Artemether_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.156427
GOLGA4 golgin A4 0.125663
AKAP12 A kinase (PRKA) anchor protein 12 0.12106
SOD2 superoxide dismutase 2, mitochondrial 0.120537
NAV2 neuron navigator 2 0.103176
PRELID2 PRELI domain containing 2 0.0945685
SDK1 sidekick cell adhesion molecule 1 0.0889001
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0882108
CANX calnexin 0.0847656
TRIO trio Rho guanine nucleotide exchange factor 0.0744759
FAM13A family with sequence similarity 13, member A 0.0728939
EFNA5 ephrin-A5 0.071935
FAM107B family with sequence similarity 107, member B 0.0709611
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0663507
SEC31A SEC31 homolog A (S. cerevisiae) 0.0662819
KDM2A lysine (K)-specific demethylase 2A 0.0660257
SMAD3 SMAD family member 3 0.0647651
USP34 ubiquitin specific peptidase 34 0.0621141
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0610005
NAMPT nicotinamide phosphoribosyltransferase 0.0594461
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0585454
CTNND1 catenin (cadherin-associated protein), delta 1 0.0583994
RBM39 RNA binding motif protein 39 0.0558419
OGA O-GlcNAcase 0.0554727
DLG1 discs, large homolog 1 (Drosophila) 0.0546475
NGLY1 N-glycanase 1 0.0542811
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0539104
FAM20C family with sequence similarity 20, member C 0.0529617
COG5 component of oligomeric golgi complex 5 0.0520688
MYOF myoferlin 0.0502798
MYH9 myosin, heavy chain 9, non-muscle 0.0497405
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.049595
GPC6 glypican 6 0.0491367
RUNX1 runt-related transcription factor 1 0.0491351
ADD3 adducin 3 (gamma) 0.0490767
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.048618
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0482029
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0473292
ITCH itchy E3 ubiquitin protein ligase 0.0472097
ELL2 elongation factor, RNA polymerase II, 2 0.0469491
FBXL13 F-box and leucine-rich repeat protein 13 0.0460243
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.045661
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0456329
DSCAM Down syndrome cell adhesion molecule 0.0445212
TTC3 tetratricopeptide repeat domain 3 0.0439547
LIMCH1 LIM and calponin homology domains 1 0.0437236
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0436986
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0436937
EIF1 eukaryotic translation initiation factor 1 0.0436659
DOCK5 dedicator of cytokinesis 5 0.0435662
COPB1 coatomer protein complex, subunit beta 1 0.043381
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0430613
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0430572
LOX lysyl oxidase 0.0428317
KMT2C lysine (K)-specific methyltransferase 2C 0.0427854
KDM3A lysine (K)-specific demethylase 3A 0.041661
BIRC6 baculoviral IAP repeat containing 6 0.0405154
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0402862
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0397772
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0396847
CALU calumenin 0.0396217
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0394008
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0392993
UBA6 ubiquitin-like modifier activating enzyme 6 0.0389624
APP amyloid beta (A4) precursor protein 0.0388228
ESYT2 extended synaptotagmin-like protein 2 0.0377767
CLTC clathrin, heavy chain (Hc) 0.0377587
ZNF638 zinc finger protein 638 0.0377498
ENO1 enolase 1, (alpha) 0.0374445
SRP54 signal recognition particle 54kDa 0.0367073
LRRC49 leucine rich repeat containing 49 0.03661
TAS2R14 taste receptor, type 2, member 14 0.036461
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0364318
PCBP2 poly(rC) binding protein 2 0.0363296
CD109 CD109 molecule 0.0362278
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0362098
NBAS neuroblastoma amplified sequence 0.0360177
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0360105
RAB8B RAB8B, member RAS oncogene family 0.0351563
MON2 MON2 homolog (S. cerevisiae) 0.0344163
SCFD1 sec1 family domain containing 1 0.0341713
RARB retinoic acid receptor, beta 0.0335987
BACE2 beta-site APP-cleaving enzyme 2 0.0334731
SEC23A Sec23 homolog A (S. cerevisiae) 0.0333785
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0332995
COPA coatomer protein complex, subunit alpha 0.0332476
SUCO SUN domain containing ossification factor 0.0332018
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.03286
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0327777
FNDC3B fibronectin type III domain containing 3B 0.0326472
ALCAM activated leukocyte cell adhesion molecule 0.0324121
CA12 carbonic anhydrase XII 0.0322898
ARHGAP32 Rho GTPase activating protein 32 0.0318113
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0317948
ARF4 ADP-ribosylation factor 4 0.0317845
FLNB filamin B, beta 0.0317113
TP53BP1 tumor protein p53 binding protein 1 0.0315413
JMJD1C jumonji domain containing 1C 0.0314324
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0313038
RB1CC1 RB1-inducible coiled-coil 1 0.0312676

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.168391
GLCCI1 glucocorticoid induced 1 -0.123746
DPYD dihydropyrimidine dehydrogenase -0.0922966
NRG1 neuregulin 1 -0.0826714
FTL ferritin, light polypeptide -0.0787812
PDE4D phosphodiesterase 4D, cAMP-specific -0.0738151
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0736927
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0661978
FN1 fibronectin 1 -0.0637185
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0625599
HMGA2 high mobility group AT-hook 2 -0.0617323
S100A6 S100 calcium binding protein A6 -0.0597025
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0595491
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0540027
RPLP1 ribosomal protein, large, P1 -0.0513361
EGR1 early growth response 1 -0.0479584
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0444388
RAB27B RAB27B, member RAS oncogene family -0.0444027
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0440004
RPS19 ribosomal protein S19 -0.0421187
NTN4 netrin 4 -0.0418268
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0418116
CLMP CXADR-like membrane protein -0.0396924
TFPI2 tissue factor pathway inhibitor 2 -0.03919
NRP1 neuropilin 1 -0.0388443
HMGA1 high mobility group AT-hook 1 -0.038559
OSMR oncostatin M receptor -0.038066
MT2A metallothionein 2A -0.0362512
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0361726
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0358912
FTH1 ferritin, heavy polypeptide 1 -0.0358583
VRK2 vaccinia related kinase 2 -0.0347999
IFI44L interferon-induced protein 44-like -0.034748
RPS21 ribosomal protein S21 -0.0346493
PKM pyruvate kinase, muscle -0.0334784
ZNF804A zinc finger protein 804A -0.0330743
IGFBP3 insulin-like growth factor binding protein 3 -0.0328463
TRPS1 trichorhinophalangeal syndrome I -0.0324467
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0317678
POTEF POTE ankyrin domain family, member F -0.0315081
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0313889
RPL34 ribosomal protein L34 -0.0311738
HEG1 heart development protein with EGF-like domains 1 -0.0307581
B2M beta-2-microglobulin -0.0306675
CDH13 cadherin 13 -0.0303062
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0294737
WLS wntless Wnt ligand secretion mediator -0.029409
SNX9 sorting nexin 9 -0.0291894
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.028982
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0284736
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0281797
RPL36 ribosomal protein L36 -0.0281147
IFI6 interferon, alpha-inducible protein 6 -0.0275202
MYADM myeloid-associated differentiation marker -0.0273354
GLIS3 GLIS family zinc finger 3 -0.0271562
ANTXR2 anthrax toxin receptor 2 -0.0271139
IL1B interleukin 1, beta -0.0265432
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0262448
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0258294
KYNU kynureninase -0.0256523
TTC28 tetratricopeptide repeat domain 28 -0.0255071
MX2 MX dynamin-like GTPase 2 -0.0254945
MSRB3 methionine sulfoxide reductase B3 -0.0254098
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0253568
WSB1 WD repeat and SOCS box containing 1 -0.0251693
LOC102724023 ES1 protein homolog, mitochondrial -0.0251163
PTPRK protein tyrosine phosphatase, receptor type, K -0.0247311
MECOM MDS1 and EVI1 complex locus -0.0246548
S100A9 S100 calcium binding protein A9 -0.0240384
LRMDA leucine rich melanocyte differentiation associated -0.0239323
DCN decorin -0.0237239
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0236614
ANTXR1 anthrax toxin receptor 1 -0.023294
PID1 phosphotyrosine interaction domain containing 1 -0.0232893
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0232792
DCLK2 doublecortin-like kinase 2 -0.0231826
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0228827
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0225883
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -0.0222874
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0222473
PRSS23 protease, serine, 23 -0.0221866
SVIL supervillin -0.0218691
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0216265
RPS12 ribosomal protein S12 -0.0216069
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0215498
SOX4 SRY (sex determining region Y)-box 4 -0.0214548
PRRX1 paired related homeobox 1 -0.0211864
ANXA10 annexin A10 -0.0208531
RPLP2 ribosomal protein, large, P2 -0.0207596
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0207023
PTGIS prostaglandin I2 (prostacyclin) synthase -0.0205582
NAV3 neuron navigator 3 -0.0205007
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0203341
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0199419
RPL23 ribosomal protein L23 -0.0198166
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0197611
IFITM3 interferon induced transmembrane protein 3 -0.0196671
TPT1 tumor protein, translationally-controlled 1 -0.0196489
PFN1 profilin 1 -0.019483
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0193752