Artemether_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.144073
ASPH aspartate beta-hydroxylase 0.121114
LAMC2 laminin, gamma 2 0.11206
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0959573
TMSB4X thymosin beta 4, X-linked 0.0883279
LAMB3 laminin, beta 3 0.0869639
MYH9 myosin, heavy chain 9, non-muscle 0.0821778
HMGB2 high mobility group box 2 0.0754779
BZW1 basic leucine zipper and W2 domains 1 0.067841
NAMPT nicotinamide phosphoribosyltransferase 0.0614164
CANX calnexin 0.0531628
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0529794
SQSTM1 sequestosome 1 0.052006
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0518919
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0505317
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.050232
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.049668
RAD21 RAD21 homolog (S. pombe) 0.0492196
FXR1 fragile X mental retardation, autosomal homolog 1 0.0490613
PGK1 phosphoglycerate kinase 1 0.0489681
MSN moesin 0.0472082
ENO1 enolase 1, (alpha) 0.0470993
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0467496
GRB10 growth factor receptor-bound protein 10 0.046179
ANXA2 annexin A2 0.0461606
KDM3A lysine (K)-specific demethylase 3A 0.0445061
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0433756
DSPP dentin sialophosphoprotein 0.0430374
TM4SF1 transmembrane 4 L six family member 1 0.0429291
MARCHF6 membrane associated ring-CH-type finger 6 0.0411406
HSPA8 heat shock 70kDa protein 8 0.0402549
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0401593
LDHA lactate dehydrogenase A 0.0397144
EPCAM epithelial cell adhesion molecule 0.0382435
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0371867
UBA6 ubiquitin-like modifier activating enzyme 6 0.0351831
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0344607
TSC22D2 TSC22 domain family, member 2 0.0343005
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0341841
ELL2 elongation factor, RNA polymerase II, 2 0.0341245
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0339172
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0333516
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0326177
ERRFI1 ERBB receptor feedback inhibitor 1 0.0319325
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0310651
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0309726
IRF6 interferon regulatory factor 6 0.0301368
RYBP RING1 and YY1 binding protein 0.0300517
CALR calreticulin 0.029742
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0285693
MYO6 myosin VI 0.0284835
MSMO1 methylsterol monooxygenase 1 0.0279232
KRT18 keratin 18, type I 0.0278483
CDC73 cell division cycle 73 0.0272922
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0267807
APP amyloid beta (A4) precursor protein 0.0266715
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0264831
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0263838
IQGAP1 IQ motif containing GTPase activating protein 1 0.0262023
ZNF292 zinc finger protein 292 0.0260313
RPL14 ribosomal protein L14 0.025881
CNN3 calponin 3, acidic 0.0256823
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0252581
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0249872
ANXA5 annexin A5 0.0249564
ANXA1 annexin A1 0.024828
RPLP0 ribosomal protein, large, P0 0.0246562
SPAG9 sperm associated antigen 9 0.0242622
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0240638
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0240261
AFDN afadin, adherens junction formation factor 0.0239448
ADAM9 ADAM metallopeptidase domain 9 0.0238261
TFG TRK-fused gene 0.0236108
NAP1L1 nucleosome assembly protein 1-like 1 0.0234993
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0234744
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0234043
ATP13A3 ATPase type 13A3 0.0232223
DSG2 desmoglein 2 0.0231026
VCL vinculin 0.0230322
RBM33 RNA binding motif protein 33 0.0226562
SOD2 superoxide dismutase 2, mitochondrial 0.0225812
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0223255
TUBA1B tubulin, alpha 1b 0.0221412
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.021574
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0214909
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0214564
PAPOLA poly(A) polymerase alpha 0.0213364
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0211711
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0211364
SET SET nuclear proto-oncogene 0.0210643
TMEM39A transmembrane protein 39A 0.021038
FAM13A family with sequence similarity 13, member A 0.0209178
CORO1C coronin, actin binding protein, 1C 0.0208368
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0208147
RPL4 ribosomal protein L4 0.0207731
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0204847
CERT1 ceramide transporter 1 0.0204753
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0202929
MYO5B myosin VB 0.020168
RLF rearranged L-myc fusion 0.0200907

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.279332
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.264562
TMSB10 thymosin beta 10 -0.172925
ACTG1 actin gamma 1 -0.127769
LIMCH1 LIM and calponin homology domains 1 -0.101393
NDRG1 N-myc downstream regulated 1 -0.0949503
SAMD4A sterile alpha motif domain containing 4A -0.0922407
IFI27 interferon, alpha-inducible protein 27 -0.084047
RPL35A ribosomal protein L35a -0.0829091
RPLP2 ribosomal protein, large, P2 -0.0818479
LPP LIM domain containing preferred translocation partner in lipoma -0.0814859
RPS19 ribosomal protein S19 -0.0804249
RPLP1 ribosomal protein, large, P1 -0.0788395
RPS23 ribosomal protein S23 -0.0777638
RPS29 ribosomal protein S29 -0.0772753
ISG15 ISG15 ubiquitin-like modifier -0.0745208
RPL8 ribosomal protein L8 -0.0734161
TMEM165 transmembrane protein 165 -0.0705084
EFNA5 ephrin-A5 -0.0694204
IGFBP3 insulin-like growth factor binding protein 3 -0.0636246
FTH1 ferritin, heavy polypeptide 1 -0.063347
RPS13 ribosomal protein S13 -0.0598393
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0590681
FBXO32 F-box protein 32 -0.0585041
HLA-B major histocompatibility complex, class I, B -0.0577733
SOX4 SRY (sex determining region Y)-box 4 -0.0566015
RPS8 ribosomal protein S8 -0.0553126
RPS6 ribosomal protein S6 -0.0526459
RPS27 ribosomal protein S27 -0.0515377
RPL23 ribosomal protein L23 -0.0505788
RPL32 ribosomal protein L32 -0.0481453
RPL28 ribosomal protein L28 -0.0454797
IFI6 interferon, alpha-inducible protein 6 -0.045061
RPL34 ribosomal protein L34 -0.0441046
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0435324
PKM pyruvate kinase, muscle -0.0433915
RBM47 RNA binding motif protein 47 -0.0432948
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0424755
MDK midkine (neurite growth-promoting factor 2) -0.040968
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0408973
EXT1 exostosin glycosyltransferase 1 -0.0395889
IFITM1 interferon induced transmembrane protein 1 -0.039549
S100A10 S100 calcium binding protein A10 -0.0392366
LY6E lymphocyte antigen 6 complex, locus E -0.0389281
RPS15 ribosomal protein S15 -0.0383193
TXNIP thioredoxin interacting protein -0.0381965
VEGFA vascular endothelial growth factor A -0.0370974
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0364123
RPS21 ribosomal protein S21 -0.0361978
IFITM3 interferon induced transmembrane protein 3 -0.0361715
MAP4 microtubule-associated protein 4 -0.0361286
HSPB1 heat shock 27kDa protein 1 -0.0357651
HLA-A major histocompatibility complex, class I, A -0.0351027
POTEF POTE ankyrin domain family, member F -0.0342139
RPS11 ribosomal protein S11 -0.0338413
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0336242
RPS10 ribosomal protein S10 -0.0328487
ZBTB20 zinc finger and BTB domain containing 20 -0.0327637
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0324587
RPL9 ribosomal protein L9 -0.0323794
RPS14 ribosomal protein S14 -0.0318741
RPL19 ribosomal protein L19 -0.0318184
RPL31 ribosomal protein L31 -0.0313527
HMGA1 high mobility group AT-hook 1 -0.0309467
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0307999
RPS25 ribosomal protein S25 -0.030649
RPL36 ribosomal protein L36 -0.0303709
ATXN1 ataxin 1 -0.0302717
MT2A metallothionein 2A -0.0299117
ENO2 enolase 2 (gamma, neuronal) -0.0298219
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.029706
RPL15 ribosomal protein L15 -0.0291265
UPP1 uridine phosphorylase 1 -0.0287648
FAM3C family with sequence similarity 3, member C -0.0286832
LMNA lamin A/C -0.0282715
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0280469
KMT2C lysine (K)-specific methyltransferase 2C -0.0280292
OSMR oncostatin M receptor -0.0276759
STRN3 striatin, calmodulin binding protein 3 -0.0275337
KDM2A lysine (K)-specific demethylase 2A -0.0272779
SAMD12 sterile alpha motif domain containing 12 -0.0272326
RAB6A RAB6A, member RAS oncogene family -0.027067
S100A9 S100 calcium binding protein A9 -0.026883
BBX bobby sox homolog (Drosophila) -0.0264975
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0260587
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.025922
RAD51B RAD51 paralog B -0.0258929
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0257801
CDCP1 CUB domain containing protein 1 -0.0257208
AFF1 AF4/FMR2 family, member 1 -0.0256429
ERBIN erbb2 interacting protein -0.0256022
ASTN2 astrotactin 2 -0.0254751
RPL37A ribosomal protein L37a -0.025467
RPL5 ribosomal protein L5 -0.0253501
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0253378
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0252496
YY1 YY1 transcription factor -0.0252204
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0252117
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.024874
EGFR epidermal growth factor receptor -0.0248687