| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Arbutin perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Arbutin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHA | lactate dehydrogenase A | 0.120563 |
| MCL1 | myeloid cell leukemia 1 | 0.115364 |
| RPL3 | ribosomal protein L3 | 0.102686 |
| PLEC | plectin | 0.0876654 |
| EGFR | epidermal growth factor receptor | 0.0856817 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0794382 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.064799 |
| CES1 | carboxylesterase 1 | 0.0626246 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0625654 |
| PCBP2 | poly(rC) binding protein 2 | 0.0594689 |
| NDRG1 | N-myc downstream regulated 1 | 0.0565885 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0543991 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0541621 |
| ARRDC3 | arrestin domain containing 3 | 0.0540488 |
| HDLBP | high density lipoprotein binding protein | 0.0493219 |
| HYOU1 | hypoxia up-regulated 1 | 0.0474849 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0424683 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0412068 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0408127 |
| UBC | ubiquitin C | 0.0366856 |
| ADAR | adenosine deaminase, RNA-specific | 0.0355981 |
| TOP1 | topoisomerase (DNA) I | 0.0355745 |
| NPTN | neuroplastin | 0.0351741 |
| SMAD3 | SMAD family member 3 | 0.0344818 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0343828 |
| TXNRD1 | thioredoxin reductase 1 | 0.033898 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0333706 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0332709 |
| SLTM | SAFB-like, transcription modulator | 0.032823 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0326759 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0316865 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0314154 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0312166 |
| MSN | moesin | 0.03116 |
| YTHDC1 | YTH domain containing 1 | 0.0310587 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0304989 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0303129 |
| GRB10 | growth factor receptor-bound protein 10 | 0.029987 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.029704 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0296697 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0289714 |
| KRT18 | keratin 18, type I | 0.0286363 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0278285 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0275576 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0274549 |
| RPS4X | ribosomal protein S4, X-linked | 0.0271551 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0268948 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0268893 |
| PTEN | phosphatase and tensin homolog | 0.0263013 |
| CANX | calnexin | 0.0261452 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.025939 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0257986 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0252879 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0251851 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0250585 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0250557 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0248355 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0247413 |
| LAMB3 | laminin, beta 3 | 0.0246559 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0245567 |
| MKI67 | marker of proliferation Ki-67 | 0.0238372 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0236843 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0233155 |
| ATP11A | ATPase, class VI, type 11A | 0.0233138 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0229138 |
| CCNL1 | cyclin L1 | 0.0225364 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0222683 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0222652 |
| RPL4 | ribosomal protein L4 | 0.0222208 |
| BRD2 | bromodomain containing 2 | 0.0221667 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.022063 |
| ZNF638 | zinc finger protein 638 | 0.0219269 |
| DOCK5 | dedicator of cytokinesis 5 | 0.021888 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0218367 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0215162 |
| CTTN | cortactin | 0.0214685 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0213678 |
| TPM3 | tropomyosin 3 | 0.0212895 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0211037 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0207965 |
| HLA-A | major histocompatibility complex, class I, A | 0.0207001 |
| HDGF | hepatoma-derived growth factor | 0.0204643 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0197287 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0197283 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0195869 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0194464 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0194311 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0191281 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0190517 |
| RUNX1 | runt-related transcription factor 1 | 0.018908 |
| VEGFA | vascular endothelial growth factor A | 0.0186915 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0186607 |
| STK24 | serine/threonine kinase 24 | 0.0185877 |
| YEATS2 | YEATS domain containing 2 | 0.018467 |
| RPL18A | ribosomal protein L18a | 0.0182019 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0181669 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.018097 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0180516 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0180415 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0179621 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.390265 |
| TMSB10 | thymosin beta 10 | -0.177889 |
| PTMA | prothymosin, alpha | -0.0995643 |
| MT2A | metallothionein 2A | -0.0871352 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0819496 |
| S100A10 | S100 calcium binding protein A10 | -0.0744287 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0652856 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0627746 |
| FTL | ferritin, light polypeptide | -0.0574141 |
| RPS24 | ribosomal protein S24 | -0.0572965 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0565903 |
| SEC61G | Sec61 gamma subunit | -0.0561733 |
| ACTG1 | actin gamma 1 | -0.0544776 |
| IER3 | immediate early response 3 | -0.0528806 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.051509 |
| RPLP1 | ribosomal protein, large, P1 | -0.048866 |
| RPL35A | ribosomal protein L35a | -0.0478638 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0414886 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0412484 |
| H1-0 | H1.0 linker histone | -0.0411496 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0370964 |
| RPL34 | ribosomal protein L34 | -0.036337 |
| RPS25 | ribosomal protein S25 | -0.0354681 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0345149 |
| CSTB | cystatin B (stefin B) | -0.0328529 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0328388 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0319687 |
| RPL12 | ribosomal protein L12 | -0.0316658 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0316586 |
| RPL31 | ribosomal protein L31 | -0.0309451 |
| RPS8 | ribosomal protein S8 | -0.0305519 |
| S100P | S100 calcium binding protein P | -0.0301 |
| CST3 | cystatin C | -0.0293072 |
| RPS6 | ribosomal protein S6 | -0.0291347 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0288482 |
| RPS27A | ribosomal protein S27a | -0.0277415 |
| GM2A | GM2 ganglioside activator | -0.0275501 |
| STC1 | stanniocalcin 1 | -0.0271521 |
| HMGA1 | high mobility group AT-hook 1 | -0.0265145 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0262729 |
| RPL36A | ribosomal protein L36a | -0.0261823 |
| NF1 | neurofibromin 1 | -0.0261512 |
| RPLP2 | ribosomal protein, large, P2 | -0.0253076 |
| RPLP0 | ribosomal protein, large, P0 | -0.0250757 |
| MT1X | metallothionein 1X | -0.0245862 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0243797 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0240677 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0233682 |
| RPS29 | ribosomal protein S29 | -0.0231174 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0231174 |
| ASPH | aspartate beta-hydroxylase | -0.0230995 |
| ATF4 | activating transcription factor 4 | -0.0230924 |
| RPS21 | ribosomal protein S21 | -0.0223333 |
| S100A11 | S100 calcium binding protein A11 | -0.0220647 |
| RPL37A | ribosomal protein L37a | -0.0220001 |
| CCND1 | cyclin D1 | -0.0217068 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0216503 |
| RPS23 | ribosomal protein S23 | -0.0215702 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0204802 |
| CCNI | cyclin I | -0.0204099 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0202361 |
| RPS19 | ribosomal protein S19 | -0.0201487 |
| AREG | amphiregulin | -0.0196685 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0196142 |
| WASF2 | WAS protein family, member 2 | -0.0194587 |
| ENO1 | enolase 1, (alpha) | -0.0193996 |
| S100A6 | S100 calcium binding protein A6 | -0.0193486 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0193451 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0192586 |
| EGR1 | early growth response 1 | -0.0190111 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0187302 |
| AGR2 | anterior gradient 2 | -0.01856 |
| S100A9 | S100 calcium binding protein A9 | -0.0183404 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.018124 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.018096 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0180533 |
| RPL38 | ribosomal protein L38 | -0.0179191 |
| PDE8A | phosphodiesterase 8A | -0.0178586 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0177712 |
| RPL5 | ribosomal protein L5 | -0.0176615 |
| RPL19 | ribosomal protein L19 | -0.0175975 |
| RPS27 | ribosomal protein S27 | -0.0171107 |
| RPS14 | ribosomal protein S14 | -0.0170867 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0169155 |
| ANKRD37 | ankyrin repeat domain 37 | -0.016782 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0166699 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.016575 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0164678 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.01645 |
| TRIM56 | tripartite motif containing 56 | -0.0162587 |
| LOC112694756 | uncharaterized LOC112694756 | -0.016074 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0159902 |
| CUX1 | cut-like homeobox 1 | -0.0158919 |
| EMP1 | epithelial membrane protein 1 | -0.0158397 |
| CAV2 | caveolin 2 | -0.0158109 |
| MYO1E | myosin IE | -0.0156829 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0155686 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0154943 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0153628 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0153548 |
