Arbutin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Arbutin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Arbutin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.103924
TXNRD1 thioredoxin reductase 1 0.0856022
TFPI2 tissue factor pathway inhibitor 2 0.0819552
ERRFI1 ERBB receptor feedback inhibitor 1 0.0770424
RPL3 ribosomal protein L3 0.0744354
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0739315
MYH9 myosin, heavy chain 9, non-muscle 0.0639766
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0601221
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0534665
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0530203
TRIO trio Rho guanine nucleotide exchange factor 0.0497216
CSDE1 cold shock domain containing E1, RNA-binding 0.0462199
THSD4 thrombospondin, type I, domain containing 4 0.0446204
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0440145
TPM3 tropomyosin 3 0.0422485
RRM2 ribonucleotide reductase M2 0.0405474
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0403508
IGF1R insulin-like growth factor 1 receptor 0.0389408
PLEC plectin 0.0382961
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0374797
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0363637
HSPA8 heat shock 70kDa protein 8 0.0358448
MYL12B myosin, light chain 12B, regulatory 0.0337331
MKI67 marker of proliferation Ki-67 0.0336898
XPO1 exportin 1 0.0333305
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0333173
SMAD3 SMAD family member 3 0.0327263
ZFAND3 zinc finger, AN1-type domain 3 0.0320867
ADAR adenosine deaminase, RNA-specific 0.0318373
PGK1 phosphoglycerate kinase 1 0.0317851
LDHA lactate dehydrogenase A 0.031525
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0308242
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0298963
AHNAK AHNAK nucleoprotein 0.0298295
NCAPD2 non-SMC condensin I complex, subunit D2 0.0297828
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0297188
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0293972
KRT18 keratin 18, type I 0.0293317
CPNE1 copine I 0.0290607
MARCHF4 membrane associated ring-CH-type finger 4 0.0289851
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0286538
CHD4 chromodomain helicase DNA binding protein 4 0.0285201
ANKRD36 ankyrin repeat domain 36 0.0281488
FLNA filamin A, alpha 0.0277141
EIF4B eukaryotic translation initiation factor 4B 0.0263762
ATP11A ATPase, class VI, type 11A 0.0261099
MSH6 mutS homolog 6 0.0255139
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0255041
ACTN1 actinin, alpha 1 0.0253913
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0252777
EXOC4 exocyst complex component 4 0.0252144
SFPQ splicing factor proline/glutamine-rich 0.0251472
CAPRIN1 cell cycle associated protein 1 0.0245466
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0240674
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0239228
MED13L mediator complex subunit 13-like 0.0239173
RUSC2 RUN and SH3 domain containing 2 0.0237979
SRSF5 serine/arginine-rich splicing factor 5 0.0237821
CEP250 centrosomal protein 250kDa 0.0237662
SMC4 structural maintenance of chromosomes 4 0.0236135
PFKP phosphofructokinase, platelet 0.0233527
APP amyloid beta (A4) precursor protein 0.0229556
ICAM1 intercellular adhesion molecule 1 0.0229402
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.022811
RTN4 reticulon 4 0.0227784
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.022662
EEF2 eukaryotic translation elongation factor 2 0.0225743
SPTBN1 spectrin, beta, non-erythrocytic 1 0.022526
MELK maternal embryonic leucine zipper kinase 0.0222636
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0221489
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0220247
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0220008
ANLN anillin, actin binding protein 0.0212823
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0212483
EPN2 epsin 2 0.021206
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0211757
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0211681
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0211608
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0207732
CTTN cortactin 0.0207604
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0205679
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0204832
FKBP4 FK506 binding protein 4, 59kDa 0.0202786
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0200293
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0199939
OGA O-GlcNAcase 0.0197401
ZNF217 zinc finger protein 217 0.0196381
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0195816
DST dystonin 0.0195288
NUMA1 nuclear mitotic apparatus protein 1 0.0194468
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0192107
TUBB tubulin, beta class I 0.0191777
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0191036
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0190736
ADAM17 ADAM metallopeptidase domain 17 0.0190084
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0189576
EIF4H eukaryotic translation initiation factor 4H 0.0188788
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0188206
STX16 syntaxin 16 0.0187142
NCAPG2 non-SMC condensin II complex, subunit G2 0.0186622

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.372832
TMSB10 thymosin beta 10 -0.105228
EGR1 early growth response 1 -0.0998675
PTMA prothymosin, alpha -0.0840342
AKAP12 A kinase (PRKA) anchor protein 12 -0.0641615
RPS8 ribosomal protein S8 -0.0612319
VIM vimentin -0.0587406
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0555234
PFN1 profilin 1 -0.0501686
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0499666
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0462193
RPS19 ribosomal protein S19 -0.0449256
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0449218
MT2A metallothionein 2A -0.0419026
RPL35A ribosomal protein L35a -0.0411449
AKAP9 A kinase (PRKA) anchor protein 9 -0.040547
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0391584
RPLP1 ribosomal protein, large, P1 -0.038575
ACTG1 actin gamma 1 -0.0384791
RPS3 ribosomal protein S3 -0.0382572
FTL ferritin, light polypeptide -0.0375608
RPS6 ribosomal protein S6 -0.0370853
RAB7A RAB7A, member RAS oncogene family -0.0346354
RPL37A ribosomal protein L37a -0.0329788
POTEF POTE ankyrin domain family, member F -0.0324402
WASF2 WAS protein family, member 2 -0.0317465
LOC102724023 ES1 protein homolog, mitochondrial -0.031609
PDIA3 protein disulfide isomerase family A, member 3 -0.0306026
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0305949
GOLGA4 golgin A4 -0.0302416
RPS21 ribosomal protein S21 -0.0299994
RPS27 ribosomal protein S27 -0.0293861
TPI1 triosephosphate isomerase 1 -0.029278
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0290325
COPA coatomer protein complex, subunit alpha -0.0287477
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0286023
RPS29 ribosomal protein S29 -0.0280948
RAB1A RAB1A, member RAS oncogene family -0.0278173
WNT2B wingless-type MMTV integration site family, member 2B -0.0265344
INTS6 integrator complex subunit 6 -0.0263893
VMP1 vacuole membrane protein 1 -0.0261696
KTN1 kinectin 1 (kinesin receptor) -0.0259857
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0258659
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0255038
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0252719
RPS12 ribosomal protein S12 -0.0246006
RPL12 ribosomal protein L12 -0.0242327
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0242094
RPL8 ribosomal protein L8 -0.0239821
SEC31A SEC31 homolog A (S. cerevisiae) -0.0230741
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0227315
RPLP0 ribosomal protein, large, P0 -0.0225776
HMGA1 high mobility group AT-hook 1 -0.0225649
RPL23 ribosomal protein L23 -0.0223494
GOLGB1 golgin B1 -0.0222771
RPL34 ribosomal protein L34 -0.0221994
BPTF bromodomain PHD finger transcription factor -0.0221274
AFF3 AF4/FMR2 family, member 3 -0.0219144
RPS13 ribosomal protein S13 -0.0217333
RPL36 ribosomal protein L36 -0.0215191
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0214908
RPS10 ribosomal protein S10 -0.0214415
YBX1 Y box binding protein 1 -0.0213151
PRRC2C proline-rich coiled-coil 2C -0.0212933
RPL31 ribosomal protein L31 -0.0212751
ATXN2 ataxin 2 -0.0212707
RPL26 ribosomal protein L26 -0.0212702
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0210341
HLA-B major histocompatibility complex, class I, B -0.0209436
RPL28 ribosomal protein L28 -0.0209284
FOS FBJ murine osteosarcoma viral oncogene homolog -0.020925
RBM25 RNA binding motif protein 25 -0.0208432
NOP58 NOP58 ribonucleoprotein -0.0207801
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0206472
TRA2A transformer 2 alpha homolog (Drosophila) -0.0205861
RPL9 ribosomal protein L9 -0.0205512
S100A10 S100 calcium binding protein A10 -0.0205126
RPS25 ribosomal protein S25 -0.0200822
GNAS GNAS complex locus -0.0200671
MCTP1 multiple C2 domains, transmembrane 1 -0.0197816
JUN jun proto-oncogene -0.0197069
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0190846
RPS15 ribosomal protein S15 -0.018878
RPLP2 ribosomal protein, large, P2 -0.018818
ARMH4 armadillo like helical domain containing 4 -0.0187064
RPL11 ribosomal protein L11 -0.0183286
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0182444
ACBD3 acyl-CoA binding domain containing 3 -0.0182403
NDRG1 N-myc downstream regulated 1 -0.0181237
AEBP2 AE binding protein 2 -0.0179631
BRD2 bromodomain containing 2 -0.0179149
ANKRD12 ankyrin repeat domain 12 -0.0178054
MT1X metallothionein 1X -0.0177889
TNRC6B trinucleotide repeat containing 6B -0.0176517
WSB1 WD repeat and SOCS box containing 1 -0.017632
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.017624
ATXN1 ataxin 1 -0.01761
ARF4 ADP-ribosylation factor 4 -0.0175356
PRH1 proline-rich protein HaeIII subfamily 1 -0.0173606
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0173402