Arbutin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Arbutin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Arbutin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.166175
LDHA lactate dehydrogenase A 0.0998817
CANX calnexin 0.0857871
RPL3 ribosomal protein L3 0.0824835
DST dystonin 0.0707169
EEF2 eukaryotic translation elongation factor 2 0.0654443
APP amyloid beta (A4) precursor protein 0.0575639
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0552244
SET SET nuclear proto-oncogene 0.0545568
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0496747
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0493417
MYH9 myosin, heavy chain 9, non-muscle 0.0490842
MACF1 microtubule-actin crosslinking factor 1 0.048843
AHNAK AHNAK nucleoprotein 0.0479037
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0443003
TMSB4X thymosin beta 4, X-linked 0.0384422
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0379154
PSD3 pleckstrin and Sec7 domain containing 3 0.0378628
RPL13A ribosomal protein L13a 0.0372504
HDLBP high density lipoprotein binding protein 0.0362004
KRT18 keratin 18, type I 0.0346552
BCAR3 breast cancer anti-estrogen resistance 3 0.0332465
APLP2 amyloid beta (A4) precursor-like protein 2 0.0329974
RPL18A ribosomal protein L18a 0.0321232
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0320671
EZR ezrin 0.0315622
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0314116
RPS4X ribosomal protein S4, X-linked 0.0289718
MCL1 myeloid cell leukemia 1 0.0285679
HSPA8 heat shock 70kDa protein 8 0.0279889
YEATS2 YEATS domain containing 2 0.0276149
CENPF centromere protein F, 350/400kDa 0.0275619
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0272805
TPM3 tropomyosin 3 0.0271437
AHNAK2 AHNAK nucleoprotein 2 0.0263558
RAI1 retinoic acid induced 1 0.0261704
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0261093
EIF4H eukaryotic translation initiation factor 4H 0.0260083
ADAR adenosine deaminase, RNA-specific 0.0251423
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0248784
PLEC plectin 0.0247029
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0235306
CSDE1 cold shock domain containing E1, RNA-binding 0.0234172
ANKRD36 ankyrin repeat domain 36 0.0232389
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0231912
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0230169
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0229554
MKI67 marker of proliferation Ki-67 0.0226224
CAPRIN2 caprin family member 2 0.0226221
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0218685
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0216498
TRIP12 thyroid hormone receptor interactor 12 0.0212563
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0212369
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0210371
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0210025
CEP250 centrosomal protein 250kDa 0.0209666
GIGYF2 GRB10 interacting GYF protein 2 0.0209546
SLK STE20-like kinase 0.0209175
DPYSL2 dihydropyrimidinase-like 2 0.0208858
DOCK11 dedicator of cytokinesis 11 0.0208606
SRRM2 serine/arginine repetitive matrix 2 0.0206412
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0203588
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0202607
ACTN1 actinin, alpha 1 0.0202484
FLNB filamin B, beta 0.0201764
OGA O-GlcNAcase 0.0200983
HDGF hepatoma-derived growth factor 0.019986
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0198656
MYOF myoferlin 0.019637
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0196022
EXOC4 exocyst complex component 4 0.0192671
MSN moesin 0.0192017
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.019168
RPL4 ribosomal protein L4 0.0189679
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0188881
CKAP5 cytoskeleton associated protein 5 0.0188627
SFPQ splicing factor proline/glutamine-rich 0.01875
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0187049
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0186133
FNIP1 folliculin interacting protein 1 0.0182318
TXNRD1 thioredoxin reductase 1 0.0180421
PRRC2A proline-rich coiled-coil 2A 0.0176883
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0174906
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0170907
TRIO trio Rho guanine nucleotide exchange factor 0.0169709
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0169383
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0168476
SMAD3 SMAD family member 3 0.0166079
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0165797
SLC38A2 solute carrier family 38, member 2 0.0165437
LOXL2 lysyl oxidase-like 2 0.0165256
PODXL podocalyxin-like 0.0164743
AARS1 alanyl-tRNA synthetase 1 0.016457
CALR calreticulin 0.0161986
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0161182
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0159586
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0158598
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0158338
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0157096
MNMIP1 manchette microtubule inner protein 1 0.0153453

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.410886
MT2A metallothionein 2A -0.182663
VIM vimentin -0.178463
TMSB10 thymosin beta 10 -0.12151
FTL ferritin, light polypeptide -0.0803667
RPL35A ribosomal protein L35a -0.0608549
TPT1 tumor protein, translationally-controlled 1 -0.0519072
RPS6 ribosomal protein S6 -0.0503389
RPS8 ribosomal protein S8 -0.0467661
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.045196
POTEF POTE ankyrin domain family, member F -0.0451869
HMGA1 high mobility group AT-hook 1 -0.043836
MT1E metallothionein 1E -0.0437502
TP63 tumor protein p63 -0.0427253
RPS19 ribosomal protein S19 -0.0420356
RPL36A ribosomal protein L36a -0.0410631
RPS23 ribosomal protein S23 -0.040234
MT1X metallothionein 1X -0.0384876
TM4SF1 transmembrane 4 L six family member 1 -0.0374525
RPL31 ribosomal protein L31 -0.0370563
RPLP2 ribosomal protein, large, P2 -0.0364475
HLA-B major histocompatibility complex, class I, B -0.0358466
RPL36 ribosomal protein L36 -0.0356381
EGR1 early growth response 1 -0.0353903
RPL28 ribosomal protein L28 -0.0344891
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0334306
RPLP1 ribosomal protein, large, P1 -0.0328342
RPL12 ribosomal protein L12 -0.0319653
PTMA prothymosin, alpha -0.0309506
ACTG1 actin gamma 1 -0.0306174
RACK1 receptor for activated C kinase 1 -0.0299331
RPS25 ribosomal protein S25 -0.029842
RPS29 ribosomal protein S29 -0.029831
RPS24 ribosomal protein S24 -0.0280147
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0250232
RPS14 ribosomal protein S14 -0.0248139
RPL37A ribosomal protein L37a -0.0247319
KMT2E lysine (K)-specific methyltransferase 2E -0.024656
S100A10 S100 calcium binding protein A10 -0.0243053
RPL26 ribosomal protein L26 -0.0240546
B2M beta-2-microglobulin -0.0239717
RPS27 ribosomal protein S27 -0.0238431
RPL34 ribosomal protein L34 -0.0238195
RPS16 ribosomal protein S16 -0.0233611
TXNIP thioredoxin interacting protein -0.0231231
GCLM glutamate-cysteine ligase, modifier subunit -0.0227607
RPL7A ribosomal protein L7a -0.0227384
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0223456
SRGN serglycin -0.0222121
RPS12 ribosomal protein S12 -0.0219758
RPS13 ribosomal protein S13 -0.0218738
S100A9 S100 calcium binding protein A9 -0.0213872
LOC112694756 uncharaterized LOC112694756 -0.0209821
RAB7A RAB7A, member RAS oncogene family -0.0207469
S100A6 S100 calcium binding protein A6 -0.0207039
RPLP0 ribosomal protein, large, P0 -0.0206326
RPS5 ribosomal protein S5 -0.0204513
VDAC1 voltage-dependent anion channel 1 -0.0204287
RPL35 ribosomal protein L35 -0.0202792
RPL32 ribosomal protein L32 -0.0201768
IFITM1 interferon induced transmembrane protein 1 -0.0201031
PFN1 profilin 1 -0.0194948
RPS21 ribosomal protein S21 -0.019302
WASF2 WAS protein family, member 2 -0.0192396
LOC102724023 ES1 protein homolog, mitochondrial -0.0179758
RPS15 ribosomal protein S15 -0.0177122
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0176796
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0176367
RPS10 ribosomal protein S10 -0.016984
RPL38 ribosomal protein L38 -0.0168566
NPEPPS aminopeptidase puromycin sensitive -0.0165358
CD44 CD44 molecule (Indian blood group) -0.0161374
EREG epiregulin -0.0160496
RPL5 ribosomal protein L5 -0.0157935
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0157571
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0154553
FOSL1 FOS-like antigen 1 -0.0153338
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0151712
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0149014
RPL18 ribosomal protein L18 -0.0148806
AREG amphiregulin -0.0147197
RPS28 ribosomal protein S28 -0.0147013
RPL9 ribosomal protein L9 -0.0146478
IFI6 interferon, alpha-inducible protein 6 -0.014531
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0144493
RPS3 ribosomal protein S3 -0.0143914
SEPTIN7 septin 7 -0.0142711
ASTN2 astrotactin 2 -0.014218
RPS2 ribosomal protein S2 -0.0140382
RPS27A ribosomal protein S27a -0.0139361
UBE2B ubiquitin-conjugating enzyme E2B -0.0138699
PKM pyruvate kinase, muscle -0.013766
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0136966
WSB1 WD repeat and SOCS box containing 1 -0.0133
TMEM41B transmembrane protein 41B -0.0132312
RPL27A ribosomal protein L27a -0.013174
CCNI cyclin I -0.0129723
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0126767
TUBA1B tubulin, alpha 1b -0.0124741
JUN jun proto-oncogene -0.0123643