| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Arbutin perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Arbutin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.187689 |
| LDHA | lactate dehydrogenase A | 0.166653 |
| RPL3 | ribosomal protein L3 | 0.146052 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.131149 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.113244 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.104957 |
| FGB | fibrinogen beta chain | 0.101692 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0937501 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.092584 |
| VIM | vimentin | 0.0921824 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0920839 |
| APP | amyloid beta (A4) precursor protein | 0.0893337 |
| MCL1 | myeloid cell leukemia 1 | 0.0892998 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0874852 |
| RPL4 | ribosomal protein L4 | 0.0745781 |
| RPL13A | ribosomal protein L13a | 0.0739526 |
| CANX | calnexin | 0.0662416 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0587833 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0574364 |
| AHNAK | AHNAK nucleoprotein | 0.0570707 |
| TPM4 | tropomyosin 4 | 0.0538423 |
| FLNA | filamin A, alpha | 0.0535733 |
| ACTN1 | actinin, alpha 1 | 0.0529798 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0518392 |
| HDGF | hepatoma-derived growth factor | 0.051727 |
| RPL23 | ribosomal protein L23 | 0.050768 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0495818 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0495707 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0483746 |
| RPL11 | ribosomal protein L11 | 0.0474447 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.047117 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0460001 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0458907 |
| RPL18A | ribosomal protein L18a | 0.0441389 |
| CALR | calreticulin | 0.0435924 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0435456 |
| THBS1 | thrombospondin 1 | 0.0428556 |
| CAVIN1 | caveolae associated protein 1 | 0.039619 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0392845 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0386425 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0385847 |
| PCBP2 | poly(rC) binding protein 2 | 0.0384758 |
| GNAS | GNAS complex locus | 0.0378046 |
| TPM3 | tropomyosin 3 | 0.0377708 |
| RPS4X | ribosomal protein S4, X-linked | 0.0375609 |
| RPL8 | ribosomal protein L8 | 0.036217 |
| ENO1 | enolase 1, (alpha) | 0.0347419 |
| YBX1 | Y box binding protein 1 | 0.0346832 |
| PLEC | plectin | 0.0346129 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0341799 |
| RPL19 | ribosomal protein L19 | 0.0339116 |
| ANXA2 | annexin A2 | 0.0333417 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0333172 |
| TUBB | tubulin, beta class I | 0.0328023 |
| COTL1 | coactosin-like F-actin binding protein 1 | 0.0327231 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0326818 |
| FLNB | filamin B, beta | 0.0319054 |
| HDLBP | high density lipoprotein binding protein | 0.0316477 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0315855 |
| TCP1 | t-complex 1 | 0.0304874 |
| TXNRD1 | thioredoxin reductase 1 | 0.0303081 |
| PFKP | phosphofructokinase, platelet | 0.0301757 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0300852 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0300268 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0296353 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0294913 |
| RRM2 | ribonucleotide reductase M2 | 0.0293458 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0292513 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0288392 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.028373 |
| KRT18 | keratin 18, type I | 0.0283055 |
| RPL37 | ribosomal protein L37 | 0.0282292 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0282225 |
| HYOU1 | hypoxia up-regulated 1 | 0.0281191 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0277594 |
| CALU | calumenin | 0.0276575 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0261211 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0260816 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0257814 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0256091 |
| LASP1 | LIM and SH3 protein 1 | 0.0255 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0254229 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.025408 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0253602 |
| ERBIN | erbb2 interacting protein | 0.0252065 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | 0.0245751 |
| TAGLN2 | transgelin 2 | 0.0245257 |
| FAM168A | family with sequence similarity 168, member A | 0.0242938 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.024064 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0236996 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0231816 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0228799 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0224283 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0223915 |
| MYOF | myoferlin | 0.0222047 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0221997 |
| PRRC2A | proline-rich coiled-coil 2A | 0.022167 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0221466 |
| EZR | ezrin | 0.0219059 |
| RBM8A | RNA binding motif protein 8A | 0.0217343 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.119919 |
| RPS2 | ribosomal protein S2 | -0.0791558 |
| MT2A | metallothionein 2A | -0.0750912 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0678919 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0566201 |
| PM20D1 | peptidase M20 domain containing 1 | -0.053795 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0509703 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0450907 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0439027 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.042048 |
| POTEF | POTE ankyrin domain family, member F | -0.0417261 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0389473 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0373044 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0372901 |
| USP34 | ubiquitin specific peptidase 34 | -0.0372145 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0366508 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0363164 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0352896 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.033132 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0330271 |
| STC1 | stanniocalcin 1 | -0.0321994 |
| DENND4A | DENN/MADD domain containing 4A | -0.0321018 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0300422 |
| JMJD1C | jumonji domain containing 1C | -0.0297795 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0296056 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0294933 |
| RHEB | Ras homolog enriched in brain | -0.0291446 |
| RTN4 | reticulon 4 | -0.0279839 |
| IGF2 | insulin-like growth factor 2 | -0.0279323 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0278383 |
| NUMB | numb homolog (Drosophila) | -0.0274762 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0273822 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0267713 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0266772 |
| CLTC | clathrin, heavy chain (Hc) | -0.0259925 |
| PFDN2 | prefoldin subunit 2 | -0.0252079 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0249846 |
| SRPK1 | SRSF protein kinase 1 | -0.0233861 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0231206 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0230998 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0227798 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0224821 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0223393 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0222447 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0222262 |
| ATXN1 | ataxin 1 | -0.0221665 |
| GOLT1B | golgi transport 1B | -0.0219118 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0218732 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0216349 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.021372 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | -0.0212747 |
| GOLGB1 | golgin B1 | -0.0212741 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0211416 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0205861 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0205836 |
| PARD3 | par-3 family cell polarity regulator | -0.020574 |
| RASAL2 | RAS protein activator like 2 | -0.0205706 |
| ATF4 | activating transcription factor 4 | -0.0202072 |
| EXOC6B | exocyst complex component 6B | -0.0197363 |
| DSCAM | Down syndrome cell adhesion molecule | -0.01965 |
| IER3 | immediate early response 3 | -0.0195784 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0195081 |
| GOLGA4 | golgin A4 | -0.0194554 |
| GPHN | gephyrin | -0.0194328 |
| EGFR | epidermal growth factor receptor | -0.0193462 |
| FAM13B | family with sequence similarity 13, member B | -0.0192472 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -0.0192068 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.018923 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0189019 |
| HMGA1 | high mobility group AT-hook 1 | -0.0187316 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0187054 |
| NCKAP1 | NCK-associated protein 1 | -0.0183017 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0179833 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0178824 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0177939 |
| PHIP | pleckstrin homology domain interacting protein | -0.017421 |
| NUP98 | nucleoporin 98kDa | -0.0174167 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0173927 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0172477 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0172045 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0171365 |
| RPS6 | ribosomal protein S6 | -0.016806 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0167235 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0167222 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0167123 |
| ABI2 | abl-interactor 2 | -0.0165856 |
| CDK13 | cyclin-dependent kinase 13 | -0.0165351 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0164607 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0164534 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0163345 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0163239 |
| KIF5B | kinesin family member 5B | -0.0163128 |
| YLPM1 | YLP motif containing 1 | -0.0162995 |
| NBEAL1 | neurobeachin-like 1 | -0.016273 |
| PSMA3 | proteasome (prosome, macropain) subunit, alpha type, 3 | -0.0162135 |
| PFN1 | profilin 1 | -0.0162057 |
| NOP58 | NOP58 ribonucleoprotein | -0.0161512 |
| PAPOLA | poly(A) polymerase alpha | -0.0160906 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0160431 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0159713 |
