Artemether_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.183587
TXNRD1 thioredoxin reductase 1 0.131369
FAM13A family with sequence similarity 13, member A 0.0994324
SOD2 superoxide dismutase 2, mitochondrial 0.0971939
NGLY1 N-glycanase 1 0.0811403
CES1 carboxylesterase 1 0.0775982
LAMC2 laminin, gamma 2 0.0748128
SPAG9 sperm associated antigen 9 0.0732858
ARRDC3 arrestin domain containing 3 0.0657485
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0623806
MKI67 marker of proliferation Ki-67 0.0601578
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0585395
NAMPT nicotinamide phosphoribosyltransferase 0.0565989
JMJD1C jumonji domain containing 1C 0.0516134
NDRG1 N-myc downstream regulated 1 0.0481446
ZNF638 zinc finger protein 638 0.0478564
UBA6 ubiquitin-like modifier activating enzyme 6 0.0462444
ANO6 anoctamin 6 0.0449634
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0446127
LAMA4 laminin, alpha 4 0.0432512
ZC3H11A zinc finger CCCH-type containing 11A 0.0425656
MCL1 myeloid cell leukemia 1 0.0425628
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0425506
USP34 ubiquitin specific peptidase 34 0.0423038
FTH1 ferritin, heavy polypeptide 1 0.0422919
ATP13A3 ATPase type 13A3 0.0410978
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0402565
ERRFI1 ERBB receptor feedback inhibitor 1 0.0399795
SLTM SAFB-like, transcription modulator 0.0398152
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.039733
CAMTA1 calmodulin binding transcription activator 1 0.0395573
ELL2 elongation factor, RNA polymerase II, 2 0.0389959
TSC22D2 TSC22 domain family, member 2 0.038637
RASA2 RAS p21 protein activator 2 0.0374688
OGA O-GlcNAcase 0.0372539
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0367741
MYH9 myosin, heavy chain 9, non-muscle 0.0364657
GCLC glutamate-cysteine ligase, catalytic subunit 0.036406
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0363249
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0363061
TMF1 TATA element modulatory factor 1 0.0358676
AGO2 argonaute RISC catalytic component 2 0.0355408
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0353134
UBC ubiquitin C 0.0346954
SUCO SUN domain containing ossification factor 0.0346848
CYLD cylindromatosis (turban tumor syndrome) 0.0336848
RICTOR RPTOR independent companion of MTOR, complex 2 0.0333713
SAMD4A sterile alpha motif domain containing 4A 0.031416
BLZF1 basic leucine zipper nuclear factor 1 0.0313203
CLTC clathrin, heavy chain (Hc) 0.0310533
KDM2A lysine (K)-specific demethylase 2A 0.0309221
RNF149 ring finger protein 149 0.0307461
ZFC3H1 zinc finger, C3H1-type containing 0.0306566
GSK3B glycogen synthase kinase 3 beta 0.0305701
PCBP2 poly(rC) binding protein 2 0.0305275
MSN moesin 0.0299651
TBC1D22A TBC1 domain family, member 22A 0.0296269
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0296222
SRP54 signal recognition particle 54kDa 0.0293316
MYO1B myosin IB 0.0291848
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0290874
ANXA5 annexin A5 0.0281792
CANX calnexin 0.0281532
CSNK1A1 casein kinase 1, alpha 1 0.0277366
FNIP1 folliculin interacting protein 1 0.0277008
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.027382
GOLGB1 golgin B1 0.0272496
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.027184
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0269413
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0268987
PGK1 phosphoglycerate kinase 1 0.0268291
RUNX1 runt-related transcription factor 1 0.0267643
PUM2 pumilio RNA-binding family member 2 0.0264821
WDR45B WD repeat domain 45B 0.026282
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0261421
GPATCH2L G patch domain containing 2-like 0.0260898
PTEN phosphatase and tensin homolog 0.0260897
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.025892
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0257308
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0256311
COPA coatomer protein complex, subunit alpha 0.025241
OFD1 oral-facial-digital syndrome 1 0.0245053
BLTP1 bridge-like lipid transfer protein family member 1 0.0243918
ITSN2 intersectin 2 0.0243475
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0242853
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0242062
TNIP1 TNFAIP3 interacting protein 1 0.0241983
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0240909
LAMB3 laminin, beta 3 0.0240378
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0239805
BIRC2 baculoviral IAP repeat containing 2 0.0239536
CDCP1 CUB domain containing protein 1 0.0239379
GIGYF2 GRB10 interacting GYF protein 2 0.0236732
EP300 E1A binding protein p300 0.0234313
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0233358
YTHDC1 YTH domain containing 1 0.0232673
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0229571
VEZT vezatin, adherens junctions transmembrane protein 0.0228902
KDM5A lysine (K)-specific demethylase 5A 0.0228766
SEC31A SEC31 homolog A (S. cerevisiae) 0.0228474

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.212899
TMSB10 thymosin beta 10 -0.207561
PTPRM protein tyrosine phosphatase, receptor type, M -0.120819
TPT1 tumor protein, translationally-controlled 1 -0.105409
THSD4 thrombospondin, type I, domain containing 4 -0.10492
PTMA prothymosin, alpha -0.0956018
RPS3 ribosomal protein S3 -0.0936648
ASPH aspartate beta-hydroxylase -0.0868706
INTS6 integrator complex subunit 6 -0.0833071
RPLP1 ribosomal protein, large, P1 -0.0785849
FTL ferritin, light polypeptide -0.0780962
RPL37A ribosomal protein L37a -0.0778961
RPL35A ribosomal protein L35a -0.0774135
PDE4D phosphodiesterase 4D, cAMP-specific -0.0747188
RPS25 ribosomal protein S25 -0.0686353
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0668336
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0659384
EGR1 early growth response 1 -0.0656769
RPS24 ribosomal protein S24 -0.0646008
ANXA2 annexin A2 -0.0616485
ACTG1 actin gamma 1 -0.0591131
RPS6 ribosomal protein S6 -0.059021
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.058521
EFNA5 ephrin-A5 -0.0571591
RPL34 ribosomal protein L34 -0.0570236
RPS12 ribosomal protein S12 -0.0566857
RPS8 ribosomal protein S8 -0.0551881
S100A10 S100 calcium binding protein A10 -0.0544655
PKM pyruvate kinase, muscle -0.0543883
CAV1 caveolin 1, caveolae protein, 22kDa -0.0527789
PDLIM5 PDZ and LIM domain 5 -0.0523047
CST3 cystatin C -0.0512746
RPL31 ribosomal protein L31 -0.0506745
RNF213 ring finger protein 213 -0.0491223
KRT7 keratin 7, type II -0.0469155
RPL12 ribosomal protein L12 -0.0456768
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0441093
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0429426
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0426211
RPL19 ribosomal protein L19 -0.0424928
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0414104
RPS27A ribosomal protein S27a -0.0411074
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.040714
RPS17 ribosomal protein S17 -0.0399308
RPL37 ribosomal protein L37 -0.039425
LPP LIM domain containing preferred translocation partner in lipoma -0.039073
CCND1 cyclin D1 -0.0385283
AHNAK AHNAK nucleoprotein -0.037935
RPL36 ribosomal protein L36 -0.0374632
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0370765
RPLP2 ribosomal protein, large, P2 -0.0368788
CUX1 cut-like homeobox 1 -0.0367237
HOMER1 homer scaffolding protein 1 -0.0364901
MCTP1 multiple C2 domains, transmembrane 1 -0.0364078
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0362925
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0362321
TNS3 tensin 3 -0.0357773
SP100 SP100 nuclear antigen -0.0356202
RPL30 ribosomal protein L30 -0.0354926
MAML3 mastermind-like 3 (Drosophila) -0.0352118
RPS29 ribosomal protein S29 -0.035063
RPS27 ribosomal protein S27 -0.0348476
RPS19 ribosomal protein S19 -0.0343761
CATSPERB catsper channel auxiliary subunit beta -0.0343147
RPS14 ribosomal protein S14 -0.0341894
IFI6 interferon, alpha-inducible protein 6 -0.0341199
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0339251
S100P S100 calcium binding protein P -0.0334841
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0329285
GRAMD1B GRAM domain containing 1B -0.0328569
CCSER1 coiled-coil serine-rich protein 1 -0.0327668
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0327598
LMO7 LIM domain 7 -0.0313328
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0312984
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0310665
PRKCA protein kinase C, alpha -0.0305342
SEC61G Sec61 gamma subunit -0.0300037
NCOA7 nuclear receptor coactivator 7 -0.0295658
RACK1 receptor for activated C kinase 1 -0.0291243
RPL11 ribosomal protein L11 -0.0290833
RPL8 ribosomal protein L8 -0.0288655
LIMCH1 LIM and calponin homology domains 1 -0.0286936
RPL23 ribosomal protein L23 -0.0285176
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.028239
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0282312
RPS16 ribosomal protein S16 -0.0279615
HLA-B major histocompatibility complex, class I, B -0.0272257
KRT18 keratin 18, type I -0.0272237
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0271682
B2M beta-2-microglobulin -0.0269835
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0268309
RPL9 ribosomal protein L9 -0.0268047
RPL36A ribosomal protein L36a -0.0261649
CMIP c-Maf inducing protein -0.025968
RIMS2 regulating synaptic membrane exocytosis 2 -0.0259676
NSUN6 NOP2/Sun domain family, member 6 -0.0258989
RPS13 ribosomal protein S13 -0.0256148
GNAS GNAS complex locus -0.0256017
RAD51B RAD51 paralog B -0.0255358
FNDC3B fibronectin type III domain containing 3B -0.0252714