| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Arbutin perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Arbutin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.161523 |
| LDHA | lactate dehydrogenase A | 0.157288 |
| RPL3 | ribosomal protein L3 | 0.145091 |
| PCBP2 | poly(rC) binding protein 2 | 0.121937 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.109982 |
| VEGFA | vascular endothelial growth factor A | 0.0950932 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0938616 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0913516 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0882687 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0850482 |
| CANX | calnexin | 0.080413 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0790649 |
| FAM20C | family with sequence similarity 20, member C | 0.0783279 |
| RPL13A | ribosomal protein L13a | 0.0779821 |
| MCL1 | myeloid cell leukemia 1 | 0.0696794 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0643824 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0635305 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0631641 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0606786 |
| SMAD3 | SMAD family member 3 | 0.0533038 |
| HDLBP | high density lipoprotein binding protein | 0.0532866 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0524617 |
| APP | amyloid beta (A4) precursor protein | 0.0516305 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0510553 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0498802 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0486888 |
| RPL4 | ribosomal protein L4 | 0.0468982 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0462202 |
| CEP250 | centrosomal protein 250kDa | 0.0457052 |
| CPNE1 | copine I | 0.0456584 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0449419 |
| FLNB | filamin B, beta | 0.0432211 |
| RPL18A | ribosomal protein L18a | 0.0427627 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0424125 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0417242 |
| RPL23 | ribosomal protein L23 | 0.0402052 |
| FLNA | filamin A, alpha | 0.0393417 |
| RPS4X | ribosomal protein S4, X-linked | 0.0387795 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0381704 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0380441 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 0.0368552 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0362282 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0362238 |
| CTDSP2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | 0.036176 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0358422 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0353497 |
| SET | SET nuclear proto-oncogene | 0.0333883 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0330367 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0324003 |
| RPL11 | ribosomal protein L11 | 0.0321898 |
| CALR | calreticulin | 0.03191 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0317152 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0317003 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.03166 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0313545 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.031322 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.031204 |
| HYOU1 | hypoxia up-regulated 1 | 0.0306908 |
| PRELID2 | PRELI domain containing 2 | 0.0306442 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0305257 |
| TMSB4X | thymosin beta 4, X-linked | 0.0300695 |
| CDH13 | cadherin 13 | 0.0293816 |
| RBM39 | RNA binding motif protein 39 | 0.0293602 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.028802 |
| LOXL2 | lysyl oxidase-like 2 | 0.0287012 |
| YBX1 | Y box binding protein 1 | 0.0285105 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0284086 |
| ADAR | adenosine deaminase, RNA-specific | 0.0282669 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.028137 |
| RPL37 | ribosomal protein L37 | 0.0280654 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0279666 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0274008 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0270902 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0269986 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0266815 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0257681 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0257582 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0254124 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0252315 |
| YEATS2 | YEATS domain containing 2 | 0.0251886 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0251825 |
| GNAS | GNAS complex locus | 0.0250859 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0250414 |
| AHNAK | AHNAK nucleoprotein | 0.0250344 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0250228 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0250041 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0249329 |
| GOLGA3 | golgin A3 | 0.0248727 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0248527 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.024201 |
| ENO1 | enolase 1, (alpha) | 0.0241963 |
| HDGF | hepatoma-derived growth factor | 0.0236677 |
| BRD2 | bromodomain containing 2 | 0.0236669 |
| TCP1 | t-complex 1 | 0.0236183 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0233661 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0232642 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0230823 |
| RPS17 | ribosomal protein S17 | 0.0230696 |
| RPS12 | ribosomal protein S12 | 0.0229155 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0226016 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.129815 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.108598 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0976868 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0856247 |
| CD44 | CD44 molecule (Indian blood group) | -0.0834537 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0759356 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0694192 |
| USP34 | ubiquitin specific peptidase 34 | -0.0688381 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0683608 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0541046 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0512248 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0496793 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0469868 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0442876 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0435759 |
| LOX | lysyl oxidase | -0.0431568 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0429381 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0427594 |
| EFNA5 | ephrin-A5 | -0.0424089 |
| IL6ST | interleukin 6 signal transducer | -0.0421799 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.041937 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0416518 |
| JMJD1C | jumonji domain containing 1C | -0.0392974 |
| HMGA1 | high mobility group AT-hook 1 | -0.0390871 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0386652 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.036962 |
| RNF24 | ring finger protein 24 | -0.0365046 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0364763 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0362822 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0353829 |
| CDCP1 | CUB domain containing protein 1 | -0.0351201 |
| B2M | beta-2-microglobulin | -0.0342747 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0321876 |
| FTL | ferritin, light polypeptide | -0.0317418 |
| VMP1 | vacuole membrane protein 1 | -0.0316834 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0316194 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0315797 |
| KYNU | kynureninase | -0.0313563 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0306212 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0297567 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.0294916 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0286051 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0285826 |
| RPS2 | ribosomal protein S2 | -0.0277824 |
| ECE1 | endothelin converting enzyme 1 | -0.0256524 |
| ATP13A3 | ATPase type 13A3 | -0.0255548 |
| ZNF292 | zinc finger protein 292 | -0.0253893 |
| STK38L | serine/threonine kinase 38 like | -0.0252503 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0251407 |
| TMEM263 | transmembrane protein 263 | -0.0249405 |
| HAS2 | hyaluronan synthase 2 | -0.0245258 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0244347 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0243556 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0241655 |
| GPHN | gephyrin | -0.0240685 |
| PLSCR1 | phospholipid scramblase 1 | -0.0234744 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.023311 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0232207 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0231708 |
| VIM | vimentin | -0.0229529 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | -0.0227391 |
| ITGAV | integrin, alpha V | -0.0227077 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0226997 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0226135 |
| CA12 | carbonic anhydrase XII | -0.022434 |
| GPC6 | glypican 6 | -0.0222552 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.022143 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0221053 |
| AHR | aryl hydrocarbon receptor | -0.022098 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0219268 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0218798 |
| IFI44L | interferon-induced protein 44-like | -0.0218219 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.02182 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0215237 |
| PHIP | pleckstrin homology domain interacting protein | -0.0214198 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0213813 |
| NF1 | neurofibromin 1 | -0.0212638 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0211535 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0210573 |
| CCNI | cyclin I | -0.0209313 |
| DSG2 | desmoglein 2 | -0.0208458 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0208352 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0207493 |
| MAP1B | microtubule-associated protein 1B | -0.0206711 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0206633 |
| HDAC9 | histone deacetylase 9 | -0.020472 |
| SEC24A | SEC24 family member A | -0.0204285 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0203525 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0202994 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0199804 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0198049 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0196437 |
| TXNIP | thioredoxin interacting protein | -0.019576 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.0195285 |
| FOXP1 | forkhead box P1 | -0.0194136 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0192476 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0192071 |
| TCF12 | transcription factor 12 | -0.0191996 |
| FAM3C | family with sequence similarity 3, member C | -0.0191718 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0191317 |
