Arbutin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Arbutin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

104 genes differentially expressed following the Arbutin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.282664
USP34 ubiquitin specific peptidase 34 0.178431
IGFBP3 insulin-like growth factor binding protein 3 0.150371
PDE4D phosphodiesterase 4D, cAMP-specific 0.147734
GRB10 growth factor receptor-bound protein 10 0.131308
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.126998
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.126884
ASPH aspartate beta-hydroxylase 0.120213
CANX calnexin 0.113065
RICTOR RPTOR independent companion of MTOR, complex 2 0.108701
LDHA lactate dehydrogenase A 0.106259
AHNAK AHNAK nucleoprotein 0.10059
SAMD4A sterile alpha motif domain containing 4A 0.100358
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.094554
PDIA4 protein disulfide isomerase family A, member 4 0.0943703
PDLIM5 PDZ and LIM domain 5 0.0853139
GOLGA4 golgin A4 0.0796927
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0779765
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0704497
SRRM2 serine/arginine repetitive matrix 2 0.0700684
EFNA5 ephrin-A5 0.0698839
DST dystonin 0.0671922
EZR ezrin 0.0668243
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0629473
NKD1 naked cuticle homolog 1 (Drosophila) 0.061266
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.058677
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0557989
JMJD1C jumonji domain containing 1C 0.0519352
STC1 stanniocalcin 1 0.0474125
ITGA6 integrin, alpha 6 0.0462104
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0461315
CALU calumenin 0.0419892
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0353328
FLNB filamin B, beta 0.034871
ZFAND3 zinc finger, AN1-type domain 3 0.0289106
ESYT2 extended synaptotagmin-like protein 2 0.0247788
BIRC6 baculoviral IAP repeat containing 6 0.0239472
MAML2 mastermind-like 2 (Drosophila) 0.0196767
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0171425
STAG2 stromal antigen 2 0.0139535
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0129568
GMDS GDP-mannose 4,6-dehydratase 0.00803896
B2M beta-2-microglobulin 0.0057829
TRIO trio Rho guanine nucleotide exchange factor 0.0052226
ANXA2 annexin A2 0.00427723
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00387415
LAMB3 laminin, beta 3 3.90109E-5

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.206859
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188256
VIM vimentin -0.175216
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.145968
PCCA propionyl CoA carboxylase, alpha polypeptide -0.137784
PTMA prothymosin, alpha -0.130149
RAP1B RAP1B, member of RAS oncogene family -0.127408
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.119744
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.10663
RPS16 ribosomal protein S16 -0.0990009
NAV2 neuron navigator 2 -0.0961855
RBM25 RNA binding motif protein 25 -0.0955465
FNDC3B fibronectin type III domain containing 3B -0.0906978
TPT1 tumor protein, translationally-controlled 1 -0.0848824
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0838044
ZBTB20 zinc finger and BTB domain containing 20 -0.0778691
RPS8 ribosomal protein S8 -0.0747717
WASF2 WAS protein family, member 2 -0.0735673
RPL26 ribosomal protein L26 -0.072683
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0715821
RORA RAR-related orphan receptor A -0.0705111
ANKRD11 ankyrin repeat domain 11 -0.0695469
RPLP1 ribosomal protein, large, P1 -0.0689791
MACF1 microtubule-actin crosslinking factor 1 -0.0673321
SNX9 sorting nexin 9 -0.0647284
RPLP2 ribosomal protein, large, P2 -0.0636436
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0538698
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0402406
IGF2 insulin-like growth factor 2 -0.0374515
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.037053
PARD3 par-3 family cell polarity regulator -0.0339538
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0319078
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0318889
RAB2A RAB2A, member RAS oncogene family -0.0312964
FN1 fibronectin 1 -0.0302151
CEMIP cell migration inducing protein, hyaluronan binding -0.0299851
NAP1L1 nucleosome assembly protein 1-like 1 -0.0295955
NDRG1 N-myc downstream regulated 1 -0.028594
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0283798
FTL ferritin, light polypeptide -0.0283152
MT2A metallothionein 2A -0.027834
PRRC2C proline-rich coiled-coil 2C -0.0273017
MYO5B myosin VB -0.0255979
CARD16 caspase recruitment domain family, member 16 -0.0235305
ENO1 enolase 1, (alpha) -0.0224296
NAMPT nicotinamide phosphoribosyltransferase -0.0202167
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0182814
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0163378
PGK1 phosphoglycerate kinase 1 -0.0156717
PTK2 protein tyrosine kinase 2 -0.0148846
DSCAM Down syndrome cell adhesion molecule -0.0126214
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0116932
TMSB10 thymosin beta 10 -0.00962894
PDE10A phosphodiesterase 10A -0.00918458
LMO7 LIM domain 7 -0.00489468
KMT2C lysine (K)-specific methyltransferase 2C -0.00396947
RPS6 ribosomal protein S6 -0.00345635