| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Arbutin perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Arbutin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.143215 |
| RPL3 | ribosomal protein L3 | 0.137443 |
| MCL1 | myeloid cell leukemia 1 | 0.112974 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.109691 |
| LDHA | lactate dehydrogenase A | 0.0922806 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0806076 |
| COL5A2 | collagen, type V, alpha 2 | 0.0725457 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0719159 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0683041 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.068267 |
| NEK7 | NIMA-related kinase 7 | 0.0653166 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0604004 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0600178 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0595378 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0541763 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0532446 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0530588 |
| FLNA | filamin A, alpha | 0.0515331 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0509077 |
| RPS4X | ribosomal protein S4, X-linked | 0.0503691 |
| GDA | guanine deaminase | 0.0502148 |
| MYOF | myoferlin | 0.0499771 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0476026 |
| GRAMD1B | GRAM domain containing 1B | 0.0464226 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0460903 |
| NRCAM | neuronal cell adhesion molecule | 0.0460403 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0435666 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0427726 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0425642 |
| FLNB | filamin B, beta | 0.0421824 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0409756 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0394702 |
| SET | SET nuclear proto-oncogene | 0.038686 |
| NCOR2 | nuclear receptor corepressor 2 | 0.038254 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0381035 |
| KYNU | kynureninase | 0.0380577 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0376755 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0354743 |
| TPM3 | tropomyosin 3 | 0.035455 |
| MSN | moesin | 0.0353325 |
| RPL13A | ribosomal protein L13a | 0.0347055 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0343219 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.03374 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0329533 |
| RBM39 | RNA binding motif protein 39 | 0.0327859 |
| PCBP2 | poly(rC) binding protein 2 | 0.0321691 |
| RPL4 | ribosomal protein L4 | 0.0317736 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0310329 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0304343 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0296899 |
| OGA | O-GlcNAcase | 0.0295344 |
| PDE10A | phosphodiesterase 10A | 0.0292562 |
| COL4A6 | collagen, type IV, alpha 6 | 0.028952 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0288181 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0284177 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0280912 |
| APP | amyloid beta (A4) precursor protein | 0.0279815 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.027778 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0276946 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0270659 |
| CD109 | CD109 molecule | 0.0267483 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0263042 |
| TXNRD1 | thioredoxin reductase 1 | 0.0262009 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0254407 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0250987 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0250272 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0248368 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0243306 |
| PCBP3 | poly(rC) binding protein 3 | 0.024233 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.024225 |
| ENAH | enabled homolog (Drosophila) | 0.0240321 |
| MKI67 | marker of proliferation Ki-67 | 0.0239592 |
| EZR | ezrin | 0.0235167 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0231199 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0227069 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0226019 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0224898 |
| CTSC | cathepsin C | 0.0224599 |
| DST | dystonin | 0.0224586 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0218937 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0215149 |
| ADAR | adenosine deaminase, RNA-specific | 0.021311 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.021178 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0209156 |
| PLEC | plectin | 0.0207962 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0207948 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0207613 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0207574 |
| CANX | calnexin | 0.0206346 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0205867 |
| CENPF | centromere protein F, 350/400kDa | 0.0205365 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0204844 |
| NONO | non-POU domain containing, octamer-binding | 0.0204308 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0202291 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0201976 |
| MATR3 | matrin 3 | 0.0200408 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0200073 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0199786 |
| HDGF | hepatoma-derived growth factor | 0.019894 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0198564 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.239362 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.209908 |
| FN1 | fibronectin 1 | -0.114123 |
| VIM | vimentin | -0.111 |
| TMSB10 | thymosin beta 10 | -0.0895105 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0845851 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0701761 |
| FTL | ferritin, light polypeptide | -0.0652133 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0643732 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0543109 |
| RPS6 | ribosomal protein S6 | -0.0537217 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0534247 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0512798 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0487217 |
| PTMA | prothymosin, alpha | -0.047773 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0464955 |
| S100A6 | S100 calcium binding protein A6 | -0.0460693 |
| STC1 | stanniocalcin 1 | -0.0449416 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0440185 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0410777 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.041026 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0404265 |
| B2M | beta-2-microglobulin | -0.0401917 |
| MT2A | metallothionein 2A | -0.0388256 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.038722 |
| RPS24 | ribosomal protein S24 | -0.0384898 |
| RPS23 | ribosomal protein S23 | -0.0379821 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0370733 |
| RPL31 | ribosomal protein L31 | -0.0365146 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0355453 |
| RPS8 | ribosomal protein S8 | -0.034012 |
| EGR1 | early growth response 1 | -0.0335622 |
| RPLP1 | ribosomal protein, large, P1 | -0.033331 |
| RPL36A | ribosomal protein L36a | -0.0332271 |
| S100A10 | S100 calcium binding protein A10 | -0.0331765 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.031894 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0310973 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0306481 |
| HLA-B | major histocompatibility complex, class I, B | -0.0303863 |
| VDAC1 | voltage-dependent anion channel 1 | -0.029923 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0284077 |
| CUX1 | cut-like homeobox 1 | -0.028138 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0280668 |
| RPL35A | ribosomal protein L35a | -0.0279483 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0274518 |
| RPL7A | ribosomal protein L7a | -0.0269334 |
| RPL12 | ribosomal protein L12 | -0.0263619 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0261968 |
| IL6 | interleukin 6 | -0.0260511 |
| MAP7 | microtubule-associated protein 7 | -0.0257078 |
| RPS19 | ribosomal protein S19 | -0.0254896 |
| RPS29 | ribosomal protein S29 | -0.0252755 |
| RPLP0 | ribosomal protein, large, P0 | -0.0249081 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0249023 |
| RPS25 | ribosomal protein S25 | -0.0243059 |
| RPLP2 | ribosomal protein, large, P2 | -0.0240506 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0240131 |
| SRGN | serglycin | -0.0237274 |
| RPS14 | ribosomal protein S14 | -0.0235675 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0234846 |
| RPS13 | ribosomal protein S13 | -0.0234172 |
| RPS16 | ribosomal protein S16 | -0.0230407 |
| RPL34 | ribosomal protein L34 | -0.0221333 |
| NCKAP5 | NCK-associated protein 5 | -0.0219416 |
| RACK1 | receptor for activated C kinase 1 | -0.0215264 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0214025 |
| BPTF | bromodomain PHD finger transcription factor | -0.0212207 |
| RGS2 | regulator of G-protein signaling 2 | -0.0210951 |
| RPL37A | ribosomal protein L37a | -0.0205074 |
| ASTN2 | astrotactin 2 | -0.0196786 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0194985 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0191656 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0191037 |
| CCNI | cyclin I | -0.0190999 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0189641 |
| PFN1 | profilin 1 | -0.0188904 |
| RPL36 | ribosomal protein L36 | -0.0187393 |
| RPL32 | ribosomal protein L32 | -0.0186763 |
| ACTG1 | actin gamma 1 | -0.0186475 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0185716 |
| RPS27 | ribosomal protein S27 | -0.0185053 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.018483 |
| KIAA0825 | KIAA0825 | -0.0184259 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0183396 |
| IER3 | immediate early response 3 | -0.0183033 |
| RPS3 | ribosomal protein S3 | -0.0181067 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0180177 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0179961 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0179626 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0178231 |
| RPS21 | ribosomal protein S21 | -0.0177351 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0176049 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0175975 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0173304 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0172836 |
| NDRG1 | N-myc downstream regulated 1 | -0.0170969 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0168542 |
| RPS5 | ribosomal protein S5 | -0.0168003 |
| S100A11 | S100 calcium binding protein A11 | -0.0165888 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0165688 |
