Artemether_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Artemether_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.150225
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.123822
DSCAM Down syndrome cell adhesion molecule 0.12038
PABPC1 poly(A) binding protein, cytoplasmic 1 0.116892
LMO7 LIM domain 7 0.110185
DSPP dentin sialophosphoprotein 0.0999606
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0909527
FAT1 FAT atypical cadherin 1 0.0886432
GOLGA4 golgin A4 0.0880193
LDHA lactate dehydrogenase A 0.0855864
MACF1 microtubule-actin crosslinking factor 1 0.0819274
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0799582
FAM13A family with sequence similarity 13, member A 0.0790347
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0780328
ITGA6 integrin, alpha 6 0.0775672
TXNIP thioredoxin interacting protein 0.0772223
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0771792
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0746189
NDRG1 N-myc downstream regulated 1 0.0721778
AREG amphiregulin 0.0704991
MED13L mediator complex subunit 13-like 0.0679859
RNF145 ring finger protein 145 0.0671253
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0657997
EREG epiregulin 0.0656584
VMP1 vacuole membrane protein 1 0.0644523
MBNL2 muscleblind-like splicing regulator 2 0.0617449
ENO1 enolase 1, (alpha) 0.0595639
VCL vinculin 0.0589475
MYH9 myosin, heavy chain 9, non-muscle 0.0571136
PGK1 phosphoglycerate kinase 1 0.0556589
ANXA1 annexin A1 0.0553461
CANX calnexin 0.0551253
EPS8 epidermal growth factor receptor pathway substrate 8 0.0549643
MED13 mediator complex subunit 13 0.0545184
MYO1E myosin IE 0.0532127
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0520357
ERRFI1 ERBB receptor feedback inhibitor 1 0.0516037
PCBP2 poly(rC) binding protein 2 0.0508765
WAC WW domain containing adaptor with coiled-coil 0.0508073
ZFAND3 zinc finger, AN1-type domain 3 0.0505222
EIF1 eukaryotic translation initiation factor 1 0.050448
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0502553
CCNY cyclin Y 0.0490159
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0490105
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0483444
SEC31A SEC31 homolog A (S. cerevisiae) 0.0478358
RBM39 RNA binding motif protein 39 0.0478287
ITPRID2 ITPR interacting domain containing 2 0.0478101
UBA6 ubiquitin-like modifier activating enzyme 6 0.0468465
PICALM phosphatidylinositol binding clathrin assembly protein 0.0460475
EEF2 eukaryotic translation elongation factor 2 0.0458329
EZR ezrin 0.0455212
FNDC3B fibronectin type III domain containing 3B 0.0453288
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0450097
KDM3A lysine (K)-specific demethylase 3A 0.0446602
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0437156
PUM2 pumilio RNA-binding family member 2 0.043163
ZNF292 zinc finger protein 292 0.0429043
TRIM2 tripartite motif containing 2 0.0427418
KMT2E lysine (K)-specific methyltransferase 2E 0.0423149
CLTC clathrin, heavy chain (Hc) 0.0423045
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0417711
WDR45B WD repeat domain 45B 0.0417366
GARS1 glycyl-tRNA synthetase 1 0.0407655
UBC ubiquitin C 0.0406109
ESYT2 extended synaptotagmin-like protein 2 0.0401853
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.04004
CSNK1A1 casein kinase 1, alpha 1 0.0399783
PTEN phosphatase and tensin homolog 0.0399181
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0399006
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0398926
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0391346
RAB1A RAB1A, member RAS oncogene family 0.0391198
CTNND1 catenin (cadherin-associated protein), delta 1 0.0389892
TPD52 tumor protein D52 0.038621
COPA coatomer protein complex, subunit alpha 0.038584
COG5 component of oligomeric golgi complex 5 0.0380869
SHROOM3 shroom family member 3 0.0380722
EIF4A2 eukaryotic translation initiation factor 4A2 0.0379692
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0377298
PDZD8 PDZ domain containing 8 0.0376926
OGA O-GlcNAcase 0.0376294
HELZ helicase with zinc finger 0.0375095
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0374935
TTC3 tetratricopeptide repeat domain 3 0.0365834
CALR calreticulin 0.0364751
TFG TRK-fused gene 0.0364197
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.036147
BIRC6 baculoviral IAP repeat containing 6 0.0360271
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0358647
AKAP13 A kinase (PRKA) anchor protein 13 0.0358317
ANKRD11 ankyrin repeat domain 11 0.035502
AFF1 AF4/FMR2 family, member 1 0.035346
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0353437
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0352767
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0351119
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0349756
STRN3 striatin, calmodulin binding protein 3 0.0348771
VEGFA vascular endothelial growth factor A 0.0348765
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0347119

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.142606
TMSB10 thymosin beta 10 -0.118737
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.103495
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.084248
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0761105
NALF1 NALCN channel auxiliary factor 1 -0.0711472
ALCAM activated leukocyte cell adhesion molecule -0.0609389
RPLP1 ribosomal protein, large, P1 -0.060193
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0558134
TPT1 tumor protein, translationally-controlled 1 -0.054364
FTL ferritin, light polypeptide -0.0529946
S100A6 S100 calcium binding protein A6 -0.0492419
ONECUT3 one cut homeobox 3 -0.0472412
RPL35A ribosomal protein L35a -0.0471796
RPS6 ribosomal protein S6 -0.0470812
TNS4 tensin 4 -0.0428852
PDE4D phosphodiesterase 4D, cAMP-specific -0.0422224
SLC35F3 solute carrier family 35, member F3 -0.0398213
RPS19 ribosomal protein S19 -0.0378398
PRSS3 protease, serine, 3 -0.0359203
MT2A metallothionein 2A -0.0343885
CCND1 cyclin D1 -0.0343572
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0321422
ANTXR2 anthrax toxin receptor 2 -0.0321328
RPS8 ribosomal protein S8 -0.0314479
HMGB1 high mobility group box 1 -0.0311475
MUC17 mucin 17, cell surface associated -0.0283929
RPL23 ribosomal protein L23 -0.027451
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0265005
ACTG1 actin gamma 1 -0.0262424
RPL5 ribosomal protein L5 -0.0260652
MAML3 mastermind-like 3 (Drosophila) -0.0259834
FAF1 Fas (TNFRSF6) associated factor 1 -0.0256385
RPL34 ribosomal protein L34 -0.0255806
PFN1 profilin 1 -0.0239253
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0237563
HMGA1 high mobility group AT-hook 1 -0.0237109
TFF3 trefoil factor 3 (intestinal) -0.0235243
RPS2 ribosomal protein S2 -0.0235143
DEK DEK proto-oncogene -0.0231231
FRMD5 FERM domain containing 5 -0.0230486
EHBP1 EH domain binding protein 1 -0.0229839
FERMT1 fermitin family member 1 -0.022851
MTAP methylthioadenosine phosphorylase -0.0228047
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0225897
KLK10 kallikrein-related peptidase 10 -0.0225222
RPLP2 ribosomal protein, large, P2 -0.0224799
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0222028
CCSER1 coiled-coil serine-rich protein 1 -0.0220136
KLF3 Kruppel-like factor 3 (basic) -0.0220096
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0219823
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0219189
FHIT fragile histidine triad -0.0214564
GTF2IRD1 GTF2I repeat domain containing 1 -0.0213653
RPL36 ribosomal protein L36 -0.0213083
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0212144
RABGAP1L RAB GTPase activating protein 1-like -0.0211831
TFF1 trefoil factor 1 -0.0209934
DGKH diacylglycerol kinase, eta -0.0207366
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0206261
RAD51B RAD51 paralog B -0.0205477
IGF1R insulin-like growth factor 1 receptor -0.0202736
SH3D19 SH3 domain containing 19 -0.0201801
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0197472
AGR2 anterior gradient 2 -0.0197158
RPL37A ribosomal protein L37a -0.0197044
FLNB filamin B, beta -0.019684
RNF217 ring finger protein 217 -0.0195461
ZNF33A zinc finger protein 33A -0.0194797
RPL26 ribosomal protein L26 -0.0190804
PCDH9 protocadherin 9 -0.0188875
ABR active BCR-related -0.0188636
FOXP2 forkhead box P2 -0.018697
LARP1 La ribonucleoprotein domain family, member 1 -0.0186473
ANO1 anoctamin 1, calcium activated chloride channel -0.0185969
SAMD5 sterile alpha motif domain containing 5 -0.0185813
PSD3 pleckstrin and Sec7 domain containing 3 -0.0184928
VCAN versican -0.0182371
LSAMP limbic system-associated membrane protein -0.0182317
RIN2 Ras and Rab interactor 2 -0.0181319
CBX3 chromobox homolog 3 -0.0181309
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0178039
AFG2A AFG2 AAA ATPase homolog A -0.0176847
RPS21 ribosomal protein S21 -0.017683
RPL9 ribosomal protein L9 -0.017651
TPM4 tropomyosin 4 -0.0175331
TRAPPC9 trafficking protein particle complex 9 -0.0174718
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.017433
CSTB cystatin B (stefin B) -0.0173747
HDAC2 histone deacetylase 2 -0.0171362
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0170146
RPL18 ribosomal protein L18 -0.0170061
CALB1 calbindin 1, 28kDa -0.0168459
PKP4 plakophilin 4 -0.0168133
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0167418
MSI2 musashi RNA-binding protein 2 -0.0167229
RPL35 ribosomal protein L35 -0.0167204
ACTN4 actinin, alpha 4 -0.0166964
CCDC91 coiled-coil domain containing 91 -0.0166419
RPL12 ribosomal protein L12 -0.0164912