Artemether_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.12626
AKAP12 A kinase (PRKA) anchor protein 12 0.115333
MEF2A myocyte enhancer factor 2A 0.0975579
DST dystonin 0.0790265
LIMCH1 LIM and calponin homology domains 1 0.0782701
SOS1 son of sevenless homolog 1 (Drosophila) 0.0756697
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0736206
FAM13A family with sequence similarity 13, member A 0.0728368
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0705686
MEIS2 Meis homeobox 2 0.0685047
HELZ helicase with zinc finger 0.0680632
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.062677
DSCAM Down syndrome cell adhesion molecule 0.0604634
ITPRID2 ITPR interacting domain containing 2 0.0580453
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.056204
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0546326
LINGO2 leucine rich repeat and Ig domain containing 2 0.0527305
ZNF292 zinc finger protein 292 0.0512253
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.051091
DPH6 diphthamine biosynthesis 6 0.050731
PTPRD protein tyrosine phosphatase, receptor type, D 0.0497464
COL3A1 collagen, type III, alpha 1 0.0487861
MACF1 microtubule-actin crosslinking factor 1 0.0481277
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0475927
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0469301
TLE4 transducin-like enhancer of split 4 0.0468818
ZBTB20 zinc finger and BTB domain containing 20 0.0462709
NRIP1 nuclear receptor interacting protein 1 0.0460151
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0431604
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0427645
AKAP13 A kinase (PRKA) anchor protein 13 0.0412696
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0412297
PDE4D phosphodiesterase 4D, cAMP-specific 0.0397768
B2M beta-2-microglobulin 0.0388953
CEMIP cell migration inducing protein, hyaluronan binding 0.0361842
SLITRK6 SLIT and NTRK-like family, member 6 0.0359326
ENO1 enolase 1, (alpha) 0.0358253
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0354814
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.035453
TIMP3 TIMP metallopeptidase inhibitor 3 0.0348083
NDRG1 N-myc downstream regulated 1 0.0343585
ANO6 anoctamin 6 0.0336651
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0335458
CSDE1 cold shock domain containing E1, RNA-binding 0.0324775
ZNF148 zinc finger protein 148 0.0318825
XRN1 5'-3' exoribonuclease 1 0.031816
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0316069
ERRFI1 ERBB receptor feedback inhibitor 1 0.0314401
ARHGAP9 Rho GTPase activating protein 9 0.0314185
RAD51B RAD51 paralog B 0.0306174
SMAD3 SMAD family member 3 0.0306022
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0304829
CLTC clathrin, heavy chain (Hc) 0.0301204
KDM4C lysine (K)-specific demethylase 4C 0.0298517
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0297497
AFDN afadin, adherens junction formation factor 0.029367
ADGRG6 adhesion G protein-coupled receptor G6 0.0291128
OXR1 oxidation resistance 1 0.0286604
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0280159
AHNAK AHNAK nucleoprotein 0.0279738
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0277332
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0277033
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0276524
USP34 ubiquitin specific peptidase 34 0.0275817
EIF4H eukaryotic translation initiation factor 4H 0.027544
C1ORF21 chromosome 1 open reading frame 21 0.0275332
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0274883
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0273941
ZC3H11A zinc finger CCCH-type containing 11A 0.0273788
TPI1 triosephosphate isomerase 1 0.0272785
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0272628
SH3RF1 SH3 domain containing ring finger 1 0.0269743
PLAT plasminogen activator, tissue 0.0269253
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.026851
ASPH aspartate beta-hydroxylase 0.0267938
FNBP1 formin binding protein 1 0.0264385
SEPTIN9 septin 9 0.0261705
TRIO trio Rho guanine nucleotide exchange factor 0.025958
SOX9 SRY (sex determining region Y)-box 9 0.0259167
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0258697
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0257728
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.025745
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0252815
DLG1 discs, large homolog 1 (Drosophila) 0.025155
LOC112694756 uncharaterized LOC112694756 0.0246729
VGLL4 vestigial-like family member 4 0.0246224
GLI3 GLI family zinc finger 3 0.0244814
STC1 stanniocalcin 1 0.0243568
ANKRD12 ankyrin repeat domain 12 0.0242449
CD164 CD164 molecule, sialomucin 0.0241767
CCDC47 coiled-coil domain containing 47 0.024142
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0239575
SSBP3 single stranded DNA binding protein 3 0.0238823
PRKCE protein kinase C, epsilon 0.0236512
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0236043
MSI2 musashi RNA-binding protein 2 0.0235217
TAS2R14 taste receptor, type 2, member 14 0.0234162
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0233711
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0233313
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0233116

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.281603
IGF2 insulin-like growth factor 2 -0.189844
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0654133
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0653557
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0626639
HMGB2 high mobility group box 2 -0.047317
GREM2 gremlin 2, DAN family BMP antagonist -0.0409473
TMSB10 thymosin beta 10 -0.0393805
EGR1 early growth response 1 -0.0391956
VCL vinculin -0.0390946
TPM4 tropomyosin 4 -0.0387814
GNAS GNAS complex locus -0.0385786
PDE10A phosphodiesterase 10A -0.0361514
FTL ferritin, light polypeptide -0.0359831
SYT1 synaptotagmin I -0.0357983
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0355371
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.035386
ACBD3 acyl-CoA binding domain containing 3 -0.0348693
SIK2 salt-inducible kinase 2 -0.0346302
KLHL13 kelch-like family member 13 -0.0333972
FRMD4A FERM domain containing 4A -0.033281
RPL19 ribosomal protein L19 -0.0331451
RPL35A ribosomal protein L35a -0.0310786
GLCCI1 glucocorticoid induced 1 -0.0310585
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0303869
FNDC3A fibronectin type III domain containing 3A -0.0301435
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0298401
RPLP1 ribosomal protein, large, P1 -0.0296605
RPL34 ribosomal protein L34 -0.0290737
POTEF POTE ankyrin domain family, member F -0.0288508
P4HB prolyl 4-hydroxylase, beta polypeptide -0.028533
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0283829
TPST1 tyrosylprotein sulfotransferase 1 -0.02829
RPL37A ribosomal protein L37a -0.0281169
DSTN destrin (actin depolymerizing factor) -0.0277106
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0275264
FNBP4 formin binding protein 4 -0.0269823
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0264082
WSB1 WD repeat and SOCS box containing 1 -0.0262484
MED13 mediator complex subunit 13 -0.0258006
CADM2 cell adhesion molecule 2 -0.0253916
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0249064
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0248638
GARS1 glycyl-tRNA synthetase 1 -0.0246708
TPT1 tumor protein, translationally-controlled 1 -0.024607
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0240302
FTO fat mass and obesity associated -0.0238529
HMGA1 high mobility group AT-hook 1 -0.0238497
MORF4L2 mortality factor 4 like 2 -0.0238386
PLPP1 phospholipid phosphatase 1 -0.0238058
IWS1 IWS1 homolog (S. cerevisiae) -0.0237401
MMP2 matrix metallopeptidase 2 -0.0235813
AKAP9 A kinase (PRKA) anchor protein 9 -0.0234495
NCKAP1 NCK-associated protein 1 -0.0232112
SEC24A SEC24 family member A -0.0232079
RPL23 ribosomal protein L23 -0.0229169
NCOA7 nuclear receptor coactivator 7 -0.0228996
COL1A1 collagen, type I, alpha 1 -0.0228102
NOP58 NOP58 ribonucleoprotein -0.0228008
RPS12 ribosomal protein S12 -0.0227267
KMT2C lysine (K)-specific methyltransferase 2C -0.0226837
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0224488
CADM1 cell adhesion molecule 1 -0.0224365
INTS6 integrator complex subunit 6 -0.0224222
NALF1 NALCN channel auxiliary factor 1 -0.0219283
RNASEH2A ribonuclease H2, subunit A -0.0217715
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0216008
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0215934
TXNRD1 thioredoxin reductase 1 -0.0215469
COL4A5 collagen, type IV, alpha 5 -0.0215359
STK38L serine/threonine kinase 38 like -0.0213475
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0212627
PHKB phosphorylase kinase, beta -0.0212074
PIAS1 protein inhibitor of activated STAT, 1 -0.0212031
RPS24 ribosomal protein S24 -0.0211843
STAU1 staufen double-stranded RNA binding protein 1 -0.0211584
FHL2 four and a half LIM domains 2 -0.0208738
PDIA3 protein disulfide isomerase family A, member 3 -0.0207709
SEM1 SEM1 26S proteasome subunit -0.0207503
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0206092
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0203462
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0203004
VAV2 vav 2 guanine nucleotide exchange factor -0.0202756
RAP1B RAP1B, member of RAS oncogene family -0.0202371
FAM107B family with sequence similarity 107, member B -0.020021
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0199536
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.019925
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0198477
ARID5B AT rich interactive domain 5B (MRF1-like) -0.019801
EIF5B eukaryotic translation initiation factor 5B -0.0197847
RPTOR regulatory associated protein of MTOR, complex 1 -0.0196381
TTC17 tetratricopeptide repeat domain 17 -0.0193287
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0191538
UBAP1 ubiquitin associated protein 1 -0.0188832
ENAH enabled homolog (Drosophila) -0.0187863
COL18A1 collagen, type XVIII, alpha 1 -0.0186268
S100A10 S100 calcium binding protein A10 -0.018571
THSD4 thrombospondin, type I, domain containing 4 -0.0185629
FOXK2 forkhead box K2 -0.0184244
RPL5 ribosomal protein L5 -0.0183935