribosomal protein L18a 0.0212226
HSPA8 heat shock 70kDa protein 8 0.0211471
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0211373
RBM39 RNA binding motif protein 39 0.0210223
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0209052
ANO1 anoctamin 1, calcium activated chloride channel 0.0206935
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0206899
NTSR1 neurotensin receptor 1 (high affinity) 0.0205834
TNIP1 TNFAIP3 interacting protein 1 0.0204329
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.020167
EXOC4 exocyst complex component 4 0.0200505
ITGA6 integrin, alpha 6 0.0200243
BMAL2 basic helix-loop-helix ARNT like 2 0.019606
DOK5 docking protein 5 0.0195893
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.019574
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0195358

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228281
TMSB10 thymosin beta 10 -0.119449
B2M beta-2-microglobulin -0.108945
MT2A metallothionein 2A -0.0999907
S100A10 S100 calcium binding protein A10 -0.0934539
RPS6 ribosomal protein S6 -0.0905277
PTMA prothymosin, alpha -0.0899554
TPT1 tumor protein, translationally-controlled 1 -0.0679244
NDRG1 N-myc downstream regulated 1 -0.0665552
RPLP2 ribosomal protein, large, P2 -0.0642529
RPS21 ribosomal protein S21 -0.0631111
RPS8 ribosomal protein S8 -0.0590236
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0578998
IGF2 insulin-like growth factor 2 -0.0565416
RPS13 ribosomal protein S13 -0.0552578
POTEF POTE ankyrin domain family, member F -0.0531665
TIMP3 TIMP metallopeptidase inhibitor 3 -0.052873
IFITM3 interferon induced transmembrane protein 3 -0.0513695
RPLP1 ribosomal protein, large, P1 -0.0512188
FTL ferritin, light polypeptide -0.0505366
CAV1 caveolin 1, caveolae protein, 22kDa -0.0503239
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0482653
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.047138
S100A6 S100 calcium binding protein A6 -0.0469443
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0468502
RPS19 ribosomal protein S19 -0.0466671
STC1 stanniocalcin 1 -0.046399
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0463514
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0434413
S100A9 S100 calcium binding protein A9 -0.0425141
IFITM1 interferon induced transmembrane protein 1 -0.0423901
RPS24 ribosomal protein S24 -0.0422915
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0403683
MT1X metallothionein 1X -0.039483
S100A11 S100 calcium binding protein A11 -0.0394739
RPS25 ribosomal protein S25 -0.0393937
WASF2 WAS protein family, member 2 -0.0391805
RPL12 ribosomal protein L12 -0.0390987
VDAC1 voltage-dependent anion channel 1 -0.0383909
ANXA1 annexin A1 -0.0381807
HLA-B major histocompatibility complex, class I, B -0.0380883
RPL35A ribosomal protein L35a -0.0369767
DSTN destrin (actin depolymerizing factor) -0.0356314
RPS23 ribosomal protein S23 -0.0353306
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.035181
RPL34 ribosomal protein L34 -0.0345237
RPS3 ribosomal protein S3 -0.0342582
RPL31 ribosomal protein L31 -0.0334718
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0334378
RPLP0 ribosomal protein, large, P0 -0.0325954
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0314585
PFN1 profilin 1 -0.0312441
S100A2 S100 calcium binding protein A2 -0.0312052
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0311838
FSCN1 fascin actin-bundling protein 1 -0.0310394
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0310108
RACK1 receptor for activated C kinase 1 -0.0304608
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0303173
CYB5R3 cytochrome b5 reductase 3 -0.0301702
RPL37A ribosomal protein L37a -0.0296477
LOC112694756 uncharaterized LOC112694756 -0.0296312
RPS14 ribosomal protein S14 -0.0296306
RPL32 ribosomal protein L32 -0.029596
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0295055
TXNIP thioredoxin interacting protein -0.0294865
SEPTIN7 septin 7 -0.0289405
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0282157
RPL36 ribosomal protein L36 -0.0281843
RPS29 ribosomal protein S29 -0.0281617
KTN1 kinectin 1 (kinesin receptor) -0.0281542
RPL36A ribosomal protein L36a -0.0279741
RPL7A ribosomal protein L7a -0.0274274
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0274069
PDIA3 protein disulfide isomerase family A, member 3 -0.0272815
RPS12 ribosomal protein S12 -0.0270964
RPS27 ribosomal protein S27 -0.0269503
RPL28 ribosomal protein L28 -0.0266554
NPEPPS aminopeptidase puromycin sensitive -0.0265037
GOLGA4 golgin A4 -0.0264894
LMNA lamin A/C -0.0262227
RPL23 ribosomal protein L23 -0.0260794
FNDC3A fibronectin type III domain containing 3A -0.026068
IFI6 interferon, alpha-inducible protein 6 -0.0256699
RPL35 ribosomal protein L35 -0.0255304
ISG15 ISG15 ubiquitin-like modifier -0.0255188
KMT2E lysine (K)-specific methyltransferase 2E -0.0254861
RPL27A ribosomal protein L27a -0.0252495
RIOK3 RIO kinase 3 -0.0251976
RPS16 ribosomal protein S16 -0.0249123
CNRIP1 cannabinoid receptor interacting protein 1 -0.024802
CLU clusterin -0.0246475
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0245603
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0244334
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0242127
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0241907
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0239081
PKM pyruvate kinase, muscle -0.0237705
RPL8 ribosomal protein L8 -0.0237647
CCNI cyclin I -0.0237637
UBE2B ubiquitin-conjugating enzyme E2B -0.0229726