Artemether_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANXA1 annexin A1 0.114348
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.109519
LMO7 LIM domain 7 0.0976467
CD44 CD44 molecule (Indian blood group) 0.089142
MTSS1 metastasis suppressor 1 0.0846805
NDRG1 N-myc downstream regulated 1 0.0664606
TIMP3 TIMP metallopeptidase inhibitor 3 0.0656932
MSN moesin 0.0603171
MBNL2 muscleblind-like splicing regulator 2 0.0599784
TMSB4X thymosin beta 4, X-linked 0.0598561
FN1 fibronectin 1 0.0569803
MEF2A myocyte enhancer factor 2A 0.0498679
ESYT2 extended synaptotagmin-like protein 2 0.0498059
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0489902
PODXL podocalyxin-like 0.0473483
TRIO trio Rho guanine nucleotide exchange factor 0.0449632
FNDC3B fibronectin type III domain containing 3B 0.0409989
JMJD1C jumonji domain containing 1C 0.0400828
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0395071
EZR ezrin 0.0384298
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0371142
PGK1 phosphoglycerate kinase 1 0.0348522
ARHGAP21 Rho GTPase activating protein 21 0.0339349
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.033876
AKAP13 A kinase (PRKA) anchor protein 13 0.0337409
ALCAM activated leukocyte cell adhesion molecule 0.0327503
PLS3 plastin 3 0.032394
SLK STE20-like kinase 0.0323204
PICALM phosphatidylinositol binding clathrin assembly protein 0.031125
PDLIM5 PDZ and LIM domain 5 0.030379
SQLE squalene epoxidase 0.0302085
IQGAP1 IQ motif containing GTPase activating protein 1 0.0293878
FAM107B family with sequence similarity 107, member B 0.0289681
VCL vinculin 0.0287335
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0282456
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0276348
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0271948
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.027089
KDM6A lysine (K)-specific demethylase 6A 0.0268959
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0260755
DSPP dentin sialophosphoprotein 0.0260645
FOXO1 forkhead box O1 0.0255696
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0255586
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0249353
KIAA1217 KIAA1217 0.0245138
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0241053
ITCH itchy E3 ubiquitin protein ligase 0.0238491
MLF1 myeloid leukemia factor 1 0.0230837
SPAG9 sperm associated antigen 9 0.0225627
UBA6 ubiquitin-like modifier activating enzyme 6 0.0222209
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0218943
PSD3 pleckstrin and Sec7 domain containing 3 0.0216036
KLF5 Kruppel-like factor 5 (intestinal) 0.0215202
EMP1 epithelial membrane protein 1 0.0214037
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0210646
RBM39 RNA binding motif protein 39 0.0209897
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0209333
RAB14 RAB14, member RAS oncogene family 0.0209265
EXT1 exostosin glycosyltransferase 1 0.0206308
ANKRD33B ankyrin repeat domain 33B 0.0205837
SIK3 SIK family kinase 3 0.0205413
LAMC2 laminin, gamma 2 0.0204161
PDE4D phosphodiesterase 4D, cAMP-specific 0.0198369
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0197483
GOLGB1 golgin B1 0.01973
BAIAP2L1 BAI1-associated protein 2-like 1 0.0196295
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0195071
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0191591
BZW1 basic leucine zipper and W2 domains 1 0.0190037
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0188019
F3 coagulation factor III (thromboplastin, tissue factor) 0.0187597
KMT2E lysine (K)-specific methyltransferase 2E 0.0186826
NCOR2 nuclear receptor corepressor 2 0.018673
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0185683
DPY19L1 dpy-19-like 1 (C. elegans) 0.0180883
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0178129
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0178024
CYSTM1 cysteine-rich transmembrane module containing 1 0.0177903
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0174327
ARRDC3 arrestin domain containing 3 0.0174243
ITPRID2 ITPR interacting domain containing 2 0.0172895
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0172335
KDM2A lysine (K)-specific demethylase 2A 0.016769
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0167615
DIAPH1 diaphanous-related formin 1 0.0166795
CD47 CD47 molecule 0.0166661
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.0166635
RNF217 ring finger protein 217 0.0161381
TPR translocated promoter region, nuclear basket protein 0.0160124
SQSTM1 sequestosome 1 0.0159379
CALB1 calbindin 1, 28kDa 0.015839
RASAL2 RAS protein activator like 2 0.0157792
ANLN anillin, actin binding protein 0.0157407
CRY1 cryptochrome circadian clock 1 0.0156114
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.015534
DST dystonin 0.0154752
ZSWIM6 zinc finger, SWIM-type containing 6 0.0154263
ERRFI1 ERBB receptor feedback inhibitor 1 0.015396
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0152014
SUCO SUN domain containing ossification factor 0.0151044

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.143672
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.13366
AHNAK AHNAK nucleoprotein -0.120159
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100627
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0936788
PTMA prothymosin, alpha -0.0883005
MT2A metallothionein 2A -0.0732658
RPS8 ribosomal protein S8 -0.0712846
RPS21 ribosomal protein S21 -0.0678873
RPS27A ribosomal protein S27a -0.0668431
RPS3 ribosomal protein S3 -0.0644918
RPS6 ribosomal protein S6 -0.0643467
RPL23 ribosomal protein L23 -0.0634895
RPLP2 ribosomal protein, large, P2 -0.0634761
KRT17 keratin 17, type I -0.0590331
RPLP1 ribosomal protein, large, P1 -0.0561047
RPS12 ribosomal protein S12 -0.0541674
RPS25 ribosomal protein S25 -0.0496519
ENO1 enolase 1, (alpha) -0.0494489
RPL12 ribosomal protein L12 -0.0489699
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0487553
UBC ubiquitin C -0.0475367
RPS19 ribosomal protein S19 -0.0467008
FLNB filamin B, beta -0.0459541
GARS1 glycyl-tRNA synthetase 1 -0.0419455
PKM pyruvate kinase, muscle -0.0417341
DPYD dihydropyrimidine dehydrogenase -0.0411342
RPS13 ribosomal protein S13 -0.0404533
S100A6 S100 calcium binding protein A6 -0.0402425
RPL37A ribosomal protein L37a -0.0384756
CALR calreticulin -0.0383528
ASPH aspartate beta-hydroxylase -0.038236
RPL8 ribosomal protein L8 -0.037804
RPL34 ribosomal protein L34 -0.0377166
TOP1 topoisomerase (DNA) I -0.0375742
RPL26 ribosomal protein L26 -0.0372181
YBX1 Y box binding protein 1 -0.0366444
RPL5 ribosomal protein L5 -0.0365105
RPS20 ribosomal protein S20 -0.0362278
RPL28 ribosomal protein L28 -0.0361334
PLEC plectin -0.036106
RPL36 ribosomal protein L36 -0.0359978
RPS27 ribosomal protein S27 -0.0359866
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0359562
RPL11 ribosomal protein L11 -0.0355923
ARHGAP29 Rho GTPase activating protein 29 -0.0355637
RPS14 ribosomal protein S14 -0.0352294
RPL19 ribosomal protein L19 -0.0351473
TPT1 tumor protein, translationally-controlled 1 -0.0349261
RPL35 ribosomal protein L35 -0.034248
LMNA lamin A/C -0.0340565
RPS29 ribosomal protein S29 -0.033253
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0330664
RPS24 ribosomal protein S24 -0.0327816
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0325646
RACK1 receptor for activated C kinase 1 -0.0324478
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0324382
MECOM MDS1 and EVI1 complex locus -0.0320678
PLAT plasminogen activator, tissue -0.0320157
RPS16 ribosomal protein S16 -0.031821
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0317745
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0312076
CEMIP cell migration inducing protein, hyaluronan binding -0.0312053
RPL37 ribosomal protein L37 -0.0310728
EEF2 eukaryotic translation elongation factor 2 -0.031014
LOC112694756 uncharaterized LOC112694756 -0.0309939
S100A2 S100 calcium binding protein A2 -0.0305506
BCL2L1 BCL2-like 1 -0.0301345
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.030009
S100A10 S100 calcium binding protein A10 -0.0299293
FTL ferritin, light polypeptide -0.0297819
RPS2 ribosomal protein S2 -0.0295339
DOCK5 dedicator of cytokinesis 5 -0.0295257
CLU clusterin -0.0294711
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0292699
RPL32 ribosomal protein L32 -0.0291853
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0290298
IFITM3 interferon induced transmembrane protein 3 -0.0283716
RPL30 ribosomal protein L30 -0.0279627
GNAS GNAS complex locus -0.0279432
CNRIP1 cannabinoid receptor interacting protein 1 -0.0269103
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.026463
RPL18 ribosomal protein L18 -0.0264292
RPL7A ribosomal protein L7a -0.0263694
RPL27A ribosomal protein L27a -0.0262212
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0260513
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0259911
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0258799
RPL35A ribosomal protein L35a -0.0257154
PDIA3 protein disulfide isomerase family A, member 3 -0.0254169
NAP1L1 nucleosome assembly protein 1-like 1 -0.0250361
S100A9 S100 calcium binding protein A9 -0.0250027
DLG1 discs, large homolog 1 (Drosophila) -0.0242529
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0235604
FOXP1 forkhead box P1 -0.0234727
ANKRD11 ankyrin repeat domain 11 -0.0232898
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0232882
RPS11 ribosomal protein S11 -0.0232027
SEC61G Sec61 gamma subunit -0.0227631
FSCN1 fascin actin-bundling protein 1 -0.0224597