Arbutin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Arbutin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Arbutin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL3 ribosomal protein L3 0.22387
LDHA lactate dehydrogenase A 0.103436
TMSB4X thymosin beta 4, X-linked 0.102995
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0978103
EEF2 eukaryotic translation elongation factor 2 0.0944309
CAMTA1 calmodulin binding transcription activator 1 0.0943371
PDE4B phosphodiesterase 4B, cAMP-specific 0.0835122
AHNAK AHNAK nucleoprotein 0.0820916
SOX6 SRY (sex determining region Y)-box 6 0.0753481
FLNB filamin B, beta 0.0713244
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0683379
GNPDA1 glucosamine-6-phosphate deaminase 1 0.061838
EZR ezrin 0.0617801
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0617355
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0600993
HSPA8 heat shock 70kDa protein 8 0.0595957
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0595402
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0574277
EIF4A2 eukaryotic translation initiation factor 4A2 0.0565817
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0560888
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0533368
APP amyloid beta (A4) precursor protein 0.0528652
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0517382
RBM39 RNA binding motif protein 39 0.0515744
PLXNA1 plexin A1 0.0508345
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0504591
DSCAM Down syndrome cell adhesion molecule 0.0477848
ECT2 epithelial cell transforming 2 0.0468257
HDLBP high density lipoprotein binding protein 0.0461659
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0452729
MKI67 marker of proliferation Ki-67 0.0433441
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0421792
PRPF38B pre-mRNA processing factor 38B 0.0419008
SRRM2 serine/arginine repetitive matrix 2 0.0416617
LOXL3 lysyl oxidase-like 3 0.0405933
TJP1 tight junction protein 1 0.0371758
XPO1 exportin 1 0.0370152
RPL4 ribosomal protein L4 0.0362011
SET SET nuclear proto-oncogene 0.0358238
PDGFC platelet derived growth factor C 0.0355815
APLP2 amyloid beta (A4) precursor-like protein 2 0.035568
BMP10 bone morphogenetic protein 10 0.0352198
ANKRD36 ankyrin repeat domain 36 0.0349595
PGK1 phosphoglycerate kinase 1 0.0348142
UBC ubiquitin C 0.0346107
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0344823
PCBP2 poly(rC) binding protein 2 0.0340084
KDM3A lysine (K)-specific demethylase 3A 0.0337836
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0336386
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0333462
LPP LIM domain containing preferred translocation partner in lipoma 0.0331425
SAMD4A sterile alpha motif domain containing 4A 0.0331057
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0328922
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0322655
MSI2 musashi RNA-binding protein 2 0.0320176
OGA O-GlcNAcase 0.0318011
TPM4 tropomyosin 4 0.0317092
AMOTL2 angiomotin like 2 0.0315474
HDGF hepatoma-derived growth factor 0.031487
GLI2 GLI family zinc finger 2 0.0311081
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0310312
CENPF centromere protein F, 350/400kDa 0.0308079
TGFBR3 transforming growth factor, beta receptor III 0.029935
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0296894
ENO1 enolase 1, (alpha) 0.0296232
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0294061
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0290204
CKAP5 cytoskeleton associated protein 5 0.0287997
SSBP2 single-stranded DNA binding protein 2 0.0287565
FXR1 fragile X mental retardation, autosomal homolog 1 0.0285369
KDM6A lysine (K)-specific demethylase 6A 0.0283806
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0271623
ZMIZ1 zinc finger, MIZ-type containing 1 0.0270706
RPL13A ribosomal protein L13a 0.0270557
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0263458
NUMA1 nuclear mitotic apparatus protein 1 0.0261426
ZNF608 zinc finger protein 608 0.0261034
GSE1 Gse1 coiled-coil protein 0.0260818
NUP58 nucleoporin 58 0.0259655
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0259025
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0257441
TBC1D22A TBC1 domain family, member 22A 0.0251311
EVI5 ecotropic viral integration site 5 0.0250095
ZEB1 zinc finger E-box binding homeobox 1 0.0249978
MYH9 myosin, heavy chain 9, non-muscle 0.0249532
FBLN2 fibulin 2 0.024874
PICALM phosphatidylinositol binding clathrin assembly protein 0.0248128
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0247914
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0246862
HOOK2 hook microtubule-tethering protein 2 0.0246299
CEP250 centrosomal protein 250kDa 0.0245854
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0245219
CSDE1 cold shock domain containing E1, RNA-binding 0.024484
UNC13A unc-13 homolog A (C. elegans) 0.0243456
SEPTIN9 septin 9 0.024207
TPX2 TPX2, microtubule-associated 0.0241184
PER1 period circadian clock 1 0.0240869
INSIG2 insulin induced gene 2 0.0240048
ADAR adenosine deaminase, RNA-specific 0.0235851
NBAS neuroblastoma amplified sequence 0.02358

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.27297
PTMA prothymosin, alpha -0.125961
RPS6 ribosomal protein S6 -0.0914317
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0729623
ACTG1 actin gamma 1 -0.0728033
S100A6 S100 calcium binding protein A6 -0.0597876
RPS23 ribosomal protein S23 -0.0478072
RPL35A ribosomal protein L35a -0.0471692
PDE4D phosphodiesterase 4D, cAMP-specific -0.0450506
FOXP1 forkhead box P1 -0.044362
RPLP2 ribosomal protein, large, P2 -0.0439074
TPT1 tumor protein, translationally-controlled 1 -0.0438864
PFN1 profilin 1 -0.0417747
EGFR epidermal growth factor receptor -0.0401846
RPL12 ribosomal protein L12 -0.0387808
RPL31 ribosomal protein L31 -0.0386244
RPS8 ribosomal protein S8 -0.0370165
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0352614
RPS19 ribosomal protein S19 -0.0334541
ZBTB20 zinc finger and BTB domain containing 20 -0.0334162
TXNRD1 thioredoxin reductase 1 -0.0331977
RPL34 ribosomal protein L34 -0.0331936
TMSB10 thymosin beta 10 -0.0331598
FTL ferritin, light polypeptide -0.0322936
RPS13 ribosomal protein S13 -0.031477
RPLP1 ribosomal protein, large, P1 -0.0314036
RPLP0 ribosomal protein, large, P0 -0.0304786
ZMYND8 zinc finger, MYND-type containing 8 -0.0303658
B2M beta-2-microglobulin -0.0294351
NF1 neurofibromin 1 -0.0275338
RPS29 ribosomal protein S29 -0.0270583
RPL9 ribosomal protein L9 -0.0265413
TMEM41B transmembrane protein 41B -0.0265306
RPL7A ribosomal protein L7a -0.0260673
PRDX2 peroxiredoxin 2 -0.0258138
RPL36A ribosomal protein L36a -0.0257962
MT2A metallothionein 2A -0.025527
RPL36 ribosomal protein L36 -0.0254665
RPS25 ribosomal protein S25 -0.0252786
RPS2 ribosomal protein S2 -0.0247202
S100A4 S100 calcium binding protein A4 -0.0244635
BCAS3 breast carcinoma amplified sequence 3 -0.0242476
PHF14 PHD finger protein 14 -0.0235825
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0234714
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0232958
GARS1 glycyl-tRNA synthetase 1 -0.0230715
RPL23 ribosomal protein L23 -0.0229241
ADNP activity-dependent neuroprotector homeobox -0.0225378
RPS14 ribosomal protein S14 -0.0224396
RPS24 ribosomal protein S24 -0.022329
S100A9 S100 calcium binding protein A9 -0.022227
RPS5 ribosomal protein S5 -0.02217
HMGA1 high mobility group AT-hook 1 -0.0221687
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0219474
HLA-B major histocompatibility complex, class I, B -0.021904
RPL26 ribosomal protein L26 -0.0217742
IFI6 interferon, alpha-inducible protein 6 -0.0217654
GLI3 GLI family zinc finger 3 -0.0217067
CCNI cyclin I -0.0216234
RPS16 ribosomal protein S16 -0.0208672
OSMR oncostatin M receptor -0.020749
RPL28 ribosomal protein L28 -0.0206895
RPS3 ribosomal protein S3 -0.0199654
RPS12 ribosomal protein S12 -0.0198282
DUSP6 dual specificity phosphatase 6 -0.0196891
RACK1 receptor for activated C kinase 1 -0.019523
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0195178
RIGI RNA sensor RIG-I -0.0194425
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0193015
HSPB1 heat shock 27kDa protein 1 -0.0188914
RPL30 ribosomal protein L30 -0.0187016
DIAPH2 diaphanous-related formin 2 -0.0185374
PKM pyruvate kinase, muscle -0.0184482
RTN4 reticulon 4 -0.0182717
RPL32 ribosomal protein L32 -0.018161
RPS21 ribosomal protein S21 -0.0181536
ATF4 activating transcription factor 4 -0.0180784
RPL37A ribosomal protein L37a -0.0179535
VDAC1 voltage-dependent anion channel 1 -0.0178009
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0177793
AHI1 Abelson helper integration site 1 -0.0175199
HDAC8 histone deacetylase 8 -0.0173002
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0171364
S100A10 S100 calcium binding protein A10 -0.017021
EIF1 eukaryotic translation initiation factor 1 -0.0168555
WSB1 WD repeat and SOCS box containing 1 -0.0168338
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0166988
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0166426
SPIDR scaffolding protein involved in DNA repair -0.0165441
IFITM1 interferon induced transmembrane protein 1 -0.0164498
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0164013
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0163953
RPS15 ribosomal protein S15 -0.0162114
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0161079
NACA nascent polypeptide-associated complex alpha subunit -0.0159224
DOCK3 dedicator of cytokinesis 3 -0.0158605
NKTR natural killer cell triggering receptor -0.0157827
VIM vimentin -0.0156426
TAPBP TAP binding protein (tapasin) -0.0155626
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0154807