| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A quinolone that has formula C23H27Cl2N3O2. (Chemical Entities of Biological Interest Ontology, CHEBI_31236) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/60795 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Aripiprazole relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| JAK3 | Janus kinase 3 | 5.81 |
| ABHD2 | abhydrolase domain containing 2 | 2.47 |
| SPIN4 | spindlin family, member 4 | 1.36 |
| APOB | apolipoprotein B | 1.09 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.04 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.03 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.99 |
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.84 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.79 |
| TSPAN3 | tetraspanin 3 | 0.73 |
| PRELID1 | PRELI domain containing 1 | 0.72 |
| FAM219B | family with sequence similarity 219, member B | 0.71 |
| CD63 | CD63 molecule | 0.7 |
| PRELID3B | PRELI domain containing 3B | 0.67 |
| MLH3 | mutL homolog 3 | 0.63 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.62 |
| F10 | coagulation factor X | 0.61 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.61 |
| FGB | fibrinogen beta chain | 0.6 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.57 |
| C7 | complement component 7 | 0.57 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.56 |
| ZNF623 | zinc finger protein 623 | 0.55 |
| SQLE | squalene epoxidase | 0.55 |
| PAH | phenylalanine hydroxylase | 0.55 |
| SLC49A4 | solute carrier family 49 member 4 | 0.54 |
| MCL1 | myeloid cell leukemia 1 | 0.54 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | 0.52 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | 0.51 |
| C4BPA | complement component 4 binding protein, alpha | 0.51 |
| C6ORF47 | chromosome 6 open reading frame 47 | 0.51 |
| MERTK | MER proto-oncogene, tyrosine kinase | 0.51 |
| ARG2 | arginase 2 | 0.5 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.5 |
| NIBAN1 | niban apoptosis regulator 1 | 0.49 |
| LPIN1 | lipin 1 | 0.48 |
| FAM221A | family with sequence similarity 221, member A | 0.48 |
| TPM4 | tropomyosin 4 | 0.47 |
| SUCO | SUN domain containing ossification factor | 0.46 |
| GAS6 | growth arrest-specific 6 | 0.46 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.46 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.45 |
| TTN | titin | 0.44 |
| PWWP3B | PWWP domain containing 3B | 0.44 |
| MVK | mevalonate kinase | 0.42 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.42 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.41 |
| FLNA | filamin A, alpha | 0.41 |
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 | 0.4 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.4 |
| AMOTL1 | angiomotin like 1 | 0.4 |
| ONECUT3 | one cut homeobox 3 | 0.4 |
| NPHP1 | nephronophthisis 1 (juvenile) | 0.39 |
| NAV3 | neuron navigator 3 | 0.39 |
| MSMO1 | methylsterol monooxygenase 1 | 0.39 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.39 |
| LDLR | low density lipoprotein receptor | 0.39 |
| RPL26 | ribosomal protein L26 | 0.39 |
| COX5A | cytochrome c oxidase subunit Va | 0.39 |
| ABHD4 | abhydrolase domain containing 4 | 0.38 |
| DES | desmin | 0.38 |
| C1ORF52 | chromosome 1 open reading frame 52 | 0.38 |
| ENO1 | enolase 1, (alpha) | 0.38 |
| CORO2B | coronin, actin binding protein, 2B | 0.38 |
| GRAMD4 | GRAM domain containing 4 | 0.38 |
| ENSA | endosulfine alpha | 0.38 |
| BORCS5 | BLOC-1 related complex subunit 5 | 0.38 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.37 |
| ECM1 | extracellular matrix protein 1 | 0.37 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 0.36 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.36 |
| GGT2 | gamma-glutamyltransferase 2 | 0.36 |
| ZNF397 | zinc finger protein 397 | 0.36 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.36 |
| FOSL1 | FOS-like antigen 1 | 0.36 |
| GJB3 | gap junction protein, beta 3, 31kDa | 0.36 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.35 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.35 |
| GAS2L1 | growth arrest-specific 2 like 1 | 0.35 |
| LARP6 | La ribonucleoprotein domain family, member 6 | 0.35 |
| ABHD3 | abhydrolase domain containing 3 | 0.35 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.35 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | 0.35 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.34 |
| APOE | apolipoprotein E | 0.34 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.34 |
| SLFN5 | schlafen family member 5 | 0.34 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.34 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | 0.34 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.34 |
| MLXIPL | MLX interacting protein-like | 0.34 |
| HPCAL1 | hippocalcin-like 1 | 0.34 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.34 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | 0.34 |
| HMOX1 | heme oxygenase 1 | 0.34 |
| H1-0 | H1.0 linker histone | 0.33 |
| LAMC2 | laminin, gamma 2 | 0.33 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.33 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMOD1 | leiomodin 1 (smooth muscle) | -1.22 |
| SLC35F3 | solute carrier family 35, member F3 | -0.81 |
| TMEM67 | transmembrane protein 67 | -0.74 |
| LYRM1 | LYR motif containing 1 | -0.68 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.67 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.62 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | -0.61 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.6 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.59 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.58 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | -0.53 |
| TMLHE | trimethyllysine hydroxylase, epsilon | -0.51 |
| RNF220 | ring finger protein 220 | -0.49 |
| PLSCR1 | phospholipid scramblase 1 | -0.48 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.48 |
| WDR90 | WD repeat domain 90 | -0.48 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.47 |
| ZNF33A | zinc finger protein 33A | -0.47 |
| ZFP64 | ZFP64 zinc finger protein | -0.46 |
| CFAP58 | cilia and flagella associated protein 58 | -0.44 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | -0.44 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | -0.43 |
| ZNF566 | zinc finger protein 566 | -0.43 |
| RPUSD1 | RNA pseudouridylate synthase domain containing 1 | -0.43 |
| MRFAP1 | Morf4 family associated protein 1 | -0.42 |
| VSIR | V-set immunoregulatory receptor | -0.42 |
| ZNF268 | zinc finger protein 268 | -0.41 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.41 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | -0.4 |
| RUBCN | rubicon autophagy regulator | -0.4 |
| ZNF496 | zinc finger protein 496 | -0.4 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.39 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.39 |
| TOR4A | torsin family 4, member A | -0.38 |
| RNF26 | ring finger protein 26 | -0.38 |
| TYMS | thymidylate synthetase | -0.38 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | -0.38 |
| EFCAB14 | EF-hand calcium binding domain 14 | -0.37 |
| SLC10A4 | solute carrier family 10, member 4 | -0.37 |
| MTFR2 | mitochondrial fission regulator 2 | -0.37 |
| MTRF1L | mitochondrial translational release factor 1-like | -0.36 |
| WDR25 | WD repeat domain 25 | -0.36 |
| HOXB4 | homeobox B4 | -0.36 |
| VKORC1L1 | vitamin K epoxide reductase complex, subunit 1-like 1 | -0.36 |
| MTFMT | mitochondrial methionyl-tRNA formyltransferase | -0.35 |
| NAAA | N-acylethanolamine acid amidase | -0.35 |
| TSPAN31 | tetraspanin 31 | -0.35 |
| PCLAF | PCNA clamp associated factor | -0.35 |
| SYTL3 | synaptotagmin-like 3 | -0.35 |
| SPPL2B | signal peptide peptidase like 2B | -0.34 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -0.34 |
| KLHL2 | kelch-like family member 2 | -0.34 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.34 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.34 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | -0.34 |
| SNAP47 | synaptosomal-associated protein, 47kDa | -0.33 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -0.33 |
| TTYH3 | tweety family member 3 | -0.33 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.33 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | -0.33 |
| ACAD10 | acyl-CoA dehydrogenase family, member 10 | -0.33 |
| CHST7 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 | -0.33 |
| FCHSD1 | FCH and double SH3 domains 1 | -0.33 |
| NET1 | neuroepithelial cell transforming 1 | -0.33 |
| PUSL1 | pseudouridylate synthase-like 1 | -0.32 |
| DMAC2L | distal membrane arm assembly component 2 like | -0.32 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -0.32 |
| CASZ1 | castor zinc finger 1 | -0.32 |
| TK1 | thymidine kinase 1, soluble | -0.32 |
| KIF20A | kinesin family member 20A | -0.32 |
| ADM | adrenomedullin | -0.32 |
| CCNB1 | cyclin B1 | -0.32 |
| TMEM248 | transmembrane protein 248 | -0.31 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.31 |
| PLK1 | polo-like kinase 1 | -0.31 |
| NARF | nuclear prelamin A recognition factor | -0.31 |
| ZNF594 | zinc finger protein 594 | -0.31 |
| PLIN2 | perilipin 2 | -0.31 |
| TMEM70 | transmembrane protein 70 | -0.31 |
| SH3BP4 | SH3-domain binding protein 4 | -0.31 |
| AURKB | aurora kinase B | -0.31 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | -0.3 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.3 |
| DONSON | downstream neighbor of SON | -0.3 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.3 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | -0.3 |
| CLSTN3 | calsyntenin 3 | -0.3 |
| CCDC138 | coiled-coil domain containing 138 | -0.3 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | -0.3 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.3 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | -0.3 |
| ARHGEF26 | Rho guanine nucleotide exchange factor (GEF) 26 | -0.3 |
| ATL1 | atlastin GTPase 1 | -0.3 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.3 |
| ZNHIT2 | zinc finger, HIT-type containing 2 | -0.3 |
| CREBZF | CREB/ATF bZIP transcription factor | -0.3 |
| NSUN3 | NOP2/Sun domain family, member 3 | -0.3 |
| ALKBH7 | alkB, alkylation repair homolog 7 (E. coli) | -0.3 |
| AURKA | aurora kinase A | -0.29 |
| C6ORF136 | chromosome 6 open reading frame 136 | -0.29 |
