| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Arbutin perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Arbutin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.20406 |
| LDHA | lactate dehydrogenase A | 0.198601 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.198599 |
| NDRG1 | N-myc downstream regulated 1 | 0.164658 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.140988 |
| PLEC | plectin | 0.137599 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.131271 |
| RPL3 | ribosomal protein L3 | 0.125166 |
| VEGFA | vascular endothelial growth factor A | 0.12224 |
| KRT18 | keratin 18, type I | 0.114007 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.100433 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0979304 |
| LAMB3 | laminin, beta 3 | 0.0920737 |
| ASPH | aspartate beta-hydroxylase | 0.0917364 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0902293 |
| MSN | moesin | 0.0862947 |
| CANX | calnexin | 0.0784708 |
| CALR | calreticulin | 0.0772549 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0752616 |
| POTEF | POTE ankyrin domain family, member F | 0.0732797 |
| PLAU | plasminogen activator, urokinase | 0.0730939 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0699272 |
| FLNA | filamin A, alpha | 0.0673479 |
| HDGF | hepatoma-derived growth factor | 0.0654102 |
| DSPP | dentin sialophosphoprotein | 0.0653151 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0626466 |
| TPM3 | tropomyosin 3 | 0.0617045 |
| ENO1 | enolase 1, (alpha) | 0.061547 |
| ADAR | adenosine deaminase, RNA-specific | 0.0594943 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0549974 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.054125 |
| FLNB | filamin B, beta | 0.0531847 |
| PCBP2 | poly(rC) binding protein 2 | 0.0528342 |
| UBC | ubiquitin C | 0.0521526 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0516958 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0515005 |
| RPS4X | ribosomal protein S4, X-linked | 0.0514366 |
| SET | SET nuclear proto-oncogene | 0.0511187 |
| MCL1 | myeloid cell leukemia 1 | 0.0510158 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0505337 |
| KRT7 | keratin 7, type II | 0.0504218 |
| LAMC2 | laminin, gamma 2 | 0.0504078 |
| TMSB4X | thymosin beta 4, X-linked | 0.0495024 |
| RPL11 | ribosomal protein L11 | 0.0492543 |
| RPL13A | ribosomal protein L13a | 0.0488209 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0480683 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0469691 |
| MKI67 | marker of proliferation Ki-67 | 0.0467957 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0462409 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0452532 |
| APP | amyloid beta (A4) precursor protein | 0.0447763 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0446082 |
| RPL18A | ribosomal protein L18a | 0.0445599 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0442472 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0441531 |
| PKM | pyruvate kinase, muscle | 0.0436705 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0422932 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0412013 |
| YTHDC1 | YTH domain containing 1 | 0.0407919 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0397858 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0392267 |
| RPL4 | ribosomal protein L4 | 0.0388419 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0385347 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0384724 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0375074 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.037366 |
| NAV2 | neuron navigator 2 | 0.0370377 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0366768 |
| CENPF | centromere protein F, 350/400kDa | 0.0363258 |
| NPTN | neuroplastin | 0.0362901 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0359559 |
| TOP1 | topoisomerase (DNA) I | 0.0359114 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.035889 |
| AHNAK | AHNAK nucleoprotein | 0.0358175 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0355124 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0350996 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0350095 |
| ARRDC3 | arrestin domain containing 3 | 0.0343176 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0339992 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0338789 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.033389 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0330667 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0325145 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0321723 |
| ANXA11 | annexin A11 | 0.0321293 |
| RPL37 | ribosomal protein L37 | 0.0317511 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0316424 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0313681 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0312292 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0311466 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0311347 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0309647 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0308601 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0305574 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0302758 |
| EZR | ezrin | 0.0302445 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.030187 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.029844 |
| HLA-A | major histocompatibility complex, class I, A | 0.0298131 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0292285 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.144645 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.132402 |
| ACTG1 | actin gamma 1 | -0.0830989 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0541042 |
| EFNA5 | ephrin-A5 | -0.0494998 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0474772 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0459184 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0443293 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0440907 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0397631 |
| S100A10 | S100 calcium binding protein A10 | -0.0365631 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0342518 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0342163 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0325819 |
| RPL34 | ribosomal protein L34 | -0.0320743 |
| MYO1E | myosin IE | -0.0314368 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0304818 |
| FTL | ferritin, light polypeptide | -0.0297779 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0289704 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0285047 |
| NF1 | neurofibromin 1 | -0.0281009 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0268135 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0267666 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0267485 |
| TMEM263 | transmembrane protein 263 | -0.0265049 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.026095 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0256774 |
| RPS23 | ribosomal protein S23 | -0.0253034 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.025197 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0250963 |
| RACK1 | receptor for activated C kinase 1 | -0.0246781 |
| ARF1 | ADP-ribosylation factor 1 | -0.0240489 |
| RPL35A | ribosomal protein L35a | -0.0239633 |
| LMO7 | LIM domain 7 | -0.023714 |
| TMEM165 | transmembrane protein 165 | -0.0236915 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.023491 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0224287 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0223479 |
| CDK13 | cyclin-dependent kinase 13 | -0.0220374 |
| KLHL24 | kelch-like family member 24 | -0.0218991 |
| FBXO11 | F-box protein 11 | -0.0217472 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0216905 |
| RPL36A | ribosomal protein L36a | -0.021492 |
| RASAL2 | RAS protein activator like 2 | -0.0213551 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0209997 |
| CEP350 | centrosomal protein 350kDa | -0.0205705 |
| NUMB | numb homolog (Drosophila) | -0.0202588 |
| RPLP2 | ribosomal protein, large, P2 | -0.0201587 |
| VGLL3 | vestigial-like family member 3 | -0.0201129 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.019547 |
| ARF4 | ADP-ribosylation factor 4 | -0.0194574 |
| RPS16 | ribosomal protein S16 | -0.0193965 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0192248 |
| RPS24 | ribosomal protein S24 | -0.0191516 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0189739 |
| PLSCR1 | phospholipid scramblase 1 | -0.0187826 |
| RPS29 | ribosomal protein S29 | -0.0187731 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0186786 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0185744 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0185353 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0184999 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0184411 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0181848 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0179129 |
| OSMR | oncostatin M receptor | -0.0178702 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0178169 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0177569 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.017602 |
| TXNIP | thioredoxin interacting protein | -0.0174497 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0173525 |
| MCU | mitochondrial calcium uniporter | -0.0172907 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0171582 |
| RAB1A | RAB1A, member RAS oncogene family | -0.017136 |
| EGFR | epidermal growth factor receptor | -0.0170803 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.016997 |
| CCNI | cyclin I | -0.0169874 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0169476 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.016912 |
| RPS8 | ribosomal protein S8 | -0.0167347 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0166451 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0165806 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0165601 |
| RPS6 | ribosomal protein S6 | -0.0165081 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.016493 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0164609 |
| RPL31 | ribosomal protein L31 | -0.0164581 |
| UBAP1 | ubiquitin associated protein 1 | -0.0164244 |
| MTDH | metadherin | -0.0163352 |
| FNIP1 | folliculin interacting protein 1 | -0.0162661 |
| ETV6 | ets variant 6 | -0.0162092 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0159213 |
| RTN3 | reticulon 3 | -0.0158677 |
| JMJD1C | jumonji domain containing 1C | -0.0158166 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0156962 |
| GPATCH8 | G patch domain containing 8 | -0.0155771 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0154722 |
| OCLN | occludin | -0.0152077 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0151217 |
| NEMF | nuclear export mediator factor | -0.0151021 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0150614 |
