Artemether_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.228708
IGFBP3 insulin-like growth factor binding protein 3 0.144097
COL6A3 collagen, type VI, alpha 3 0.136098
MYH9 myosin, heavy chain 9, non-muscle 0.109867
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0994537
ATP13A3 ATPase type 13A3 0.0737532
CANX calnexin 0.073415
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0711417
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0678337
CADM1 cell adhesion molecule 1 0.0659652
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.065206
TRIO trio Rho guanine nucleotide exchange factor 0.0624321
SOD2 superoxide dismutase 2, mitochondrial 0.0526676
CXCL8 chemokine (C-X-C motif) ligand 8 0.0464747
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0435154
FBN1 fibrillin 1 0.0402778
SPAG9 sperm associated antigen 9 0.0397776
FNDC3B fibronectin type III domain containing 3B 0.0388497
POSTN periostin, osteoblast specific factor 0.0383754
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0374687
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0350441
FXR1 fragile X mental retardation, autosomal homolog 1 0.0336005
APP amyloid beta (A4) precursor protein 0.032653
LOX lysyl oxidase 0.0305899
TIMP3 TIMP metallopeptidase inhibitor 3 0.0299258
GOLGA4 golgin A4 0.0295226
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0281996
CALU calumenin 0.0278971
RASA2 RAS p21 protein activator 2 0.027563
RLF rearranged L-myc fusion 0.0272256
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0270011
MATR3 matrin 3 0.0267589
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0267235
TMSB4X thymosin beta 4, X-linked 0.0264087
QKI QKI, KH domain containing, RNA binding 0.0260891
CSDE1 cold shock domain containing E1, RNA-binding 0.0260853
CLINT1 clathrin interactor 1 0.0260062
EEF2 eukaryotic translation elongation factor 2 0.0259469
TFG TRK-fused gene 0.0256294
ANKRD11 ankyrin repeat domain 11 0.0255564
ZNF292 zinc finger protein 292 0.0253711
ZFAND3 zinc finger, AN1-type domain 3 0.0253085
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0252082
COPA coatomer protein complex, subunit alpha 0.0246545
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.024595
NAMPT nicotinamide phosphoribosyltransferase 0.0245879
MARCHF6 membrane associated ring-CH-type finger 6 0.0243259
MLF1 myeloid leukemia factor 1 0.0239958
COL4A1 collagen, type IV, alpha 1 0.0239451
ADAM17 ADAM metallopeptidase domain 17 0.0239019
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0238979
COL1A2 collagen, type I, alpha 2 0.0235253
ADAM9 ADAM metallopeptidase domain 9 0.0234859
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0232456
MSN moesin 0.0226769
PDE10A phosphodiesterase 10A 0.022174
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0219244
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0217008
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0216418
SPTBN1 spectrin, beta, non-erythrocytic 1 0.021557
PICALM phosphatidylinositol binding clathrin assembly protein 0.021228
ARRDC3 arrestin domain containing 3 0.0209152
TSC22D2 TSC22 domain family, member 2 0.0208708
WAC WW domain containing adaptor with coiled-coil 0.0206222
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0206173
ANXA1 annexin A1 0.0202827
PPME1 protein phosphatase methylesterase 1 0.0202444
USP3 ubiquitin specific peptidase 3 0.0202306
RNF145 ring finger protein 145 0.0199227
AZIN1 antizyme inhibitor 1 0.0198881
CLIC4 chloride intracellular channel 4 0.019766
CCNL1 cyclin L1 0.0197659
TMEM39A transmembrane protein 39A 0.0197012
KMT2E lysine (K)-specific methyltransferase 2E 0.0194673
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0194524
VCAN versican 0.0194158
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0192034
COL3A1 collagen, type III, alpha 1 0.019132
RERE arginine-glutamic acid dipeptide (RE) repeats 0.018774
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0185375
HELZ helicase with zinc finger 0.018537
CCNY cyclin Y 0.0183482
DSTN destrin (actin depolymerizing factor) 0.0183473
KMT2C lysine (K)-specific methyltransferase 2C 0.0182277
COL5A1 collagen, type V, alpha 1 0.018207
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0180486
PGK1 phosphoglycerate kinase 1 0.0180087
MRTFA myocardin related transcription factor A 0.0178932
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0178234
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.01752
PRRC1 proline-rich coiled-coil 1 0.0174768
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0173534
SUCO SUN domain containing ossification factor 0.017199
TOP2B topoisomerase (DNA) II beta 180kDa 0.0171917
UBA6 ubiquitin-like modifier activating enzyme 6 0.0171428
PCBP2 poly(rC) binding protein 2 0.0171054
RBM39 RNA binding motif protein 39 0.0170438
IQGAP1 IQ motif containing GTPase activating protein 1 0.017039
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0166658
JARID2 jumonji, AT rich interactive domain 2 0.0166201

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.221598
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.220378
TMSB10 thymosin beta 10 -0.107404
FTL ferritin, light polypeptide -0.0726754
VIM vimentin -0.0723191
RPS8 ribosomal protein S8 -0.0616313
RPL35A ribosomal protein L35a -0.0531851
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0486297
S100A9 S100 calcium binding protein A9 -0.047297
RPS6 ribosomal protein S6 -0.0470804
RPS19 ribosomal protein S19 -0.0434983
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0424841
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0423157
COL1A1 collagen, type I, alpha 1 -0.0420817
TGFBI transforming growth factor, beta-induced, 68kDa -0.0408692
RPL23 ribosomal protein L23 -0.0405719
IER3 immediate early response 3 -0.0395306
IFI6 interferon, alpha-inducible protein 6 -0.0394186
RPLP1 ribosomal protein, large, P1 -0.0383332
MT1X metallothionein 1X -0.0379531
RPLP2 ribosomal protein, large, P2 -0.036023
HLA-B major histocompatibility complex, class I, B -0.0343141
RPL28 ribosomal protein L28 -0.0328755
RPL19 ribosomal protein L19 -0.0319691
RPL37A ribosomal protein L37a -0.0317453
CD44 CD44 molecule (Indian blood group) -0.0316331
RPL36 ribosomal protein L36 -0.031288
RPS3 ribosomal protein S3 -0.0293076
RPL12 ribosomal protein L12 -0.0290632
RPL11 ribosomal protein L11 -0.0274613
RPL8 ribosomal protein L8 -0.0267837
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0266443
RPS20 ribosomal protein S20 -0.0265167
EXT1 exostosin glycosyltransferase 1 -0.026494
RPS2 ribosomal protein S2 -0.0262308
RPS11 ribosomal protein S11 -0.026195
RPL32 ribosomal protein L32 -0.0250724
CDH13 cadherin 13 -0.0249249
ACTG1 actin gamma 1 -0.0249049
RPL26 ribosomal protein L26 -0.0244047
RPL34 ribosomal protein L34 -0.0233738
RPS13 ribosomal protein S13 -0.0229499
RPS16 ribosomal protein S16 -0.0229334
RPS21 ribosomal protein S21 -0.0221869
RPL30 ribosomal protein L30 -0.0221356
ZBTB20 zinc finger and BTB domain containing 20 -0.0219975
WWTR1 WW domain containing transcription regulator 1 -0.0215611
RPS15 ribosomal protein S15 -0.0210132
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0202482
PTMA prothymosin, alpha -0.0199287
HMGA2 high mobility group AT-hook 2 -0.0198833
RPL35 ribosomal protein L35 -0.0194091
STC1 stanniocalcin 1 -0.0192747
S100A10 S100 calcium binding protein A10 -0.0191733
RPS25 ribosomal protein S25 -0.0191392
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0190131
RPL9 ribosomal protein L9 -0.0188439
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0185614
RPS14 ribosomal protein S14 -0.0184868
IFITM3 interferon induced transmembrane protein 3 -0.0184725
RPL31 ribosomal protein L31 -0.0181622
RACK1 receptor for activated C kinase 1 -0.0181363
RPL27 ribosomal protein L27 -0.0180661
RPS27A ribosomal protein S27a -0.018031
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.017646
TPT1 tumor protein, translationally-controlled 1 -0.0176405
ATXN1 ataxin 1 -0.0176098
RPS12 ribosomal protein S12 -0.0175875
RRBP1 ribosome binding protein 1 -0.0172412
RPS24 ribosomal protein S24 -0.0171095
RPS23 ribosomal protein S23 -0.0170402
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0170297
ISG15 ISG15 ubiquitin-like modifier -0.0169593
RPS29 ribosomal protein S29 -0.0169004
EGR1 early growth response 1 -0.0168643
ANTXR2 anthrax toxin receptor 2 -0.0168476
RPL38 ribosomal protein L38 -0.0167566
RPS10 ribosomal protein S10 -0.0165466
RPS5 ribosomal protein S5 -0.0163775
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0162763
S100A6 S100 calcium binding protein A6 -0.0162639
SEC61G Sec61 gamma subunit -0.0159232
RPL5 ribosomal protein L5 -0.0157511
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.015467
B2M beta-2-microglobulin -0.0153666
IGFBP7 insulin-like growth factor binding protein 7 -0.0153107
ZBTB38 zinc finger and BTB domain containing 38 -0.0149642
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0149633
RPL18 ribosomal protein L18 -0.0149214
ANKRD12 ankyrin repeat domain 12 -0.0149132
GLIS3 GLIS family zinc finger 3 -0.0149105
RPL7 ribosomal protein L7 -0.0148994
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0148593
ASPH aspartate beta-hydroxylase -0.0144024
PLAUR plasminogen activator, urokinase receptor -0.014279
PKM pyruvate kinase, muscle -0.0141322
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0139231
HAS2 hyaluronan synthase 2 -0.013838
RPL37 ribosomal protein L37 -0.0138084
ATP5F1E ATP synthase F1 subunit epsilon -0.013789