Artemether_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.159488
TMSB4X thymosin beta 4, X-linked 0.122708
DST dystonin 0.105654
CANX calnexin 0.0930735
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0844923
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0819817
MACF1 microtubule-actin crosslinking factor 1 0.0773841
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0735451
APP amyloid beta (A4) precursor protein 0.0704787
SPAG9 sperm associated antigen 9 0.0660938
DLG1 discs, large homolog 1 (Drosophila) 0.0659459
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0600245
ARHGAP5 Rho GTPase activating protein 5 0.0591784
CD44 CD44 molecule (Indian blood group) 0.0582775
FMNL2 formin-like 2 0.057676
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0551822
RAI1 retinoic acid induced 1 0.0533647
JMJD1C jumonji domain containing 1C 0.0508999
PGK1 phosphoglycerate kinase 1 0.0501684
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0486941
TRIO trio Rho guanine nucleotide exchange factor 0.0447894
MYOF myoferlin 0.0442474
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0435922
FNIP1 folliculin interacting protein 1 0.0430458
AHNAK AHNAK nucleoprotein 0.0423843
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.041982
SLC38A2 solute carrier family 38, member 2 0.0398785
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0388829
BZW1 basic leucine zipper and W2 domains 1 0.0379236
EHBP1 EH domain binding protein 1 0.0377874
OGA O-GlcNAcase 0.0374383
MYH9 myosin, heavy chain 9, non-muscle 0.0366035
ESYT2 extended synaptotagmin-like protein 2 0.0364099
PLK2 polo-like kinase 2 0.0362547
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0362281
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0359769
EZR ezrin 0.0358869
ANXA1 annexin A1 0.0349602
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0345799
VCL vinculin 0.0336159
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0335467
KDM3A lysine (K)-specific demethylase 3A 0.0334788
XPO1 exportin 1 0.0330693
AFF4 AF4/FMR2 family, member 4 0.0329328
SET SET nuclear proto-oncogene 0.0325407
TRIP12 thyroid hormone receptor interactor 12 0.0324399
DOCK11 dedicator of cytokinesis 11 0.0323901
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0321468
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0321325
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0320337
PUM2 pumilio RNA-binding family member 2 0.0319368
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0317854
LDHA lactate dehydrogenase A 0.0307036
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0305659
CKAP5 cytoskeleton associated protein 5 0.030537
USP9X ubiquitin specific peptidase 9, X-linked 0.0305214
MATR3 matrin 3 0.0304408
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0304176
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0303588
DSCAM Down syndrome cell adhesion molecule 0.030278
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0300097
FXR1 fragile X mental retardation, autosomal homolog 1 0.0293737
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0288027
PIAS2 protein inhibitor of activated STAT, 2 0.0284117
CLTC clathrin, heavy chain (Hc) 0.0281444
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0277198
RUNX1 runt-related transcription factor 1 0.0273804
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0272788
YEATS2 YEATS domain containing 2 0.0272502
PODXL podocalyxin-like 0.0272318
MBNL2 muscleblind-like splicing regulator 2 0.0271599
PABPC1 poly(A) binding protein, cytoplasmic 1 0.026837
EFNA5 ephrin-A5 0.0267669
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0267061
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0264519
SOD2 superoxide dismutase 2, mitochondrial 0.0263049
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0261906
EREG epiregulin 0.0260957
IQGAP1 IQ motif containing GTPase activating protein 1 0.0256257
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0252677
BIRC6 baculoviral IAP repeat containing 6 0.0252373
CSNK1A1 casein kinase 1, alpha 1 0.0252262
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0250591
PTK2 protein tyrosine kinase 2 0.0250277
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0249028
PTMA prothymosin, alpha 0.0248291
CENPF centromere protein F, 350/400kDa 0.0247692
SLK STE20-like kinase 0.0247679
IPO7 importin 7 0.0245687
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0245168
CSDE1 cold shock domain containing E1, RNA-binding 0.0243172
AHNAK2 AHNAK nucleoprotein 2 0.0242949
TTC3 tetratricopeptide repeat domain 3 0.0240825
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0240625
EPHA4 EPH receptor A4 0.0239797
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0239012
KMT2C lysine (K)-specific methyltransferase 2C 0.0237522
ADAM10 ADAM metallopeptidase domain 10 0.0237478
HELZ helicase with zinc finger 0.0237368
STAG2 stromal antigen 2 0.0236278

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.345781
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.334592
TMSB10 thymosin beta 10 -0.153973
FTL ferritin, light polypeptide -0.133384
VIM vimentin -0.116004
RPL35A ribosomal protein L35a -0.0834887
RPS8 ribosomal protein S8 -0.0786216
MT1E metallothionein 1E -0.0782351
RPS19 ribosomal protein S19 -0.0759884
MT1X metallothionein 1X -0.0715561
RPL23 ribosomal protein L23 -0.0620813
RPS6 ribosomal protein S6 -0.0575256
RPLP2 ribosomal protein, large, P2 -0.0535017
HMGA1 high mobility group AT-hook 1 -0.0508194
RPLP1 ribosomal protein, large, P1 -0.0506723
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0501285
RPL36 ribosomal protein L36 -0.0484282
RPL28 ribosomal protein L28 -0.0452693
RPS23 ribosomal protein S23 -0.0434699
RPL12 ribosomal protein L12 -0.0417786
RPS29 ribosomal protein S29 -0.0409442
EGR1 early growth response 1 -0.0397116
RPL31 ribosomal protein L31 -0.0396942
RPL19 ribosomal protein L19 -0.0363117
RPL5 ribosomal protein L5 -0.0358529
IFITM1 interferon induced transmembrane protein 1 -0.0349457
RPL37A ribosomal protein L37a -0.0346188
ACTG1 actin gamma 1 -0.0333202
POTEF POTE ankyrin domain family, member F -0.0325298
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0322626
SRGN serglycin -0.0317787
RPL8 ribosomal protein L8 -0.0315461
RPS27 ribosomal protein S27 -0.0311251
RPS10 ribosomal protein S10 -0.031069
S100A9 S100 calcium binding protein A9 -0.0309052
RPL34 ribosomal protein L34 -0.0307028
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0305946
TPT1 tumor protein, translationally-controlled 1 -0.0303607
RPS15 ribosomal protein S15 -0.0301176
RPL35 ribosomal protein L35 -0.0298791
RPL32 ribosomal protein L32 -0.0293067
RPS14 ribosomal protein S14 -0.0290586
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0286645
RPL27 ribosomal protein L27 -0.0284849
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0282638
RPS13 ribosomal protein S13 -0.027938
RPL11 ribosomal protein L11 -0.0267301
IFI6 interferon, alpha-inducible protein 6 -0.0253605
PKM pyruvate kinase, muscle -0.0252002
PRDX1 peroxiredoxin 1 -0.0251071
RPL18 ribosomal protein L18 -0.0250639
RPS25 ribosomal protein S25 -0.024848
S100A10 S100 calcium binding protein A10 -0.0245598
RPL26 ribosomal protein L26 -0.0244406
AREG amphiregulin -0.0242808
RPS21 ribosomal protein S21 -0.023648
RPL9 ribosomal protein L9 -0.0236019
RPS3 ribosomal protein S3 -0.0235534
FOSL1 FOS-like antigen 1 -0.0234104
TP63 tumor protein p63 -0.0232527
RPS24 ribosomal protein S24 -0.023227
RPS11 ribosomal protein S11 -0.0231585
S100A6 S100 calcium binding protein A6 -0.0230885
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0229283
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0222977
PFN1 profilin 1 -0.0220789
RPS5 ribosomal protein S5 -0.0220027
RPL38 ribosomal protein L38 -0.0209767
RACK1 receptor for activated C kinase 1 -0.0209661
RPS17 ribosomal protein S17 -0.0207022
RPS4X ribosomal protein S4, X-linked -0.0206547
RPS12 ribosomal protein S12 -0.020629
S100A11 S100 calcium binding protein A11 -0.0203159
HLA-B major histocompatibility complex, class I, B -0.0202279
RPL37 ribosomal protein L37 -0.0197918
IFITM3 interferon induced transmembrane protein 3 -0.0196913
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0194475
RPS16 ribosomal protein S16 -0.0191908
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0187553
EIF5B eukaryotic translation initiation factor 5B -0.0180466
HLA-A major histocompatibility complex, class I, A -0.0176161
RPS2 ribosomal protein S2 -0.0176119
RPL7A ribosomal protein L7a -0.0175602
RPS20 ribosomal protein S20 -0.0171678
SEC61G Sec61 gamma subunit -0.0168144
TUBB4B tubulin, beta 4B class IVb -0.0167218
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.016638
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0161465
RPL27A ribosomal protein L27a -0.0160256
YBX1 Y box binding protein 1 -0.0153984
B2M beta-2-microglobulin -0.0153585
CADM2 cell adhesion molecule 2 -0.0151473
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0150952
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0149938
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0149083
GCLM glutamate-cysteine ligase, modifier subunit -0.0148691
RPL36A ribosomal protein L36a -0.0147185
EEF1G eukaryotic translation elongation factor 1 gamma -0.0145108
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0143902
MYL12B myosin, light chain 12B, regulatory -0.014349